• Oscine Therapeutics, a new biotechnology company based on discoveries made and developed at the University of Rochester Medical Center (URMC) has received a significant multi-year investment to support both research and development of cell-based therapies for neurological disorders. (rochester.edu)
  • Neurological disorders are complex diseases, but in many instances it appears that faulty support cells of the brain are driving the disease process," said Goldman, the URMC Distinguished Professor of Neuroscience and Neurology. (rochester.edu)
  • This results in the disruption of communication between nerve cells, leading to the motor, cognitive, and behavioral symptoms of these disorders. (rochester.edu)
  • In research involving animal models of these diseases, this approach has slowed, and for some disorders even reversed, disease progression. (rochester.edu)
  • We discuss the efficacy of HBOT in treating neurological conditions and neurodevelopmental disorders in both humans and animal models. (mdpi.com)
  • Research in Dr. Guo-li Ming's laboratory centers on understanding molecular mechanisms underlying neurodevelopment and how its dysregulation may contribute to developmental neurological disorders. (upenn.edu)
  • In recent years, many studies including ours have shown that as an endogenous growth factor and immune system modulator factor, GCSF is beneficial in models of neurological disorders such as stroke and traumatic brain injury," said Jang-Yen (John) Wu, Ph.D., corresponding author, distinguished professor of biomedical science in FAU's Schmidt College of Medicine, and a member of the FAU Brain Institute (I-BRAIN). (sciencedaily.com)
  • Early-life environmental stress is a powerful disposing factor for later neurological and psychiatric disorders. (mcknight.org)
  • Suitable candidates should have a PhD by the start date and hold some expertise in any of the following areas: psycholinguistics, neuroimaging, child language development and disorders, or connectionist modeling of cognitive processes. (cllrnet.ca)
  • These studies take advantage of murine models relevant to neurodevelopmental disorders, Parkinson and Huntington diseases, and depression . (igbmc.fr)
  • We are also testing known and newly characterized retinoids for treatment of such brain disorders in relevant animal models. (igbmc.fr)
  • Led by Mohammed A. Junaid, PhD, head of IBR's Structural Neurobiology Laboratory, the study was conducted in mice that are models of neurological disorders in humans. (medicalnewstoday.com)
  • Encouraging early results in tinnitus patients suggest that VNS-directed neural plasticity might be useful for treating other common neurological disorders, including amblyopia, stroke, dyslexia, and autism. (berkeley.edu)
  • Selective Neuromodulation Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy. (umn.edu)
  • Medical disorders and behavioral applications. (nemours.org)
  • Initial behavioral disturbances are commonly mistaken for those of various psychiatric disorders. (medscape.com)
  • Although there are methodological inconsistencies, the evidence suggests that pesticide exposures are associated with performance deficits and an increased reporting of developmental and behavioral problems in children. (cdc.gov)
  • The study is the first to report on the neuroprotective effect of GCSF in vivo and showed that it improved neurological deficits that occur in the first few days following cerebral ischemia. (sciencedaily.com)
  • Results showed that GCSF improved neurological deficits that occur in the first few days following cerebral ischemia and improved long-term behavioral outcomes while also stimulating a neural progenitor recovery response. (sciencedaily.com)
  • Hematoma volume and neurological deficits were measured 24 hours later by diaminobenzidine staining and different behavioral tests. (unav.edu)
  • The brain microvasculature has recently emerged as a major determinant of sepsis-associated brain dysfunction, yet the mechanisms that underlie its associated neuroimmune perturbations and behavioral deficits are not well understood. (biorxiv.org)
  • However, studies conducted by John et al 9 , using a combination of behavioral and objective assessments (visually evoked potential recordings), provided strong evidence of a neurosensory origin for visual acuity and contrast sensitivity deficits previously reported in infants and children with DS 7 . (bvsalud.org)
  • Similar to what happens in other fields of biomedical science, the use of animal models might be one of the ways to fill in the knowledge gaps in the areas related to both the visual deficits and motor dysfunction associated with DS. (bvsalud.org)
  • Stroke results in local neural disconnection and brain-wide neuronal network dysfunction leading to neurological deficits. (lu.se)
  • We have access to a range of adult and child participants including children with specific language impairment, dyslexia and other neurological impairments. (cllrnet.ca)
  • Activated microglia and subsequent release of pro-inflammatory cytokines result in neuroinflammatory status which further damage neurological function including cognitive impairments in various neurological conditions. (imperial.ac.uk)
  • Collectively, our data provide evidence that activated microglia and complement cascade c1q signaling in the hippocampus may account for synaptic loss and cognitive impairments in a mouse model of neuroinflammation induced by repeated LPS injections. (imperial.ac.uk)
  • Animal models of disease: Fly model causes neurological rethink. (tcd.ie)
  • As reported at the 2016 Epilepsy Pipeline Conference and the 2016 Rett Syndrome Research Symposium , ANAVEX 2-73 demonstrated dose-related and significant improvements in an array of behavioral and gait paradigms in a mouse model with a MECP2-null mutation that causes neurological symptoms that mimic Rett syndrome. (anavex.com)
  • Students explore psychodynamic, humanistic, cognitive-behavioral, and developmental foundations and examine clinical applications and topics that include autism spectrum disorder, school interventions, brain injury, and trauma. (nationalccrs.org)
  • Neurological Sciences. (wikipedia.org)
  • Dr. Mills collaborates with researchers in the Department of Neurosurgery , the Division of Geriatric and Neuropsychiatry in the Department of Psychiatry and Behavioral Sciences and in the Division of Nuclear Medicine within the Department of Radiology to translate neuroimaging and neurophysiology findings into clinical applications. (hopkinsmedicine.org)
  • New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences. (nih.gov)
  • Symptomatic treatment for HD can be divided into drugs to treat the movement disorder and drugs to treat psychiatric or behavioral problems. (medscape.com)
  • Hysterectomy and hormonal dysregulation in functional neurological disorder: A comment on Stone et al. (tilburguniversity.edu)
  • Hence, epilepsy is not just a trying neurological disorder for individuals but also a broader public health challenge for society (1,4-7). (cdc.gov)
  • Neurodevelopmental disorder with or without anomalies of the brain, eye, or heart (NEDBEH) is a neurological disorder that can also affect many other body systems. (medlineplus.gov)
  • This condition primarily affects neurological development, causing intellectual disability, delayed development of speech and motor skills (such as sitting and walking), or autism spectrum disorder , which is a condition that affects communication and social interaction. (medlineplus.gov)
  • Goldman's work has focused on understanding the basic biology and molecular function of support cells in the central nervous system, devising new techniques to precisely manipulate and sort these cells, and studying how cell replacement could impact the course of neurological diseases. (rochester.edu)
  • In many neurological diseases, such as multiple sclerosis and Huntington's, glial cells have impaired development and function, or are simply lost during the course of the disease. (rochester.edu)
  • Optogenetics has been widely used to interrogate the causal functions of the activity and plasticity of specific neuronal circuits in behaviors and neurological diseases (e.g. (frontiersin.org)
  • As is the case with other neurological diseases, HD makes individuals more vulnerable to side effects from medications, particularly cognitive adverse effects. (medscape.com)
  • We also investigate the therapeutic potential of specific retinoids in neurological and psychiatric diseases. (igbmc.fr)
  • To address these questions, we use genetic, pharmacological or behavioral mouse models of specific diseases, as well as CRISPR- and viral-based approaches to control gene expression. (igbmc.fr)
  • The type-5 metabotropic glutamate receptor (mGluR5) has been shown to modulate brain plasticity and function, and is a therapeutic target in neurological diseases outside of stroke. (lu.se)
  • We investigated whether mGluR5 influences functional recovery and network reorganization rodent models of focal ischemia. (lu.se)
  • The Defense Intrepid Network for TBI and Brain Health (Intrepid Network), a group of 13 TBI clinics that includes two OCONUS sites, treats these symptoms using a comprehensive interdisciplinary model of care. (health.mil)
  • [ 4 ] This led to the development of a reductionist medical model with a dualist outlook influencing management of conversion symptoms. (medscape.com)
  • In the 20th century, thinking was influenced by Freud's psychoanalysis model, and he and Breuer speculated on possible neurological mechanisms of conversion symptoms and coined the term "conversion" to signify the substitution of somatic symptoms for repressed emotions. (medscape.com)
  • In behavioral models, conversion symptoms are viewed as a learned maladaptive behavior that is reinforced by the environment. (medscape.com)
  • We did not expect to detect any neurological damage in our mouse model that lacks our protein of interest, as they had no symptoms when they were younger. (eurekalert.org)
  • Primary and secondary endpoints include safety as well as Rett syndrome conditions such as cognitive impairment, motor impairment, behavioral symptoms and seizure activity. (anavex.com)
  • Learn about biological, psychodynamic, and cognitive-behavioral models through the example of depression. (films.com)
  • While acute brain dysfunction is common among all sepsis patients, chronic neurological impairment is prevalent among sepsis survivors. (biorxiv.org)
  • Combining these different approaches in a multimodal analysis could yield significant advances in understanding the neurocognitive mechanisms of play, and provide the basis for developing biologically grounded play models. (frontiersin.org)
  • He received his Ph.D. at the Massachusetts Institute of Technology, studying the neural mechanisms of early motor control in the juvenile songbird model system. (nih.gov)
  • Thanks to a mutant mouse model that more closely mimics human jaundice, Dr. Guilia Bortolussi is performing molecular, tissue and behavioral analysis to better understand the molecular mechanisms that damage the brain and testing therapies that could improve brain protection. (axa-research.org)
  • To do this, they use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. (nih.gov)
  • In the current study, mice received intraperitoneal administrations of LPS (0.5 mg/kg, daily, Escherichia coli O55:B5) for seven consecutive days and their different cohorts were used for behavioral assessment with open field, Y maze, and novel object recognition test or for electrophysiology recordings of mEPSC, LFP or LTP in in vivo or ex vivo preparation. (imperial.ac.uk)
  • The lab uses data collected from patients during epilepsy monitoring or in the operating room during DBS procedures to construct and calibrate the computational models. (hopkinsmedicine.org)
  • Research in our lab uses a variety of computational, behavioral and neuroimaging techniques including connectionist modeling, eye tracking, functional MRI and ERP. (cllrnet.ca)
  • Computational tools such as pharmacokinetic models can provide information that improves our understanding of exposure in Anniston. (cdc.gov)
  • We recruited 242 patients who had a stroke using convenience sampling from the neurological outpatient clinic. (nursingcenter.com)
  • The information-motivation-behavioral skills model is potentially a predictive model for self-management for patients who had a stroke. (nursingcenter.com)
  • In addition, using this model for the development of self-management interventions for patients who had a stroke could be a strategy for improving self-management in patients with stroke. (nursingcenter.com)
  • Using a mouse model, researchers investigated the efficacy of GCSF beyond the typical four-hour thrombolytic therapy (tPA) clot-busting drug -- the gold standard to treat stroke for global ischemia. (sciencedaily.com)
  • Researchers used a mechanism-based therapeutic approach for stroke first to examine the connection of mitochondrial, autophagy and ER stress inhibition in the protective action of GCSF and then to analyze relevant ER stress pathways in the bilateral common carotid artery occlusion (BCAO) model of stroke. (sciencedaily.com)
  • They confirmed the neuroprotection of GCSF gene therapy in the BCAO mouse stroke model by a decrease of dynamin-related protein (DRP1), a marker of mitochondrial stress, in the frontal and middle brain of the GCSF treated group. (sciencedaily.com)
  • Using multiple behavioral tests we observed that treatment with negative allosteric modulators (NAMs) of mGluR5 (MTEP, fenobam, and AFQ056) for 12 days, starting 2 or 10 days after stroke, restored lost sensorimotor functions, without diminishing infarct size. (lu.se)
  • Network Plasticity in Adaptive Filtering and Behavioral Habituation. (tcd.ie)
  • Our recent demonstration that map plasticity aids discrimination learning but is not needed for accurate discrimination (Neuron, 2011) suggests that a new model of brain function is needed. (berkeley.edu)
  • The model also predicts that small numbers of neurons could generate phantom percepts such as chronic pain and tinnitus, which might be reversed using large scale plasticity. (berkeley.edu)
  • Similarly to gedunin, a closely structurally related compound also found in Azadirachta indica, deoxygedunin has additionally been found to activate HSF1 and induce Hsp70, and was observed to possess neuroprotective effects in a model of Huntington's disease. (wikipedia.org)
  • A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)
  • Limitations in animal and cellular models have narrowed the study of this disease. (axa-research.org)
  • Dr Tamara Jamaspishvili is a research pathologist, translational research scientist focusing on developing, evaluating, validating, and applying tissue-based prognostic and predictive biomarkers and models for improved disease prognostication and management of cancer patients. (upstate.edu)
  • Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
  • Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)
  • IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model. (lu.se)
  • Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model. (lu.se)
  • Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease. (lu.se)
  • Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)
  • Compared to the parent murine MAbs, the human-chimeric IgM antibody had identical serological activity to CSGVs in ELISA and demonstrated equivalent reactivity compared to human immune sera in the MAC-ELISA.IMPORTANCEOrthobunyaviruses in the California serogroup cause severe neurological disease in children and adults. (cdc.gov)
  • [ 16 ] This model may facilitate further research into the pathophysiology of the disease and broaden its therapeutic options. (medscape.com)
  • The Charcot-Marie-Tooth Association (CMTA) announced today that it has entered into a collaboration with Affectis Pharmaceuticals AG to evaluate the efficacy of advanced Affectis compounds in neurological and behavioral models of CMT1A. (pr4links.com)
  • GCSF improved long-term behavioral outcomes while also stimulating a neural progenitor recovery response in a mouse model. (sciencedaily.com)
  • Pairing brief pulses of vagus nerve stimulation (VNS) with tones is sufficient to eliminate both the neural and behavioral correlates of tinnitus in rats (Nature, 2011). (berkeley.edu)
  • The models can be manipulated to explore functional changes and treatment possibilities. (hopkinsmedicine.org)
  • In contrast, comparing wild-type and Cnp −/− mice without/with NMDAR1-AB regarding hippocampal learning/memory and motor balance/coordination revealed distinct stair patterns of behavioral pathology. (nature.com)
  • The effect of CM-352 could be related to MMP-10 inhibition since Mmp10 -/- mice showed lower hemorrhage volume, better neurological score, reduced IL-6 levels and neutrophil infiltration, and increased PAI-1 after experimental ICH. (unav.edu)
  • Experimental therapies for HD currently are being tested in animal models and human trials. (medscape.com)
  • The laboratory focuses on developing new therapies for brain and skull base tumors, and has established the first primary skull base chordoma xenograft mouse model. (hopkinsmedicine.org)
  • Objectives: We evaluated the effects of CM-352 (MMP-fibrinolysis inhibitor) in an experimental ICH model associated with oral anticoagulants as compared with clinically used prothrombin complex concentrate (PCC). (unav.edu)
  • By the conclusion of this session participants should be able to discuss in small groups problems related to preclinical experimental models of SCI. (cns.org)
  • Cardiovascular and behavioral risk factors were observed more among patients with HAND compared to no-HAND. (who.int)
  • Future studies will evaluate the utility of these unique cells in cell-replacement paradigms for the treatment of PD like animal models. (scirp.org)
  • NLP's creators claim there is a connection between neurological processes (neuro-), language (linguistic) and behavioral patterns learned through experience (programming), and that these can be changed to achieve specific goals in life. (iiba.org)
  • Working with scientists in other disciplines including medicine and computer science, the psychological researchers hope their models will help clinicians identify and help individuals in immediate danger of dying by their own hand. (psychologicalscience.org)
  • Psychological tests can indicate other neurological testing. (films.com)
  • Researchers tested behavioral performance on corner and locomotor tests, used as an indicator of brain injury. (sciencedaily.com)
  • Recent studies using the information-motivation-behavioral skills model reported that the model is effective for predicting and explaining self-management behavior in chronically ill patients. (nursingcenter.com)
  • The negative effects observed in these pups were behavioral changes, including increased ultrasonic vocalizations, greater anxiety-like behavior, and hyperactivity. (medicalnewstoday.com)
  • Dr. Goodman's laboratory studies the molecular events that give rise to the sensation of touch and temperature using C. elegans nematodes as a model system. (nih.gov)
  • The platform offers diversified arrays of behavioral tests in an environment that is very close to other state-of-the-art laboratory facilities. (lu.se)
  • We have been using two complementary model systems, the genetically modified mouse system and patient-derived induced pluripotent stem cell (iPSC) model systems. (upenn.edu)
  • Our mechanistic studies are guided by combination of genomic, proteomic and metabolomic data from clinics and mouse models. (igbmc.fr)
  • METHODS: The ALI mouse model was established by intratracheal administration of lipopolysaccharide (LPS) and evaluated by haematoxylin and eosin (HE) staining, lung injury score, inflammation factors, polymorphonuclear leukocyte (PMN) count, total protein and lung wet weight/dry weight (W/D) ratio. (bvsalud.org)
  • One of the obvious advantages in the use of animal models, especially the mouse (Mus musculus), is our ability to perform scientific studies that are technically or ethically not permissible in human beings. (bvsalud.org)
  • One mouse model in particular, the Ts65Dn, has been used preponderantly in the area of DS research. (bvsalud.org)
  • A knock-out mouse model similar to the mut0 human form of methylmalonic acidemia has been developed. (medscape.com)
  • Studies in this field have yet to establish precisely whether the presentation of the ophthalmological abnormalities associated with DS is primarily of optical or neurological origin. (bvsalud.org)
  • Severe jaundice can lead to permanent neurological damage and ultimately death. (axa-research.org)
  • It is unknown why some people with NEDBEH have only neurological problems and others also have structural abnormalities. (medlineplus.gov)
  • Reduction of Seizure occurrence from exposure to auditory stimulation in individuals with neurological handicaps: A randomized controlled trial. (mindresearch.org)
  • Similarly, we could use pharmacokinetic modeling to determine whether an exposure 25 years ago could have caused blood levels seen today. (cdc.gov)
  • Some affected individuals have additional neurological features, such as weak muscle tone (hypotonia), behavioral problems, and seizures. (medlineplus.gov)
  • This investment underscores the cutting-edge nature of the neurological cell therapy research program at URMC," said Steve Dewhurst, Ph.D., vice dean for Research at the University of Rochester School of Medicine and Dentistry. (rochester.edu)
  • A challenge for current research is to converge on a common definition and measurement system for play - whether examined at a behavioral, cognitive or neurological level. (frontiersin.org)
  • This research will discuss the CybHER model for engaging and supporting young women in cybersecurity while anchoring them to this field. (hawaii.edu)
  • We summarize by discussing the challenges in this field, and explore future directions that will allow the scientific community to better understand the molecular aspects and applications of HBOT for a wide variety of neurological conditions. (mdpi.com)
  • tional models to understand how brain function is affected by neurological conditions and how this abnormal function might be corrected or minimized by neuromodulation through electrical stimulation. (hopkinsmedicine.org)
  • The behavioral platform offers setups for motor and cognitive testing. (lu.se)
  • Although statistically not-significant, the trend for cardio- metabolic and behavioral risk factors (hypertension, diabetes mellitus, dyslipidemia, smoking, alcohol and khat use) was higher in the group diagnosed with HAND. (who.int)
  • This patient-centric approach includes traditional rehabilitation, neurological, and behavioral health treatments combined with integrative medicine interventions and skills-based training. (health.mil)
  • Idea: Create a center for complex care transitions to improve the process for young adults (age 16-25) with complex medical needs transitioning from a pediatric to an adult care model to decrease stress to patients and caregivers navigating a complex care system. (clevelandclinic.org)
  • Of these, several have small financial initiatives to assist with medical services for low-income patients, and others have used the Behavioral Risk Factor Surveillance System to develop state estimates of epilepsy's prevalence (7,8). (cdc.gov)
  • 16 y) forms progress slowly, and patients tend to present with behavioral disturbances or decreased cognitive function. (medscape.com)
  • That is why authors decided to study behavioral and MRI changes in a porcine SCI model. (cns.org)
  • The study confirmed reliability and reproducibility of the proposed model of incomplete SCI in minipigs. (cns.org)
  • She received her M.P.H. in Community Health Education and her Ph.D. in Social and Behavioral Epidemiology from the University of Minnesota. (nih.gov)
  • Behavioral health topics of particular interest are identified here, and include clinically appropriate tools, guides and resources. (triwest.com)