Metastatic castration-resistant prostate cancerTestosteroneTesticlesUndesirable behaviorsCalvesProstateMalesDecreaseChemicalAggressive behaviorMale cat'sAnalgesiaAggressionTesticularCircumcisionRoutine2023IncisionRiskyBehavioralBeef cattleSurgical proceduresSexualTestesTerritorialTendOnset2022ResistanceHealthAdultSubsequentEffectsReducesExhibitDogsPatientsConsistentProcedurePhysicalEffectConsequencesPersonalityAnimalsTreatmentHormonesMethodDevelopmentCommonImpact
Metastatic castration-resistant prostate cancer3
- ERLEADA ® has shown a statistically significant improvement in OS with a consistent safety profile in both approved indications of mCSPC (TITAN) and non-metastatic castration-resistant prostate cancer or nmCRPC (SPARTAN). (jnj.com)
- The US Food and Drug Administration (FDA) has approved niraparib and abiraterone acetate (Akeega, Janssen Pharmaceuticals) to treat BRCA -positive, metastatic castration-resistant prostate cancer in adult patients with deleterious or suspected deleterious disease, as determined by an FDA-approved test. (medscape.com)
- About 10% - 15% of patients who develop metastatic castration-resistant prostate cancer have BRCA gene alterations, and those patients are more likely to have aggressive disease, poor outcomes, and shorter survival. (medscape.com)
Testosterone6
- The first use of chemical castration occurred in 1944, when diethylstilbestrol was used with the purpose of lowering men's testosterone. (wikipedia.org)
- The antipsychotic agent benperidol was sometimes used to decrease sexual urges in people who displayed what was thought of as inappropriate sexual behavior, and as likewise given by depot injection, though benperidol does not affect testosterone and is therefore not a castration agent. (wikipedia.org)
- How does testosterone alter cell behavior? (helix.com)
- Similarly, testosterone-depletion treatment (either surgical removal of both testicles or [[chemical castration]]) is used to greatly reduce sexual drive or interest in those with sexual drives, obsessions, or behaviors, or any combination of those that may be considered deviant. (wikidoc.org)
- peacock blenny Salaria pavo: effects of castration, aromatase inhibition, testosterone and estradiol. (thewebsiteofeverything.com)
- Two experiments were conducted to investigate a 1 mL intratesticular zinc (100 mg Zn) injection administered into each testicle at weaning (Z) and its effects on growth, health, behavior and testosterone. (uark.edu)
Testicles4
- Cryptorchid horses usually exhibit standard stallion behavior, but visibly/palpably lack one or both scrotal testicles. (acvs.org)
- Closed castration describes removing the testicles along with the tunics without making an incision into the tunics. (dvm360.com)
- In males, the process is called castration, in which the male cat's testicles are entirely removed. (gatoisland.com)
- Castration refers to the male and its the process where the testicles are removed. (shpetcare.com)
Undesirable behaviors2
- Although in practice, the goal would be to use rewards to encourage desirable behavior, many undesirable behaviors are encouraged because of rewards. (vcahospitals.com)
- It prevents a range of health issues, undesirable behaviors, and the birth of unwanted kittens. (catsworldclub.com)
Calves5
- The main reasons calves are castrated are to reduce meat toughness, remove aggressive behavior and dark cutters. (thecattlesite.com)
- After castration, calves start loosing weight and their average daily gain drops for a period. (thecattlesite.com)
- Rubber banding may be, if done appropriately less stressful and safer for young calves particularly because surgical castration is often associated with severe complications such as infections and hemorrhages. (thecattlesite.com)
- Zinc castrated calves spent more time on their side compared to B one day post castration (P = 0.03) until d 3 and 4 where B spent more time on their side (P ≤ 0.02). (uark.edu)
- Injecting zinc, as formulated and administered in these trails, does not result in complete castration of beef calves at this age and therefore cannot be considered a true castration alternative. (uark.edu)
Prostate3
- RARITAN, N.J., February 8, 2021 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today results from the final analysis of the Phase 3 TITAN study, which demonstrated the continued statistically significant benefit of the addition of ERLEADA ® (apalutamide) to androgen deprivation therapy (ADT) in overall survival (OS) in patients with metastatic castration-sensitive prostate cancer (mCSPC), regardless of extent of disease, when compared to placebo plus ADT. (jnj.com)
- In prostate cells, AR regulates other genes that are important for cell duplication-a helpful behavior during embryonic development when the body needs to generate more cells to build organs. (helix.com)
- Docetaxel is a primary chemotherapy agent used for the treatment of Castration-Resistant Prostate Cancer (CRPC) ( 1 , 2 ). (iiarjournals.org)
Males2
- Effect of castration in adolescent and young adult males upon further changes in the proportion of bare and hairy scalp. (wikidoc.org)
- For example, the claim is ' Biological males that were castrated at birth and raised as females often still identify and act like males ' , which clearly refers to the ' biological males ' as being ' raised as females ' after castration, not being females after castration. (stackexchange.com)
Decrease2
- When a pet's actions result in unpleasant consequences (e.g., deterrents), the chances of repeating the behavior will decrease. (vcahospitals.com)
- Usually a decrease in hormonally related sexual behaviors, such as mounting, flagging and marking etc. (justweimaraners.com)
Chemical15
- Chemical castration is castration via anaphrodisiac drugs, whether to reduce libido and sexual activity, to treat cancer, or otherwise. (wikipedia.org)
- Unlike surgical castration, where the gonads are removed through an incision in the body, chemical castration does not remove organs, nor is it a form of sterilization. (wikipedia.org)
- Chemical castration is generally reversible when treatment is discontinued, although permanent effects in body chemistry can sometimes be seen, as in the case of bone density loss increasing with length of use of depot medroxyprogesterone acetate (DMPA). (wikipedia.org)
- In May 2016, The New York Times reported that a number of countries use chemical castration on sex offenders, often in return for reduced sentences. (wikipedia.org)
- full development is less common unless chemical castration is combined with feminizing oestrogen therapy. (wikipedia.org)
- Chemical castration was often seen as an easier alternative to life imprisonment or the death penalty because it allowed the release of the convicted. (wikipedia.org)
- Leuprolide acetate is an LHRH agonist that is most commonly used in chemical castration today. (wikipedia.org)
- Psychotherapy has also recently been used in conjunction with chemical castration in order to maximize and prolong the beneficial results. (wikipedia.org)
- Chemical castration therapy reduces an individual's libido which then makes some offenders more responsive to the introduction of psychotherapy. (wikipedia.org)
- Offering criminals the option of chemical castration for a reduction in sentence is an example of compulsory sterilization as it can leave a subject sterile if they are required to continue treatment for more than 3 years. (wikipedia.org)
- Some criminologists argue that the appearance of a lower recidivism rate in male sex offenders who take chemical castration treatment than in those who do not can be explained by factors other than biological effects of the medication. (wikipedia.org)
- Chemical castration is an ethically interesting alternative to surgical castration and can improve the dog immediate welfare because the implant is reported to induce the same positive effect as surgical castration with regard to aggression, fear and play behavior ( 3 ) while avoiding a general anesthesia and pain from the surgery ( 4 - 6 ). (frontiersin.org)
- Chemical Castration==== Chemical castration is a form of temporary castration caused by hormonal medication. (wikidoc.org)
- In the case of chemical castration, ongoing regular injections of [[anti-androgen]]s are administered. (wikidoc.org)
- Chemical castration seems to have a greater effect on bone density than physical castration. (wikidoc.org)
Aggressive behavior1
- Aggressive behavior, while in part is a learned response, can easily be contributed to by unsettled sex drives in dogs. (professorshouse.com)
Male cat's1
- In this blog, our Danbury vets share the details of neutering you should know, including what to expect after your male cat's procedure, such as recovery and behaviors. (catsworldclub.com)
Analgesia1
- 2022. Evaluating pain and analgesia effectiveness following routine castration in rabbits using behavior and facial expressions. (awionline.org)
Aggression1
- Aggression is more along the lines of his desire to eat the mail carrier or a desire (with matching behavior) to eat the dog being walked on the other side of the street. (professorshouse.com)
Testicular1
- Castration eliminates the risk of testicular cancer. (wikidoc.org)
Circumcision1
- Discussion of castration, circumcision, and more. (netflix.com)
Routine2
- Immature horses may be undetected until they are examined just prior to routine castration. (acvs.org)
- Any change in the environment or the daily routine may contribute to the emergence of behavior problems. (vcahospitals.com)
20232
- 2023. Behavior of piglets in an observation arena before and after castration with local anesthesia. (awionline.org)
- 2023. Validation of the Unesp-Botucatu pig composite acute pain scale (UPAPS) in piglets undergoing castration. (awionline.org)
Incision1
- Open castration describes making an incision into the tunic (open) and removing the testicle, vas deferens, and associated vessels but leaving the incised tunic. (dvm360.com)
Risky2
- Free sex in adolescents can be interpreted as a variety of risky teen behaviors. (researchgate.net)
- This anonymity and ease of access, however, may delay the identification or management of risky behaviors. (jaapl.org)
Behavioral2
- The condition is considered heritable, so affected pets should be gelded to help prevent continuation of this congenital defect and for safety/behavioral reasons (although a testicle is undescended, it still produces male hormones leading to characteristic stallion behavior). (acvs.org)
- Behavior problems can be due to medical or behavioral causes, or both. (vcahospitals.com)
Beef cattle2
- The process of castration is very stressful on beef cattle and leads also to a weight loss. (thecattlesite.com)
- However, the age and method of castration have an important impact on growth performance and stress response of beef cattle. (thecattlesite.com)
Surgical procedures1
- Spaying and Castration are the surgical procedures that make your pet incapable of reproduction. (shpetcare.com)
Sexual7
- Pathologization of Sexual Behavior 2.1.2. (cirp.org)
- A variety of sexual behaviors occur online, including those that are highly unusual or even plainly illicit. (jaapl.org)
- Neutering the dog is an effective way for reducing the sexual appetite of male dogs, as well as solving some unwanted behavior issues like humping. (thedailytail.com)
- The STI hypothesis not only explains the mechanisms behind the lifestyle risk factors discussed above, namely by confounding with sexual behavior, but also why TB has ceased to be a major cause of death in Western societies. (cdc.gov)
- Paraphilic disorders must be distinguished from nonpathologic use of sexual fantasies, behaviors, or objects as stimuli for sexual excitement. (medscape.com)
- Pharmacologic interventions may be used to suppress sexual behavior. (medscape.com)
- The concert of perversions was used in Psychiatry to list sexual behaviors turning aside from the normal course. (bvsalud.org)
Testes1
- Most people think of castration as the physical destruction of testes or ovaries. (relationshipsactually.org)
Territorial1
- Reduced territorial behavior , as neutering or spraying can reduce your dog's instinct to defend a territory. (thedailytail.com)
Tend2
- He was simply recognizing a reality of our society: male/female interests and behavior tend to differ due to all sorts of cultural influences. (sciencebasedmedicine.org)
- Cats tend to have annoying behaviors when they go through their phases of "heat. (gatoisland.com)
Onset3
- These cats showed late-age onset of male behavior years after castration. (msu.edu)
- Medical consequences === A subject of castration who is castrated before the onset of [[puberty]] will retain a high voice, non-muscular build, and small genitals. (wikidoc.org)
- Castrations after the onset of puberty will typically reduce the sex drive considerably or eliminate it altogether. (wikidoc.org)
20222
- 2022. Piglets' acute responses to local anesthetic injection and surgical castration: Effects of the injection method and interval between injection and castration. (awionline.org)
- 2022. Comparative study of pain-related responses of male piglets up to seven days of age to the application of different local anaesthetics and subsequent castration. (awionline.org)
Resistance1
Health3
- What they get in return is often a happier dog with better behavior and overall better health. (professorshouse.com)
- Beyond that, as forensic psychiatrists, we have learned to explore the thin line that separates fantasy from enactment, health from psychopathology, and acceptable preferences from unlawful behaviors. (jaapl.org)
- Although there may be a single cause for a behavior problem, it is often the combined effect of the environment and learning on the pet's mental and physical health that determines behavior. (vcahospitals.com)
Adult1
- In adult male rats, spinal nucleus of the bulbocavernosus (SNB) motoneurons shrink after castration and are restored in size after androgen treatment. (jneurosci.org)
Subsequent1
Effects1
- Why is it so important to evaluate the effects of age and method of castration? (thecattlesite.com)
Reduces1
- Castration at birth or close to birth reduces drastically the weight loss and associated stress. (thecattlesite.com)
Exhibit2
- Some dogs may continue to exhibit certain behavior problems even after the surgery. (thedailytail.com)
- Even a neutered dog can exhibit some behavior problems. (thedailytail.com)
Dogs2
- After all, we are talking about the castration of dogs. (professorshouse.com)
- Hormones give us those annoying boy behaviors and bitch behaviors, but they also do things like control the closing of growth plates (in neutered dogs the growth plates close more slowly). (justweimaraners.com)
Patients1
- Based on these data, ADT alone should no longer be considered sufficient for patients with advanced, castration-sensitive disease. (jnj.com)
Consistent1
Procedure1
- Surgical castration of piglets is generally recognized as a painful procedure, but there is currently no gold standard for the assessment of pain behavior in piglets. (awionline.org)
Physical3
- If there is behavior and/or physical changes suggesting of estrus, the initial diagnostic evaluation is histological examination of vaginal epithelium. (msu.edu)
- Exempting physical abuse, it is the most destructive behavior that one person can do to the other's core sense of self. (relationshipsactually.org)
- Clothing, physical appearance and other external presentations and behaviors that express aspects of gender identity or role. (msdmanuals.com)
Effect3
- 2021. Effect of two methods and two anaesthetics for local anaesthesia of piglets during castration. (awionline.org)
- Effect of castration on performance is independent of the breed and feeding systems. (thecattlesite.com)
- Castration reduced the expression of R1 mRNA in SNB motoneurons, an effect that was blocked by androgen replacement in castrates. (jneurosci.org)
Consequences2
- If a behavior is followed by pleasant consequences such as obtaining food, attention, or affection (rewards), the behavior is likely to be repeated (positive reinforcement). (vcahospitals.com)
- These consequences could be administered unintentionally by the owners, as when the owner gives a reward following a behavior, or obtained by the pet itself through its actions (as when the pet gets a favored treat when rolling around its feeding toy). (vcahospitals.com)
Personality1
- As we said before, neutering is not a guarantee that the personality and behavior of your dog will change. (thedailytail.com)
Animals2
- Spaying is observed to cause female animals to stop mating in the same way as castration causes male animals to stop mating. (wikipedia.org)
- In most species, castration makes male mammals less aggressive both to other animals and to their owners. (dvm360.com)
Treatment1
- So there are scientists who argue that it makes no biological sense to assume that any treatment that emulates castration would remove sex drive in men but not in women. (wikipedia.org)
Hormones1
Method2
- What about the method of castration? (thecattlesite.com)
- Castration in humans has been proposed, and sometimes used, as a method of birth control in certain poorer regions. (wikidoc.org)
Development1
- What role do genetics and early experience have in the development of behavior problems? (vcahospitals.com)
Common1
Impact2
- The impact that these behaviors may have on clinical or forensic psychiatric evaluations is discussed, along with pertinent legal regulations and ethics-related considerations. (jaapl.org)
- Lack of stimulation, lack of handling, lack of exposure, insufficient socialization, and particularly stressful or traumatic events during these times can have a major impact on the pet's behavior. (vcahospitals.com)