• vaccination
  • BCG vaccination is recommended to be given intradermally. (wikipedia.org)
  • A previous BCG vaccination can cause a false positive Mantoux test, although a very high-grade reading is usually due to active disease. (wikipedia.org)
  • The World Health Organization currently recommends BCG vaccination for newborns in high-burden countries, although the protection against TB is thought to dissipate within 10-20 years. (clinicalcorrelations.org)
  • The purpose of this study is to test the safety and immunogenicity of MTBVAC as a potential substitute for BCG vaccination. (clinicaltrials.gov)
  • Occurrence of grade 3 vaccine related local and general symptoms during the 210-day follow-up period following vaccination and occurrence of serious adverse events throughout the entire study period. (clinicaltrials.gov)
  • A review looking at the pneumococcal vaccine in pregnancy found that there was not enough research to say that this vaccination reduced the number of babies developing pneumococcal disease. (wikipedia.org)
  • Faustman's team was the first to document type 1 diabetes reversal in mice and in a subsequent phase I trial demonstrated successful human clinical results who had received the BCG vaccination. (wikipedia.org)
  • Prevention of TB involves screening those at high risk, early detection and treatment of cases, and vaccination with the bacillus Calmette-Guérin vaccine. (wikipedia.org)
  • They eventually managed to open a BCG vaccination unit in St Ultan's Hospital. (wikipedia.org)
  • Only two of these conditions are generally considered to be permanent: severe (anaphylactic) allergic reaction to a vaccine component or following a prior dose of a vaccine, and encephalopathy not due to another identifiable cause occurring within 7 days of pertussis vaccination. (wikipedia.org)
  • Patients who exhibited a negative reaction to the test were considered for BCG vaccination. (wikipedia.org)
  • doses
  • As the only TB vaccine, BCG has been in use since 1921,[ and is now the most widely used vaccine worldwide, with more than 3 billion total doses given. (clinicalcorrelations.org)
  • Overall, the rate of any adverse reaction has been reported to be between 0.1% and 19% and serious adverse reactions such as osteitis, osteomyelitis, and disseminated BCG infection are rare and estimated to occur less than once per 1 million doses given. (clinicalcorrelations.org)
  • The study involves random allocation of up to 36 subjects (4 vaccine groups of 9 volunteers fulfilling the inclusion criteria) to MTBVAC (tested at three separate doses) or standard dose BCG (on a 3 verum : 1control basis) in a dose-escalation manner to one of three cohorts. (clinicaltrials.gov)
  • The National Business Group on Health (NBGH) states an analysis of pregnant women who received at least two doses had 98% effectiveness of the tetanus vaccine(NBGH, 2011). (wikipedia.org)
  • In some human trials, BCG was not found to prevent type 1 diabetes, or lead to type 1 diabetes remission in those who are newly diagnosed, although one study from Israel showed disease remission in newly diagnosed type 1 diabetes, and an observational study from Turkey suggestsed that multiple doses of the BCG vaccine in childhood may protect against the development of type 1 diabetes. (wikipedia.org)
  • anthrax vaccine
  • Pasteur had already discovered molecular chirality, investigated fermentation, refuted spontaneous generation, inspired Lister's introduction of antisepsis, introduced pasteurization to France's wine industry, answered the silkworm diseases blighting France's silkworm industry, applied bacteriology to attenuate a Pasteurella species and introduce chicken cholera vaccine (1879), and introduced anthrax vaccine (1881). (wikipedia.org)
  • In July 1880 Toussaint reported developing a technique of chemical deactivation to produce anthrax vaccine that successfully protected dogs and cattle, and was praised by the Academy of Science, but Pasteur attacked the feat-chemical deactivation and not virulence attenuation to make a vaccine-as impossible. (wikipedia.org)
  • Pasteur soon introduced his own anthrax vaccine in a highly successful public experiment, and entered commerce with it. (wikipedia.org)
  • The anthrax vaccine was administered to 25 sheep while another 25 were used as a control. (wikipedia.org)
  • tumour
  • A sample of the tumour mixed with formalin and BCG marks the malignant cells so the immune system might react and attack the cancer. (wikipedia.org)
  • complication
  • This complication carries a high mortality rate of 80-83%, and the incidence of fatality is estimated at 0.19-1.56 cases per 1 million vaccines given. (clinicalcorrelations.org)
  • This study confirms a high perioperative complication rate associated with the primary surgical treatment of BCG lymphadenitis in both HIV-positive and negative patients. (scielo.org.za)
  • trials
  • Genetic variation in BCG strains: Genetic variation in the BCG strains used may explain the variable efficacy reported in different trials. (wikipedia.org)
  • immunity
  • 0.00001), it is hypothesized that exposure to certain endemic mycobacteria, thought to be more common in lower latitudes, might provide natural immunity to the indigenous people, and the addition of BCG vaccine does not add much to this natural protection. (clinicalcorrelations.org)
  • meningitis
  • It is currently accepted that the BCG vaccine provides protection against TB meningitis and disseminated TB in children, as well as leprosy in endemic areas such as Brazil, India, and Africa. (clinicalcorrelations.org)
  • infants
  • This route of administration was stopped in 1930 following the Lübeck (Germany) disaster, in which 27% of 249 infants receiving the vaccine developed and died from TB. (clinicalcorrelations.org)
  • hepatitis
  • Hepatitis B immune globulin may interfere with the immune response to BCG. (drugs.com)
  • Contrary to what the majority of doctors may think, vaccines against hepatitis B and tetanus can be applied in any period of the pregnancy. (wikipedia.org)
  • widely
  • Although widely used, the efficacy of the vaccine in preventing pulmonary TB is uncertain, with studies showing 0-80% protective benefit. (clinicalcorrelations.org)
  • Other reasons why the observed efficacy of BCG vaccines may vary so widely is that they are produced at different sites around the world, with inconsistent quality control. (clinicalcorrelations.org)
  • immune
  • Faustman hypothesizes that BCG could induce a permanent gene expression that restores regulatory T cells (Tregs), helping to prevent the immune system attack which characterizes type 1 diabetes. (wikipedia.org)
  • clinical
  • Safety results from a Phase I human clinical trial testing the BCG vaccine in individuals with advanced type 1 diabetes were announced in June 2010. (wikipedia.org)
  • years
  • This can happen from 4 months to 2 years after the vaccine is received. (mskcc.org)
  • Venezuela's National Institute of Biomedicine soon published a note clarifying that they have been working for the previous three years on a vaccine against cancer and it is still in development. (wikipedia.org)
  • In the double-blind, placebo-controlled proof-of-concept study, six participants with long-term (mean duration of disease 15 years) type 1 diabetes were randomized to repeated BCG vaccinations (n=3) or placebo (n=3). (wikipedia.org)
  • found
  • A review into haemophilus influenza type B (Hib) and viral influenza found one good piece of research that showed the flu vaccine reduced the number of women and babies who caught flu. (wikipedia.org)
  • There was not enough research found in the review to show whether giving the Hib vaccine reduced the number of mothers and babies with Hib. (wikipedia.org)
  • BCG was found to be safe as administered in this trial, with no serious adverse events reported and only expected mild inflammation at the injection site. (wikipedia.org)
  • known
  • The duration of protection of BCG is not clearly known. (wikipedia.org)
  • Jacinto Convit García (11 September 1913 - 12 May 2014) was a Venezuelan physician and scientist, known for developing a vaccine to fight leprosy and his studies to cure different types of cancer. (wikipedia.org)
  • study
  • A retrospective study was undertaken of 23 cases of suspected ipsilateral BCG adenitis following neo-natal BCG inoculation (2001 - 2004). (scielo.org.za)
  • A randomized, double-blind, controlled Phase I study conducted at CHUV, Lausanne, Switzerland, to compare MTBVAC to licensed BCG in healthy, PPD-negative adult male and female volunteers. (clinicaltrials.gov)
  • high
  • This vaccine is generally administered to children at birth in countries with high incidence of TB. (medindia.net)
  • primary surgical treatment (incisional drainage or biopsy) is therefore not considered an ideal form of management in BCG lymphadenitis because of the high fistulisation and poor wound healing, especially in the HIV-positive patient. (scielo.org.za)
  • shown
  • The trial, based in Birmingham, United Kingdom, examined children born to families who originated from the Indian Subcontinent (where vaccine efficacy had previously been shown to be zero). (wikipedia.org)
  • Koch's bacteriologists regarded a bacterial species' properties as unalterable, a position shown false by Pasteur's modification of virulence to develop vaccine. (wikipedia.org)
  • prevent
  • On June 7, 2010, a Venezuelan newspaper incorrectly announced the successful development by Convit of a new cancer vaccine intended to prevent colon, stomach and breast cancer. (wikipedia.org)