Loading...
  • tissue
  • It used to be thought that basophils that have migrated from blood into their resident tissues (connective tissue) are known as mast cells, but this is no longer thought to be the case. (wikipedia.org)
  • Although mast cells were once thought to be tissue resident basophils, it has been shown that the two cells develop from different hematopoietic lineages and thus cannot be the same cells. (wikipedia.org)
  • differentiation
  • This is highly relevant with respect to human allergy and autoimmunity because a possible modulation of B cell differentiation by basophils could point to new therapeutic targets. (jimmunol.org)
  • Using two different methods to induce PC differentiation, we found that human basophils enhance B cell proliferation, class switching, differentiation into PC, maturation of PC, and production of Igs, especially IgG. (jimmunol.org)
  • Basophil supernatants enhanced the expression of the B cell markers CD23 and CD40, which are important for B cell differentiation into IgG-producing PC. (jimmunol.org)
  • Thus, human basophils modulate B cell differentiation into Ab-producing PC. (jimmunol.org)
  • Our data demonstrate that human basophils support PC differentiation in an IL-3- and IL-4-dependent way. (jimmunol.org)
  • bind
  • Several minutes at room temperature gives the marker time to bind to the CD63 proteins on the cell membrane of the basophil. (wikipedia.org)
  • severity
  • B cell-basophil interaction might also impact the pathogenesis of autoimmune diseases as indicated by the fact that basophils are differently activated in systemic lupus erythematosus (SLE) depending on the disease severity ( 10 ). (jimmunol.org)
  • systemic
  • The term cutaneous basophil hypersensitivity (CBH) initially referred to a systemic but evanescent pattern of delayed-onset reactivity in guinea pigs sensitized to protein antigens administered without mycobacterial adjuvants (Richerson et al . (springer.com)
  • Basophils from patients with systemic lupus erythematosus show an activated phenotype, correlating to disease activity. (jimmunol.org)
  • human
  • Therefore, the interaction between human B cells and basophils and the mechanism underlying this interaction were investigated in detail. (jimmunol.org)
  • Human basophils are known to play a role in Th2 responses by producing IL-4 ( 21 ), and could theoretically support IgG and IgE production. (jimmunol.org)
  • In the current study, we therefore investigated whether human basophils and B cells interact and which mechanisms underlie this interaction. (jimmunol.org)
  • markers
  • Basophils also express several surface markers that stimulate surrounding cells, for example CD62L ( 10 ), CD40L ( 11 ), OX40-L ( 12 ), and receptor activator of NF-κB ligand ( 13 , 14 ). (jimmunol.org)
  • functions
  • Thus, basophils are well equipped to react to a wide range of signals, and to influence the functions of other cells such as B cells. (jimmunol.org)
  • Source
  • Recent evidence suggests that basophils are an important source of the cytokine, interleukin-4, perhaps more important than T cells. (wikipedia.org)