• Standards for the classification of pathogenicity of somatic variants in cancer (oncogenicity): Joint recommendations of Clinical Genome Resource (ClinGen), Cancer Genomics Consortium (CGC), and Variant Interpretation for Cancer Consortium (VICC). (cdc.gov)
  • Our understanding of the landscape of pediatric cancer genomics has improved markedly in the past 20 years with the advent of next generation sequencing and other high throughput genetic sequencing. (medscape.com)
  • She works to synthesize multi-omics datasets from a diversity of species, bringing a comparative evolutionary perspective to unlock the genomic bases of neural cell types and their resultant phenotypes. (alleninstitute.org)
  • Her research seeks to understand the evolution of complex motor behaviors in a diversity of species through a synthesis of comparative genomics and experimental neurobiology, as well as developing new methods for exploring neurogenomics questions in naturalistic field settings. (alleninstitute.org)
  • This research program will combine studies of candidate genes with large-scale gene expression analysis, several mapping approaches and comparative genomics to study the genetic basis of trait evolution in wild bird populations. (europa.eu)
  • Third, we will identify the targets for adaptive evolution during avian evolution using comparative genomics. (europa.eu)
  • We integrate a variety of interdisciplinary approaches, including comparative 'omics' (Genomics, Transcriptomics, Epigenomics and Metabolomics) and Eco-physiology to uncover the molecular basis underlying the processes of adaptive evolution. (kent.edu)
  • In chapter 5, we introduced how the concept of protein domains and corresponding architectures can be used in comparative functional genomics to provide for a fast, efficient and scalable alternative to sequence-based methods. (wur.nl)
  • As discussed in chapter 10, the here developed semantic systems biology workflows were successfully applied in the discovery of key elements in symbiotic relationships, to improve functional genome annotation and in comparative genomics studies. (wur.nl)
  • New experimental and computational techniques provide exciting opportunities to study the evolutionary history of genomes using comparative genomics. (dfg.de)
  • Insects are the most species rich class of metazoans with a huge variation in various traits making them the ideal system to investigate general principles of the evolutionary dynamics underlying major innovations based on a comparative genomics framework. (dfg.de)
  • Specifically, we solicit proposals that use a genome wide comparative approach to reveal the genomic dynamics, which underlie the evolution of novel traits. (dfg.de)
  • We do not encourage projects focusing on single-genes and/or single-organisms, nor studies and approaches with a strong focus on ecological, taxonomic, comparative physiology, population genetics or short-term adaptation. (dfg.de)
  • This includes the development of robust aging clocks and clinical biomarkers, advances in systemic rejuvenation, comparative and multi-omics approaches, applications of machine learning and artificial intelligence, better understanding of the molecular basis of aging, identification of longevity interventions in model organisms that may soon be translated to humans, and other advances. (grc.org)
  • The taxonomic status of all species of the genus Elizabethkingia was re-evaluated by comparative genomics based on whole-genome sequencing. (microbiologyresearch.org)
  • We propose a more rapid identification scheme on the basis of an in silico PCR assay derived from comparative genomics of whole-genome sequences (WGS) from 29 well-curated strains. (microbiologyresearch.org)
  • Sub-objective 1.A: Perform comparative genomics of bacterial pathogens. (usda.gov)
  • allow proceeding to the in silico comparative genomics analysis of Leishmania DNAs and annotating the sequences identified. (who.int)
  • Genome structure, comparative genomics, and bioinformatics. (lu.se)
  • Ability to plan and elaborate experimental tasks using biochemical and molecular biology methods in the fields of proteomics, genomics, transcriptomics and metabolomics. (uni-sofia.bg)
  • The goal of the Priority Programme is to exploit new methods to reveal in the insect taxon the role of: coding vs. regulatory changes, transposable elements, epigenetic regulation, gene family evolution, copy number dynamics, structural genomic rearrangements etc. in trait evolution by using multiple cutting edge quantitative OMICs resources (e.g. genomics, transcriptomics and epigenomics). (dfg.de)
  • Large-scale genomics and transcriptomics approaches have been proven to enable the identification of pathogenicity genes in fungi affecting humans or plants [ 8 ], which makes them valuable tools towards a better understanding of fungal infection mechanisms. (biomedcentral.com)
  • To address these longstanding problems we combine population genetics and population genomics, functional genetics, transcriptomics, physiology, and experimental evolution and apply them to natural and laboratory populations of D. melanogaster that are phenotypically differentiated for fitness-related traits. (unifr.ch)
  • Our master's or doctorate program in forest molecular genetics and biotechnology focuses on researching functional genomics, ecological genetics, gene expression profiling at the whole-genome scale, and genetic improvement of trees for sustainable biofuel. (mtu.edu)
  • The role of these candidates is tested using gene knock-out plants and functional characterization of confirmed candidates is performed using a combination of physiological, biochemical and genetic approaches. (mpg.de)
  • Wherever possible, functional genomics (e.g. (dfg.de)
  • Our objective was to identify genetic markers of colistin cytotoxicity that were also associated with expression of key proteins using an unbiased, whole genome approach and further evaluate the functional significance in renal cell lines . (bvsalud.org)
  • This change characterizes the movement into the era signal processing community in relation to attacking the fun- of functional genomics. (lu.se)
  • Central to this movement is an ap- damental issues of expression-based functional genomics. (lu.se)
  • eling require a broad range of signal processing approaches, Two salient goals of functional genomics are to screen for including signal representation relevant to transcription and key genes and gene combinations that explain specific cel- system modeling using nonlinear dynamical systems. (lu.se)
  • More- ing with the global understanding of functional genomics, over, signal processing is based on a holistic view of regu- with special emphasis on genomic regulation. (lu.se)
  • Your degree and research area is bespoke to you, however, our supervisors can provide projects in many areas of current interest in genetics and genomics, ranging from fundamental questions in cell biology to variation and disease in humans. (nottingham.ac.uk)
  • A writing group of cardiologists and genetics professionals updated guidance, first published in 2009 for the Heart Failure Society of America (HFSA), in a collaboration with the American College of Medical Genetics and Genomics (ACMG). (nih.gov)
  • More Dr. Chander received her PhD in Genetics and Genomics from the Human Genome Sequencing Center at Baylor College of Medicine under the mentorship of Dr. Richard Gibbs. (stanford.edu)
  • Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. (genomeweb.com)
  • My research currently focuses on the evolution of the flowering gene network in Arabidopsis and soybean, taking an interdisciplinary approach encompassing molecular genetics, genomics, biochemistry, population genetics and systems biology, with an ultimate goal of plant improvement for higher adaptation to diverse and changing environments. (csun.edu)
  • Dr. Hall's research career spans the fields of genetics, genomics, bioinformatics and data science. (yale.edu)
  • He has also served as an Associate Editor at Genome Research (2009-2014) and Genes, Genomes and Genetics (2011-2018).Most recently, Dr. Hall has played a leadership role in several large collaborative projects funded by NIH/NHGRI including the Centers for Common Disease Genomics, the AnVIL cloud-based data repository and analysis platform, and the Human Pangenome Project. (yale.edu)
  • This translational (turning discoveries into practical applications) research is focused on understanding genetics and the basis of genetic disorders in children, as well as interactions between the environment and genes that contribute to human malformations. (nemours.org)
  • We are interested in the population genetics and evolutionary genomics of adaptation , mainly by using the fruit fly Drosophila melanogaster as an experimentally tractable model. (unifr.ch)
  • The mission of the Psychiatric & Neurodevelopmental Genetics Unit Mass General is to identify and characterize the genetic basis of psychiatric, behavioral and neurodevelopmental disorders and to translate these discoveries to improvements in clinical care and public health. (massgeneral.org)
  • His approach has been highly collaborative and multidisciplinary - combining human genomics and statistical genetics with in-vitro and in-vivo characterization of model systems and human samples. (vicc.org)
  • Approaching discussions about genetics with palliative patients and their families: a qualitative exploration with genetic health professionals. (cdc.gov)
  • In 2015, the field of pathogen genomics continued to expand. (cdc.gov)
  • Recent developments in the field of pathogen genomics herald a new paradigm for analytical food microbiology in which pathogenic bacteria will be characterized on the basis of their genetic profile rather than traditional approaches relying on phenotypic properties. (intechopen.com)
  • Here we present several scenarios illustrating current and prospective roles for pathogen genomics in food inspection. (intechopen.com)
  • All fellows are required to complete one course offering in each of the program competency areas including translational genomics and bioinformatics, translational cancer research, precision medicine approaches, and ethics (maximum of 4 classes over 2 years). (mdanderson.org)
  • Reaping the benefits from these advances requires new approaches to biological and biomedical research and an increasing role for computational analysis of biological sequence data (bioinformatics). (exeter.ac.uk)
  • This module aims to discuss concepts, techniques and applications of genomics and introduces the bioinformatics methods that support them. (exeter.ac.uk)
  • Pharmacogenomics is the application of genomics technology to the development of specific drugs and its relationship with dentistry is a recent area of research. (bvsalud.org)
  • Pharmacogenomics is the application of genomics technology to the discovery and development of drugs. (bvsalud.org)
  • I explore this problem by approaching computational genomics from the perspective of an evolutionary biologist. (alleninstitute.org)
  • Because of the rapid evolution of genomic medicine, a crucial function in public health genomics is to identify evidence-based genomic applications that can improve health, inform and engage various stakeholders, and integrate genomics into ongoing public health programs . (cdc.gov)
  • To help with this daunting task, the CDC launched in 2015 the Public Health Genomics Knowledge Base in an effort to continue capturing evolving snapshots of the field while tracking the translational trajectory of genome-based discoveries into population health impact. (cdc.gov)
  • From all of us in the Office of Public Health Genomics, all the best for a happy holiday season and successful 2016! (cdc.gov)
  • My research leverages the power of the house mouse model system to address open questions in evolutionary genomics. (jax.org)
  • In March 2021, the Senate of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) established the Priority Programme "Genomic Basis of Evolutionary Innovations (GEvol)" (SPP 2349). (dfg.de)
  • However, still little is known about the genetic basis of variation and evolutionary changes in such fitness-related traits. (unifr.ch)
  • identifying nutritional biomarkers scale population-based studies with that integrates omics data, including and metabolic fingerprints of diet through laboratory and biostatistical expertise to metabolomics, hormone measurements, interventions and observational studies identify causal links between nutrition, genomics, and epigenomics within and studying their relationship with metabolic factors, and cancer. (who.int)
  • Her laboratory has focused on the use of genomics-based approaches to discover immunogenic antigen targets and to understand the molecular basis of therapeutic response and resistance. (nki.nl)
  • Our results significantly contribute to both routine laboratory experiments and large-scale genomics or transcriptomic studies in C. graminicola . (biomedcentral.com)
  • NEW YORK (GenomeWeb News) - Three US research teams have reeled in $4.9 million in funding from the National Institutes of Health to use genomics and systems biology approaches to delve into the molecular basis of Alzheimer's disease. (genomeweb.com)
  • They plan to use a systems biology approach to integrate and analyze genomic, gene expression, and pathological data from Alzheimer's patients and mouse models. (genomeweb.com)
  • Across arachnids, transcriptomic approaches may generate thousands of loci, and target‐capture methods, using the previously designed arachnid‐specific probe‐set, can target a maximum of about 1,000 loci. (researchgate.net)
  • Our main approach has been to use population genomics to identify candidate loci and polymorphisms and then to study and validate these candidates experimentally. (unifr.ch)
  • We used whole-genome sequencing to differentiate locally acquired cases in Washington on the basis of the previously identified phylogeographic population structure of Coccidioides spp. (cdc.gov)
  • During the first semester, students will gain fundamental knowledge about biochemical fields, interdisciplinary approaches and experimental methods that are important and compulsory for the four specialized modules. (uni-sofia.bg)
  • The figure shows a schematic representation of the experimental approaches taken in this project. (mpg.de)
  • Purpose of this approach is to propagate and catalyse the usage of novel and cutting edge computational and experimental techniques across groups and, eventually, the whole German research landscape. (dfg.de)
  • The theoretical part covers the molecular principles and mechanisms underlying the experimental approaches. (lu.se)
  • To investigate the genomic basis of desert adaptation in cactus mice, we built a chromosome-level genome assembly and resequenced 26 additional cactus mouse genomes from two locations in southern California (USA). (unh.edu)
  • Whether or not that happens, new sequencing approaches could in the short term facilitate large-scale decoding of smaller genomes. (the-scientist.com)
  • Previous postdoctoral training involved modified CRISPR-Cas system for increasing the efficiency of gene editing in mammalian cells/ Xenopus embryos and alternative gene therapy approach to treat various muscle disorders using the diseased mouse models. (stanford.edu)
  • Our aim is to define the molecular bases of the interactions that are established between chromatin and the components of the nuclear envelope, and determine how they 1) regulate epigenetic state of genes and their transcription, 2) participate in spatial organization of the genome, and 3) contribute to cellular functions during mammalian development. (duke.edu)
  • Genomics has revolutionised biological research in recent years. (exeter.ac.uk)
  • During the computer-based practical exercises and coursework task, you will explore some of the freely available sequence data and computational tools on which modern genomics research relies and make new discoveries. (exeter.ac.uk)
  • Our intent is to establish the Center as a focal point to enhance collaboration and accelerate the science, applications, methods and discoveries in single-cell genomics research," said Ken Livak, Ph.D., Fluidigm Senior Scientific Fellow, who will act as the Alliance Manager at the Broad Institute, overseeing research projects amongst the Center and project partners. (labbulletin.com)
  • At DFCI, she has initiated an integrated program of research and clinical activities that focuses on dissecting the basis of effective anti-tumor immunity. (nki.nl)
  • 9 Increasingly, there is recognition of the importance of implementation research to identify strategies which assist the adoption of genomics by clinicians. (nature.com)
  • A primary goal of my research is to understand the genetic bases of reproductive transition of plants (flowering) in response to environmental signals, and to clarify how these mechanisms have evolved. (csun.edu)
  • We approach these two main areas of research by utilizing a variety of genetic, cell biological and genomics tools using mouse stem cells and mouse models. (duke.edu)
  • First, we agree that the results of our review should not be read as a "death knell" for research on this topic but rather as the basis for subsequent studies with more methodologically robust designs than many of those in the 18 included RCTs. (bmj.com)
  • Research aimed at understanding the basis of mental disorders has expanded exponentially in the last decades. (elsevier.es)
  • The focus of my research is on the application of microbial genomics to address fundamental questions in emerging infectious diseases. (utsa.edu)
  • He looks forward to seeing patients in the Vanderbilt Genomics and Therapeutics Clinic and aims to translate what is learned from his research studies back to the care of his patients. (vicc.org)
  • By drawing on our pioneering scientific research, and by applying our collaborative learning approach, the course provides you with a platform for science career success. (salford.ac.uk)
  • NIH researchers included Drs. Fasil Tekola Ayele, Charles N. Rotimi and Adebowale A. Adeyemo, all at NHGRI's Center for Research on Genomics and Global Health. (nih.gov)
  • Human Heredity and Health in Africa (H3Africa) aims to enhance the ability of African scientists to use cutting-edge research approaches to study the genes and environment behind common diseases and, ultimately, to improve health in African populations. (nih.gov)
  • Beyond race: Recruitment of diverse participants in clinical genomics research for rare disease. (cdc.gov)
  • The journal was launched to meet the need in the community for a platform to publish impactful and open science that advances basic and clinical research—using genetic, genomic, omic, and systems approaches—that has the potential to revolutionize the practice of medicine. (cdc.gov)
  • We have seen the journal evolve along with the changing landscape of health and disease, including the increasing use of genome-scale approaches in medical research and clinical practice, the generation and analysis of patient- and population-level data, and the clinical implementation of these approaches in precision medicine and public health. (cdc.gov)
  • An important basis of this work is the Swedish Research Council Research Environment on Single molecule bioanalytical sensing for precision cancer diagnostics funded 2020 - 2025. (lu.se)
  • The approach and lessons learned may assist others in determining how best to integrate genomics into their healthcare system. (nature.com)
  • In her dissertation work, she sought to identify the fundamental genomic and molecular properties that characterize brain circuits for vocal learning, the basis for birdsong and human speech. (alleninstitute.org)
  • Although some aspects of the pathogenic development of C. graminicola are well-understood, the molecular basis underlying the fundamental morphological and physiological switches that are indispensable for virulence of C. graminicola is still elusive. (biomedcentral.com)
  • The sequences were analyzed in silico by BLAST searching for homologies with other DNAs deposited in the local and public data bases. (who.int)
  • Recommendations herein are considered expert opinion per current ACMG policy as no systematic approach to literature review was conducted. (nih.gov)
  • Through this collaborative effort, the Center intends to develop novel single-cell, microfluidic approaches for gene expression profiling, RNA/DNA sequencing and epigenetic analysis. (labbulletin.com)
  • Our long-term goal is to delineate the molecular bases and order of genetic, epigenetic and cellular processes that link altered expression of long ncRNAs and pathways driven by these molecules to cancer. (duke.edu)
  • The rapid adoption of data-intensive biology approaches creates enormous challenges for computational visualization techniques, which are needed to enable researchers to gain insight from their large and highly complex data sets. (iscb.org)
  • The Single-Cell Genomics Center is also expected to act as a hub for collaboration among single-cell genomics researchers in many pioneering fields, including stem cells and cancer biology. (labbulletin.com)
  • With the Single-Cell Genomics Center, we will enable researchers to access the exciting new world of single-cell genomics, catalyze discoveries and advance our understanding of this important area of biology," said Wendy Winckler, Ph.D., Director of the Genetic Analysis Platform at the Broad Institute. (labbulletin.com)
  • At Mount Sinai, Eric Schadt, director of the Icahn Institute for Genomics and Multiscale Biology, will lead an effort to build models of biological networks based on molecular, cellular, and clinical data that will be used to study Alzheimer's and identify therapeutic targets. (genomeweb.com)
  • a theoretical and practical basis for further academic studies or professional practice in areas related to molecular biology. (lu.se)
  • This course provides a good theoretical and practical basis for understanding molecular techniques, and is thus recommended for students who envision their future career in any area featuring molecular biology and/or biotechnology. (lu.se)
  • Since then, the field has expanded, with many exciting advances involving quantitative and whole-organismal approaches to aging and age-related diseases. (grc.org)
  • Here, we use a computational approach to perform genome-wide identification and analysis of 611 orthologues of the Arabidopsis thaliana flowering genes. (springer.com)
  • We are investigating the molecular consequences of HNT and the basis of the varying tolerance using a wide range of physiological approaches in addition to metabolite, enzyme activity and gene expression profiling. (mpg.de)
  • Ethical, Legal, and Social Implications of Genomics in China: A Scoping Review and Implications for Precision Public Health. (cdc.gov)
  • Here, we present the Melbourne Genomics Health Alliance demonstration project as an exemplar of a collaborative, holistic approach to phased implementation of genomics across multiple autonomous institutions. (nature.com)
  • However, numerous barriers to the implementation of genomics into clinical practice exist. (nature.com)
  • 10 Governments and organisations considering the implementation of genomics need to design a high-level, holistic model for how genomics will be delivered in the future, tailored to their own unique context. (nature.com)
  • Major breakthroughs in medical genomics have been enabled by the implementation of clinical exome sequencing (ES) for molecular diagnosis, by genomics approaches for understanding the genetic basis of complex traits and diseases, and by progress in understanding genotype–phenotype relationships. (cdc.gov)
  • The structural basis of immunology. (iscb.org)
  • Dr. Varuna Chander is a postdoctoral fellow in the Snyder lab investigating the genomic basis of human diseases, both rare and common using multi-omics and machine learning approaches. (stanford.edu)
  • However, current knowledge of the molecular basis of quinoa flowering is limited and the details of flowering genes and associated pathways in quinoa remain elusive (Jarvis et al. (springer.com)
  • However, our understanding of the molecular basis of flower initiation and development in quinoa is limited. (springer.com)
  • It is interesting to note that the study of the genetic basis of hearing loss continues to enhance the understanding of the molecular basis of normal hearing. (medscape.com)
  • She uses genetic approaches to identify novel disease genes for dominantly inherited polycystic kidney and liver diseases: a phenotypic spectrum from autosomal dominant polycystic kidney disease (ADPKD) to isolated polycystic liver disease (PCLD), and both in vitro and animal models to further disease gene mechanism investigation. (yale.edu)
  • This is an excellent example of how genomics can further our understanding on how to prevent terrible diseases that have a genetic basis," Rotimi said. (nih.gov)
  • Through our H3Africa initiative, we hope to build capacity in genomics throughout Africa so that scientists can discover genetic links for other diseases. (nih.gov)
  • In addition, we use genetic approaches such as RNA interference, overexpression or GFP tagging to study the function and localization of the proteins in planta . (mpg.de)
  • Organisations and governments seeking to implement genomics into clinical practice face numerous challenges across multiple, diverse aspects of the health care system. (nature.com)
  • Second, we will track the genetic basis of behaviour using a unique breeding population of zebra finches and benefitting from the recently obtained genome sequence of this species. (europa.eu)
  • Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach. (bvsalud.org)
  • He holds an M.S. degree in computer sci- damental discipline that brings to genomics the structural ence from Stevens Institute of Technology model-based analysis and synthesis that form the basis of in 1986 and a Ph.D. degree in mathemat- ics from Rutgers University in 1974. (lu.se)
  • 4. A structured approach to evaluating life course hypotheses: Moving beyond analyses of exposed versus unexposed in the omics context. (massgeneral.org)