• renal
  • Immunofluorescence of normal human kidney and skin tissues revealed linear alpha5 (IV) staining in the basement membrane (BM) of glomerulus, Bowman's capsule, in some tubules and also in the epidermal BM.Renal specimens from 5 male patients of 4 families with X-linked Alport syndrome showed no reactivity for alpha5 (IV) in glomerulus, Bowman's capsules and tubules. (nii.ac.jp)
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  • Although their basement membranes may be thin and urine tests may show small amounts of blood or protein in the urine, ARAS carriers generally do not develop progressive kidney dysfunction. (kidney.ca)
  • In addition, these membranes show a distict chemical alteration c haracterized by a significant decrease in lysine, accoumpanied by an equivalent increase in hydroxylysine and hydroxylysine-linked disaccharide units. (sciencemag.org)