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Bowman'sEpitheliumEndotheliumRenalAntiglomerular Basement Membrane DiseaseCalled Anterior basement membrane dystrophyGlomerulusDystrophyEndothelialPodocytesAlveolarFiltration membraneLight microscopyStromaRuptureAnti-GBM antibodiesBasal epithelial cellsCollagen fibersDescemet'sAbnormalSecreteLayer is replacedAntigensSubepithelialTubulesCapillaryDegenerationClinicalFocalAbsentPatientsNephritisSpaceSyndromeBloodSimilarDisease

Bowman's12

• In a combined 52-week toxicity and 127-week carcinogenicity study in rats, degeneration of the kidneys and hyalinization of basement membranes and Bowman's capsule were observed at oral doses of 100 mg/kg/day (about 0.54 times the recommended human intra-rectal dose, based on body surface area) and above. (theodora.com)
• Lined by endothelial cells and supported by a basement membrane and covered by the visceral layer of Bowman's capsule. (onteenstoday.com)
• Thin basement membrane nephropathy biopsy results demonstrate cystic dilatation of the Bowman's capsule and atrophy of the glomerular tuft, with a thin glomerular basement membrane. (medscape.com)
• A filtrate derived from plasma in the glomerulus must pass through the a basement membrane of the glomerular capillaries and through slits in the processes of the podocytes- the cells that compose the inner layer of the Bowman's capsule. (flashcardmachine.com)
• Bowman's capsule (or the Bowman capsule, capsula glomeruli, or glomerular capsule) is a cup-like sac at the beginning of the tubular component of a nephron in the mammalian kidney that performs the first step in the filtration of blood to form urine. (worldsrichpeople.com)
• Lying directly below the basement membrane of the epithelium is a transparent sheet of tissue known as Bowman's layer. (johnsoncityeye.com)
• Rupture of the glomerular basement membrane and Bowman's capsule may be seen, especially if highlighted by silver stain. (surgpath4u.com)
• Where the fenestrae (windows) in the glomerular capillaries match the spaces between the podocyte "fingers," the only thing separating the capillary lumen and the lumen of Bowman's capsule is their shared basement membrane (Figure 17.4.2). (pressbooks.pub)
• Situated in the gaps between glomerular capillaries, these cells connect to the basement membrane that helps make up the capillary walls and forms part of the filter through which blood passes before entering Bowman's capsule. (thehealthboard.com)
• Their cell processes connect to the basement membrane of Bowman's capsule and the blood vessels passing through, helping to strengthen and close the glomerular entrance. (thehealthboard.com)
• The histopathology of RCES has been studied with light and electron microscopy, and anomalous structural findings have been described in three regions: the epithelium, basement membrane and Bowman's layer 3 . (eophtha.com)
• Type II (dense deposit disease): Characterized by electron-dense ribbon-like deposits along the basement membranes of the glomeruli, tubules, and Bowman's capsule, consisting mostly of complement. (msdmanuals.com)

Epithelium6

• On confocal microscopy, distinct deposits are found in the epithelium and Bowman layer. (aao.org)
• The part of the epithelium that serves as the foundation on which the epithelial cells anchor and organize themselves is called the basement membrane. (johnsoncityeye.com)
• Primary: These include conditions that affect the basement membrane of the corneal epithelium. (entokey.com)
• The ultrastructural changes which reduce adhesion of the corneal epithelium include a deficient epithelial basement membrane, the absence and abnormality of hemidesmosome, and the loss of anchoring fibrils 6 . (eophtha.com)
• The 2 main features were the presence of an irregular and thickened epithelial basement membrane duplicating or insinuating into the corneal epithelium layer, or both, and the presence of hyperreflective dots. (entokey.com)
• This dystrophy is characterized, histologically, by an abnormal basement membrane that protrudes into the epithelium and the presence of intraepithelial microcysts. (entokey.com)

Endothelium2

• Destruction of the inner corneal layers may lead to localized damage of Descemet's membrane and the corneal endothelium. (aao.org)
• The capillary wall, which serves as a filtration barrier, consists of three well-defined layers: fenestrated endothelium, glomerular basement membrane (GBM), and epithelial cell layer. (basicmedicalkey.com)

Renal4

• Coexistence of ANCAs (mostly myeloperoxidase [MPO-ANCAs]) with anti-GBM antibodies is thought to occur when the renal involvement in ANCA vasculitis leads to the exposure of antigens from the basement membrane and the formation of anti-GBM antibodies. (medscape.com)
• Goodpasture's name has been used in a more specific clinical condition known as Goodpasture disease, which is the pulmonary renal syndrome specifically associated with anti-glomerular basement membrane (anti-GBM) antibodies. (medscape.com)
• The kidney is surrounding by an outer membrane called the renal capsule. (armandoh.org)
• The fluid passes from the pores of capillaries to the basement membrane and eventually into the renal tubules through the filtrations slits of podocytes. (microbenotes.com)

Antiglomerular Basement Membrane Disease1

• Characteristics and outcome of antiglomerular basement membrane disease: a single-center experience. (arkanalabs.com)

Called Anterior basement membrane dystrophy1

• Epithelial basement membrane dystrophy (EBMD), also called Anterior basement membrane dystrophy (ABMD) or Cogan's Map Dot Fingerprint Dystrophy, and Lattice Stromal Corneal Dystrophy are other non-traumatic causes of RCES. (eophtha.com)

Glomerulus2

• The pathogenesis of anti-glomerular basement membrane (anti-GBM) disease (Goodpasture disease) is linked to the presence of autoantibodies that react with the alveolus in the lung and the basement membrane of the glomerulus in the kidney. (medscape.com)
• What is difference between Bowman capsule and glomerulus? (worldsrichpeople.com)

Dystrophy16

• Reis-Bücklers corneal dystrophy appears in the first few years of life and mainly affects the Bowman layer. (aao.org)
• A familial tendency has been reported among patients with map dot fingerprint epithelial basement membrane dystrophy (EBMD). (entokey.com)
• Fuchs endothelial dystrophy (Fuchs) is a bilateral, non-inflammatory disorder characterized by the formation of Hassall-Henle warts in between the corneal endothelial cells on Descemet membrane. (eyestein.org)
• To investigate the features of corneal epithelial basement membrane dystrophy using spectral-domain optical coherence tomography (SD OCT) and to examine the reliability of SD OCT in distinguishing epithelial basement membrane dystrophy from the normal cornea. (entokey.com)
• Forty-five individuals with epithelial basement membrane dystrophy and 45 age- and sex-matched controls with normal corneas were examined, and SD OCT scans of their corneas were performed. (entokey.com)
• In vivo confocal microscopy was performed to confirm or rule out the diagnosis of epithelial basement membrane dystrophy. (entokey.com)
• The structural corneal changes occurring in eyes with epithelial basement membrane dystrophy based on SD OCT findings were described. (entokey.com)
• Epithelial abnormalities were observed in 86 of 87 eyes with epithelial basement membrane dystrophy (45 patients) on SD OCT scans. (entokey.com)
• We found a perfect correlation between in vivo confocal microscopy and SD OCT findings in the diagnosis of epithelial basement membrane dystrophy (κ = 0.98). (entokey.com)
• SD OCT provides an accurate assessment of the structural changes occurring in eyes with epithelial basement membrane dystrophy. (entokey.com)
• Corneal epithelial basement membrane dystrophy (Online Mendelian Inheritance in Man 121820) -also known as Cogan microcystic dystrophy, map-dot-fingerprint dystrophy, or microcystic corneal dystrophy-is the most common of the anterior corneal dystrophies. (entokey.com)
• Although, as a general rule, epithelial basement membrane dystrophy is asymptomatic, approximately 10% of patients develop painful, recurrent epithelial erosions. (entokey.com)
• Over the last decade, in vivo confocal microscopy has provided greater insight into the morphologic anomalies that occur in eyes with corneal epithelial basement membrane dystrophy, thereby improving our understanding of the disease. (entokey.com)
• We performed a prospective study of patients with corneal epithelial basement membrane dystrophy seeking treatment at an ophthalmic unit in Paris. (entokey.com)
• The main aim of the study was to investigate the SD OCT features of corneal epithelial basement membrane dystrophy. (entokey.com)
• We also evaluated whether these SD OCT features permit eyes with corneal epithelial basement membrane dystrophy to be distinguished from normal eyes. (entokey.com)

Endothelial4

• Descemet's membrane is composed of collagen fibers (different from those of the stroma) and is made by the endothelial cells that lie below it. (johnsoncityeye.com)
• Advanced treatment modalities suchs as (advanced) Descemet membrane endothelial keratoplasty (DMEK) , developed by NIIOS, enable earlier intervention and improved the prognosis and rate of visual rehabilitation. (eyestein.org)
• Patients with markedly reduced visual acuity are eligible for posterior lamellar keratoplasty, and in particular Descemet stripping endothelial keratoplasty (DSEK) or Descemet membrane endothelial keratoplasty (DMEK), both techniques developed by NIIOS. (eyestein.org)
• With advanced treatment modalities, such as Descemet membrane endothelial keratoplasty (DMEK), complete visual rehabilitation may be achieved with an excellent long-term prognosis. (eyestein.org)

Podocytes1

• Podocytes secrete and maintain the basement membrane. (wikipedia.org)

Alveolar7

• Anti-glomerular basement membrane (anti-GBM) disease is a classic autoimmune disorder characterized by the presence of circulating pathogenic autoantibodies directed against proteins in the glomerular and alveolar basement membranes. (medscape.com)
• In Goodpasture syndrome , glomerulonephritis is accompanied by pulmonary hemorrhage due to anti-GBM antibodies acting on the alveolar basement membrane. (medscape.com)
• The syndrome was subsequently shown to be caused by an antibody response against antigens present in the alveolar and glomerular basement membranes. (medscape.com)
• it is found only in a few specialized basement membranes, including the glomerular and alveolar basement membranes. (medscape.com)
• These autoantibodies are believed to cross-react with the alveolar basement membrane and cause similar damage. (medscape.com)
• The degree of cross-linking of the α3NC1 hexamer subunits is approximately 3 times greater in the alveolar basement membrane than in the GBM. (medscape.com)
• When antibodies react with lung alveolar and glomerular basement membranes, it results in Goodpasture syndrome. (surgpath4u.com)

Filtration membrane2

• The major structures comprising the filtration membrane are fenestrations and podocyte fenestra, fused basement membrane, and filtration slits. (worldsrichpeople.com)
• These three features comprise what is known as the filtration membrane. (pressbooks.pub)

Light microscopy4

• On light microscopy, the Bowman layer is disrupted or absent and replaced by a sheetlike connective tissue layer with granular deposits that stain red with Masson trichrome stain. (aao.org)
• Light microscopy shows irregular thickening and thinning of the epithelial layer, which offset the ridges and furrows in the underlying stroma and the focal absences of the epithelial basement membrane. (aao.org)
• Membranoproliferative glomerulonephritis (MPGN) is characterized by a pattern of glomerular injury on light microscopy, including hypercellularity and thickening of the glomerular basement membrane. (msdmanuals.com)
• Membranoproliferative glomerulonephritis (MPGN) is characterized histologically by glomerular basement membrane (GBM) thickening and proliferative changes on light microscopy. (msdmanuals.com)

Stroma5

• Confluent, irregular, and coarse geographic opacities with varying densities develop at the level of the Bowman layer and superficial stroma, mostly centrally (Fig 7-6B). (aao.org)
• The dystrophies typically have an autosomal dominant inheritance and involve Bowman layer and stroma (3). (uiowa.edu)
• Irregular, grey-white, geographic-like opacities are located in the Bowman layer and anterior stroma. (uiowa.edu)
• Under the stroma is Descemet's membrane, a thin but strong sheet of tissue that serves as a protective barrier against infection and injuries. (johnsoncityeye.com)
• For example, intraepithelial cysts, deposits in basal epithelial cells, subbasal microfolds, reduplicated basement membrane, damaged subbasal nerves, and altered morphology of anterior stroma can be seen in MD without erosions. (entokey.com)

Rupture1

• Descemet membrane rupture may result in acute hydrops with stromal edema and subepithelial central scarring. (eyestein.org)

Anti-GBM antibodies1

• The anti-GBM antibodies can also cross-react with basement membranes in other locations such as the lung. (surgpath4u.com)

Basal epithelial cells1

• The epithelial basement membrane may be disorganized with overlying abnormalities in the basal epithelial cells. (aao.org)

Collagen fibers1

• We found that lyophilizing corneas and rehydrating them with 11 mL of BSS for 30 minutes preserved the general corneal structure, the parallelism of the collagen fibers, the Bowman layer, and the epithelial basement membrane for 15 and 30 days and for as long as 1 year or more.Conclusions: Lyophilization with sacarousis and rehydration with BSS may be a good method for anterior lamellar transplantation. (unifesp.br)

Descemet's3

• Histologic analyses of the thinned zone have shown various abnormalities in Descemet's membrane, such as disorganized and widely spaced collagen with abnormal banding and a multilaminar configuration. (aao.org)
• Descemet's membrane is generally intact, although there may be small breaks and hyaline excrescences. (aao.org)
• Descemet's membrane is regenerated readily after injury. (johnsoncityeye.com)

Abnormal1

• Abnormal basement membrane, abnormal or deficient hemidesmosomes, defective anchoring system, and accumulation of collagenous debris between and beneath epithelial cells result in easy slippage or tearing of the basal cells from the underlying connective tissue. (entokey.com)

Secrete1

• Some mucous membranes secrete mucus , a thick protective fluid. (goldrally118.click)

Layer is replaced4

• The Bowman layer is replaced with highly reflective irregular material. (aao.org)
• The Bowman layer is replaced with fibrocellular material in a pathognomonic wavy, "sawtoothed" pattern. (aao.org)
• The Bowman layer is replaced with irregular reflective material that is less reflective than in RBCD. (aao.org)
• Electron microscopy has identified areas where Bowman layer is replaced by randomly arranged collagen and fibroblasts. (aao.org)

Antigens1

• Anti-GBM disease is the result of antibodies direct against antigens in the glomerular basement membrane. (surgpath4u.com)

Subepithelial1

• Membranous nephropathy is an autoimmune disorder in which immune complexes deposit along the subepithelial region of the glomerular basement membrane. (medscape.com)

Tubules1

• Connected firmly to the membrane by cell processes and tiny tubules known as microfibrils, the bridging arrangement of each mesangial cell helps to ensure glomerular structure is stable. (thehealthboard.com)

Capillary1

• This membrane permits very rapid movement of filtrate from capillary to capsule though pores that are only 70 nm in diameter. (pressbooks.pub)

Degeneration1

• In the post-traumatic setting, upregulation of these components is thought to lead to basement membrane degeneration, aberrant epithelial basement production and poor epithelial adhesion 3 . (eophtha.com)

Clinical1

• Recurrent corneal erosion (RCE) is a clinical syndrome characterized by inadequate epithelial basement membrane adhesions, resulting in repeated episodes of corneal epithelial defects 4 . (eophtha.com)

Focal1

• Abnormalities in hemidesmosome formation and function, along with a focal absence of the basement membrane, have been reported in patients with RCES 8,14,20 . (eophtha.com)

Absent1

• 1 Bowman"s membrane is often damaged or focally absent, replaced by material that is similar to basement membrane. (reviewofoptometry.com)

Patients2

• In the majority of patients with RCES, trauma is the initiating factor, especially trauma from a scratch that damages or destroys the corneal basement membrane 6 . (eophtha.com)
• In patients with pain due to local corneal decompensation associated with relatively good visual acuity, anterior stromal micropuncture, excimer laser surface ablation (PTK) or amniotic membrane transplantation may be performed. (eyestein.org)

Nephritis1

• Anti-glomerular basement membrane (GBM) nephritis is clinically and pathologically one of the most aggressive form of glomerulonephritis. (arkanalabs.com)

Space3

• Breaks develop in the GBM, plasma proteins and cells leak into the Bowman space, and, eventually, crescents develop. (medscape.com)
• Fibrinogen leaks through the damaged GBM into the Bowman space, and it is polymerized to fibrin through procoagulant factors from activated monocytes, resulting in crescent formation. (medscape.com)
• Resident phagocytes in the mesangium are responsible for moving macromolecules trapped in the basement membrane into the urinary space. (basicmedicalkey.com)

Syndrome1

• In Alport syndrome , the glomerular basement membrane is irregularly thickened, and the central lamina densa is split and splintered into a heterogeneous network of strands, which enclose electron-lucent areas that may contain microgranulations. (medscape.com)

Blood1

• The matrix is called the basement membrane, which leads to blood filtration. (microbenotes.com)

Similar1

• In some cases, we detected hyporeflective spaces between the corneal epithelial layer and the Bowman layer similar to a corneal epithelial detachment. (entokey.com)

Disease2

• Anti-glomerular basement membrane disease: outcomes of different therapeutic regimens in a large single center Chinese cohort study. (arkanalabs.com)
• Antiglomerular basement membrane antibody mediated disease in the British Isles 1980-4. (arkanalabs.com)