AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
DepressionDepressive Disorder, MajorDepressive DisorderAntidepressive AgentsPsychiatric Status Rating ScalesDepression, PostpartumDiagnostic and Statistical Manual of Mental DisordersAntidepressive Agents, Second-GenerationCortical Spreading DepressionAnxiety DisordersElectroconvulsive TherapyDysthymic DisorderSerotonin Uptake InhibitorsComorbidityAnxietyPsychotherapyInterview, PsychologicalPersonality InventorySeverity of Illness IndexCitalopramBipolar DisorderQuestionnairesTreatment OutcomeRisk FactorsAffectFluoxetineSertralineSuicideStress, PsychologicalFollow-Up StudiesParoxetineLong-Term Synaptic DepressionPanic DisorderLongitudinal StudiesProspective StudiesMood DisordersCognitive TherapyTime FactorsLife Change EventsAffective Disorders, PsychoticPrevalenceDepressive Disorder, Treatment-ResistantSuicide, AttemptedAnalysis of VarianceNortriptylinePsychometricsAntidepressive Agents, TricyclicMental DisordersStress Disorders, Post-TraumaticDouble-Blind MethodPrimary Health CareSuicidal IdeationPersonality AssessmentCross-Sectional StudiesSerotonin Plasma Membrane Transport ProteinsNeurotic DisordersCohort StudiesNeuropsychological TestsNondirective TherapyBrainLogistic ModelsQuality of LifeUnited StatesCognition DisordersMagnetic Resonance ImagingCase-Control StudiesAdjustment DisordersSeasonal Affective DisorderHydrocortisoneGriefCyclohexanolsRecurrenceDiseases in TwinsMianserinAge of OnsetGyrus CinguliPsychotherapeutic ProcessesChild of Impaired ParentsHypothalamo-Hypophyseal SystemPrefrontal CortexAnhedoniaEmotionsSomatoform DisordersPostmortem ChangesAdaptation, PsychologicalRegression AnalysisPersonalityChronic DiseaseReproducibility of ResultsPhobic DisordersPituitary-Adrenal SystemHippocampusSocial SupportAgoraphobiaDiagnosis, Dual (Psychiatry)Premenstrual SyndromeSubstance-Related DisordersSchizophreniaPredictive Value of TestsSocioeconomic Factors
Monitoring symptomsParticipantsAnxietyRecurrentClinicalPredictorsHamilton DepreBeck Depression IAbstractPositron emission tUnipolar major depressionOutcomesAdultsGeriatric DepreReductionComorbidPatients with major depressionMethodsRemissionClinicallyDiagnosisSchizophreniaCause of disabilityConclusionsSevere major depressionPrevalentOutcomePrevalence of depressionAntidepressantDepressive episodeAssessMental illnessesSeverity of depressionModerateOnsetPsychosisPsychiatricBurdenPathophysiologySignificantlyRisk for depressionTreatment for depressionCardiovascular risk factorsIndividuals with depressionMildInterventionsDiabetesEtiologyDisabilityCognitiveEpisode of major depressionSerumMortalityEpisodesPopulationsSubjectiveDecreasesPatient Health QuestionnaireAssessmentLifetime2022Myocardial infarctionIntervention practicesPrimaryHispanicsHomocysteine
Monitoring symptoms1
  • Intervention For two years, a depression care manager worked with primary care physicians in intervention practices to provide algorithm based care for depression, offering psychotherapy, increasing antidepressant dose if indicated, and monitoring symptoms, adverse effects of drugs, and adherence to treatment. (bmj.com)
Participants13
  • A general problem of reports on the effects of exercise on depression is the lack of information about the psychiatric diagnosis of participants according to standard references-for example, the Diagnostic and Statistic Manual of the American Society of Psychiatry (DSM IV). (bmj.com)
  • Participants were also excluded if they were already undergoing antidepressant or herbal therapies or had other major illness that may affect mood or cognition. (naturalmedicinejournal.com)
  • Participants visited an automated website that distributed exercise instructions, provided email reminders, and contained the baseline and follow-up assessments. (jmir.org)
  • The policy did not have a significant impact on participants with wellcontrolled diabetes at baseline. (ajmc.com)
  • Participants with a major comorbid psychiatric disorder or suicide risk were excluded. (psychiatrictimes.com)
  • We hypothesized that, if initially elevated, symptoms of depression, anxiety, and trauma would decrease and participants' utilization of positive coping mechanisms would increase post-intervention. (stanford.edu)
  • The 1,701 non-frail participants reported their diet and depressive symptoms at baseline and were followed for ~11 years when frailty status was reassessed. (hebrewseniorlife.org)
  • Participants were assessed at baseline, 6 weeks, 1 year, and 2 years for physical health functioning (the Physical Component Summary of the 36-Item Short-Form Health Survey) and chronic medical burden (the Chronic Disease Score). (ucla.edu)
  • Our study also assessed whether SCD participants showed different cognitive and biomarker trajectories according to baseline amyloid deposition. (biomedcentral.com)
  • After 24 months, plasma amyloid markers were higher, and regional volumes (entorhinal, hippocampal, and pallidum) were smaller in the Aβ + SCD participants compared with Aβ-SCD participants adjusted by age, sex, and baseline volumes. (biomedcentral.com)
  • We planned a prospective cohort study to observe clinical progression and assess baseline predictors related with clinical progression in elderly participants with SCD. (biomedcentral.com)
  • We evaluated 94 participants with MDD from the Beck Depression Inventory (BDI-II). (bvsalud.org)
  • A major limitation is that all measurements, including major depressive episodes, are self-reported and may be affected by situational factors at work and participants' perceptions. (vu.nl)
Anxiety12
Recurrent6
  • Being able to distinguish between recurrent and nonrecurrent depression subtypes around the time of the onset would allow both acute-phase therapies and prevention strategies to become more focused and personalized. (medpagetoday.com)
  • According to the authors of an invited article in Annual Review of Clinical Psychology , an urgent research goal for major depressive disorder (MDD) should be to advance understanding of the variable lifetime course of the disorder and to determine how to best predict whether someone will follow a clinical trajectory of recurrent or nonrecurrent depression. (medpagetoday.com)
  • By distinguishing between recurrent and nonrecurrent depression subtypes, both acute-phase therapies and prevention strategies could become more focused and personalized. (medpagetoday.com)
  • In 2000, Berman et al published the first double-blind, placebo-controlled, crossover trial evaluating the use a single dose of 0.5 mg/kg ketamine over 40 minutes in eight patients with recurrent unipolar major depression and one with bipolar disorder, which showed progressive decreases in depressive symptoms within 3 days of treatment. (uspharmacist.com)
  • Bipolar disorder is characterized by recurrent episodes of mania and depression and affects about 1% of the adult population. (safetylit.org)
  • Mr Blythe" is a 29-year-old AfricanAmerican male with a history of recurrent, sever major depressive disorder (MDD) without psychosis. (psychiatrictimes.com)
Clinical20
  • The primary outcome was change in the total score for the 9 BPD criteria on a 1-to-7 Likert scale, the Clinical Global Impressions scale modified for borderline personality disorder (CGI-BPD), using an analysis of covariance model including baseline score as covariate. (psychiatrist.com)
  • As well, 40% of the patients receiving citalopram had moderate or marked improvement from baseline severity on the 7-point modified Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change score, which assesses items specific to agitation in AD. (medscape.com)
  • Results In baseline clinical interviews, 396 people were classified as having major depression, 203 had clinically significant minor depression, and 627 did not meet criteria for depression. (bmj.com)
  • Twenty-one had current diagnoses of major or minor depression on the Structured Clinical Interview for the DSM-IV. (biomedcentral.com)
  • Patients were assessed at baseline using the HAM-D as the primary outcome assessment with the Beck Depression Inventory (BDI) and Clinical Global Impression Change (CGI/C) scores for secondary outcome measurements. (naturalmedicinejournal.com)
  • Major Depression: Can We Predict Its Clinical Trajectory? (medpagetoday.com)
  • Research on predicting which individuals will experience MDD recurrence needs to start with the initial clinical episode of major depression, before multiple episodes occur, since recurrences and corresponding treatments confound comparisons. (medpagetoday.com)
  • Epidemiological and clinical studies have found associations between depression and cardiovascular disease risk factors, and coronary artery disease patients with depression have worse prognosis. (plos.org)
  • Safety outcomes included electrocardiogram (ECG), vital signs, clinical laboratory tests, adverse events, and change from baseline in the Columbia Suicide Severity Rating Scale (C-SSRS). (psychiatrictimes.com)
  • Self-reported clinical questionnaires and perceptual task performance were gathered to assess anxious-depression and metacognitive bias at baseline and 4-week follow-up. (elifesciences.org)
  • A change in rapid eye movement sleeping pattern as measured by quantitative EEG in patients with major depressive disorder after just a single week on a first-line antidepressant predicts eventual clinical response or nonresponse to the medication weeks later, Thorsten Mikoteit, MD, reported at the virtual congress of the European College of Neuropsychopharmacology. (medscape.com)
  • A prior history of clinical depression is associated with a faster deterioration of physical health in community-dwelling older adults, which is not explained by current levels of depressive symptoms and mental health functioning or by recurrence of depressive episodes. (ucla.edu)
  • Clinical guidelines recommend screening for depression in the general adult population but recognizes that the optimum interval for screening is unknown. (jmir.org)
  • This study describes a predictive analytics approach for mining clinical and patient-reported data from a large clinical study for the identification of primary care patients at high risk for depression to match depression screening intervals with patient risk profiles. (jmir.org)
  • A regression-based data mining technique was used to examine 53 demographics, clinical variables, and patient-reported variables to develop three prediction models for major depression at 6, 12, and 18 months from baseline. (jmir.org)
  • This study demonstrated that leveraging patient-reported data and prediction models can help improve identification of high-risk patients and clinical decisions about the depression screening interval for diabetes patients. (jmir.org)
  • Hence, the identification of biomarker status and baseline factors related with underlying pathologies is clinically important to predict future clinical progression. (biomedcentral.com)
  • Major depressive disorder (MDD) is known for being a common clinical condition that generates a big economic impact on health policies due to its high prevalence and its debilitating nature (Greenberg, Fournier, Sisitsky, Pike, & Kessler, 2015). (bvsalud.org)
  • The objectives of this study were was confirmed by medical evaluation nosis of major depressive disorder, at to translate and adapt the MDI into and results of the Structured Clinical least in certain countries, is connected Arabic, to test the reliability of the result- Interview for DSM Disorders (SCID). (who.int)
  • Our study shows greater CVD risk for both clinical and subclinical depres- depression, 53.2% for mild depression, and 66.5% for major de- sion, including higher lifetime CVD risk among adults aged 20 to 39 years. (cdc.gov)
Predictors1
  • This study parallels previous studies, in that physical disability and comorbid medical illness are predictors of menopausal depression. (womensmentalhealth.org)
Hamilton Depre2
  • The investigators recruited adult outpatients aged 18 years or older with TRD, defined as a depressive episode without psychotic features, a Hamilton Depression Rating Scale (HAM-D) ≥ 18, and failure to respond to an adequate dose and duration (≥ 8 weeks) of 2 to 4 pharmacological treatments for the current episode, including their current SSRI. (psychiatrictimes.com)
  • All underwent baseline evaluation using the Hamilton Depression Rating Scale (HAMD) and were placed on the first-line antidepressant of their psychiatrist's choice. (medscape.com)
Beck Depression I1
  • The primary outcome will be depressive symptoms as assessed by the Beck Depression Inventory-II (BDI-II) at baseline, three-, and six-month follow-ups. (vu.nl)
Abstract1
  • ABSTRACT The Major Depression Inventory (MDI) is a brief questionnaire to assess the presence of a depressive disorder. (who.int)
Positron emission t1
  • However, our previous study had several limitations, including a small sample size, sampling bias in a single center, and lack of biomarker information except the baseline amyloid positron emission tomography (PET) finding. (biomedcentral.com)
Unipolar major depression1
  • Adults with SPD unipolar major depression, bipolar were more likely to be female, have less than a high school diploma, and live in disorder, schizophrenia, and obsessive- poverty, and less likely to be married than adults without SPD. (cdc.gov)
Outcomes6
  • Potential baseline, process, health outcomes, and organizational change measures for these programs are listed under evaluation of depression programs. (cdc.gov)
  • Moreover, changes in these stress measures over time correlate with depression outcomes. (nih.gov)
  • Depression worsens outcomes of physical illness. (ucla.edu)
  • Baseline factors associated with cognitive outcomes were investigated. (biomedcentral.com)
  • It is important to note that the majority of patients in our study did not meet criteria for diagnosis of major depressive disorder, but many still experienced suboptimal outcomes," Dr. Cash said. (medscape.com)
  • This means that even mild symptoms of depression may interfere with head and neck cancer treatment outcomes. (medscape.com)
Adults19
  • Depression is a major cause of disability, absenteeism, presenteeism, and productivity loss among working-age adults. (cdc.gov)
  • Objective To investigate whether an intervention to improve treatment of depression in older adults in primary care modified the increased risk of death associated with depression. (bmj.com)
  • Conclusions Older adults with major depression in practices provided with additional resources to intensively manage depression had a mortality risk lower than that observed in usual care and similar to older adults without depression. (bmj.com)
  • Prospective studies have consistently shown an association between depression and increased mortality in older adults. (bmj.com)
  • The U.S. Preventive Services Task Force (USPSTF) recommends that clinicians screen all adults for depression , highlighting the importance of screening in populations at particularly high risk for depression. (womensmentalhealth.org)
  • Matt is a Developmental Psychologist whose primary research area is the prevention and treatment of common mental illnesses such as depression, with a particular focus on understanding the underlying mechanisms involved in its aetiology and pathogenesis in children, adolescents and young adults. (exeter.ac.uk)
  • Effect of Multinutrient Supplementation and Food-Related Behavioral Activation Therapy on Prevention of Major Depressive Disorder Among Overweight or Obese Adults with Subsyndromal Depressive Symptoms. (exeter.ac.uk)
  • Middle-aged and older adults with depression may be more vulnerable to the effects of dietary inflammation on the development of frailty and other health issues. (hebrewseniorlife.org)
  • Frailty, defined as a recognizable state of increased vulnerability resulting from a decline in function across multiple physiological systems, affects 10-15% older adults and often co-occurs with other health conditions, like depression. (hebrewseniorlife.org)
  • Prior depression history and deterioration of physical health in community-dwelling older adults--a prospective cohort study. (ucla.edu)
  • This study examined whether prior depression history predicts deterioration of physical health in community-dwelling older adults. (ucla.edu)
  • Three hundred fifty-one adults aged 60 years or older-145 with a history of major or nonmajor depression in full remission and 206 concurrent age- and gender-matched comparison subjects with no history of mental illness. (ucla.edu)
  • Careful screening for a history of depression may identify those older adults at greatest risk for physical declines and chronic medical burden. (ucla.edu)
  • To our knowledge , this will be the first RCT of universal primary prevention for depression in adults and the first to test a personalized intervention implemented by FPs. (bvsalud.org)
  • Among psychotherapeutic alternatives, cognitive behavioral therapy (CBT) is regarded as being the most suitable and the most researched for the treatment of depression in adults. (bvsalud.org)
  • In a meta-analysis carried out with 115 studies, which verified the effects of CBT compared to control groups, other psychotherapies, and pharmacologic intervention, it was shown that CBT is an effective treatment for depression in adults when compared to the control group (Cuijpers et al. (bvsalud.org)
  • Among working-age results from previous studies of the characteristics of adults with serious mental adults, mental illness is a major and illnesses that cause significant disability, such as severe major depression, bipolar expensive cause of lowered work disorder, and schizophrenia. (cdc.gov)
  • prevalence of mental illness and Conclusions --The associations between SPD and sociodemographic characteristics of adults with mental characteristics, health status, and health care utilization are similar to the disorders is important in planning relationships found between serious mental illnesses (for example, major depression policies for treatment and prevention, or schizophrenia) and these same variables. (cdc.gov)
  • Although an association between depression and incident cardi- forts to younger adults are warranted. (cdc.gov)
Geriatric Depre2
Reduction3
  • If patients were assessed to be at less than 50% reduction of the Hamilton Depression Rating (HAM-D) scale, the dosage was moved up to 2 capsules daily for weeks 3 and 4. (naturalmedicinejournal.com)
  • After 6 weeks, if reduction still did not improve to a 50% HAM-D reduction vs baseline, dosage was increased to 4 capsules for the remainder of the study. (naturalmedicinejournal.com)
  • A treatment response was defined as at least a 50% reduction in HAMD score from baseline to week 5. (medscape.com)
Comorbid2
Patients with major depression3
  • Patients with major depression in usual care were more likely to die than were those without depression (hazard ratio 1.90, 95% confidence interval 1.57 to 2.31). (bmj.com)
  • In contrast, patients with major depression in intervention practices were at no greater risk than were people without depression (hazard ratio 1.09, 0.83 to 1.44). (bmj.com)
  • There is a huge unmet need for a biomarker predictive of response to antidepressant medication in patients with major depression , the psychiatrist added. (medscape.com)
Methods1
  • METHODS: Women were assessed at baseline (N = 1307) and at 3- and 5-year follow-ups. (cdc.gov)
Remission4
  • Two-hundred and sixteen depressed subjects aged 60 years or older were categorized by remission status (Montgomery-Asberg depression rating scale≤6) at 6 and 12 months. (nih.gov)
  • At 6 months, greater baseline numbers of self-reported negative and total SLEs and greater baseline perceived stress severity were associated with lower odds of remission. (nih.gov)
  • At 12 months, only baseline perceived stress predicted remission. (nih.gov)
  • For many Hispanics, response to depression treatment may require a considerable amount of time to reach remission, as much as two and a half years [ 4 ] Additionally, relapse rates are high and the slow response to treatment may explain the premature discontinuation of medication by patients. (biomedcentral.com)
Clinically2
  • Both groups improved clinically in mood and subjective sleep measures from baseline, with no differences between groups. (nih.gov)
  • Baseline comparisons between people who never have any additional episodes and those who eventually experience multiple episodes could provide clinically useful information about biologic, endophenotypic, genetic, psychological, social, and other contributing factors of recurrences. (medpagetoday.com)
Diagnosis1
  • The severity of MDD, which was defined at the time of diagnosis by the self-rating Montgomery-Åsberg Depression Rating Scale, was identified as the most important prognostic factor for TRD (C index = 0.69). (medpagetoday.com)
Schizophrenia2
Cause of disability2
  • Projections assume that depression will be the leading cause of disability worldwide by 2030 ( 9 ), which might be partly due to the high comorbidity with cardiovascular diseases (CVDs) ( 10 , 11 ). (frontiersin.org)
  • 2 The World Health Organization ranks depression as a leading cause of disability, and predicts that by 2030, depression will be the leading cause of global disease burden. (uspharmacist.com)
Conclusions1
  • Conclusions -Aerobic exercise can produce substantial improvement in mood in patients with major depressive disorders in a short time. (bmj.com)
Severe major depression2
  • Objective -To evaluate the short term effects of a training programme on patients with moderate to severe major depression. (bmj.com)
  • For selected patients with moderate to severe major depression, aerobic exercise may result in a substantial improvement in symptoms in a short time. (bmj.com)
Prevalent2
  • Depression is more prevalent among women than men (about 2:1 ratio), and the median age of onset is around 25 years ( 6 , 7 ). (frontiersin.org)
  • Depression in pregnancy is prevalent, under-treated, and has serious impacts on the wellbeing of women and on child development. (biomedcentral.com)
Outcome6
  • Although he cited us,3 he overlooked the evidence we provided indicating that the Bacloville article4 was published without acknowledging major changes to the initial protocol, affecting the primary outcome. (psychiatrist.com)
  • The aim of the study was to test whether disease-specific severity indicators moderate the treatment outcome in a 6-week minimally guided web-based self-help intervention on depression and diabetes (GET.ON Mood Enhancer Diabetes (GET.ON M.E.D.)) and to determine its effectiveness in a nonsuicidal severely depressed subgroup. (hindawi.com)
  • A common comorbidity is major depressive disorder (MDD), which affects 10 to 20% of adult diabetes patients, resulting in poorer diabetes self-management, poorer general health outcome, higher frequency of secondary diseases, decreased quality of life, and a higher mortality rate. (hindawi.com)
  • Cerebellar-FPN, -SN PPI values at baseline were also associated with treatment outcome. (northwestern.edu)
  • Our primary outcome will be the cumulative incidence of major depression (measured by CIDI each 6 months) over 18 months of follow-up. (bvsalud.org)
  • The major determinant of the outcome of treatment is patient adherence to the drug regimen. (cdc.gov)
Prevalence of depression2
Antidepressant5
  • In this population-based, observational cohort study, Dr. Lundberg and his colleagues used data from the Stockholm Major Depressive Disorder (MDD) Cohort for episodes of MDD recorded between January 1, 2012, and December 31, 2017, that fulfilled the predefined criteria for TRD-at least three consecutive pharmacologic antidepressant treatments. (medpagetoday.com)
  • The median time from the start of a major depressive episode to TRD was 552 days, and selective serotonin reuptake inhibitors were the most common class of antidepressant treatment in all treatment steps. (medpagetoday.com)
  • 8 Ketamine has generated significant interest in the treatment of MDD, bipolar depression, and in depression with suicidal ideation after the publication of a number of studies demonstrating its rapid-acting antidepressant effect following low IV doses. (uspharmacist.com)
  • Psilocybin has demonstrated antidepressant properties in patients with MDD and treatment-resistant depression ( TRD ). (psychiatrictimes.com)
  • Of note, in the landmark National Institute of Mental Health-sponsored Sequenced Treatment Alternatives to Relieve Depression ( STAR*D ) study, slightly less than half of patients with major depressive disorder achieved a treatment response to their first-line antidepressant, and it took an average of 6 weeks of therapy to do. (medscape.com)
Depressive episode1
  • five men, seven women) with a major depressive episode according to the Diagnostic and Statistical Manual of the American Society of Psychiatry (DSM IV) criteria participated. (bmj.com)
Assess1
Mental illnesses1
  • In the areas of pathophysiology and etiology, psychiatry has more uncharted territory than the rest of medicine…Much of the current investigative research in psychiatry is directed toward the goal of identifying the pathophysiology and etiology of major mental illnesses, but this goal has been achieved for only a few disorders (Alzheimer's disease, multi-infarct dementia, Huntington's disease, and substance-induced syndromes such as amphetamine-related psychosis or Wernicke-Korsakoff syndrome). (mindfreedom.org)
Severity of depression1
Moderate7
  • Additionally, we examined whether within the patient sample, cardiovascular risk factors differ between patients with mild, moderate and severe depression, and whether the relationship between symptom severity and cardiovascular risk is moderated by patients' CRF levels. (frontiersin.org)
  • Few differences in risk markers were found between patients with mild, moderate and severe depression, and no interaction occurred between depression severity and CRF. (frontiersin.org)
  • A total of 57 subjects with mild to moderate major depression (MDD) were recruited for this study. (naturalmedicinejournal.com)
  • Meta-analysis has shown that in cases of mild to moderate depression, pharmaceuticals generally do not work any better than placebo, 1 which boasts a 25%-to-30% effectiveness rate. (naturalmedicinejournal.com)
  • This study pitting Rhodiola rosea against sertraline is consistent with a greater body of research that shows minimal but measurable effects for monotherapeutic approaches to mild and moderate depression. (naturalmedicinejournal.com)
  • Our objectives were (1) to examine how baseline stress and change in stress is associated with course of geriatric depression and (2) to test whether polymorphisms of serotonin transporter (5-HTTLPR) and catechol-O-methyltransferase (COMT Val158Met) genes moderate this relation. (nih.gov)
  • Consistent with similar work (15), we hypothesized that mild and cing CVD risk are therefore paramount for public health, and the moderate depression are associated with higher 10-year and life- prevalence and comorbidity of these conditions underscore the im- time CVD risk relative to no depression. (cdc.gov)
Onset6
  • Among patients experiencing first-onset depression, research has shown that some will have recurrences over their lifetime, while others will never experience another episode. (medpagetoday.com)
  • The onset of his depression was around age 20 years. (psychiatrictimes.com)
  • Preventing the onset of major depression based on the level and profile of risk of primary care attendees: protocol of a cluster randomised trial (the predictD-CCRT study). (bvsalud.org)
  • The 'predictD algorithm ' provides an estimate of the level and profile of risk of the onset of major depression in primary care attendees. (bvsalud.org)
  • We aim to evaluate the effectiveness, cost - effectiveness and cost -utility of a new intervention, personalized and implemented by family physicians (FPs), to prevent the onset of episodes of major depression . (bvsalud.org)
  • We will perform multi-level logistic regressions and will adjust for the probability of the onset of major depression at 12 months measured at baseline as well as for unbalanced variables if appropriate. (bvsalud.org)
Psychosis1
Psychiatric1
  • [ 7 ] Some degree of preoccupation with disease is apparently common, because 10-20% of people who are healthy and 45% of people without a major psychiatric disorder have intermittent unfounded worries about illness. (medscape.com)
Burden4
  • 2,3 The economic burden of depression, including MDD, bipolar disorder, and dysthymia, has also increased from an estimated $83.1 billion in 2000 to $210.5 billion in 2010. (uspharmacist.com)
  • Both physical functioning and chronic medical burden deteriorated more rapidly over time in the group with prior depression history compared with comparison subjects, and these changes were independent of the measures of mental health functioning, depressive symptoms, and sleep quality. (ucla.edu)
  • Notably, depression is recognized by the World Health Organization (WHO) as a major contributor to the overall global burden of disease. (psychiatrist.com)
  • Baseline neurodegeneration and amyloid burden were related with future cognitive trajectories in SCD. (biomedcentral.com)
Pathophysiology1
  • Genetic analysis supports the role of aldosterone and of MR-related pathways in the pathophysiology of depression. (karger.com)
Significantly2
  • citation needed] In a cardiac stress test, an ST depression of at least 1 mm after adenosine administration indicates a reversible ischaemia, while an exercise stress test requires an ST depression of at least 2 mm to significantly indicate reversible ischaemia. (wikipedia.org)
  • Baseline depressive symptoms were significantly associated with subsequent treatment interruption and poorer treatment response, but treatment response was the only significant mediator of the relationship between depressive symptoms and 2-year overall survival. (medscape.com)
Risk for depression3
  • Loci associated with increased risk for depression were also associated with increased risk of coronary artery disease and higher total cholesterol, low-density lipoprotein and c-reactive protein levels, while there was a mixed pattern of effect direction for the other risk factors. (plos.org)
  • Patients and clinicians may not be fully aware that women are at increased risk for depression during the menopausal transition. (womensmentalhealth.org)
  • Among the 6 "typical" types of patients, the algorithms suggest that patients who reported impaired daily functioning by health status are at an elevated risk for depression in all three periods. (jmir.org)
Treatment for depression1
  • Hispanics initiate anti-depressant medication treatment at a much lower rate than whites, and are more likely to discontinue their treatment for depression without consulting their physician, in spite of being equally likely as whites to have received a medication prescription from their primary care provider [ 8 ]. (biomedcentral.com)
Cardiovascular risk factors7
  • Therefore, we examined whether common physiological cardiovascular risk factors differ between patients with depression and healthy (non-depressed) controls, whether patients and controls differ in CRF, and whether higher CRF is associated with a lower cardiovascular risk in both patients and healthy controls. (frontiersin.org)
  • We here investigated overlap at the genome-wide level and in individual loci between depression, coronary artery disease and cardiovascular risk factors. (plos.org)
  • We used the bivariate causal mixture model (MiXeR) to quantify genome-wide polygenic overlap and the conditional/conjunctional false discovery rate (pleioFDR) method to identify shared loci, based on genome-wide association study summary statistics on depression (n = 450,619), coronary artery disease (n = 502,713) and nine cardiovascular risk factors (n = 204,402-776,078). (plos.org)
  • ConjFDR identified 79 unique loci associated with depression and coronary artery disease or cardiovascular risk factors. (plos.org)
  • Our results showed polygenic overlap between depression, coronary artery disease and several cardiovascular risk factors and suggest molecular mechanisms underlying the association between depression and increased cardiovascular disease risk. (plos.org)
  • We applied novel statistical tools for polygenic architectures to investigate if there are common genes for depression, coronary artery disease and cardiovascular risk factors (body mass index, blood pressure, lipids, type 2 diabetes and c-reactive protein). (plos.org)
  • People with serious mental disorders have a greater prevalence of major cardiovascular risk factors compared to the general population. (who.int)
Individuals with depression3
  • The big issue, the unanswered question, is whether 20 mg, which is a dose that is FDA-approved for use in older individuals with depression, is just as effective for agitation as 30 mg," said Dr. Porsteinsson. (medscape.com)
  • Compared to the general population, individuals with depression have an increased risk for cardiovascular diseases. (frontiersin.org)
  • Complicating our understanding of MDD and its treatment is the presence of several physical and psychological comorbidities among individuals with depression, demonstrating an apparent relationship between physical and mental health. (psychiatrist.com)
Mild1
  • MAY 2022 sion and CVD are associated with premature death, and both are prognostic for incident CVD (5), we compared CVD risk for both principal contributors to the rise in disability-adjusted life years mild and major depression relative to people without depression. (cdc.gov)
Interventions3
  • Although the evidence is mounting of the links between job stress and depression, there is less evidence of effective interventions to prevent depression in the workplace. (cdc.gov)
  • This gives us the opportunity to develop interventions to prevent depression in a personalized way. (bvsalud.org)
  • Due to these characteristics, in the last decade, a substantial increase in the search for alternatives to the treatment of depression occurred, mainly on psychotherapeutic interventions. (bvsalud.org)
Diabetes8
  • 3 4 A strong association exists between depression in late life and factors that increase mortality risk, such as poor adherence to medical treatment and self care for diabetes and cardiovascular disease, 5 health behaviors such as smoking and lack of physical activity, 6 cognitive impairment, 7 and disability. (bmj.com)
  • The IDEATel telemedicine intervention was associated with improvement in glycemic control, particularly in Hispanics, who had the highest baseline A1C levels, suggesting that telemedicine has the potential to help reduce disparities in diabetes management. (diabetesjournals.org)
  • Diabetes mellitus type 1 and type 2 are linked to higher prevalence and occurrences of depression. (hindawi.com)
  • Internet-based depression- and diabetes-specific cognitive behavioral therapies (CBT) can be effective in reducing depressive symptom severity and diabetes-related emotional distress. (hindawi.com)
  • Disease-specific severity indicators were not related to a differential effectiveness of guided self-help for depression and diabetes. (hindawi.com)
  • Treatment options are available for MDD and diabetes separately, but only few specialized treatments exist that take both diabetes and depression into account. (hindawi.com)
  • The majority of "double troubled" individuals remain untreated for depression, calling for integration of depression treatment in routine diabetes care [ 2 ]. (hindawi.com)
  • This paper analyzed data from a large safety-net primary care study for diabetes and depression. (jmir.org)
Etiology1
  • Distinguishing individuals who will have no or very few MDD recurrences from those who will have multiple episodes over their lifetimes "forces a reevaluation of almost everything presently believed about depression, from etiology through acute phase treatments and recurrence prevention, to questioning the utility of extant research on predicting and preventing recurrences," the authors wrote. (medpagetoday.com)
Disability1
  • Depression strongly contributes to higher Disability Adjusted Life Years (DALYs) ( 8 ). (frontiersin.org)
Cognitive6
  • Patients with major depressive disorder (MDD) exhibit impaired control of cognitive and emotional systems, including deficient response selection and inhibition. (northwestern.edu)
  • Major depressive disorder (MDD) is a common emotional cognitive disorder that seriously affects people's physical and mental health and their quality of life. (frontiersin.org)
  • We conducted an observational study and aimed to investigate baseline characteristics and biomarkers related with cognitive declines in SCD. (biomedcentral.com)
  • Baseline cognitive scores were not different between the two groups, except the Seoul Verbal Learning Test (SVLT) scores showing lower scores in the Aβ + SCD group. (biomedcentral.com)
  • In Brazil, little is known about the maintenance of results after treatment of cognitive-behavioral therapy (CBT) for major depressive disorder (MDD). (bvsalud.org)
  • This randomized controlled trial (RCT) study aims to investigate the effects of a newly developed internet-based cognitive behavioral therapy (iCBT) program on depressive symptoms, measured at baseline and three- and six-month follow-ups, among nurses in Japan. (vu.nl)
Episode of major depression1
Serum2
  • Serum folate, serum vitamin B 12 and plasma homocysteine levels were assayed at both baseline and follow-up. (cambridge.org)
  • In this study, including 531 women and 423 men who were 65 years of age or older, serum vitamin D levels were assessed at baseline, and after 3 and 6 years of follow-up. (womensmentalhealth.org)
Mortality3
  • No significant effect on mortality was found for minor depression. (bmj.com)
  • 1 2 The biological, social, psychological, and behavioral mechanisms that mediate the effect of depression on mortality have only recently begun to be elucidated. (bmj.com)
  • Patients with head and neck cancer have depression rates that are among the highest of all cancer patients, and growing evidence supports the relation between depression and early mortality. (medscape.com)
Episodes1
  • Correspondingly, in major depressive disorder there is a new appreciation for the recommendation of prophylaxis after the third episode or two closely occurring episodes. (beatcfsandfms.org)
Populations2
  • Depression in working populations is equally complex and the causes are not well understood. (cdc.gov)
  • Barriers to depression treatment among Hispanic populations include persistent stigma, inadequate doctor patient communication (DPC) and resultant sub-optimal use of anti-depressant medications. (biomedcentral.com)
Subjective1
  • Subjective and objective changes in depression scores correlated strongly ( r = 0.66, p = 0.01). (bmj.com)
Decreases1
Patient Health Questionnaire1
  • DESEO will implement universal screening with a self-report depression screening tool (the 9-item Patient Health Questionnaire (PHQ-9)) that is presented through a customized web application and a Depression Education Intervention (DEI) designed to increase disease literacy, and dispel myths about depression and its treatment among Hispanic patients thus reducing stigma and increasing treatment engagement. (biomedcentral.com)
Assessment4
  • There has not been adequate assessment of vitamin D as a therapy for major depressive disorder (MDD) or seasonal affective disorder (SAD). (womensmentalhealth.org)
  • Implementation of this approach can be coupled with application of modern technologies such as telehealth and mobile health assessment for collecting patient-reported data to improve privacy, reducing stigma and costs, and promoting a personalized depression screening that matches screening intervals with patient risk profiles. (jmir.org)
  • Among men aged 40 to 79, however, this association has not been characterized using contemporary the corresponding absolute ASCVD risks were 9.9%, 11.1%, and US primary prevention assessment standards for depression and CVD. (cdc.gov)
  • Au total, 103 personnes âgées dans trois maisons de retraite ont été interrogées en entretien individuel en recourant à la version en langue arabe de l'échelle d'évaluation de l'état nutritionnel Mini Nutritional Assessment (MNA), et des mesures anthropométriques ont été réalisées pour évaluer leur état nutritionnel. (who.int)
Lifetime2
  • Depending on the geographic region, estimates of lifetime prevalence of major depressive disorder vary between 2 and 30% ( 2 - 5 ). (frontiersin.org)
  • Depression is also people aged 40 to 79 years and 2) high lifetime CVD risk preval- an established marker of incident cardiovascular disease (CVD) ence for people aged 20 to 39 years. (cdc.gov)
20221
Myocardial infarction1
  • ST depression in leads I & aVL with acute inferior myocardial infarction) ST segment depression and T-wave changes may be seen in patients with unstable angina Depressed but upsloping ST segment generally rules out ischemia as a cause. (wikipedia.org)
Intervention practices1
  • The level and profile of risk of depression will be communicated to patients by the FPs in the intervention practices at baseline, 6 and 12 months. (bvsalud.org)
Primary3
  • The primary endpoint was change from baseline to Week 8 on the DSST (ANCOVA). (takeda.com)
  • Primary care providers and OB-GYNs play a pivotal role in the detection of and management of perimenopausal depression. (womensmentalhealth.org)
  • hence, it is important to develop a primary prevention strategy to manage depression among nurses. (vu.nl)
Hispanics2
  • At baseline, A1C levels (mean ± SD) were 7.02 ± 1.25% in non-Hispanic whites ( n = 821), 7.58 ± 1.78% in non-Hispanic blacks ( n = 248), and 7.79 ± 1.68% in Hispanics ( n = 585). (diabetesjournals.org)
  • Common concerns about depression treatments among Hispanics include fears about the addictive and harmful properties of antidepressants, worries about taking too many pills, and the stigma attached to taking psychotropic medications. (biomedcentral.com)
Homocysteine6
  • The role of folate, vitamin B 12 and homocysteine levels in depression is not clear. (cambridge.org)
  • To investigate cross-sectional and prospective associations between folate, B 12 and homocysteine levels and late-life depression. (cambridge.org)
  • Lower levels of folate and vitamin B 12 and higher homocysteine levels at baseline were associated with a higher risk of incident depression at follow-up. (cambridge.org)
  • Incident depression was associated with a decline in vitamin B 12 and an increase in homocysteine levels over the follow-up period. (cambridge.org)
  • Lower folate, lower vitamin B 12 and raised homocysteine levels may be risk factors for late-life depression. (cambridge.org)
  • Plasma homocysteine concentration declined from baseline by 22% in the vitamin B12 group, by 19% in the fish oil group, and by 39% in the combination-supplement group. (nutritionaloutlook.com)