Baseline tolerability patient dropouts. Medical search. Frequent questions

We hypothesize that nabilone will improve NMS in patients with PD and have a favorable safety profile. (springer.com)
Combined buprenorphine/naloxone, however, also demonstrates significant efficacy and favorable safety and tolerability in multiple populations, including youth and prescription opioid-dependent individuals, as does buprenorphine monotherapy in pregnant women. (lww.com)

Improvement in depressive symptoms and reduction in functional impairment were associated with reduction in anxiety symptoms moderated by baseline sleep disturbance during lurasidone treatment.Trial Registration: ClinicalTrials.gov identifiers: NCT00868699 and NCT00868452. (bvsalud.org)
Nevertheless, a definite remission-inducing drug has yet to be discovered, and the vast majority of rheumatoid arthritis (RA) patients are dependent on lifelong treatment in order to suppress joint damage and functional impairment. (biomedcentral.com)
1 A maximum dosage of 20 mg once daily is recommended for patients with severe liver impairment (Child-Pugh Class C). (nih.gov)
Fatal cases of liver failure have been reported with duloxetine so it is contraindicated for patients with hepatic impairment and should not be given to patients who are drinking substantial amounts of alcohol. (pharmacologycorner.com)

This meta-analysis aimed to determine the efficacy, acceptability and tolerability of quetiapine treatment for major depressive disorder (MDD). (biomedcentral.com)

This study should be the basis for further evaluations of long-term efficacy and safety of the use of cannabinoids in PD patients. (springer.com)
It will explore several secondary measures including change in health resource utilisation, effect on patient reported outcomes of migraine disability and the safety and tolerability of each medication. (bmj.com)
The trial design allows the first placebo-controlled data collection on the efficacy and safety of secukinumab in patients with GCA. (biomedcentral.com)
The study evaluated the effects of transitioning to denosumab on changes in BMD and biochemical markers of bone turnover, and on safety and tolerability compared with continuation of alendronate therapy. (healthplexus.net)
A phase II study and two phase III studies showed efficacy and safety in patients with episodic migraine, 5-7 and a randomised phase II trial showed efficacy and safety in patients with in chronic migraine ( Table 1 ). (touchneurology.com)
In July 2015, a long-term safety and tolerability study began enrolling 100 patients from previous Phase 1 and 2 trials who were willing to continue their randomized, blinded treatment for another year. (alzforum.org)
To evaluate the safety and efficacy of abatacept plus methotrexate (MTX) over 5 years in patients with rheumatoid arthritis. (jrheum.org)
We describe safety analyses for all patients who received at least 1 dose of abatacept and efficacy analyses for the original ~10 mg/kg abatacept-treated group, over 5 years. (jrheum.org)
Abatacept maintained the efficacy observed at Year 1 over 5 years of treatment, and demonstrated consistent safety and tolerability. (jrheum.org)
This Phase IIb study demonstrated the safety and efficacy of abatacept plus methotrexate (MTX) over 1 year of double-blind (DB) treatment in patients with RA and an inadequate response to MTX 3 , 4 , and confirmed ~10 mg/kg to be the most effective dose. (jrheum.org)
Subsequent Phase III studies verified the efficacy and safety of abatacept both in patients with an inadequate response to MTX 5 and in patients with an inadequate response to anti-TNF agents 6 . (jrheum.org)
We describe the safety, tolerability, and efficacy of abatacept ~10 mg/kg over 5 years of treatment in the continuing open-label longterm extension (LTE) of a Phase IIb study. (jrheum.org)
We report on the safety and tolerability of all patients who received at least 1 dose of abatacept over 5 years, and the efficacy and health-related quality of life (HRQOL) of patients who had received ~10 mg/kg abatacept over 5 years in this continuing open-label extension of a Phase IIb study. (jrheum.org)
This study aimed to assess the efficacy and safety of direct switch from once-daily tiotropium (TIO) 18 μg to indacaterol/glycopyrronium (IND/GLY) 110/50 μg once daily in COPD patients in Korea. (e-trd.org)
A direct switch from TIO to IND/GLY provided improvements in lung function and other patient-reported outcomes with an acceptable safety profile in patients with mild-to-moderate airflow limitation. (e-trd.org)
A safety analysis revealed significantly more nausea, dry mouth, vomiting and yawning reported by patients on duloxetine treatment compared to those on escitalopram or placebo. (pharmacologycorner.com)
The study is not designed to assess safety or tolerability of the influenza vaccines administered as part of this proposed study. (uchc.edu)
RESPITE investigated the safety, feasibility and benefit of switching from PDE5i to riociguat in these patients. (ersjournals.com)

The primary outcome was the number of migraine headache days per month at baseline versus last month. (bmj.com)
A randomized trial of 16 808 postmenopausal women receiving hormone replacement therapy (HRT) versus placebo demonstrated that HRT-treated patients experienced an increase in major adverse events, such as breast cancer, venous thromboembolism, and cardiovascular events. (allenpress.com)
Incidence rates of adverse events (AE) and serious AE were 489.7 and 20.0/100 patient-years in Year 1 versus 374.9 and 18.9/100 patient-years in the cumulative period, respectively. (jrheum.org)
Duloxetine versus escitalopram and placebo in the treatment of patients with major depressive disorder: onset of antidepressant action, a non-inferiority study. (pharmacologycorner.com)
Effectiveness measured by Plasmodium falciparum prevalence at baseline and 10 weeks post-campaign were similar: 1.31% versus 1.43%, respectively. (cdc.gov)

Although open-label observations report a positive effect of cannabinoids on non-motor symptoms (NMS) in Parkinson's disease (PD) patients, these effects remain to be investigated in a controlled trial for a broader use in NMS in PD patients. (springer.com)
In short-term studies, the results of randomized placebo-controlled trials and meta-analyses have suggested that lurasidone was superior to placebo in improving total psychopathology, positive symptoms, negative symptoms, and general psychopathology in patients with acute schizophrenia. (bvsalud.org)
Decrease in sleep at baseline predicted change in anxiety symptoms with lurasidone treatment at week 6.Conclusions: Lurasidone was superior to placebo in reducing psychic and somatic anxiety in the short-term treatment of bipolar depression. (bvsalud.org)
There are conflicting data regarding the use of SSRIs and SNRIs for patients with vasomotor symptoms related to menopause, and these agents may not be ideal for all patients. (allenpress.com)
Minimal-Clinically Important Improvement (MCII), Patient-Acceptable Symptoms State (PASS) were used as secondary endpoints. (bmj.com)
Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. (e-trd.org)
Because of the silent nature of glaucoma, patients will not usually present with any symptoms or visual complaints until late in the disease course, particularly with POAG. (medscape.com)
Short-term treatment of heartburn and other symptoms associated GERD in adults and pediatric patients 12 years to 17 years of age. (nih.gov)
The primary end point was the proportion of week 12 responders (patients with moderate or substantial improvement in IBS symptoms) on the 7-point Likert Global Improvement Scale (GIS). (researchgate.net)

The prevalence of chronic obstructive pulmonary disease (COPD) is considerably high, affecting 251 million patients globally. (e-trd.org)
There were considerably more dropouts due to nausea in the duloxetine group than in the escitalopram group. (pharmacologycorner.com)

2 Although migraine prophylaxis guidelines from North American, South American and European societies are available, only 3-5% of patients receive adequate preventive therapy. (bmj.com)
7 Newer effective and tolerable options for migraine prophylaxis are necessary to reduce this gap and improve patients' quality of life. (bmj.com)
however, current therapeutic options for migraine prophylaxis are associated with low efficacy and/or tolerability. (touchneurology.com)

Dropout rates were similar in both arms, and the incidence and type of adverse and serious adverse events were balanced. (healthplexus.net)
The discontinuation rate due to adverse events was a measure of tolerability. (biomedcentral.com)
The high dropout rate due to adverse events suggests that some MDD patients may not be able to tolerate quetiapine XR. (biomedcentral.com)
Adverse effects are not extensively reported in the literature, and they are usually mild and self-limiting, in part caused by lack of patient compliance with penile traction therapy (PTT). (wikipedia.org)
Nausea was the most common adverse event occurring in 23.8% of patients taking duloxetine, 12% of patients taking escitalopram and 8.8% of patients taking placebo. (pharmacologycorner.com)
Constipation was the most common adverse event (9%, 16%, and 19% patients in the 0.5 mg, 1 mg once daily, and 1 mg twice daily groups, respectively). (researchgate.net)
32 patients (52%) experienced study drug-related adverse events and 10 (16%) experienced serious adverse events (2 (3%) study drug-related, none during the PDE5i treatment-free period). (ersjournals.com)

After a 4-week baseline phase, 196 participants were randomised to placebo, amitriptyline 25 mg or melatonin 3 mg, and 178 took a study medication and were followed for 3 months (12 weeks). (bmj.com)
The baseline mean lumbar spine BMD T-score of participants was -1.61. (healthplexus.net)
At baseline, 39% of participants had previously unsuccessfully tried two preventive drugs, 93 (38%) had tried three, and 56 (23%) had tried four. (touchneurology.com)
Patients with open-angle glaucoma who have a worse mean deviation to their visual field, a greater vertical cup-to-disc ratio at baseline, or who are older are significantly more likely to experience a rapid decay of their visual field, according to a recent study of 767 eyes from 566 participants in the Advanced Glaucoma Intervention Study. (medscape.com)

A total of 38 patients will have 80% power to detect a probability of 0.231 that an observation in the treatment group is less than an observation in the placebo group using a Wilcoxon rank-sum test with a 0.050 two-sided significance level assuming a true difference of 2.5 points between nabilone and placebo in the primary outcome measure and a standard deviation of the change of 2.4 points. (springer.com)
Furthermore, lurasidone improves cognitive and functional performance of patients with schizophrenia, especially in long-term treatment. (bvsalud.org)
For patients who fail to respond to simple analgesia, triptans and intravenous prochlorperazine or chlorpromazine, there are limited treatment options, and a paucity of high-quality evidence to guide clinical practice. (bmj.com)
Patients in both treatment arms receive a 26-week prednisolone taper regimen. (biomedcentral.com)
According to the published results, denosumab treatment resulted in significantly greater increases in the percent change from baseline in BMD at all skeletal sites measured compared with alendronate. (healthplexus.net)
6 She described this study as having particular utility given the common scenario of patients on a regime of alendronate who seek to switch treatment. (healthplexus.net)
2 Some patients treat their migraine attacks with drugs to relieve pain but, in some patients, the frequency, severity and impact on quality of life necessitates the use of preventive treatment to reduce the occurrence of acute attacks. (touchneurology.com)
The primary endpoint was slowing of cognitive decline, as measured by change on the Alzheimer's Disease Cooperative Study Preclinical Alzheimer Cognitive Composite (ADCS-PACC) between baseline and 54 months of treatment with either 10 or 25 mg of drug, or placebo. (alzforum.org)
The objective of this work is to compare the adherence to therapy of patients receiving etanercept and infliximab during first tumour necrosis factor (TNF)-blocking treatment course in rheumatoid arthritis. (biomedcentral.com)
Emphasis is placed on the impact of concomitant methotrexate (MTX) or other DMARDs and patient characteristics at treatment initiation. (biomedcentral.com)
The evidence strongly supports the use of agonist therapies to reduce opioid use and to retain patients in treatment, with methadone maintenance remaining the gold standard of care. (lww.com)
Our aim was to evaluate the achievement of low-density lipoprotein cholesterol (LDL-C) treatment goals in FH patients younger than 18 years enrolled in a large national registry. (revespcardiol.org)
Short-term treatment in the healing of erosive esophagitis (EE) in adults and pediatric patients 12 years to 17 years of age. (nih.gov)
After eight weeks, the probability of responding to treatment (defined as a 50% improvement from baseline on the Hamilton Rating Scale for Depression) was not statistically different between patients given active drug or placebo. (pharmacologycorner.com)
The current state of pharmacology research for CUD highlights the need to consider particular characteristics of patients, such as gender, impulsivity, and severity of cannabis use, when selecting a medication in the off-label treatment of CUD or cannabis withdrawal. (nature.com)
They are becoming the treatment of choice for patients during their first psychotic break and indicated through their lifetime. (statpearls.com)
Treatment with second-generation antipsychotics can contribute to weight gain and, subsequently, metabolic syndrome with high blood sugar, hypertension, abnormal cholesterol, and triglyceride concentrations, posing a patient at risk for stroke, myocardial disease, and diabetes mellitus. (statpearls.com)
Most currently available interventions have similar overall efficacy, and treatment choices should reflect the situation of individual patients. (psychiatrist.com)
A total of 287 patients with HBeAg positive chronic hepatitis B and seroconversion after nucleot(s)ide analog treatment were assigned randomly to three treatment groups for 48 weeks, TDF alone (control), PEGIFN-α2b + TDF, and PEGIFN-α2b + TDF + GM-CSF + HBV vaccine. (xiahepublishing.com)
In patients with HBeAg-positive chronic hepatitis B and seroconversion after nucleot(s)ide analog treatment, immunomodulatory/antiviral treatment regimens effectively improved HBsAg loss, and the regimen including GM-CSF and HBV vaccination was most effective. (xiahepublishing.com)
A proportion of pulmonary arterial hypertension (PAH) patients do not reach treatment goals with phosphodiesterase-5 inhibitors (PDE5i). (ersjournals.com)
The median AUC 0-48 and Cmax of rifabutin in patients taking 150 mg rifabutin tiw was significantly reduced compared to the other treatment arms. (biomedcentral.com)

Prevalence of serological markers were similar at 10 weeks post-campaign compared with baseline, and increased at 6 months. (cdc.gov)

Methods 60 patients with type 2 diabetes were enrolled and randomized to switch from mealtime dosing of a rapid-acting insulin analog to either sitagliptin or mitiglinide for 16 weeks. (bmj.com)

Fifty patients are randomly assigned in a 1:1 ratio to receive either 300 mg secukinumab or placebo subcutaneously at baseline, weeks 1, 2 and 3, and every 4 weeks from week 4. (biomedcentral.com)
Eligible patients were randomized in a 1:1 ratio to either IND/GLY or TIO. (e-trd.org)
The efficacy of duloxetine (60 mg/day) has been compared to that of escitalopram (10 mg/day) and placebo in a randomised study of 684 patients (randomised in a 2:2:1 ratio). (pharmacologycorner.com)

Functional outcome was assessed by the Sheehan Disability Scale.Results: All subjects (n = 824) had at least 1 psychic anxiety and 729 (88.5%) had at least 1 somatic anxiety symptom at baseline. (bvsalud.org)
A functional cure, or hepatitis B virus (HBV) surface antigen (HBsAg) loss, is difficult to achieve in patients with hepatitis B virus e antigen (HBeAg)-positive chronic hepatitis B. The HBV vaccine and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been reported to help reduce HBsAg levels and promote HBsAg loss. (xiahepublishing.com)

Femoral and lumbar BMD were measured at baseline and after 12 months by DEXA. (biomedcentral.com)
4 This 2-year study of 332 postmenopausal North American women with low bone mass investigated denosumab or placebo in patients with lumbar spine bone mineral density (BMD) -1.0 to -2.5 who did not meet the criteria for osteoporosis and were without previous fracture. (healthplexus.net)
Lumbar spine BMD increased by 6.5% over baseline in the denosumab group compared to a reduction of 0.6% in the placebo arm. (healthplexus.net)

Patients were divided into six groups according to TNF-blocking drugs and concomitant DMARDs. (biomedcentral.com)
Risk is increased for children under 16, and is also more common with concomitant valproate use, and in patients who have experienced rash on other anti-epileptic drugs. (pocketdrugguide.com)

All but one study [79] did not exclude patients with severe OSA. (researchgate.net)

Little is known about the characteristics of persons with familial hypercholesterolemia (FH) younger than 18 years, the lipid-lowering therapy used in these patients, and the lipid goals reached in real life. (revespcardiol.org)

This study randomises forty patients (1:1) to receive either eptinezumab or an infusion of intravenous lignocaine for up to 5 days. (bmj.com)
Strengths of this study include its controlled design, which will increase the quality of data on status migrainosus, the use of an active control, which will provide clinically meaningful outcomes and the incorporation of patient-centred and health-economic outcomes. (bmj.com)
This is a randomized, parallel-group, double-blind, placebo-controlled, multi-center, phase II study in which patients, treating physicians, and the associated clinical staff as well as the sponsor clinical team are blinded. (biomedcentral.com)
All patients who completed the 1-year, DB period of this study (clinical trial registration number: NCT00254293) 3 , 4 were eligible to enter the open-label LTE period. (jrheum.org)
Patients eligible for the study had a diagnosis of RA according to clinical judgement by the treating physician. (biomedcentral.com)
This was a randomized, open-label, parallel group, 12-week trial in mild-to-moderate COPD patients who received TIO 18 μg once daily for ≥12 weeks prior to study initiation. (e-trd.org)
Of the 442 patients screened, 379 were randomized and 347 completed the study. (e-trd.org)
Multiple dosing regimens were assessed in a randomized, double-blind, placebo-controlled study (S3B30040) to determine efficacy, tolerability, and evaluate constipation rate. (researchgate.net)
A recent very large, randomized open-label study indicated that lamotrigine might be the drug of choice in patients with partial epilepsy, as it was equally effective but better tolerated, but in a companion study it was substantially less effective than valproate in patients with generalized or unclassified epilepsy. (pocketdrugguide.com)
Six patients (10%) experienced clinical worsening, including death in two (not study drug-related). (ersjournals.com)

Patients were randomly assigned to a night with a positional device (PD) and a night on CPAP (10 +/- 3 cm H2O). (researchgate.net)
A total of 246 patients were randomly assigned (1:1) to erenumab (140 mg, administered by subcutaneous injection) or placebo. (touchneurology.com)

Melatonin was superior to amitriptyline in the percentage of patients with a greater than 50% reduction in migraine frequency. (bmj.com)
half of the patients show 50% reduction in attack frequency. (bmj.com)
The primary endpoint was the proportion of patients achieving a reduction of at least 50% from baseline in monthly migraine days (MMDs) during weeks 9-12. (touchneurology.com)

Patients ( n = 1,161) with active rheumatoid arthritis, not responding to at least two DMARDs including MTX starting etanercept or infliximab therapy for the first time, were included in a structured clinical follow-up protocol. (biomedcentral.com)

Perform screening at least every 3-5 years in asymptomatic patients aged 40 years or younger and more often if the person is African American or older than 40 years. (medscape.com)
We analyzed patients younger than 18 years enrolled in a large ongoing registry of molecularly-defined patients with FH in Spain. (revespcardiol.org)

Patients whose mean total daily doses of rapid-acting insulin analog were 16.6 and 17.8 units were switched to sitagliptin and mitiglinide, respectively, without a change in the HbA1c level. (bmj.com)
The mean increase in weight over a ten-week period for patients treated with standard doses of atypical antipsychotics was 4.45 kg with clozapine and 4.15 kg with olanzapine. (statpearls.com)
If the patient is receiving valproate at the time of initiation, starting doses and doses during titration should be cut in half, whereas if they are receiving enzyme-inducing anti-epileptic drugs such as phenytoin, carbamazepine or phenobarbital, doses can be doubled. (pocketdrugguide.com)
Typical doses for patients with newly diagnosed epilepsy are 100-200 mg/day. (pocketdrugguide.com)
In refractory patients, doses may be as high as 500-1000 mg/day. (pocketdrugguide.com)

Emphasize the following points during the examination to distinguish POAG from either secondary causes of glaucoma or from OHT in patients with only elevated IOP and no damage. (medscape.com)

If any visual field or optic nerve changes consistent with early glaucoma are present, then diagnose the patient as having such. (medscape.com)

Patients who do not achieve remission by week 12 experience a flare after remission or cannot adhere to the prednisolone tapering will enter the escape arm and receive prednisolone at a dose determined by the investigator's clinical judgment. (biomedcentral.com)

Based on the limited evidence obtained from three RCTs, quetiapine XR is effective for adult patients with MDD. (biomedcentral.com)
Helicobacter pylori eradication in adult patients to reduce the risk of duodenal ulcer recurrence in combination with amoxicillin and clarithromycin. (nih.gov)

The primary endpoint is the proportion of patients in sustained remission until week 28 in the secukinumab group compared to the proportion of patients in the placebo group. (biomedcentral.com)

And it should not be used by patients with penile tumor, chronic disorders affecting blood circulation, oxygenation and regeneration of tissues (advanced or uncontrolled diabetes, liver cirrhosis, advanced respiratory failure). (wikipedia.org)
Studies were excluded if they did not utilise the American College of Rheumatology classification criteria, were not clinical trials, or included patients with chronic fatigue syndrome or myalgic encephalomyelitis. (bmj.com)

Other factors associated with an increased risk for progression that did not reach significance included being male and having worse baseline visual acuity. (medscape.com)

The primary endpoints were the proportions of patients with HBsAg loss and seroconversion at 48 and 72 weeks. (xiahepublishing.com)

One case of uveitis (grade 4), occurred in a patient taking rifabutin 300 mg daily prior to starting ART, and grade 3 neutropenia (asymptomatic) was reported in 4 patients. (biomedcentral.com)

Patients included are naïve to biological therapy and have newly diagnosed or relapsing GCA. (biomedcentral.com)

These represent the majority of migraine patients seen by neurologists in clinical practice, but who are often excluded from clinical studies. (touchneurology.com)
Thus, we compare the adherence to therapy of etanercept and infliximab in biologic-naïve RA patients treated in clinical practice. (biomedcentral.com)
Enlargement of Penis in Patients with Hypogonadism Complex Approach to the Clinical Practice. (wikipedia.org)

Conclusion A 800 mg/day pharmaceutical-grade CS is superior to placebo and similar to celecoxib in reducing pain and improving function over 6 months in symptomatic knee osteoarthritis (OA) patients. (bmj.com)
In conclusion, selected patients with PAH may benefit from switching from PDE5i to riociguat, but this strategy needs to be further studied. (ersjournals.com)

We found evidence suggesting that a clinically important difference between agomelatine and placebo in patients with unipolar major depression is unlikely. (cambridge.org)
Starting dosage is 40 mg twice daily 4 (varies with the individual patient) as long as clinically indicated. (nih.gov)

Currently available preventive therapies are associated with low adherence rates due to lack of efficacy and/or poor tolerability. (touchneurology.com)

A multidisciplinary group of experts, including pulmonary, surgical, dentistry and ear-nose-throat specialists, methodologists and patient representatives considered the most relevant clinical questions (for both clinicians and patients) relating to the management of OSA. (researchgate.net)
Ranked the #1 clinical journal covering gastroenterology and hepatology*, The American Journal of Gastroenterology (AJG) provides practical and professional support for clinicians dealing with the gastroenterological disorders seen most often in patients. (researchgate.net)

Having a baseline ECG is important for patients with childhood-onset schizophrenia as some medications used to treat psychosis have the potential of prolonging the QTc and having a baseline measurement could be of benefit. (medscape.com)

We hypothesized that positional therapy would be equivalent to continuous positive airway pressure (CPAP) at normalizing the apnea-hypopnea index (AHI) in patients with positional obstructive sleep apnea (OSA). (researchgate.net)
Positional therapy is equivalent to CPAP at normalizing the AHI in patients with positional OSA, with similar effects on sleep quality and nocturnal oxygenation. (researchgate.net)
Purpose We determined the feasibility of substituting sitagliptin or mitiglinide for bolus insulin injection therapy in patients with type 2 diabetes. (bmj.com)
Additional therapy to sitagliptin or mitiglinide is clearly required to obtain equivalent glycemic control in patients using a higher dose of insulin. (bmj.com)

Bone formation markers in serum and urinary resorption markers were measured at baseline, and after 6 and 12 months. (biomedcentral.com)
Denosumab, which reduces bone turnover markers, is delivered via subcutaneous injection every 6 months, an advantage in an older patient population. (healthplexus.net)
Patients were randomized to denosumab injections (60 mg every 6 months) plus oral placebo weekly or oral alendronate weekly (70 mg) plus subcutaneous placebo injections every 6 months. (healthplexus.net)

Some patients may do well at serum concentrations of 2mg/l, while others may need levels of up to 20 mg/1. (pocketdrugguide.com)

5 events/h) identified on a baseline polysomnogram were studied. (researchgate.net)

The primary efficacy criterion will be the change in Movement Disorders Society-Unified Parkinson's Disease-Rating Scale Part I score between baseline (i.e. randomization) and week 4. (springer.com)

Patient education on orthostatic hypertension and advice on factors that influence blood pressure (for example, high environmental temperatures, sudden changes in posture, alcohol, and large, carbohydrate‑rich meals). (nice.org.uk)
Patients in whom the assault took place within the preceding 72 hours and are deemed by the clinician to be at high risk for HIV exposure should be offered nPEP. (medscape.com)

In this prospective randomized trial, we evaluated HBsAg loss in patients receiving pegylated interferon-α2b (PEGIFN-α2b) and tenofovir disoproxil fumarate (TDF), with and without GM-CSF and HBV vaccination. (xiahepublishing.com)

The initial patient interview is extremely important in the evaluation for POAG or other ocular diseases secondarily causing elevated IOP. (medscape.com)
Yet, felbamate may still be an important drug in the armamentarium for refractory patients, because it may control seizures when other drugs fail, and tends to be alerting rather than sedating. (pocketdrugguide.com)

The patients were treated at eight hospital centers in southern Sweden serving a population of about 1.3 million during the period of March 1999 through December 2004. (biomedcentral.com)

Some studies have advocated combining lamotrigine with valproate in refractory patients, to achieve maximum efficacy through a favourable pharmacodynamic interaction. (pocketdrugguide.com)

Psychiatry and Psychology1

Anthropology, Education, Sociology and Social Phenomena1

Named Groups2

Favorable safety2

Impairment4

Acceptability1

Safety18

Versus5

Symptoms9

Considerably2

Migraine prophylaxis3

Adverse7

Participants4

Treatment22

Prevalence1

Methods1

Ratio3

Functional2

Lumbar3

Concomitant2

Severe1

Characteristics1

Study10

Randomly assigned2

Reduction3

Rheumatoid arthritis1

Younger2

Doses5

Secondary1

Consistent1

Week 121

Adult patients2

Primary endpoint1

Chronic2

Worse1

Endpoints1

Asymptomatic1

Newly diagnosed1

Clinical practice3

Conclusion2

Clinically2

Preventive1

Clinicians2

Schizophrenia1

Therapy4

Months3

Serum1

Events1

Change1

High2

Prospective1

Important2

Population1

Studies1