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  • possible
  • By labeling such complementary probe nucleic acids with some readily detectable chemical group, it was then made possible to detect the presence of any polynucleotide sequence of interest in a test medium containing sample nucleic acids in single stranded form. (google.ca)
  • presence
  • We now know that this effect is due to increased stacking interactions between GC base pairs (and not the presence of three hydrogen bonds) [ DNA Denaturation and Renaturation and the Role of Hydrogen Bonds and Stacking Interactions ]. (blogspot.ca)
  • mutations
  • Based on Hadoop and HBase, we developed SeqHBase, a big data-based toolset for analysing family based sequencing data to detect de novo, inherited homozygous, or compound heterozygous mutations that may contribute to disease manifestations. (bmj.com)
  • The remaining 8 were new mutations and all were single base changes: Four were in families that are strongly associated with cancer pathogenesis (PTPRT, CDH24, PCLKC and SLC15A1). (wikipedia.org)
  • The initiative allows such exceptional patients (who have responded positively for at least six months to a cancer drug that usually fails) to have their genomes sequenced to identify the relevant mutations. (wikipedia.org)
  • Conserved sequences, such as mitochondrial DNA, are expected to accumulate mutations over time, and assuming a constant rate of mutation, provides a molecular clock for dating divergence. (wikipedia.org)
  • contiguous
  • Results show that the use of exponential decay weighting schemes when taking into account non contiguous sequences to compute recommendations enhances the accuracy. (inria.fr)
  • A comprehensive step-by-step protocol on constructing phylogenetic tree, including DNA/Amino Acid contiguous sequence assembly, multiple sequence alignment, model-test (testing best-fitting substitution models) and phylogeny reconstruction using Maximum Likelihood and Bayesian Inference, is available at Nature Protocol Early attempts at molecular systematics were also termed as chemotaxonomy and made use of proteins, enzymes, carbohydrates, and other molecules that were separated and characterized using techniques such as chromatography. (wikipedia.org)
  • protein
  • tRNA does this by carrying an amino acid to the protein synthetic machinery of a cell (ribosome) as directed by a three-nucleotide sequence (codon) in a messenger RNA (mRNA). (wikipedia.org)
  • In 1999, working with John Carlson at Yale, he developed a novel algorithm for computationally identifying G Protein-Coupled Receptors (GPCR) without using primary sequence homology, which led to the cloning of olfactory receptors in insects. (wikipedia.org)
  • next-generation
  • NEW YORK (GenomeWeb) - Investigators at the Scripps Research Institute, the International AIDS Vaccine Initiative, and the Ragon Institute of Massachusetts General Hospital have come up with a set of next-generation sequencing techniques for profiling antibody repertoires of immune B cells - collections that provide clues for treating and tracking some forms of infectious disease. (genomeweb.com)
  • Automated on the HTG EdgeSeq system, HTG EdgeSeq Immuno-Oncology Assay couples HTG's proprietary nuclease protection chemistry with next-generation sequencing (NGS). (cnbc.com)
  • HTG Edge system capabilities have been expanded to fully automate sample and targeted library preparation for next-generation sequencing. (cnbc.com)
  • The SRA was started by NCBI in 2007 to collect sequence data produced by next-generation sequencing instruments. (wikipedia.org)
  • detect
  • DNA denaturation can also be used to detect sequence differences between two different DNA sequences. (wikipedia.org)
  • In the context of a single isolated region of DNA, denaturing gradient gels and temperature gradient gels can be used to detect the presence of small mismatches between two sequences, a process known as temperature gradient gel electrophoresis. (wikipedia.org)
  • homology
  • examined misidentification of VGS submitted to antimicrobial surveillance programs as pneumococci and found that the distinction of S. pneumoniae from the VGS can be difficult, which is not surprising in light of the fact that S. mitis and S. oralis possess >99% sequence homology with S. pneumoniae (47). (wikipedia.org)
  • restriction
  • citation needed] While a postdoctoral fellow with Hamilton O. Smith at the Johns Hopkins University School of Medicine during 1969-70, Kelly determined the DNA sequences recognized by type II restriction enzymes, which subsequently became major tools in recombinant DNA research. (wikipedia.org)
  • canonical
  • In the canonical Watson-Crick base pairing, adenine (A) forms a base pair with thymine (T) and guanine (G) forms one with cytosine (C) in DNA. (wikipedia.org)
  • Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix). (wikipedia.org)
  • The viral polymerase incorporates these compounds with non-canonical bases. (wikipedia.org)
  • These nucleoside triphosphates possess a non-canonical sugar, dideoxyribose, which lacks the 3' hydroxyl group normally present in DNA and therefore cannot bond with the next base. (wikipedia.org)
  • targets
  • The subjects were instructed to voluntarily control a virtual cursor in multiple trials to hit different pre-programmed targets on a screen in an optimized sequence. (springer.com)
  • user's
  • This paper describes a new approach of generating suitable recommendations based on the active user's navigation stream. (inria.fr)
  • This approach is derived from a basic shared control strategy where the robotic arm is responsible for carrying out complex maneuvers based on the user's intention. (springer.com)
  • wobble
  • In RNA, thymine is replaced by uracil (U). Alternate hydrogen bonding patterns, such as the wobble base pair and Hoogsteen base pair, also occur-particularly in RNA-giving rise to complex and functional tertiary structures. (wikipedia.org)
  • The GU wobble base pair, with two hydrogen bonds, does occur fairly often in RNA. (wikipedia.org)
  • The first anticodon base, or wobble-position, is sometimes modified to inosine (derived from adenine), pseudouridine or lysidine (derived from cytosine). (wikipedia.org)
  • Some anticodons can pair with more than one codon due to a phenomenon known as wobble base pairing. (wikipedia.org)
  • naturally
  • Naturally occurring bases can be divided into two classes according to their structure: pyrimidines are six-membered heterocyclic with nitrogen atoms in position 1 and 3. (wikipedia.org)
  • patterns
  • Recurrent Neural Networks (RNNs) have become the state-of-the-art choice for extracting patterns from temporal sequences. (arxiv.org)
  • representation
  • DNA samples from two groups of Italian Large White pigs with divergent estimating breeding value (EBV) for BFT were separately pooled and sequenced, after preparation of reduced representation libraries (RRLs), on the Ion Torrent technology. (hindawi.com)
  • Methodology
  • For building the optimized test schedule, frequency based pseudo damage methodology called Relative Damage Spectrum (RDS) is incorporated.This method enhances the proving ground durability validation process by providing optimized test schedules to prevent redundant vehicle testing. (sae.org)
  • purely
  • This study investigated whether negative priming can be observed in a sequence learning that is purely perceptual-based. (arvojournals.org)
  • A library providing persistent (purely functional) vectors for Haskell based on array mapped tries. (haskell.org)
  • different
  • If the 16S sequence is different, you can be sure that the isolates are different strains. (criver.com)
  • PG validation requires a specific durability test sequence for every segment of commercial vehicles due to different customer usage applications and terrain conditions. (sae.org)
  • Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. (wikipedia.org)
  • typical
  • they also lack either the polysaccharide-based capsule typical of S. pneumoniae or the Lancefield antigens of the pyogenic members of the genus. (wikipedia.org)
  • recognition
  • EcoRII is a bacterial Type IIE REase that interacts with two or three copies of the pseudopalindromic DNA recognition sequence 5'-CCWGG-3' (W = A or T), one being the actual target of cleavage, the other(s) serving as the allosteric activator(s). (wikipedia.org)
  • require
  • Even with the sparse updates imposed by the oscillation, the Phased LSTM network achieves faster convergence than regular LSTMs on tasks which require learning of long sequences. (arxiv.org)
  • current
  • These forward-looking statements are based upon management's current expectations, are subject to known and unknown risks, and involve assumptions that may never materialize or may prove to be incorrect. (cnbc.com)
  • a substantial sample of individuals of the target species or other taxon is used, however many current studies are based on single individuals. (wikipedia.org)
  • slower
  • Updating an element at an index in a vector is slower than updating an index in a Sequence (but still faster than an IntMap). (haskell.org)
  • library
  • We can create a library database of sequences from the microorganisms found in your manufacturing environment. (criver.com)
  • The API is modeled after Data.Sequence from the containers library. (haskell.org)
  • These persistent vectors are modeled on the persistent vector used by clojure, with an API modeled after Data.Sequence from the containers library. (haskell.org)
  • pair
  • For each base pair, considered relative to its predecessor, there are the following base pair geometries to consider: Shear Stretch Stagger Buckle Propeller: rotation of one base with respect to the other in the same base pair. (wikipedia.org)
  • Opening Shift: displacement along an axis in the base-pair plane perpendicular to the first, directed from the minor to the major groove. (wikipedia.org)
  • Slide: displacement along an axis in the plane of the base pair directed from one strand to the other. (wikipedia.org)
  • Note that "tilt" has often been used differently in the scientific literature, referring to the deviation of the first, inter-strand base-pair axis from perpendicularity to the helix axis. (wikipedia.org)
  • fragments
  • So they wanted to focus on genetic fragments containing paternally inherited sequences the mother did not share, but had traveled from the fetal blood into the maternal blood through the placenta. (wikipedia.org)
  • Phage eluted in the final step can be used to infect a suitable bacterial host, from which the phagemids can be collected and the relevant DNA sequence excised and sequenced to identify the relevant, interacting proteins or protein fragments. (wikipedia.org)
  • Analysis
  • This apparent discrepancy between structural and sequence based similarities is really intriguing and requires further analysis. (burnham.org)
  • Analysis of sequence conservation among homologs indicated that a cluster of buried hydrophilic residues around H56 are highly conserved. (burnham.org)
  • Based on this distribution of values, it would appear from our preliminary analysis that almost half of the individuals sampled from the Harappa cemetery have isotope values outside the local baseline (0.7158-0.7189). (blogspot.com)
  • An analysis of DNA sequences indicate Geogenanthus is closely related to the genus Plowmanianthus followed by Cochliostema. (wikipedia.org)
  • Analysis of morphological characters in Commelinaceae indicate Geogenanthus is closely related to Dichoriscantieae and Siderasis, but Geogenanthus is placed as the sister to Dichoriscantieae and Siderasis in the cladogram from the combined morphology and sequence analysis, with high bootstrap value supporting the placement. (wikipedia.org)
  • available
  • Estimated shipping dates are accurate to the best of our knowledge, based on the latest stock information made available to us from the supplier. (boomkat.com)
  • The Netherlands - November 10, 2017 - Bluebee, a company driving genomic data-driven medicine, announces the successful integration of the SLAMdunk pipeline on Bluebee's private cloud-based platform, making it available to analyze data generated by every user of the SLAMseq Metabolic RNA Labeling Kit from Lexogen. (delftenterprises.nl)
  • company
  • Kerala Evergreen FC is the first team from Thiruvananthapuram to play in the I-League and will be part of the 2017-18 I-League.The team is owned by a Singapore based company MySports Management and India based company Liwing Sports.The team's home stadium is Trivandrum International Stadium in Thiruvananthapuram, Kerala. (wikipedia.org)
  • problem
  • based) - Amy Morin - shortcut - CBT Cognitive PhD TherapySee moreCounseling WorksheetsCounseling ActivitiesSocial Work WorksheetsCognitive such research WorksheetsCognitive ActivitiesGroup Therapy ActivitiesAnxiety ActivitiesBehavioral PsychologyPsychology inwards best human Great quality thieves, forces and bands so in one hash paper CBT Counseling Game: Providing, Problem Solving, Perspective adding, FeelingsAnxiety ActivitiesCoping compounds ActivitiesPlay organization assumption GamesLearning SkillsCognitive foolish record WorksheetsBehavioral PsychologyCounseling WorksheetsCognitive such new diseases about possible preference? (lprock.com)
  • Positive
  • Positive territory sequencing should radically be confused with dna profiling, which n't determines the roof that military dairy came from a added school or election, and does primarily contain mobile surgeon on next opponents, violence or design to appropriate contents. (tenant-credit-check.life)
  • However it is easily extended to accept sequences containing negative numbers using an overlap and interleave scheme, in which all values are reassigned to some positive number in a unique and reversible way. (wikipedia.org)
  • methods
  • This market includes and costs some scientific server for 4 Free functionality interests: trademark sites to understand approximation OS, browser mealtimes seen with newsgroup herds of counter and software misinterpretations, basics from next in account articles riveted away by the Federal Bureau of Investigation( FBI), and wsn avoid with domain-based important methods. (forza-fiume.com)
  • Complex
  • siRNA Danshensu of 20 pmol (against TRPC3) or the siRNA bad control complex, having a 1:125 last dilution of Lipofectamine 2000 (Invitrogen) was utilized based on the producers guidelines. (cancercurehere.com)
  • large
  • U.S. Navy, Marine Corps, and Army as well as Australian and New Zealand forces under the command of Admiral Nimitz and Admiral William F. Halsey, Jr. had isolated the large Japanese South Pacific base at Rabaul, New Britain, by capturing a ring of islands around Rabaul, and then building air bases on them from which to bomb and blockade the Japanese forces at Rabaul into military impotence. (wikipedia.org)
  • The story begins on a dark and stormy night as the victim (voiced by Kent Rogers doing an impression of Richard Haydn), presumably the master of the very large "Gruesome Gables" mansion, is reading a book based on the cartoon he's in. (wikipedia.org)
  • already
  • Aircraft carrier-based warplanes were already conducting air strikes and fighter sweeps against the Japanese in the Philippines, especially their military airfields. (wikipedia.org)
  • The sequence -nh- had already undergone a similar change in late Proto-Germanic several hundred years earlier, and affected all Germanic languages, not only the Ingvaeonic subgroup. (wikipedia.org)
  • means
  • COX-2 is naturally inhibited by Calcitriol (the active form of Vitamin D). Both the peroxidase and PTGS activities are inactivated during catalysis by mechanism-based, first-order processes, which means that PGHS-2 peroxidase or PTGS activities fall to zero within 1-2 minutes, even in the presence of sufficient substrates. (wikipedia.org)
  • structure
  • get libraries Of MassageMassage TipsMassage TherapyMassage QuotesThe BenefitsThai MassageMassage BusinessPhysical TherapyHealthy LivingForwardsBenefits of Massage: pain jordan, is structure-activity and cost-utility Applications Of MassageHealth BenefitsHealth TipsThe BenefitsMassage TipsMassage QuotesHealth CareNews HealthThai MassageForwardsWellness Massage is Agri-Mark of all 4th Web-based cocktails. (lprock.com)
  • Houdini's operator-based structure is divided into several main groups: OBJs - nodes that pass transform information (Traditionally these contain SOPs. (wikipedia.org)
  • similar
  • This node graph architecture is similar to that employed in node-based compositors such as Shake or Nuke. (wikipedia.org)