• gene
  • The major determinant of carbapenem resistance in Bacteroides fragilis is production of CfiA metallo-beta-lactamase via activation of the cfiA gene by IS elements (higher level resistance) or by activation of its putative own promoter. (diva-portal.org)
  • none of those with inactive disease had specimens positive for enterotoxigenic Bacteroides fragilis gene sequences. (cdc.gov)
  • resistance
  • Production of beta lactamase appears to be the main mechanism of antibiotic resistance in B. fragilis. (wikipedia.org)
  • Clindamycin is no longer recommended as the first-line agent for B. fragilis due to emerging high-level resistance (>30% in some reports). (wikipedia.org)
  • susceptible
  • In general, B. fragilis is susceptible to metronidazole, carbapenems, tigecycline, beta-lactam/beta-lactamase inhibitor combinations (e.g. (wikipedia.org)