AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
AminoglycosidesGentamicinsAnti-Bacterial AgentsFramycetinTobramycinAmikacinKanamycinNetilmicinParomomycinMicrobial Sensitivity TestsNeomycinDibekacinDrug Resistance, MicrobialSisomicinStreptomycinPseudomonas aeruginosaRibostamycinKanamycin KinaseNebramycinDrug Resistance, BacterialDrug Resistance, Multiple, BacterialEnterobacteriaceaebeta-LactamsAcetyltransferasesProvidenciaHygromycin BPenicillinsDihydrostreptomycin SulfateMezlocillinEnterobacteriaceae InfectionsButirosin SulfateDrug SynergismCarbenicillinEar DiseasesPseudomonas InfectionsCapreomycinbeta-LactamasesEscherichia coliGram-Negative Bacterial InfectionsHearing DisordersCephalosporinsBacterial InfectionsEnterococcus faecalisKlebsiella pneumoniaeBacteriaCodon, NonsenseViomycinEnterococcusConjugation, GeneticPiperacillinCross InfectionBacterial ProteinsFluoroquinolonesSerratia marcescensTetracyclinesTicarcillinSerratia InfectionsPolymyxin BStria VascularisDNA, BacterialAmpicillinSalvia officinalisRibosome Subunits, Small, BacterialEndocarditis, BacterialMethyltransferasesR FactorsVancomycinIntegronsCiprofloxacinLactamsStaphylococcus aureusAzlocillinPlasmidsMenthaCeftazidimeAnti-Infective AgentsCarbapenemsAcinetobacter baumanniiRNA, Ribosomal, 16SStaphylococcusGram-Positive Bacterial InfectionsKlebsiella InfectionsAcinetobacter InfectionsCefotaximetRNA MethyltransferasesGram-Negative BacteriaAcinetobacterCodon, TerminatorLateral Line SystemStreptococcusNucleotidyltransferasesCulture MediaNorfloxacinPenicillin Resistancebeta-Lactam ResistanceDrug Therapy, CombinationCefoperazoneDrug Resistance, MultipleProteus mirabilisEnterobacter
AntibioticsGentamicinNeomycinAmikacinTobramycinBacteriaStreptomycinOtotoxicityConcentrationTetracyclinesPenicillinSubunitNephrotoxicConcentrationsVancomycinAntimicrobialsGlycopeptidesSynthesisResistantPharmacokineticsTrimethoprimBacterial cellEffective againstInfectionsSystemicRibosomeExtracellular fluidPoorlyAntimicrobialEfficacyActivity1987RenalHypersensitivityExertUptakeVitroPatientsColiAdverse effectsClinical
Antibiotics29
  • Aminoglycosides are broad-spectrum antibiotics whose mechanism of action is under debate. (elifesciences.org)
  • Aminoglycosides are a potent class of translation inhibitor antibiotics with a broad activity spectrum. (elifesciences.org)
  • Tobramycin is contraindicated in people with hypersensitivity against aminoglycoside antibiotics. (wikipedia.org)
  • Aminoglycoside antibiotics such as paromomycin can cause oto- and nephrotoxicity. (hyperdrug.co.uk)
  • For antibiotics with concentration-dependent killing (e.g., aminoglycosides), the higher the concentration, the greater the effect. (vin.com)
  • The antibiotics work with two terms- minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). (starhealth.in)
  • Inhibition of DNA replication initiation by aminoglycoside antibiotics. (microbiologyresearch.org)
  • There are some gram-positive Staphyloccus that are sensitive to amikacin although generally the aminoglycosides are combined with other antibiotics when both gram-negative and gram-positive bacteria are present. (wedgewoodpharmacy.com)
  • Aminoglycoside antibiotics have poor activity in the presence of pus and cellular debris. (wedgewoodpharmacy.com)
  • If renal function or hydration status is questionable, other antibiotics outside the aminoglycoside family may be preferable. (wedgewoodpharmacy.com)
  • Systemic use of amikacin and other aminoglycoside antibiotics are usually reserved for serious illnesses because of the risk of nephrotoxicity and ototoxicity. (wedgewoodpharmacy.com)
  • When using amikacin or other aminoglycoside antibiotics, monitoring of renal function and peak trough drug concentrations can be very useful to decrease the risks of nephrotoxicity. (wedgewoodpharmacy.com)
  • The global aminoglycosides antibiotics market size was USD 1.028 billion in 2021 and is projected to touch USD 1.221 billion by 2028, exhibiting a CAGR of 2.5% during the forecasted period. (businessresearchinsights.com)
  • Aminoglycosides antibiotics are a class of anti-infection agents utilized primarily in the treatment of vigorous gram-negative bacilli diseases, in spite of the fact that they are likewise successful against different microbes including staphylococci and mycobacterium tuberculosis. (businessresearchinsights.com)
  • The different uses and benefits of it in the pharmaceutical industry facilitates the growth of the aminoglycosides antibiotics market. (businessresearchinsights.com)
  • With every one of the current circumstances additionally, the advancement of the market of aminoglycosides antibiotics figures post-COVID-19 is shown in the market. (businessresearchinsights.com)
  • These antibiotics may not be the restraint of protein combination that delivers the bactericidal which is microbes killing impact. (businessresearchinsights.com)
  • Such demands are expected to pose an opportunity for global aminoglycosides antibiotics market growth during the forecast period. (businessresearchinsights.com)
  • In vitro inactivation of aminoglycoside antibiotics by beta-lactam antibiotics is well doc-umented. (elephantcare.org)
  • Pharmacology - Tobramycin, like the other aminoglycoside antibiotics, act on susceptible bacteria presumably by irreversibly binding to the 30S ribosomal subunit thereby inhibit-ing protein synthesis. (elephantcare.org)
  • The aminoglycoside antibiotics are inactive against fungi, viruses and most anaerobic bacteria. (elephantcare.org)
  • The inherent toxicity of the aminoglycosides limit their systemic use to serious infec-tions when there is either a documented lack of susceptibility to other less toxic antibiotics or when the clinical situation dictates immediate treatment of a presumed gram negative infection before culture and susceptibility results are reported. (elephantcare.org)
  • Explain the indications, and adverse effects of frequently used antibiotics.Describe the major adverse effects and clinical uses of aminoglycosides. (academiasupport.co.uk)
  • The drugs Group: Antibiotics: aminoglycoside + + polyene cyclic polypeptide. (pharmru.com)
  • Loss of sensory hair cells from exposure to certain licit drugs, such as aminoglycoside antibiotics, can result in permanent hearing damage. (bvsalud.org)
  • Using either plate or liquid growth assays we found that MM-201 did not alter the bactericidal efficacy of aminoglycoside antibiotics at therapeutically relevant concentrations. (bvsalud.org)
  • Aminoglycosides (gentamicin, tobramycin and amikacin) are bactericidal antibiotics used to treat infections caused by Gram-negative organisms. (medicinesinformation.co.nz)
  • Doxycycline and other tetracycline antibiotics are generally not used with bactericidal antibiotics such as penicillin, cephalosporin and aminoglycosides. (davisislandspharmacy.com)
  • Aminoglycoside antibiotics such as gentamicin and amikacin may thus be introduced as a treatment regimen for typhoid fever. (who.int)
Gentamicin9
  • Gentamicin sulfate is an aminoglycoside antibiotic active against a wide variety of pathogenic gram-negative and gram-positive bacteria. (medi-vet.com)
  • Gentamicin is bactericidal and acts by inhibiting normal protein synthesis in susceptible microorganisms. (medi-vet.com)
  • Gentamicin, Tobramycin are some of the most nephrotoxic aminoglycosides. (brainscape.com)
  • As with other aminoglycosides, gentamicin injection is potentially nephrotoxic. (nih.gov)
  • Gentamicin sulfate, a water-soluble antibiotic of the aminoglycoside group, is derived by the growth of Micromonospora purpurea , an actinomycete. (nih.gov)
  • Combination therapy with a cell wall-active agent (eg, ampicillin, vancomycin) and an aminoglycoside (eg, gentamicin, streptomycin) has long been regarded as the standard of care for E faecalis native valve endocarditis. (medscape.com)
  • It is less nephrotoxic than gentamicin although all aminoglycosides have the potential for both renal and otic toxicity. (wedgewoodpharmacy.com)
  • Similarly, a potentiating effect of chlorpromazine on kanamycin, gentamicin and neomycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides. (springer.com)
  • Gentamicin is an aminoglycoside antibiotic which is bactericidal by inhibiting protein synthesis in susceptible bacteria. (pawsomepet.co)
Neomycin4
  • Framycetin Sulfate (syn: Neomycin B Sulfate) is the sulfate salt form of Neomycin, a broad-spectrum aminoglycoside antibiotic derived from Streptomyces fradiae . (toku-e.com)
  • Neomycin is an antibiotic from the aminoglycoside group with bactericidal activity. (bayeraflak.ir)
  • rn Neomycin is an aminoglycoside antibiotic. (medicmex.com.mx)
  • Treda (Neomycin Sulfate) is a bactericidal aminoglycoside antibiotic that binds to the 30S ribosome of susceptible organisms. (medicmex.com.mx)
Amikacin5
Tobramycin6
  • Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius that is used to treat various types of bacterial infections, particularly Gram-negative infections. (wikipedia.org)
  • Like all aminoglycosides, tobramycin does not pass the gastro-intestinal tract, so for systemic use it can only be given intravenously or by injection into a muscle. (wikipedia.org)
  • Like other aminoglycosides, a major side effect for tobramycin is ototoxicity or a loss of equilibrioception, or both in genetically susceptible individuals. (wikipedia.org)
  • Chemistry - An aminoglycoside derived from Streptomyces tenebrarius , tobramycin oc-curs as a white to off-white, hygroscopic powder that is freely soluble in water and very slightly soluble in alcohol. (elephantcare.org)
  • Pharmacokinetics - Tobramycin, like the other aminoglycosides is not appreciably ab-sorbed after oral or intrauterine administration, but it is absorbed from topical administra-tion (not skin or urinary bladder) when used in irrigations during surgical procedures. (elephantcare.org)
  • Tobramycin is a frequently prescribed bactericidal antibiotic, or aminoglycoside, that's effective in dealing with CF exacerbations. (cysticfibrosisnewstoday.com)
Bacteria4
Streptomycin1
  • Dihydrostreptomycin Sulfate, a derivative of streptomycin, is a semi-synthetic aminoglycoside with bactericidal properties. (toku-e.com)
Ototoxicity3
  • Aminoglycoside-induced ototoxicity is usually irreversible. (nih.gov)
  • Exogenous application of the neurotrophic molecule hepatocyte growth factor (HGF) promotes neuronal cell survival in a variety of contexts, including protecting hair cells from aminoglycoside ototoxicity. (bvsalud.org)
  • We previously demonstrated that MM-201 robustly protects zebrafish lateral line hair cells from aminoglycoside ototoxicity. (bvsalud.org)
Concentration6
  • In addition, when administered intravenously, diuretics may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue. (nih.gov)
  • Minimum bacteriocidal concentration is the concentration of the antibiotic that can reduce the bacterial density by 1000 folds at 24 hours. (starhealth.in)
  • This is due to the concentration-dependent killing and postantibiotic effect exhibited by aminoglycosides. (medscape.com)
  • Aminoglycosides work more effectively when the peak concentration exceeds the minimum inhibitory concentration (MIC) of the target organism. (medscape.com)
  • Aminoglycosides demonstrate concentration-dependent bactericidal activity, which is optimal when the maximum concentration (C max ) is ≥ 10 times the minimum inhibitory concentration (MIC) of the organism. (medicinesinformation.co.nz)
  • The bacteriostatic antimicrobials are therefore time dependent on their killing effect where as the bactericidal ones are more concentration dependent, except for the penicillins. (octagon-services.co.uk)
Tetracyclines2
Penicillin1
  • Vancomycin resistance in enterococci has emerged amidst the increasing incidence of high-level enterococcal resistance to penicillin and aminoglycosides, thus presenting a serious challenge for physicians treating patients with infections due to these microorganisms[1,4]. (cdc.gov)
Subunit4
  • The aminoglycosides essentially act by restricting to the aminoacyl site of 16S ribosomal RNA inside the 30S ribosomal subunit, prompting misreading of the hereditary code and hindrance of movement. (businessresearchinsights.com)
  • Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein. (toku-e.com)
  • Aminoglycosides target the 30S ribosomal subunit, specifically binding to the 16S rRNA and S12 protein. (toku-e.com)
  • Aminoglycosides target the 30S ribosomal subunit (irreversible binding to S12 protein) resulting in an inability to read mRNA since this interferes with the initiation complex between the mRNA and the bacterial ribosome. (toku-e.com)
Nephrotoxic2
  • All aminoglycosides are nephrotoxic, most likely if taken more than 5 days. (brainscape.com)
  • In sensitive E faecalis native valve endocarditis treated with ampicillin plus an aminoglycoside, consideration should be given to limiting the aminoglycoside component to 2 weeks in order to avoid nephrotoxic, vestibular, and ototoxic events. (medscape.com)
Concentrations6
  • Serum concentrations of aminoglycosides should be monitored when feasible to assure adequate levels and to avoid potentially toxic levels. (nih.gov)
  • Excessive peak and/or trough serum concentrations of aminoglycosides may increase the risk of renal and eighth cranial nerve toxicity. (nih.gov)
  • The effect of sub-inhibitory concentrations of 16 antibacterials on the bactericidal activity of the 4-quinolones nalidixic acid, ciprofloxacin and ofloxacin against Escherichia coli KL16 in nutrient broth was investigated. (microbiologyresearch.org)
  • Sub-inhibitory concentrations of rifampicin, clindamycin, chloramphenicol, erythromycin or tetracycline antagonised the bactericidal activity of the 4-quinolones. (microbiologyresearch.org)
  • It achieves high, sustained serum concentrations but, like other aminoglycosides, has a narrow therapeutic index. (medscape.com)
  • Aminoglycosides concentrate in the urine at higher concentrations than in the plasma, so an AUC 24 at the lower end of the range (e.g. 70 mg/L.h) is usually sufficient for a urinary tract infection. (medicinesinformation.co.nz)
Vancomycin2
Antimicrobials1
Glycopeptides1
Synthesis1
  • It interferes with bacterial protein synthesis and is commonly used to study aminoglycoside uptake. (toku-e.com)
Resistant1
Pharmacokinetics1
  • Pharmacokinetics: Evenly distributed over the vaginal mucosa, providing local bactericidal and fungicidal effect. (pharmru.com)
Trimethoprim1
Bacterial cell1
  • Aminoglycosides additionally seem to uproot cations in the bacterial cell biofilm that are answerable for connecting the lipopolysaccharide particles normal for gram-negative bacterial cell walls. (businessresearchinsights.com)
Effective against1
  • Aminoglycosides and sulfonamides are only effective against aerobic organisms, while nitroimidazoles are generally only effective for anaerobes. (microbiologyinfo.com)
Infections1
  • In clinical practice, combination therapy with a cell wall-active agent and a synergistic aminoglycoside should be considered for treating serious enterococcal infections in critically ill patients and in those with evidence of sepsis , as well as in patients with endocarditis, meningitis, osteomyelitis, or joint infections. (medscape.com)
Systemic1
Ribosome2
  • into the cytoplasm where they can exert their bactericidal effect which requires binding to the ribosome ( Davis, 1987 ). (elifesciences.org)
  • This makes openings in the cell wall that might kill the microorganisms before the aminoglycoside even arrives at the ribosome. (businessresearchinsights.com)
Extracellular fluid2
  • Aminoglycosides are distributed well into extracellular fluid except for vitreous humor, cerebrospinal fluid, respiratory secretions, and bile (particularly in patients with biliary obstruction). (msdmanuals.com)
  • After absorption, aminoglycosides are distributed primarily in the extracellular fluid. (elephantcare.org)
Poorly2
  • Aminoglycosides are poorly absorbed from the gastrointestinal (GI) tract and must be given parenterally. (wedgewoodpharmacy.com)
  • Aminoglycosides are poorly absorbed orally but are well absorbed from the peritoneum, pleural cavity, joints , and from denuded skin. (msdmanuals.com)
Antimicrobial2
  • In this study an ethanol extract of Turnera ulmifolia L. and chlorpromazine were tested for their antimicrobial activity alone or in combination with aminoglycosides against an MRSA strain. (springer.com)
  • Antimicrobial activity of the aminoglycosides are enhanced in an alkaline environment. (elephantcare.org)
Efficacy1
  • Peak serum levels correspond to the efficacy or bactericidal effect of the drug. (medscape.com)
Activity10
  • It is widely accepted that membrane voltage potentiates aminoglycoside activity, which is ascribed to voltage-dependent drug uptake. (elifesciences.org)
  • Heterologous expression of an ATPase inhibitor completely eliminated bactericidal activity, while loss of the F-ATPase reduced the electrophysiological response to aminoglycosides. (elifesciences.org)
  • Bryan and Van den Elzen, 1976 ), is thought to be essential for the bactericidal activity of aminoglycosides, and requires respiration ( Bryan and Van den Elzen, 1976 ). (elifesciences.org)
  • Throughout these early studies, uptake of the aminoglycosides was often treated as synonymous with bactericidal activity. (elifesciences.org)
  • The first is that the uptake mechanism, and therefore the resulting bactericidal activity, is voltage dependent ( Damper and Epstein, 1981 ). (elifesciences.org)
  • This combination results in synergistic bactericidal activity against susceptible enterococcal strains. (medscape.com)
  • Aminoglycosides also have poor activity in the presence of pus or organic debris. (wedgewoodpharmacy.com)
  • bactericidal activity. (msdmanuals.com)
  • The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. (buyotcantibiotics.com)
  • It has antibacterial, bactericidal and antifungal activity. (pharmru.com)
19871
Renal1
  • As with the other aminoglycosides, on rare occasions changes in renal and eighth cranial nerve function may not become manifest until soon after completion of therapy. (nih.gov)
Hypersensitivity2
Exert1
Uptake1
  • In this paper, we measured the response of Escherichia coli treated with aminoglycosides and discovered that the bactericidal action arises not from the downstream effects of voltage-dependent drug uptake, but rather directly from dysregulated membrane potential. (elifesciences.org)
Vitro1
  • Fountain MW, Weiss S J, Fountain AG, Shen A, Lenk RP (1985) T reatment of Brucella canis and Brucella abortu s in vitro and in vivo by stable plurilamellar vesicle-encapsulated aminoglycosides. (toku-e.com)
Patients2
  • Patients treated with aminoglycosides should be under close clinical observation because of the potential toxicity associated with their use. (nih.gov)
  • Patients receiving oral aminoglycosides with hemorrhagic or necrotic enteritises may ab-sorb appreciable quantities of the drug. (elephantcare.org)
Coli1
  • Our data support a model of voltage-induced death, and separates aminoglycoside bacteriostasis and bactericide in E. coli . (elifesciences.org)
Adverse effects1
Clinical1
  • Here, we examined the ability of MM-201 to protect mammalian sensory hair cells from aminoglycoside damage to further evaluate MM-201's clinical potential. (bvsalud.org)