• bacteria
  • and evaluate these semi- and full-synthetic glycoconjugates and develop carbohydrate-based vaccines against cancer and bacteria. (wayne.edu)
  • Stating that bacterial meningitis can be deadly and contagious among people in close contact, the Laboratories said the bacteria can spread from person to person through coughing and sneezing. (india.com)
  • A person develops bacterial meningitis when bacteria gets into the bloodstream from the sinuses, ears or other parts of the upper respiratory tract, it added. (india.com)
  • These vaccines are directed against enteric or non-enteric flagellin-producing bacteria. (patentsencyclopedia.com)
  • This approach can be applied to a variety of live vaccines that are based on bacteria that produce flagellins. (patentsencyclopedia.com)
  • Bacterial disease agents included in the embodiments of the present invention include flagellin-producing bacteria such as Vibrio, Escherichia coli, Campylobacter, Salmonella, Shigella, Aeromonas, or Pseudomonas. (patentsencyclopedia.com)
  • Inactivated vaccines can be self-possessed either by whole viruses or bacteria, or portions of either. (omicsonline.org)
  • attenuated Y. ruckeri bacteria were examined in vivo as bivalent vaccine delivery vehicles, either through the expression of a fragment of the IHNV glycoprotein or by carrying a plasmid DNA vaccine encoding the complete IHNV glycoprotein. (oregonstate.edu)
  • They also showed that 'toxoidation' of whole bacteria with formaldehyde - the method all manufacturers used to produce the highly neurotoxic pertussis vaccine - did not work on Bordetella pertussis because there are no free amino groups on the toxin of over 200 amino acids. (wikipedia.org)
  • Because those bacterial strains induce antibodies that react with human antigens, the vaccines for those bacteria needed to not contain homologies to proteins encoded in the human genome in order to not cause adverse reactions, thus establishing the need for genome-based Reverse Vaccinology. (wikipedia.org)
  • He enjoys international recognition as an authority on the basic biology and medical significance of atypical bacterial organisms and is considered a pioneer and an expert on the role of these unusual bacteria in the persistence and expression of kidney and urological infectious diseases. (wikipedia.org)
  • They noted that the forms, which they called electron dense bodies were so small that they could pass through bacterial filters that normally withheld ordinary bacteria with cell walls. (wikipedia.org)
  • After applying these data to the human condition, Domingue reasoned that in some patients who suffer from chronic bacterial infections, the disease process could be related to the fact that bacteria are able to differentiate into the resistant electron dense bodies that he observed in tissue cultures. (wikipedia.org)
  • The papers detail how L-form bacteria inside an experimental human embryonic kidney tissue culture system are able to persist in cells and explains how they are able to revert into the cell wall-containing parent bacterial form. (wikipedia.org)
  • infectious diseases
  • The incidence of infectious diseases caused by several bacterial pathogens such as Haemophilus influenzae type b, Streptococcus pneumoniae , and Neisseria meningitidis , has been dramatically reduced over the last 25 years through the use of glycoconjugate vaccines. (mdpi.com)
  • In addition, the company entered into a distribution agreement with the Inoculation Department of St Mary's (London) and distributed a number of vaccines for infectious diseases and even acne and cancer. (wikipedia.org)
  • George Rainer Siber (born September 7, 1944) is an internationally recognized medical researcher and vaccine expert with 42 years of experience in developing numerous vaccines, therapeutic antibodies, and diagnostic agents for infectious diseases. (wikipedia.org)
  • Immunization
  • The role of the formulation in the vaccine scenario in terms of accessibility, affordability and acceptability, besides the contribution in bridging the immunization gap in the country would also be assessed, the statement quoted Gill. (india.com)
  • Immunization (vaccination) can be discrete as active immunity formed by vaccine. (omicsonline.org)
  • The Anthrax Vaccine Immunization Program (AVIP), is the name of the policy set forth by the U.S. federal government to immunize its military and certain civilian personnel with the BioThrax anthrax vaccine. (wikipedia.org)
  • Immunization during pregnancy, that is the administration of a vaccine to a pregnant woman, is not a routine event as it is generally preferred to administer vaccines either prior to conception or in the postpartum period. (wikipedia.org)
  • It is recommended by the American Congress of Obstetrics and Gynecologists(ACOG) the following schedule for pregnant women to receive the vaccine-- Schedule if never immunized: three doses in 0, 4, and 6-12 months Schedule if unknown immunization: at least two doses** in the late second or third trimester. (wikipedia.org)
  • PT Bio Farma (Persero) is an Indonesian state-owned enterprise based in Bandung, Indonesia which produces vaccines and sera to support immunization in Indonesia and other countries. (wikipedia.org)
  • pertussis toxin
  • Briefly, they cloned the pertussis toxin, mapped the antigenic epitopes using antibodies from individuals, who had the disease and or were vaccinated with the old whole-cell vaccine, and attached these antigenic peptides onto the diphtheria toxin as a carrier and adjuvant in one. (wikipedia.org)
  • viral
  • A review into haemophilus influenza type B (Hib) and viral influenza found one good piece of research that showed the flu vaccine reduced the number of women and babies who caught flu. (wikipedia.org)
  • glycoprotein
  • However, there are still some issues existing in glycoprotein vaccines, such as poor reproducibility of the conjugates, difficulties in quality control and so on. (wayne.edu)
  • Rappuoli
  • Rappuoli, R. Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines. (mdpi.com)
  • As a result, Rino Rappuoli and other scientists turned towards bioinformatics to design a functional vaccine. (wikipedia.org)
  • Rino Rappuoli is Chief Scientist & Head of External Research and Development (R&D) at GlaxoSmithKline (GSK) Vaccines. (wikipedia.org)
  • Rappuoli joined Chiron as head of European vaccines research in 1992 with the acquisition of Italian vaccines company Sclavo SpA, where he served as head of research and development. (wikipedia.org)
  • Rappuoli, was previously the Global Head of Vaccines Research for Novartis Vaccines & Diagnostics (Siena, Italy) Since 2015, Dr. Rappuoli serves as the Chief Scientist and Head of External R&D at the vaccines division of GlaxoSmithKline and is based in Siena, Italy. (wikipedia.org)
  • serogroup
  • Guwahati: Hilleman Laboratories has made developments with respect to increased efficacy and reduced cost of Bacterial Meningitis vaccine and published a scientific report based on the synthesis of the meningitis vaccine for Neisseria Meningitidis serogroup X. (india.com)
  • polysaccharides
  • Instead of using polysaccharides isolated from bacterial cells, oligomers of the polysaccharide antigen repeating units were synthesized and then conjugated with a carrier protein, such KLH, or a MPLA derivative to form semi- or full-synthetic vaccines. (wayne.edu)
  • clinical trials
  • Today, a vaccine called RTS,S based on coat protein of sporozoites of the Plasmodium falciparum is the most advanced subunit vaccine and is in the phase III clinical trials. (wikipedia.org)
  • Series of clinical trials of the PfSPZ Vaccine administered with IV injection are planned in 2014 in Africa, Europe, and the United States to expand critical data on the vaccine for clinical development as a method to prevent malaria. (wikipedia.org)
  • development
  • The resultant conjugates were evaluated in mice and their structure-activity relationships were analyzed to identify the proper repeating unit oligomers for vaccine development. (wayne.edu)
  • While research is still under process and trials are ongoing, the first report has shown positive results and it is ten times more effective than the existing vaccine, said the statement of the global vaccine research and development organization. (india.com)
  • Hilleman Laboratories acts as a catalyst in bridging the gap between academic research and product development by targeting novel vaccines and increasing the efficiency of existing vaccines. (india.com)
  • This step should make preparation and further development of vaccine much faster and easier. (wikipedia.org)
  • Bio Farma's history began during the Dutch East Indies period, when the colonial government founded Parc-vaccinogène (State Vaccine Development Agency) on 6 August 1890. (wikipedia.org)
  • structures
  • In the meantime, our group has also developed new vaccine carriers, such as monophosphoryl lipid A (MPLA), to construct full-synthetic carbohydrate-based vaccines that have well-defined structures and improved immunological properties. (wayne.edu)
  • doses
  • Thereafter it ran into Food and Drug Administration (FDA) and judicial obstacles (mainly concerning the methods and viability of the vaccine manufactured by BioPort, a subsidiary of Emergent BioSolutions Inc.). Over 8 million doses of BioThrax were administered to over 2 million U.S. military personnel as part of the program between March 1998 and June 2008. (wikipedia.org)
  • laboratory
  • Indian Immunologicals Limited or IIL is a vaccine manufacturing facility and biotechnology laboratory in Hyderabad, Ooty and Rajkot. (wikipedia.org)
  • human
  • Even when the genes for the major toxin of this pathogen are deleted, human trials have shown that live attenuated vaccines cause residual diarrhea or other symptoms of reactogenicity. (patentsencyclopedia.com)
  • Between the years 1965-1968, Livingston received Fleet Foundation and Kerr Grants, and continued her investigation into a bacterial cause of human cancer. (wikipedia.org)
  • Patients
  • He first became interested in the role of atypical bacterial forms after noting that a large number of patients with urinary tract infections suffer from continual relapsing illness. (wikipedia.org)
  • Search
  • This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine. (wikipedia.org)
  • disease
  • The vaccine available for the disease is extremely expensive which becomes difficult for developing countries like India to have affordability and accessibility to the vaccine. (india.com)
  • The definition of the disease is a bacterial disease that affects the throat and can cause serious or fatal complications. (midtermpapers.com)
  • The benefit is that 85% of the people who received three injections of the vaccine will be protected from the disease for ten years. (midtermpapers.com)
  • Inactivated bacterial vaccine is used during pregnancy for women who have a specific risk of exposure and disease. (wikipedia.org)
  • A review looking at the pneumococcal vaccine in pregnancy found that there was not enough research to say that this vaccination reduced the number of babies developing pneumococcal disease. (wikipedia.org)
  • At the beginning Pasteur´s approach of developing bacterial vaccines was used as a big hope in eradication of this fatal disease. (wikipedia.org)