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BacteriumOral spirocheteDenticolaPathogenSpeciesPathogensSyphilis spirochetePallidum spirochetesCausative agentPeriodontalBorreliaGenomesPertenueSpiral-shaped bacteriaSpirochaetaLymeChlamydiaObligatePathogenicSubspProteinsInfection causedAntigenSystemicSpirochetalViscousAntibodiesCommon bacterialNeurosyphilisSexually transmittedEncodesSpirillumBurgdorferiChromatographicDiseasePathogenesisGenomeEndocarditisTransmission1982PrevalentVitroCytoplasmicElectronBacteria basedCharacteristicPrimarilyDetectionOrganismsSpreadsAgentCellStagesStructuralHuman

Bacterium10

• Treponema denticola is a Gram-negative, obligate anaerobic, motile and highly proteolytic spirochete bacterium. (wikipedia.org)
• Syphilis is a bacterial infection caused by the spirochete bacterium Treponema pallidum. (syphilistreatment.net)
• TP is a spirochete bacterium with an outer envelope and a cytoplasmic membrane. (coretests.com)
• The pathogenic oral spirochete bacterium Treponema denticola lacks a long-RSH homologue but encodes putative small alarmone synthetase (Tde-SAS, TDE1711) and small alarmone hydrolase (Tde-SAH, TDE1690) proteins. (bvsalud.org)
• IMPORTANCE The spirochete bacterium Treponema denticola is a common component of the oral microbiota. (bvsalud.org)
• Treponema pallidum is a gram-negative spirochaete bacterium and is considered to be metabolically crippled. (prospecbio.com)
• Yaws is an infectious tropical disease caused by the spirochete bacterium known as Treponema pertenue. (personalizedcause.com)
• Syphilis - One of the chronic infectious venereal diseases caused by the bacterium Treponema pallidum. (chlamydiadoxycycline.com)
• Syphilis caused by a spirochete bacterium that is contracted sexually. (bartleby.com)
• This 1966 microscope photo made available by the Centers for Disease Control and Prevention shows a tissue sample with the presence of numerous, corkscrew-shaped, darkly-stained, Treponema pallidum spirochetes, the bacterium responsible for causing syphilis. (wsaz.com)

Oral spirochete2

• Treponema denticola, a subgingival oral spirochete has been associated with many periodontal disease conditions such as: the early stage of periodontitis, acute pericoronitis (infection under the gum tissue covering a partially erupted tooth)3, as well as necrotising ulcerative gingivitis (severe inflammation of the gum more common in immunocompromised patients). (wikipedia.org)
• Virulence factors of the oral spirochete Treponema denticola. (granthaalayahpublication.org)

Denticola10

• Treponema denticola is one of three bacteria that form the Red Complex, the other two being Porphyromonas gingivalis and Tannerella forsythia. (wikipedia.org)
• T. denticola is related to the syphilis-causing obligate human pathogen, Treponema pallidum subsp. (wikipedia.org)
• Spirochetes, including Treponema denticola , are therefore able to navigate through particularly viscous environments, unlike that of other prokaryotes. (wikipedia.org)
• Clinical evidence and research shows that periodontal pockets contain large numbers of treponema denticola together with other proteolytic gram negative bacteria, playing an important role in the development of periodontal disease. (wikipedia.org)
• The toxic products of these bacteria, especially treponema denticola may damage the surface lining periodontal cells making them more prone to damage as well as lysis. (wikipedia.org)
• Treponema denticola attaches to fibroblasts and epithelial cells as well as to extracellular matrix components which are found in periodontal tissues and release its own bacterial contents. (wikipedia.org)
• The bacterial components are:[citation needed] Outer sheath associated peptidases Chymotrypsin proteinases Trypsin proteinases Hemolytic activities Hemagglutinating activities outer-sheath protein with pore-forming properties A number of studies have observed an increase of T. denticola in patients with orthodontic appliances, particularly the fixed type. (wikipedia.org)
• Treponema denticola is a potential etiological bacterial agent for oral cancer. (wikipedia.org)
• We also find that the lengths of the integron attC sites shortened through Treponema speciation, and that the integron gene cassettes of T. denticola are highly strain specific. (tmu.edu.tw)
• Porphyromonasgingivalis, Treponema denticola and Tanerella forsythia: the 'red complex', a prototype polybacterial consortium in periodontitis. (granthaalayahpublication.org)

Pathogen2

• It is caused by a bacterial pathogen, the spirochaete. (chlamydiadoxycycline.com)
• Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751. (cameronlaboratory.com)

Species13

• It is one of four species of oral spirochetes to be reliably cultured, the others being Treponema pectinovorum, Treponema socranskii and Treponema vincentii. (wikipedia.org)
• Bacterial shape and arrangement vary from species to species . (biologyreader.com)
• Taken together, our results add to our holistic understanding of alarmone metabolism across diverse bacterial species. (bvsalud.org)
• The operation of the stringent response, a highly conserved survival mechanism, is known to help many bacterial species cause persistent or virulent infections. (bvsalud.org)
• Apart from this group of closely related genospecies, additional Borrelia species of interest include B. lonestari, a spirochete recently detected in the Amblyomma americanum tick (Lone Star tick) in the U.S. [7] B. lonestari is suspected of causing STARI (Southern Tick-Associated Rash Illness), also known as Masters disease in honor of its discoverer. (newworldencyclopedia.org)
• My laboratory is studying the molecular basis of pathogenesis of bacterial species, Borrelia burgdorferi , Treponema pallidum and Pseudomonas aeruginosa . (rutgers.edu)
• One of the human pathogens known to harbor chromosomal integrons, the Treponema spirochetes are the only clade among spirochete species found to carry integrons. (tmu.edu.tw)
• Results: We find that the Treponema spirochetes implicated in human periodontal diseases and those isolated from cow and swine intestines contain chromosomal integrons, but not the Treponema species isolated from termite guts. (tmu.edu.tw)
• By examining the species tree of selected spirochetes (based on 31 phylogenetic marker genes) and the phylogenetic tree of predicted integron integrases, and assisted by our analysis of predicted integron recombination sites, we found that all integron systems identified in Treponema spirochetes are likely to have evolved from a common ancestor - a horizontal gain into the clade. (tmu.edu.tw)
• Conclusions: This is the first comprehensive study to characterize the chromosomal integron systems in Treponema species. (tmu.edu.tw)
• An average adult harbors at least 300 oral bacterial species and more than 700 strains of bacteria have been isolated from test cases. (dentalcare.com)
• genomes may elucidate genes that are unique to those species of spirochetes associated with ticks. (cdc.gov)
• The genus Borrelia currently contains 37 species of spiro- spirochetes were commonly present in the midgut of infected chetes, many of which cause diseases in humans and domestic ticks and occasionally seen in the hindgut and rectal ampule. (cdc.gov)

Pathogens3

• Relatively little is known about the organism in comparison with other bacterial pathogens. (coretests.com)
• These clinically important bacterial pathogens are transmitted to humans using different mechanisms and also show different disease manifestations. (rutgers.edu)
• Often a mix of bacterial pathogens, occasionally herpesviruses producing proinflammatory cytokines → periodontal breakdown. (hopkinsguides.com)

Syphilis spirochete3

• Downstream next-generation sequencing (NGS) of the syphilis spirochete Treponema pallidum subspecies pallidum (T. pallidum) is hindered by low bacterial loads and the overwhelming presence of background metagenomic DNA in clinical specimens. (cdc.gov)
• Identification and Functional Characterization of Peptides with Antimicrobial Activity from the Syphilis Spirochete, Treponema pallidum . (cameronlaboratory.com)
• Interaction of Treponema pallidum , the syphilis spirochete, with human platelets. (cameronlaboratory.com)

Pallidum spirochetes1

• Spirochete Request For Training - CDC's Division of STD Prevention offers T. pallidum spirochetes in aliquots of 0.5 ml - 1.0 ml for training on the use of dark field microscopy. (cdc.gov)

Causative agent3

• Treponema Pallidum (TP) is the causative agent of the venereal disease Syphilis. (coretests.com)
• B. burgdorferi , a spirochete, is causative agent of Lyme disease, a multisystemic illness that affects various organs including joints, heart, nervous system and skin. (rutgers.edu)
• Functional insights from proteome-wide structural modeling of Treponema pallidum subspecies pallidum , the causative agent of syphilis. (cameronlaboratory.com)

Periodontal2

• The breadth of bacterial diversity in the human periodontal pocket and other oral sites. (granthaalayahpublication.org)
• spirochetes at the forefront of periodontal infections. (granthaalayahpublication.org)

Borrelia7

• The spirochete was named Borrelia burgdorferi in his honor. (newworldencyclopedia.org)
• Non-pathogenic Borrelia burgdorferi expressing Treponema pallidum TprK and Tp0435 antigens as a novel approach to evaluate syphilis vaccine candidates. (rutgers.edu)
• The most important spirochete is Borrelia recurrentis , which is transmitted by ticks and is responsible for sporadic cases of relapsing fever . (medscape.com)
• Rat-bite fever ( Spirillum minor ), Lyme disease ( Borrelia burgdorferi ), and syphilis ( Treponema pallidum ) are other spirochetal diseases that can cause FUO. (medscape.com)
• Pathogenic spirochetes in the genus Borrelia are transmitted primarily by two families of ticks. (cdc.gov)
• The Lyme disease spirochete, Borrelia burgdorferi , is transmitted by the slow-feeding ixodid tick Ixodes scapularis, whereas the relapsing fever spirochete, B. hermsii , is transmitted by Ornithodoros hermsi , a fast-feeding argasid tick. (cdc.gov)
• In the new era of genomics, the ticks and mammals, which in turn suggests biological func- complete DNA sequence of two spirochetes, Borrelia burg- tions for a few surface-exposed lipoproteins. (cdc.gov)

Genomes2

• pallidum has one of the smallest bacterial genomes at 1.14 million base pairs (Mb) and has limited metabolic capabilities, reflecting its adaptation through genome reduction to the rich environment of mammalian tissue. (prospecbio.com)
• With the recent release of many new Treponema genomes, we were able to study the distribution of chromosomal integrons in this genus. (tmu.edu.tw)

Pertenue2

• Yaws is the most prevalent infectious, nonvenereal treponemal disease and is caused by Treponema pallidum pertenue . (medscape.com)
• Yaws is caused by Treponema pallidum pertenue, a slender spirochete that is serologically indistinguishable from the spirochete T pallidum , which causes syphilis. (medscape.com)

Spiral-shaped bacteria1

• Bejel, yaws (frambesia), and pinta are infections caused by Treponema , which are spiral-shaped bacteria called spirochetes. (msdmanuals.com)

Spirochaeta1

• Treponema pallidum (Spirochaeta pallida), a spirochete that, because of its susceptibility, is transmitted only in warm, moist environments. (altmeyers.org)

Lyme3

• We have been studying the molecular mechanisms involved in the attachment of Lyme disease spirochetes to a variety of host cells. (rutgers.edu)
• Using a combination of bioluminescent B. burgdorferi and mouse model of infection, we will further analyze the contribution of each bacterial ligand-host receptor interaction in Lyme pathogenesis. (rutgers.edu)
• Lyme disease spirochetes are generally restricted to the midgut in unfed I. scapularis . (cdc.gov)

Chlamydia1

• Treponema pallidum , Spirillum minus , Chlamydia trachomatis etc. (biologyreader.com)

Obligate1

• Bordetella bronchiseptica, Spirochetes (especially Treponema hyodysenteriae) and obligate anaerobe organisms (like M. hyosynovial, M. hyorhinis, M. hyopneumoniae and M. caprae). (afrimash.com)

Pathogenic1

• infection of these two bacteria in strikingly different types of As additional genome sequences become available for other ticks provide examples of possible adaptations for their trans- pathogenic and free-living spirochetes, comparisons of their mission. (cdc.gov)

Subsp1

• 2019. Analysis of host cell binding specificity mediated by the Tp0136 adhesin of the syphilis agent Treponema pallidum subsp. (rutgers.edu)

Proteins1

• These spirochetes attach to proteins (including fibronectin and collagen) of local gingival fibroblasts, binding to their plasma membrane. (wikipedia.org)

Infection caused1

• Syphilitic aortitis is implied with aortic spirochetes infection (caused by syphilis). (remedyland.com)

Antigen3

• Treponema pallidum is suitable for ELISA and Western blots, excellent antigen for detection of T. Pallidum with minimal specificity problems. (prospecbio.com)
• Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of Treponema pallidum . (cameronlaboratory.com)
• Virtually all spirochetes in the midgut of an unfed nymph express outer surface protein (Osp) A. This protein is also the predominant surface antigen expressed by the spirochetes in vitro. (cdc.gov)

Systemic2

• Some systemic bacterial illnesses can manifest as FUOs. (medscape.com)
• Worldwide, bacterial, sexually transmitted infection with a typical, phasic, chronic course with initial localized to progressive systemic infectious disease. (altmeyers.org)

Spirochetal1

• One of the most striking features of B. burgdorferi as compared with other bacteria is its unusual genome, which is far more complex than that of its spirochetal cousin Treponema pallidum, the agent of syphilis. (newworldencyclopedia.org)

Viscous1

• Some bacterial cell are covered externally by a thin viscous substance which forms covering layer or envelope to the cell. (foodtechnotes.com)

Antibodies1

• One Step Syphilis Test is a rapid chromatographic immunoassay for the qualitative detection of antibodies to Treponema Pallidum (TP) to aid in the diagnosis of Syphilis. (coretests.com)

Common bacterial1

• Syphilis is a common bacterial disease transmitted through sexual contact. (stdexpressclinic.com)

Neurosyphilis2

• Here we present a case of a patient with symptomatic neurosyphilis presenting with CSF findings of bacterial meningitis. (gbmc.org)
• In the case of Cupid's Disease, the behavior being discussed is affected by a bacterial disease called neurosyphilis. (bartleby.com)

Sexually transmitted1

• Syphilis is a sexually transmitted disease spread by spirochete Treponema Pallidum, it has a varied range of symptoms and is divided into stages primary, secondary and tertiary. (gbmc.org)

Encodes1

• This is in stark contrast to the minimal genome of Treponema pallidum which encodes only 1,040 ORFs. (wikipedia.org)

Spirillum1

• whereas spirillum is a singular form that represents a single helical-shaped bacterial cell. (biologyreader.com)

Burgdorferi2

• The specific interaction between the spirochete and host cells may be responsible for the tissue tropism exhibited by B. burgdorferi . (rutgers.edu)
• Detailed studies of B. burgdorferi were initiated in 1982 used by tick-borne spirochetes to adapt for transmission by when Burgdorfer and coworkers reported these bacteria in their tick vectors, may lead to unique disease prevention strat- adult Ixodes scapularis ticks collected from vegetation on egies. (cdc.gov)

Chromatographic1

• Treponema pallidum protein was purified by proprietary chromatographic technique. (prospecbio.com)

Disease6

• To understand the relationship between our bacterial microbiome and health, it is essential to define the microbiome in the absence of disease. (biomedcentral.com)
• The bacterial microbiome of the human digestive tract contributes to both health and disease. (biomedcentral.com)
• Apart from their use in screening and diagnosis, nontreponemal antibody titers are used to measure disease activity, as higher titers are positively correlated with bacterial load. (medscape.com)
• Aotritis usually occur in patients with the biliary colic, rheumatologic diseases, Takayasu arteritis, giant cell arteritis, dental disease and other bacterial infections that can enter in the bloodstream. (remedyland.com)
• The ulcerative skin lesions that develop early in the disease course are teeming with spirochetes, which can be transmitted via direct skin-to-skin contact and via breaks in the skin due to trauma, bites, or excoriations. (medscape.com)
• Syphilis is a bacterial disease that surfaces as genital sores but can ultimately lead to severe symptoms and death if left untreated. (wsaz.com)

Pathogenesis1

• multi-omic analysis of host cellular responses to Treponema pallidum provides novel insight into syphilis pathogenesis. (cameronlaboratory.com)

Genome1

• Selective Whole-Genome Amplification as a Tool to Enrich Specimens with Low Treponema pallidum Genomic DNA Copies for Whole-Genome Sequencing. (cdc.gov)

Endocarditis1

• Bacterial endocarditis or septic endocarditis can be divided into two groups: acute bacterial endocarditis and subacute bacterial endocarditis. (remedyland.com)

Transmission1

• PERSPECTIVES other changes are taking place in the spirochete population that may lay the groundwork for eventual transmission to the host. (cdc.gov)

19821

• Soon after the spirochete was isolated by Willy Burgdorfer in 1982 - a scientist with the National Institutes of Health, who specialized in the study of spirochete microorganisms. (newworldencyclopedia.org)

Prevalent1

• Background: Integron systems are now recognized as important agents of bacterial evolution and are prevalent in most environments. (tmu.edu.tw)

Vitro1

• We use genetics, biochemical techniques and tissue culture system to identify and characterize the bacterial and host molecules involved in this interaction in vitro. (rutgers.edu)

Cytoplasmic1

• Cytoplasmic filaments, a bacterial intermediate-like filaments composed of the protein CfpA, are adjacent to the inner membrane and run parallel to the tightly organized flagellar filaments. (wikipedia.org)

Electron3

• The native cellular architecture of the bacterial cell was revealed using cryo-electron tomography, a technique observing intact plunge-frozen cells. (wikipedia.org)
• By the discovery of electron microscope in early 1940's the study of structural bacterial cell has been made very easier. (foodtechnotes.com)
• Electron micrograph of Treponema pallidum. (medscape.com)

Bacteria based1

• Through microscopic observation, we can determine the morphological or physiological characteristics of bacteria based on bacterial shape and arrangement. (biologyreader.com)

Characteristic2

• Tightly organized bundles of periplasmic flagella were observed in the periplasm, a characteristic of spirochetes. (wikipedia.org)
• The morphological characteristic of a bacterial cell is as follows. (foodtechnotes.com)

Primarily1

• Tooth abscesses are primarily caused by bacterial infections. (toothshow.com)

Detection2

• We defined a case of TBRF as detection of spirochetes on thin- or thick-blood smears or in cerebrospinal fluid (CSF) samples by using conventional microscopy after Giemsa or Wright staining ( Figure ). (cdc.gov)
• Syphilis detection tests are serologic tests used to screen for and confirm infection with Treponema pallidum. (medscape.com)

Organisms2

• These taxonomic ranks are upheld by International Codes of Nomenclature, which ensure their universal application to all living organisms, encompassing plant phyla, animal phyla, fungal phyla, protist phyla, and bacterial phyla. (microbiologynote.com)
• Why is Treponema pallidum, the causal agent of Syphilis, also deemed the Lady Proxima of Organisms in our book? (microbigals.com)

Spreads1

• It is a bacterial infection that spreads through vaginal, oral, or anal sexual contact with someone who has the infection. (medlineplus.gov)

Agent1

• The infective agent is a spirochaete, treponema pallidum. (gpnotebook.com)

Cell9

• Conversely, coccus is a singular form, which represents a single spherical-shaped bacterial cell. (biologyreader.com)
• Oppositely, coccus is a singular form representing a single rod-shaped bacterial cell. (biologyreader.com)
• The morphology of bacterial cell includes characteristics such as size, shape, structure etc. (foodtechnotes.com)
• Bacterial cell having less than one complete twist form. (foodtechnotes.com)
• The flagella helps in swimming motility of the bacterial cell. (foodtechnotes.com)
• It also has a high sensitivity and has the ability to detect a single bacterial cell. (granthaalayahpublication.org)
• For axenic growth under laboratory conditions, it specifically relies on the external supply of N -acetylmuramic acid (MurNAc), which is an essential constituent of the peptidoglycan (PGN) of bacterial cell walls. (karger.com)
• Figures 1&2, modified from Kasmar AG, Hooper D. Pharmacology of bacterial infections: cell wall synthesis. (dentalcare.com)
• On average, the diameter of a spherical bacterial cell ranges between 0.5 and 2.0 µm and between 0.25 and 1 µm for rod-shaped or filamentous bacteria. (bioexplorer.net)

Stages2

• Syphilis is caused by the spirochete Treponema pallidum and classically progresses through a series of stages with increasing symptomatology if unrecognized and untreated. (hcahealthcare.com)
• Treponema bacteria (particularly during stages I and II ) are highly contagious. (amboss.com)

Structural1

• Structural characterization of Treponema pallidum Tp0225 reveals an unexpected leucine-rich repeat architecture. (cameronlaboratory.com)

Human3

• The digestive tract includes diverse habitats and hosts the human body's greatest bacterial density. (biomedcentral.com)
• We describe the bacterial community composition of ten digestive tract sites from more than 200 normal adults enrolled in the Human Microbiome Project, and metagenomically determined metabolic potentials of four representative sites. (biomedcentral.com)
• We present a case report of a 31-year-old male with sudden left-sided weakness and numbness who tested positive for both Treponema pallidum and human immunodeficiency virus (HIV). (hcahealthcare.com)