• Recently, core photosystem II (PSII) genes were identified in cyanophages and proposed to function in photosynthesis and in increasing viral fitness by supplementing the host production of these proteins. (nih.gov)
  • Here we show evidence for the presence of photosystem I (PSI) genes in the genomes of viruses that infect these marine cyanobacteria, using pre-existing metagenomic data from the global ocean sampling expedition as well as from viral biomes. (nih.gov)
  • The seven cyanobacterial core PSI genes identified in this study, psaA, B, C, D, E, K and a unique J and F fusion, form a cluster in cyanophage genomes, suggestive of selection for a distinct function in the virus life cycle. (nih.gov)
  • Potentially, the seven proteins encoded by the viral genes are sufficient to form an intact monomeric PSI complex. (nih.gov)
  • The Viral Core in the Center for Immunity and Immunotherapies assists with the construction and production of viral vectors that can be used as vehicles for delivering genes or templates into cells for targeted integration or repair. (iths.org)
  • Using de novo gene prediction, we identified 6,996 protein-encoding genes in the MAST-4 genome. (nature.com)
  • Analysis of the genome data using ab initio gene prediction identified 6,996 protein-encoding genes in the genome of the isolate. (nature.com)
  • But a viral infection is fought with a different set of genes than a bacterial one, for instance. (rt.com)
  • The Duke team recognized 30 genes that switch on during a viral attack. (rt.com)
  • Analyze full-length infectious clones to determine the genes or gene products involved in replication, systemic movements, and pathogenicity to understand the role of viral pathogen genes in disease development and to identify new targets in the pathogen genome and tools for disease management. (usda.gov)
  • Viruses that infect bacteria may drive the evolution of drug-resistant superbugs by inserting their genes into the bacterial DNA, a new study suggests. (livescience.com)
  • We found that CRISPR works better in the less-tightly wound regions of the genome, but TALEN can access those genes in the heterochromatin region better than CRISPR," Zhao said. (vectorsjournal.org)
  • Many herpesviruses including MDV, a poultry alphaherpesvirus, carry homologous host genes presumably acquired during viral evolution. (usda.gov)
  • We've used genome-wide CRISPR libraries to discover mammalian genes mediating the sensing of pathogens (Parnas et al. (massgeneral.org)
  • This approach has been called " genomic epidemiology "-using pathogen genome sequences to detect emerging diseases, assess their potential virulence and resistance to antibiotics, and monitor their spread in populations. (cdc.gov)
  • In spite of their broad abundance, viruses, in particular bacteriophages, remain largely unknown since only about 20% of sequences obtained from viral community DNA surveys could be annotated by comparison with public databases. (mdpi.com)
  • The 100K Genome Project has added 20 newly completed genome sequences of foodborne pathogens generated using Pacific Biosciences' single-molecule sequencing technology to the National Center for Biotechnology Information's public database. (genomeweb.com)
  • Broad Genomics Platform sequences a whole human genome every four minutes. (broadinstitute.org)
  • Through the ATCC Genome Portal, you can easily search, access, and analyze thousands of reference-quality genome sequences. (atcc.org)
  • This finding provides direct evidence that host genome acquisition by MDV actually occurs during virus replication, and that one or more such MDV genomes with host sequences may exist within MDV viral stocks, which tend to be polyclonal due to the strictly cell-associated nature of its infection process. (usda.gov)
  • The sequencing of the human genome revealed that at least 1% of the human genome consists of endogenous retroviral sequences, representing past encounters with retroviruses during the course of human evolution. (msdmanuals.com)
  • Each bacterial and fungal genome is sequenced on both Illumina and Oxford Nanopore platforms, resulting in a "hybrid-assembly" incorporating both sequencing technologies. (atcc.org)
  • We are currently using the platform to develop genome-edited bananas, which are resistant to bacterial, fungal and viral diseases. (cgiar.org)
  • The virus was sequenced at the Institut Pasteur's Mutualized Platform for Microbiology (P2M), which performs genome sequencing on bacterial, viral, fungal and parasite strains received by National Reference Centers and World Health Organization Collaborating Centers for the purpose of infectious disease surveillance. (pasteur.fr)
  • The assay uses next-generation DNA sequencing (NGS) along with Fusion's novel DNA hybridization technology, QuantumProbes, to enrich bacterial/viral/fungal genomes prior to sequencing. (labroots.com)
  • Viral Ecology and Disturbances: Impact of Environmental Disruption on the Viruses of Microorganisms. (wikipedia.org)
  • Quantitative Viral Ecology: Dynamics of Viruses and Their Microbial Hosts. (wikipedia.org)
  • Bacteriophage Ecology: Population Growth, Evolution, and Impact of Bacterial Viruses. (wikipedia.org)
  • In order to shed some light into this genetic dark matter we expanded the search of orthologous groups as potential markers to viral taxonomy from bacteriophages and included eukaryotic viruses, establishing a set of 31,150 ViPhOGs (Eukaryotic Viruses and Phages Orthologous Groups). (mdpi.com)
  • Evidence that bacterial small molecules also target viruses provides fresh insights into how bacteria thwart viral infection. (nature.com)
  • Bacteria can also use general defences to combat their viral predators, in addition to having a plethora of more-specific defences that target particular viruses. (nature.com)
  • He knew that these viruses, or phages, were susceptible to CRISPR-Cas, the bacterial defence system that scientists have harnessed as a powerful tool for gene editing. (stardrive.org)
  • Promising new inhibitors that target the viral helicase-primase complex have been reported to block replication of herpes simplex and varicella-zoster viruses, but they have no activity against human cytomegalovirus (HCMV), another herpesvirus. (frontiersin.org)
  • In the experiment on retroviral genomes, 6 mouse leukaemia viruses (MLV) were recombined in a single round, giving a library of 5 million replicating recombinant viruses. (i-sis.org.uk)
  • 2) Determine the genome organization of selected viruses of major significance to ornamental and nursery crops. (usda.gov)
  • Next generation sequencing (NGS) of nucleic acid extracts from plants infected with unknown viruses is expected to yield information about the genomes of previously uncharacterized viruses without any background information on what viruses might be infecting the plant. (usda.gov)
  • CRISPR was first discovered in bacteria as a primitive acquired immune system, which cuts and pastes viral DNA into their own genomes to fight viruses. (lifeboat.com)
  • CRISPR is a bacterial molecule that detects invading viruses. (vectorsjournal.org)
  • On January 29, 2020, the Institut Pasteur, which is responsible for monitoring respiratory viruses in France, sequenced the whole genome of the coronavirus known as "2019-nCoV", becoming the first institution in Europe to sequence the virus since the start of the outbreak. (pasteur.fr)
  • Sequencing the genome of pathogens is crucial for the development of specific diagnostic tests and the identification of potential treatment options," explains Sylvie van der Werf, Director of the National Reference Center (CNR) for Respiratory Viruses at the Institut Pasteur. (pasteur.fr)
  • These metagenome-assembled genomes are critical to provide ecological, evolutionary, and metabolic context for all the microbes and viruses yet to be cultivated. (peerj.com)
  • Viruses depend completely on cells (bacterial, plant, or animal) to reproduce. (msdmanuals.com)
  • Some viruses have an outer envelope consisting of protein and lipid, surrounding a protein capsid complex with genomic RNA or DNA and sometimes enzymes needed for the first steps of viral replication. (msdmanuals.com)
  • Classification of viruses is principally according to their genome sequence taking into consideration nature and structure of their genome and their method of replication, but not according to the diseases they cause (see International Committee on Taxonomy of Viruses (ICTV), 2021 release ). (msdmanuals.com)
  • Positive-sense RNA viruses possess a single-stranded RNA genome that can serve as messenger RNA (mRNA) that can be directly translated to produce an amino acid sequence. (msdmanuals.com)
  • Negative-sense RNA viruses possess a single-stranded negative-sense genome that first must synthesize a complementary positive-sense antigenome, which is then used to make genomic negative-sense RNA. (msdmanuals.com)
  • the genome of RNA viruses ranges from 3.5 kilobases (some retroviruses) to 27 kilobases (some reoviruses), and the genome of DNA viruses ranges from 5 kilobases (some parvoviruses) to 280 kilobases (some poxviruses). (msdmanuals.com)
  • These findings warrant a close genomic monitoring of MPXV to get a better picture of the genetic micro-evolution and mutational patterns of this virus , and a close clinical monitoring of skin bacterial superinfection in monkeypox patients . (bvsalud.org)
  • What genomic studies are CDC public health scientists doing-and which genomes are they writing about? (cdc.gov)
  • Genomes are found at all three corners of the epidemiologic triangle: human or animal hosts are engaged in genomic contests with pathogens of all kinds, played out in an environment teeming with the genomes of other people, animals, plants, and microbes. (cdc.gov)
  • Scientists in the Broad community are sequencing and analyzing the genomes of a wide range of insects and microorganisms to understand their genetic regulation, population variation, and specialized genomic mechanisms. (broadinstitute.org)
  • Plasmids purified from genomic DNA, proteins, ribosomes, and the bacterial cell wall are used in molecular biology research. (sigmaaldrich.com)
  • This creates substantial risk in the trustworthiness of individual genome assemblies, and in aggregate, for several important genomic database resources. (atcc.org)
  • Recently the Bitsliced Genomic Signature Index (BIGSI) was introduced allowing the search on all viral and bacterial genomic sequence reads in the European Nucleotide Archive (ENA). (kit.edu)
  • Advances in DNA sequencing technology have made it increasingly affordable to sequence a person's entire genome, but managing genomic and related data from millions of individuals is a daunting challenge. (feedburner.com)
  • To do this, we examine the non-redundant viral diversity stored in public databases, predict proteins in genomes lacking such information, and used all annotated and predicted proteins to identify potential protein domains. (mdpi.com)
  • New drugs targeting essential viral proteins other than pUL54 are therefore urgently needed. (frontiersin.org)
  • In a series of papers between 1998 and 2002, he and his coworkers in Maxygen and other companies have used the technique to obtain greatly improved proteins, such as green fluorescent protein, fucosidase, subtilisin, thymidine kinase and interferon-alpha, as well as improved retroviral vectors and bacterial strains of Streptomyces and Lactobacillus . (i-sis.org.uk)
  • In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
  • Once the provirus is integrated into the host cell DNA, it is transcribed using typical cellular mechanisms to produce viral proteins and genetic material. (msdmanuals.com)
  • The rise of antibiotic-resistant bacterial strains, however, represents a serious threat to public health and the economy. (cdc.gov)
  • The ATCC Genome Portal was created to reestablish the trustworthiness, reliability, and accuracy of genome assemblies associated with ATCC microbial strains . (atcc.org)
  • Concrete evidence of a viral signature was first spotted in people who volunteered to be infected with differing strains of flu for the experiment. (rt.com)
  • These two "winning" strains produced small, wrinkled-looking colonies of bacteria that congregated into biofilms - clusters of bacterial cells that secrete a slimy substance that offers them protection from both the host immune system and attacks by phages. (livescience.com)
  • Instead of finding small mutations scattered throughout the DNA, the team found that entirely new segments of DNA had been added to the winning strains' genomes. (livescience.com)
  • This commentary discusses the use of nucleic acid (deoxyribonucleic acid and ribonucleic acid) vaccines against viral infections and pandemic-like settings. (canada.ca)
  • The potential advantages of the nucleic acid vaccines over conventional vaccines are presented, and the nucleic acid vaccines currently in development against viral infections and the challenges these vaccines face entering clinical trial are discussed. (canada.ca)
  • Now there is hope in the form of new genome-engineering tools, particularly one called CRISPR. (technologyreview.com)
  • Though genome editing with CRISPR is just a little over a year old, it is already reinventing genetic research. (technologyreview.com)
  • The CRISPR/Cas9 system is one of several different bacterial systems for defense against viral attacks. (leica-microsystems.com)
  • Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN. (vectorsjournal.org)
  • Their experiments revealed that TALEN is up to five times more efficient than CRISPR-Cas9 in parts of the genome, called heterochromatin, that are densely packed. (vectorsjournal.org)
  • CDC) estimates that annually, at least two million illnesses and 23,000 deaths are caused by antibiotic-resistant bacteria in the United States alone.1 If the effectiveness of antibiotics (drugs that kill or inhibit the growth of bacteria) is lost, we will no longer be able to reliably and rapidly treat bacterial infections, including bacterial pneumonias, foodborne illnesses, and healthcare- associated infections. (cdc.gov)
  • The mission of the Bacterial Genomics Group at Broad is to develop and implement 'omics methodologies to answer pressing questions related to bacteria and their role in human health. (broadinstitute.org)
  • and, (3) Characterize genomes of bacteria of major significance to ornamental and nursery crops to develop diagnostic tests for accurate pathogen detection. (usda.gov)
  • Sequencing of monkeypox virus from infected patients reveals viral genomes with APOBEC3-like editing, gene inactivation, and bacterial agents of skin superinfection. (bvsalud.org)
  • Bart Weimer, the project's director and a professor at UC Davis, told In Sequence this week that these first 20 genomes represent a gearing-up phase for the project, in which his team worked through the logistics of automating its PacBio sequencing protocol for an acceleration of the project over the next year. (genomeweb.com)
  • Over the last decade, as DNA-sequencing technology has grown ever faster and cheaper, our understanding of the human genome has increased accordingly. (technologyreview.com)
  • To date, viral genomes have been produced using only Illumina sequencing. (atcc.org)
  • Each genome entry is provided with sequencing and assembly quality metrics, annotation metrics, and additional metadata for each strain such as antibiotic susceptibility, geographical origins, and phenotypic data. (atcc.org)
  • As we continue to carry out whole-genome sequencing of ATCC's microbial collection, the number of reference genomes in the ATCC Genome Portal will continue to grow every month for the foreseeable future, and we encourage the research community to contact us with suggestions on taxa to prioritize in our pipeline. (atcc.org)
  • Dr. Jonathan Jacobs leads ATCC's Sequencing & Bioinformatics Center and the development of the ATCC Genome Portal. (atcc.org)
  • The small sequencing devices have been used previously to track the Ebola and Zika epidemics, but the human genome is many orders of magnitude larger than those bacterial and viral genomes, making this "a huge technical achievement," Benedict Paten, PhD, one of the collaborators in the latest sequencing effort, told Medscape Medical News . (medscape.com)
  • Jain is one of the first authors on the article, published online January 29 in Nature Biotechnology , that describes the genome sequencing project. (medscape.com)
  • We talk about 'whole-genome sequencing,' but it's a misnomer because there are parts of the genome that have been unseen, and there have been parts that have, what I'd call, weak assembly," Topol told Medscape Medical News . (medscape.com)
  • That same Friday evening, scientists launched the process of sequencing the viral genome based on the samples. (pasteur.fr)
  • The sequencing run was completed by early evening on the Tuesday, and the scientists used data analysis to obtain the sequence of the whole genome in two of the first three confirmed cases in France. (pasteur.fr)
  • This proves the efficacy of the CNR's process of analysis based on viral sequencing," continues Vincent Enouf. (pasteur.fr)
  • Research on zoonotic MRSA used whole genome-sequencing technologies to evaluate transmission in Africa and Asia. (cdc.gov)
  • This manageable size together with the current advances in nucleotide sequencing technology means that partial and whole virus genome sequencing will become an essential component in epidemiologic investigations of disease outbreaks. (msdmanuals.com)
  • Those ultralong reads mean scientists can see parts of the genome in ways they have not before. (medscape.com)
  • The study adds to the evidence that a broader selection of genome-editing tools is needed to target all parts of the genome, said Huimin Zhao, a professor of chemical and biomolecular engineering at the University of Illinois Urbana-Champaign who led the new research. (vectorsjournal.org)
  • The findings will lead to improved approaches for targeting various parts of the genome, Zhao said. (vectorsjournal.org)
  • We detected a high number of mutations (range, 64-73) relatively to a 2018 Nigerian genome ( genome GenBank Accession no. (bvsalud.org)
  • Viral diseases have an enormous impact on human health worldwide. (broadinstitute.org)
  • The goals of the Broad Viral Genomics Group are to pioneer the application of these technologies to address the crucial unanswered biological questions in viral disease, and to foster a community of research leaders focused on using genomics to advance preventative and therapeutic strategies for viral diseases. (broadinstitute.org)
  • The long-term objective of this project is to develop effective means for the detection and identification of new and emerging plant viral and bacterial diseases of ornamentals, thus allowing growers to select pathogen-free or pathogen-indexed plants (tested for absence of specific pathogens) for propagation. (usda.gov)
  • The HCMV helicase-primase complex (pUL105-pUL102-pUL70) is essential for viral DNA replication and could thus be a relevant antiviral target. (frontiersin.org)
  • Mutational analysis of several of these amino acids both in pUL105 and pUL70, proved that they are crucial for viral replication. (frontiersin.org)
  • and the US Food and Drug Administration, aims to sequence 100,000 bacterial and viral genomes overall. (genomeweb.com)
  • Jonas Korlach, PacBio's chief scientific officer, told In Sequence that PacBio and the 100K genomes team have been working with several vendors to adapt fluidic robot technology to automate library preparation steps. (genomeweb.com)
  • Researchers completed the first draft of the human genome sequence almost 20 years ago. (medscape.com)
  • This year, an international research team reported that they completed the human genome sequence using handheld nanopore devices in about 2 months at a cost of around $30,000. (medscape.com)
  • Eric Topol, MD, founder and director of the Scripps Translational Science Institute in La Jolla, California, seconds that statement, noting that many people thought it would take years before the human genome sequence could be assembled inexpensively from small machines. (medscape.com)
  • Over the weekend of January 11-12, the Chinese authorities shared the full sequence of the coronavirus genome, as detected in samples taken from the first patients. (pasteur.fr)
  • It is the most important type of antibacterial agent for fighting bacterial infections , and antibiotic medications are widely used in the treatment and prevention of such infections. (wikipedia.org)
  • Antibiotics are used to treat or prevent bacterial infections, [29] and sometimes protozoan infections . (wikipedia.org)
  • An important concept in the evaluation of data regarding transfusion-transmitted bacterial infections (TTBIs) is the definition of a case. (medscape.com)
  • One very pressing problem is diagnosing and saving infants with serious bacterial infections in time. (rt.com)
  • In the past few decades, there has been rapid spread of numerous severe viral infections, including human immunodeficiency virus (HIV), influenza A, severe acute respiratory syndrome (SARS), Ebola and Zika. (canada.ca)
  • and 6 (3%) concerned genomes of other animal species (Figure). (cdc.gov)
  • 1 report their analysis of an antiviral defence system that can protect more than one bacterial species. (nature.com)
  • combined with metagenomics has uncovered thousands of novel bacterial species directly from samples without isolation or culturing. (helmholtz-hzi.de)
  • Globally, HCMV represents the first viral cause of birth defect, leading to severe congenital malformations ( Leruez-Ville and Ville, 2017 ). (frontiersin.org)
  • Weimer said that the chemistry upgrade has been particularly helpful, as well as the release of PacBio's HGap de novo assembly tool, which selects for the longest available reads to create seed reads used to pre-assemble the genome, to which shorter reads are aligned to build consensus. (genomeweb.com)
  • That would not be enough to assemble a genome from scratch, but it is enough to start an analysis, especially as data continue to accumulate while the machine runs. (medscape.com)
  • In the process of cloning the entire Md11 genome in a bacterial artificial chromosome (BAC) vector, we obtained an infectious clone in which the entire terminal repeat short segment (TRS) was replaced by a portion of the duck genome. (usda.gov)
  • Restriction endonucleases (REases) function as an innate form of microbial immune systems to disrupt invasive DNA molecules, such as viral genomes, that infect bacterial and archaeal cells. (fredhutch.org)
  • Viral vectors are essential tools for the center and NGEC researchers working to advance the field of gene therapy and repair. (iths.org)
  • The Viral Core team assists with the construction and production of lentivirus (LV) vectors, including non-integrating lentivirus (NILV) vectors as well as adeno-associated virus (AAV) vectors. (iths.org)
  • This article is about treatment of bacterial infection. (wikipedia.org)
  • The focus is on pathogen genomes, applying advances in molecular and bioinformatics methods first developed for human genome research. (cdc.gov)
  • The possible roles of molecular hydrogen, a common by-product of bacterial fermentation, are also addressed. (techscience.com)
  • Until recently, only the simplest genomes were available to public health scientists and even those were generally known only by their fingerprints. (cdc.gov)
  • In particular, the bacterial infection often affects people with compromised immune systems , whether due to conditions like cystic fibrosis or drugs that suppress the immune system, like steroids. (livescience.com)
  • The Department of "Computational Biology for Infection Research" studies the human microbiome, viral and bacterial pathogens, and human cell lineages within individual patients by analysis of large-scale biological and epidemiological data sets with computational techniques. (helmholtz-hzi.de)
  • Whole-genome se- phic, forming mycelia in soil and arthroconidia capable of quencing (WGS) analysis of the recovered isolates dem- infecting humans and certain other mammals, and spher- onstrated near identical genetic identity between soil and ules in mammalian tissue ( 1 ). (cdc.gov)
  • Zhao and his colleagues used single-molecule fluorescence microscopy to directly observe how the two genome-editing tools performed in living mammalian cells. (vectorsjournal.org)
  • Martha R. J. Clokie is in the Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK. (nature.com)
  • Established diagnostic tests for COVID-19 are based on the detection of viral RNA in patient samples, such as nasal and throat swabs, from which RNA molecules must then be extracted and purified. (sciencedaily.com)
  • While binding to the lipid headgroup is detrimental for anion transport, I hypothesized that binding to the headgroup can provide membrane selectivity (e.g., bacterial membranes over human membranes) and can induce membrane perturbations similar to those observed for antimicrobial peptides. (rsc.org)
  • This means they can rewrite the human genome at will. (technologyreview.com)
  • We were able to generate enough data to put together a human genome assembly that was in many respects superior to that initial draft," continued Paten, who currently oversees the Center for Big Data in Translational Genomics and is an assistant professor in the Department of Biomolecular Engineering at the University of California, Santa Cruz. (medscape.com)
  • This grant from the National Human Genome Research Institute (NHGRI) funds the Center for Big Data in Translational Genomics, a multi-institutional partnership based at UC Santa Cruz and led by David Haussler, professor of biomolecular engineering and director of the UC Santa Cruz Genomics Institute. (feedburner.com)
  • A major focus is the evolution and spread of bacterial pathogens (and antibiotic resistance) including the interactions that these pathogens have with their host and host-associated microbiota. (broadinstitute.org)
  • Antimicrobial peptides have long been hailed as a solution to the antibiotic resistance crisis, because they target the bacterial membrane and can cause quick bactericidal activity in bacterial cells. (rsc.org)
  • My group has genetically engineered bananas, conferring resistance against the deadly bacterial Xanthomonas wilt disease. (cgiar.org)
  • Understanding viral and bacterial genome structures and functions, their mechanisms of pathogenicity and resistance, and conferring virus and bacterial resistance in plants will lead to the development of better disease control measures and increases in both productivity and quality of ornamental plants for industry and the consumer. (usda.gov)
  • But now, a new study, published Friday (July 16) in the journal Science Advances , hints that phages may also help their bacterial hosts develop resistance against antibiotic treatments . (livescience.com)
  • This pandemic, as defined by the World Health Organization, is "an epidemic occurring worldwide, or over a very wide area, crossing international boundaries and usually affecting a large number of people" Footnote 1 , led the scientific and medical communities to initiate serious efforts to limit the wave of viral spread by developing preventative vaccines. (canada.ca)
  • As of December 2016, the data set consists of 447,833 genomes using 170 TiB of space. (kit.edu)
  • We found that a pipeline combining read deduplication and an assembly algorithm originally designed to recover genomes from libraries generated after whole genome amplification (single-cell SPAdes) frequently improved assembly of contigs ≥10 kb by 10 to 100-fold for low input metagenomes. (peerj.com)
  • In recent years, this bacterial system has been adopted by researchers to snip out or insert nearly any gene in any organism or cell, quickly and efficiently. (lifeboat.com)
  • His PhD focuses on the development of hosts for bacterial lipids, in particular anionic lipids such as PG. (rsc.org)
  • The viral parasites often kill off their microbial hosts after infiltrating their DNA , said senior study author Vaughn Cooper, director of the Center for Evolutionary Biology and Medicine at the University of Pittsburgh School of Medicine. (livescience.com)
  • Phages also embed themselves in this protective matrix and release chemicals to fight off other phages in the neighborhood, again, to keep their bacterial hosts all to themselves. (livescience.com)
  • Basic Sciences member Dr. Barry Stoddard and his laboratory have long been fascinated by REases and bacterial restriction-modification systems, both in terms of their evolutionary history and their mechanisms of DNA recognition and fidelity. (fredhutch.org)
  • By replacing the collection buffer with simple and inexpensive buffer formulations, we can enable viral detection with high sensitivity directly from the original clinical sample, without any intermediate steps," says Dr Reinius. (sciencedaily.com)
  • Together, it represents a first paradigm for the recruitment of acetylated NrtR to regulate bacterial central NAD + metabolism. (elifesciences.org)
  • We are currently investigating whether the replacement of the TRS with host genome DNA influences tumor incidence. (usda.gov)
  • Finally, we are adapting our unbiased analytical strategies into real-world therapeutics, having performed clinical trials (with our collaborator Dr. Catherine Wu), in which patients are vaccinated against their own tumors with a fully personal vaccine that is designed based on a computational analysis of their tumor genome. (massgeneral.org)
  • The traceability and authentication of microbial genome assemblies to physical biological materials is typically poorly documented and not a requirement for many public genome databases. (atcc.org)
  • Here, we describe our laboratory and bioinformatics methods, the diversity of the current contents of the ATCC Genome Portal , it's current capabilities, and new features for use by the research community. (atcc.org)
  • Metagenomics has transformed our understanding of microbial diversity across ecosystems, with recent advances enabling de novo assembly of genomes from metagenomes. (peerj.com)
  • Classification of the MPXV genomes and determination of their mutational patterns were performed using Nextclade. (bvsalud.org)
  • One promising approach to study these lineages is single cell genomics (SCG), whereby an individual cell is captured from nature and genome data are produced from the amplified total DNA. (nature.com)
  • The estimated residual risk of contamination of blood products with bacterial agents is 1 in 5,000 for platelets and 1 in 30,000 for red blood cells. (medscape.com)
  • On the hardware side, the PacBio RS II [now] doubles the throughput per SMRT cell, so you only need half the cells to close a bacterial genome," Korlach said. (genomeweb.com)
  • Furthermore, we have shown that the variant MDV genome containing the duck genome substitution is present in the parental Md11 population and has been maintained through several subsequent propagations of the virus on chicken cells. (usda.gov)
  • The incidence of bacterial transmission depends on the blood product and also on the definition of the cases. (medscape.com)
  • [ 4 , 6 ] The higher incidence of bacterial transmission via platelets has been attributed to the difference in storage temperatures. (medscape.com)
  • The ATCC Genome Portal and the data contained therein is freely available for research-use and is accessible online ( https://genomes.atcc.org ) or via an authenticated REST-API. (atcc.org)
  • This has allowed us to develop genetically modified and genome-edited products and to transfer these technologies to national agricultural research systems in sub-Saharan Africa. (cgiar.org)
  • According to Shomron 7 (2010), this field of the clinical pharmacology studies the contribution of genomes, transcriptomes and proteomes in determining drug-response phenotypes (safety and efficacy). (bvsalud.org)