• Partly because of its muscle-activating function, but also because of its functions in the autonomic nervous system and brain, many important drugs exert their effects by altering cholinergic transmission. (wikipedia.org)
  • We therefore hypothesize that this molecule could displace the virus from nAChR attachment and pave the way for unimpaired cholinergic signal transmission. (biomedcentral.com)
  • Acetylcholine is the neurotransmitter used at the neuromuscular junction-in other words, it is the chemical that motor neurons of the nervous system release in order to activate muscles. (wikipedia.org)
  • The brainstem pedunculopontine (PPN) and laterodorsal tegmental (LDTg) nuclei are involved in multifarious activities, including motor control. (bvsalud.org)
  • Together, our results show that postsynaptic Group I mGluRs are critically involved in the regulation of cholinergic synaptic strength on different time scales, suggesting that cholinergic control of local thalamic circuits is highly context-dependent and regulated by the overall levels of glutamatergic afferent activity. (jneurosci.org)
  • Partly because of its muscle-activating function, but also because of its functions in the autonomic nervous system and brain, many important drugs exert their effects by altering cholinergic transmission. (wikipedia.org)
  • In the CNS, cholinergic projections from the basal forebrain to the cerebral cortex and hippocampus support the cognitive functions of those target areas. (wikipedia.org)
  • An increasing number of studies indicate that cholinergic control of these functions is highly deterministic, mediated by synaptic afferents that generate reliable and precise responses in postsynaptic neurons. (jneurosci.org)
  • Acetylcholine is the neurotransmitter used at the neuromuscular junction-in other words, it is the chemical that motor neurons of the nervous system release in order to activate muscles. (wikipedia.org)