AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Placental HormonesPlacental LactogenPlacentaHelix-Loop-Helix MotifsChorionic GonadotropinBasic Helix-Loop-Helix Transcription FactorsTrophoblastsPregnancyGene Expression ProfilingGene ExpressionGene Expression RegulationGene Expression Regulation, DevelopmentalTranscription FactorsHormonesMolecular Sequence DataDNA-Binding ProteinsIn Situ HybridizationNerve Tissue ProteinsOligonucleotide Array Sequence AnalysisThyroid HormonesRNA, MessengerCell DifferentiationBase SequenceFollicle Stimulating HormoneAmino Acid SequenceLuteinizing HormoneHomeodomain ProteinsRepressor ProteinsNervous SystemTranscription, GeneticReceptors, NotchSequence Homology, Amino AcidPromoter Regions, GeneticDrosophilaParathyroid HormoneRetinaGonadotropin-Releasing HormoneReverse Transcriptase Polymerase Chain ReactionGonadal Steroid HormonesDrosophila ProteinsGene Expression Regulation, PlantNeuronsStem CellsGene Expression Regulation, NeoplasticReceptors, Thyroid HormoneYolk SacEncyclopedias as TopicNeural CrestEF Hand Motifs
TranscriptionDataSetsProteinFamilyHumanMultipleDetailsDevelopmentLevelAdditional
Transcription6
  • A member of the HAND subclass of basic Helix-loop-helix (bHLH) transcription factors, the Heart and neural crest-derived transcript-1 (HAND1) gene is vital for the development and differentiation of three distinct embryological lineages including the cardiac muscle cells of the heart, trophoblast of the placenta, and yolk sac vasculogenesis. (wikipedia.org)
  • The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. (wikipedia.org)
  • In conjunction with HAND2 (a fellow bHLH transcription factor), complementary and overlapping expression patterns are thought to play a role in interpreting asymmetrical signals in the developing heart which leads to the characteristic looping. (wikipedia.org)
  • This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)
  • hes family bHLH transcription fa. (gsea-msigdb.org)
  • We further established that AHR, when activated by BaP, directly inhibited SIRT1 transcription, leading to downregulation of XPC and XPA, which are essential NER genes involved in the recognition and verification steps of the NER process. (bvsalud.org)
DataSets1
Protein5
  • Heart- and neural crest derivatives-expressed protein 1 is a protein that in humans is encoded by the HAND1 gene. (wikipedia.org)
  • What does this gene/protein do? (cancerindex.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikidoc.org)
Family1
  • This gene product is one of two closely related family members, the HAND proteins are expressed within the developing ventricular chambers, cardiac neural crest, endocardium (HAND2 only) and epicardium (HAND2 only). (wikipedia.org)
Human2
  • The following are some of the gene count estimates of human chromosome 1. (wikidoc.org)
  • The following is a partial list of genes on human chromosome 1. (wikidoc.org)
Multiple2
  • Most highly related to twist-like bHLH genes in amino acid identity and embryonic expression, HAND1 can form homo- and heterodimer combinations with multiple bHLH partners, mediating transcriptional activity in the nucleus. (wikipedia.org)
  • Alternative splicing of this gene results in multiple transcript variants. (cancerindex.org)
Details1
  • Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction ). (wikidoc.org)
Development2
  • HAND1 works jointly with HAND2 in cardiac development of embryos based on a crucial HAND gene dosage system. (wikipedia.org)
  • The two are implemented in cardiac development of embryos based on a crucial HAND gene dosage system. (wikipedia.org)
Level1
  • However, their relevance for investigations of drug-drug and drug-organic anion (e.g., bile acid, steroid hormone) interactions at the transporter level remains to be established. (cancerindex.org)
Additional1
  • Additional experiments demonstrated that BaP suppressed the expression of SIRT1. (bvsalud.org)