• phase
  • On Monday 30 November 2009, the World Health Organization stated that "[The WHO] recommends that countries phase out the use of Stavudine, or d4T, because of its long-term, irreversible side-effects. (wikipedia.org)
  • A subsequent phase III trial involving combinations of 3TC or FTC with stavudine and neviripine had to be stopped due to serious liver-related adverse events. (wikipedia.org)
  • treatment
  • Stavudine is used in the treatment of HIV-1 infection, but is not a cure. (wikipedia.org)
  • In a recent case report, oral administration of uridine, given in the form of NucleomaxX┬«, ameliorated the mitochondrial toxicity caused by stavudine and led to improvements in myalgias and liver and muscle enzymes, despite continuing treatment with stavudine. (clinicaltrials.gov)
  • infection
  • Stavudine can also reduce the risk of developing HIV-1 infection after coming into contact with the virus either at work (e.g., needlestick) or through exposure to infected blood or other bodily fluids. (wikipedia.org)
  • human
  • Fengdan Jin, "Liquid Chromatography-Tandem Mass Spectrometric Assay for Determination of Stavudine in Human Plasma," Journal of Spectroscopy , vol. 2014, Article ID 517089, 5 pages, 2014. (hindawi.com)