AntioxidantProteinCharacterized by the accumulation of lipidDeuterated polyunsaturated fattyAntioxidantsReactiveMembrane lipidsSuppress lipidLipoproteinProteinsMalondialdehydeEnzymeAccumulationHydroperoxidesHemolysisFerroptosisOxidative stressTBARSFattyGlutathione peroxidasePlasma oxidationFatsAssayFree RadicalDamageDegradation2002VivoCardiovascularMetabolismSubstratesTissuesMoleculesNitrogenInflammationPhospholipidsSerumMechanismsProductsGlucoseLevelsTherapeuticRadicalsErythrocytesParametersVascularDiseasesBloodStatus
Antioxidant12
- 45 (1989) 891] proposed that colchiceine (EIN) acts as an antioxidant and protective agent against lipid peroxidation in a rat model of liver injury. (cdc.gov)
- However, the metabolites did exhibit dose-dependent depletion of glutathione, resembling the behavior of etoposide, a hindered phenol with antioxidant properties against lipid peroxidation. (cdc.gov)
- Antioxidant enzyme expression, lipid peroxidation, and protein oxidation in human myometrium with parturition Reproductive Sciences. (nottingham.ac.uk)
- Bilirubin may act as an antioxidant that suppresses lipid oxidation. (ajol.info)
- Increased serum MDA concentration, as a biomarker of lipid peroxidation, low serum bilirubin and antioxidant capacity were observed in patients with angiographically defined CAD. (ajol.info)
- Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)
- Vitamin E is a fat-soluble antioxidant that protects vulnerable fatty acids in cell membranes from lipid peroxidation. (nutrametrix.com)
- There are a number of reactive nitrogen oxide species, such as N2O3 and ONOO-, that can alter critical cellular components under high local concentrations of NO. However, NO can also abate the oxidation chemistry mediated by reactive oxygen species such as H2O2 and O2- that occurs at physiological levels of NO. In addition to the antioxidant chemistry, NO protects against cell death mediated by H2O2, alkylhydroperoxides, and xanthine oxidase. (researchgate.net)
- If not for an extracellular antioxidant system to eliminate reactive oxygen and nitrogen species, lipid peroxidation and protein oxidation would become excessive, resulting in cellular damage. (go.jp)
- Many of the antioxidant molecules in grapes work to reduce that LDL lipid peroxidation process. (lifeextension.com)
- To counter high ROS levels, cells have antioxidant mechanisms that reduce the excess ROS in the cell and keep the 'redox' (from reduction and oxidation) balance of the cell. (elifesciences.org)
- Much of this has to do with pectin but also the strong antioxidant composition of apples helps prevent the oxidation of fats found in the bloodstream or linking to our blood vessels. (earnestparenting.com)
Protein6
- Lu, C., Chan, S.L., Fu, W. and Mattson, M.P. (2002) The lipid peroxidation product 4-Hydroxyneal facilitates op- ening of voltage dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation. (scirp.org)
- Chowdhury, T.D., Das, N., Chattopadhyay, A. and Datta, A.G. (1999) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. (scirp.org)
- however, Ferroptosis Suppressor Protein 1 is now known to block ferroptosis, but a changed amino acid metabolism, control of glucose and lipid levels along with minerals such as selenium appear to invoke change. (canceractive.com)
- The reduction of protein oxidation and lipids peroxidation by PS is related to antioxidants effect of this statin. (medsci.org)
- Antioxidants provide protection to living organisms from damage caused by uncontrolled production of ROS and concomitant lipid peroxidation, protein damage and DNA stand breaking. (intechopen.com)
- The effects of Yucca schidigera and Quillaja saponaria on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in streptozotocin-induced diabetic rats. (personalhealthzone.com)
Characterized by the accumulation of lipid1
- Death of GSCs was apparently due to the iron dependent form of programmed cell death characterized by the accumulation of lipid peroxides called ferroptosis. (nature.com)
Deuterated polyunsaturated fatty1
- An alternative, pharmaceutical method employs the isotope effect on lipid peroxidation of deuterated polyunsaturated fatty acids (PUFAs) at the methylene bridges (bis-allylic sites) between double bonds, which leads to the inhibition of the chain reaction. (wikipedia.org)
Antioxidants4
- Antioxidants such as vitamin C and vitamin E may inhibit lipid peroxidation. (wikipedia.org)
- However, the latter retain high reactivity towards critical biomolecules in cells such as lipids, thiols, ascorbate, thereby, rendering colchicine metabolites effective radical scavengers but not effective chain-breaking antioxidants. (cdc.gov)
- Research found that the antioxidants in spirulina may be particularly effective at reducing lipid peroxidation. (healthline.com)
- When the concentration of free radicals exceeds the neutralizing capability of the body's antioxidants, these highly reactive species can damage vital molecules such as DNA, RNA, enzymes and structural proteins and large amounts of membrane lipids though peroxidation. (nutrametrix.com)
Reactive5
- The end products of lipid peroxidation are reactive aldehydes, such as malondialdehyde (MDA) and 4-hydroxynonenal (HNE), the second one being known also as "second messenger of free radicals" and major bioactive marker of lipid peroxidation, due to its numerous biological activities resembling activities of reactive oxygen h species. (wikipedia.org)
- It has been shown to protect critical molecules in the body such as lipids, proteins, and nucleic acids from free radicals and reactive oxygen species (1). (nutrametrix.com)
- Glutathione peroxidases are a group of selenoprotein enzymes that reduce reactive oxygen species such as hydrogen peroxide and lipid hydroperoxides to harmless products such as water and simple alcohols. (nutrametrix.com)
- We therefore aimed to investigate peroxidation, measured as thiobarbituric the correlation between hypercholesterol- acid-reactive substance (TBARS). (who.int)
- Scientists are therefore keenly interested in finding ways to reduce lipid peroxidation by lowering LDL levels directly and by reducing the rate at which these molecules become damaged by reactive oxygen species. (lifeextension.com)
Membrane lipids1
- 1992). These oxygen free radicals can modify DNA, proteins and membrane lipids, leading to cellular degeneration (Olanow, 1992). (scialert.net)
Suppress lipid2
- Such D-PUFAs, for example, 11,11-D2-ethyl linoleate, suppress lipid peroxidation even at relatively low levels of incorporation into membranes. (wikipedia.org)
- It contains Ellagic Acid found naturally in many fruits and known to suppress lipid per-oxidation, helping to inhibit the development of age spots. (skin-etc.com)
Lipoprotein5
- It has also been shown to reduce the lipid oxidation of low-density lipoprotein (LDL) particles, thus promoting cardiovascular health (6). (nutrametrix.com)
- Lipoprotein oxidation induced in vitro in whole plasma is expected to be a more relevant model of the lipoprotein oxidation in the arterial wall than the in vitro oxidation of single isolated lipoproteins, e.g., low density lipoprotein (LDL). (iospress.com)
- Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)
- Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations. (cdc.gov)
- The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)
Proteins1
- Comprising both lipid and proteins, LDL particles are particularly vulnerable to the effects of oxygen free radicals. (lifeextension.com)
Malondialdehyde3
- Certain diagnostic tests are available for the quantification of the end-products of lipid peroxidation, to be specific, malondialdehyde (MDA). (wikipedia.org)
- However, there are other sources of malondialdehyde, so this test is not completely specific for lipid peroxidation. (wikipedia.org)
- Malondialdehyde (MDA) is lipid peroxidation end product. (ajol.info)
Enzyme1
- RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)
Accumulation3
- Ferroptosis is a unique form of cell death, dependent on iron and characterised by the accumulation of lipid peroxidation in the membranes. (canceractive.com)
- Hepatocellular lipid accumulation is thought to simultaneously stimulate mitochondrial fatty acid oxidation and the production of ROS, thereby promoting lipid peroxidation and damage of mitochondrial DNA (mtDNA) ( 3 ). (spandidos-publications.com)
- Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)
Hydroperoxides2
- The toxicity of lipid hydroperoxides to animals is best illustrated by the lethal phenotype of glutathione peroxidase 4 (GPX4) knockout mice. (wikipedia.org)
- These animals do not survive past embryonic day 8, indicating that the removal of lipid hydroperoxides is essential for mammalian life. (wikipedia.org)
Hemolysis5
- Lipid peroxidation, hemolysis and thiol contents were studied in intact goat erythrocytes exposed to phenylhydrazine. (scirp.org)
- An increase in lipid peroxidation, hemolysis and thiol content was observed after phenylhydrazine treatment of erythrocyte. (scirp.org)
- No effect of Ca2+ on control lipid peroxidation, hemolysis and thiol contents of erythrocytes was observed. (scirp.org)
- Diltiazem and EDTA inhibited the increased responses of lipid peroxidation and hemolysis due to Ca2+. (scirp.org)
- Lead blocks the activity of 5-aminolevulinic acid dehydratase and leads to hemoglobin oxidation, which along with the lipid peroxidation can result in red cell hemolysis. (medscape.com)
Ferroptosis3
- German researchers suggested that these immortal cells, however, could be susceptible to ferroptosis, where their iron content works against them, causing lipid peroxidation (3). (canceractive.com)
- Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. (frontiersin.org)
- Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. (cdc.gov)
Oxidative stress1
- The increase in oxidative stress leads to cell membrane damage due to lipid peroxidation. (medscape.com)
TBARS1
- The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)
Fatty3
- This radical is also an unstable species that reacts with another free fatty acid, producing a different fatty acid radical and a lipid peroxide, or a cyclic peroxide if it had reacted with itself. (wikipedia.org)
- Sperm cell membranes are high in polyunsaturated fatty acids and are sensitive to oxygen free radical induced damage mediated by lipid peroxidation. (scialert.net)
- Among these signaling lipids, a particular group of oxygenated polyunsaturated fatty acids (PUFA), so called lipid mediators, has been thoroughly investigated over several decades. (cdc.gov)
Glutathione peroxidase1
- Hypercholesterolaemia is frequently sayed on the same day for the determination associated with enhanced lipid peroxida- of glutathione peroxidase activity and lipid tion [3]. (who.int)
Plasma oxidation2
- A ferrous oxidation xylenol assay was used to assess plasma oxidation activity levels in samples from a randomized, placebo-controlled, 6-week trial of daily vitamin E supplementation in adults with asthma (n = 72). (nih.gov)
- A 27% increase in plasma oxidation activity levels was observed in patients receiving vitamin E. We demonstrate a pro-oxidant effect of high-dose vitamin E supplementation that may explain the increase in mortality observed in intervention studies using this nutrient. (nih.gov)
Fats2
- Lipid peroxidation is where free radicals steal electrons in a chain reaction causing oxidation of the fats in cell membranes. (canceractive.com)
- LDL transports lipids (fats) from the digestive system to tissues. (lifeextension.com)
Assay2
- Using our fluorescence-HPLC assay with metabolically incorporated oxidation-sensitive cis-parinaric acid (PnA) we studied the effects of colchicine metabolites on peroxidation of different classes of membrane phospholipids in HL-60 cells. (cdc.gov)
- Oxidizability of human plasma measured in the presence of Cu(II) was found to correlate with the oxidizability of LDL measured in the common Cu(II)‐based LDL oxidation assay. (iospress.com)
Free Radical2
- Lipid peroxidation is a major outcome of free radical-mediated injury to brain, where it directly damages membranes and generates a number of oxidized products. (omega-research.com)
- In a recent review by a group of Chinese scientists (4), they showed that amino acid and iron metabolism might bring about free radical formation and cause lipid peroxidation of the cancer cells. (canceractive.com)
Damage5
- It is the process in which free radicals "steal" electrons from the lipids in cell membranes, resulting in cell damage. (wikipedia.org)
- full citation needed] If not terminated fast enough, there will be damage to the cell membrane, which consists mainly of lipids. (wikipedia.org)
- In fact, one small study showed that spirulina supplementation was able to reduce exercise-induced lipid peroxidation, inflammation, and muscle damage in 17 rugby players. (healthline.com)
- If healthy cells do not have enough glutathione, lipid peroxidation can damage them. (canceractive.com)
- NO is also involved in cell kil ing but often used as a marker of oxidative Hanahan and Weinberg (2011), i n can also react with superoxide at DNA damage, although other bas- their landmark review "Hallmarks diffusion-limited rates to form per- es are also susceptible to oxidation. (who.int)
Degradation1
- Lipid peroxidation is the chain of reactions of oxidative degradation of lipids. (wikipedia.org)
20021
- In a study published in 2002, human volunteers consumed a lipid-rich meal, either with or without 300 mg of a proanthocyanidin-rich grape seed extract. (lifeextension.com)
Vivo1
- Some of the chemically and metabolically stable oxidation products are useful in vivo biomarkers of lipid peroxidation. (omega-research.com)
Cardiovascular2
- Cardiovascular disease involves a cascade of aberrant biological processes, but one area of interest even amongst the medical establishment is LDL oxidation. (lifeextension.com)
- Decades of research have demonstrated that serum concentrations of blood lipids are associated with increased risk for cardiovascular disease and mortality [ 1 - 4 ]. (cdc.gov)
Metabolism1
- Studies have shown that pectin and polyphenols, which are both found in apples, enhance lipid metabolism and reduce the production of LDL. (earnestparenting.com)
Substrates1
- However, spermatozoa's lipids are the main substrates for peroxidation, which may provoke severe functional disorder of sperm. (scialert.net)
Tissues2
- In recent years, development of immunochemical detection of HNE-histidine adducts opened more advanced methodological possibilities for qualitative and quantitative detection of lipid peroxidation in various human and animal tissues[full citation needed] as well as in body fluids, including human serum and plasma samples. (wikipedia.org)
- In the process, they cause oxidation of body tissues. (smart-publications.com)
Molecules1
- Indeed, a number of signaling functions of (phospho)lipid molecules has been discovered. (cdc.gov)
Nitrogen2
- Nitrogen oxides form naturally during the oxidation of nitrogen-containing compounds such as coal, diesel fuel, and silage. (cdc.gov)
- They are produced commercially, usually as the first step in the production of nitric acid, either by the direct oxidation of atmospheric nitrogen in the electric arc (Birkeland-Eyder Process) or by the catalytic oxidation of anhydrous ammonia (Oswald Process). (cdc.gov)
Inflammation1
- The process, known as lipid peroxidation, is a powerful stimulant of inflammation in blood vessels, eventually leading to plaque formation. (lifeextension.com)
Phospholipids2
- None of the colchicine metabolites in concentrations ranging from 10(-6) to 10(-4) M was able to protect phospholipids against peroxidation induced by either azo-initiators of peroxyl radicals or via myeloperoxidase (MPO)-catalyzed reactions in the presence of hydrogen peroxide. (cdc.gov)
- VitE deficiency resulted in peroxidation of docosahexaenoic acid (DHA), depleting DHA-containing phospholipids, especially phosphatidylcholine, which also caused choline depletion. (oregonstate.edu)
Serum1
- The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. (cdc.gov)
Mechanisms2
- On the other hand, it's unclear whether dietary lipid peroxides are bioavailable and play a role in disease, as a healthy human body has protective mechanisms in place against such hazards. (wikipedia.org)
- The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
Products5
- The chemical products of this oxidation are known as lipid peroxides or lipid oxidation products (LOPs). (wikipedia.org)
- In addition, end-products of lipid peroxidation may be mutagenic and carcinogenic. (wikipedia.org)
- There are additional reactants in the indoor environment which can facilitate the oxidation of these consumer products. (cdc.gov)
- Many of these oxidation products are not captured by conventional sampling methods, leading some researchers to suspect that workers who are exposed to oxidized chemicals may not know it. (cdc.gov)
- Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. (omega-research.com)
Glucose1
- This increased lipid peroxidation also increased NADPH oxidation, which depleted glucose by shunting it to the pentose phosphate pathway. (oregonstate.edu)
Levels1
- Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)
Therapeutic1
- These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD and HD, that CSF IsoPs may aid in the assessment of anti-oxidant experimental therapeutics and laboratory diagnosis of AD. (omega-research.com)
Radicals1
- Electron spin resonance (ESR) experiments demonstrated that in a catalytic system containing horseradish peroxidase (HRP)/H(2)O(2), colchicine metabolites undergo one-electron oxidation to form phenoxyl radicals that, in turn, cause ESR-detectable ascorbate radicals by oxidation of ascorbate. (cdc.gov)
Erythrocytes1
- Extracellular Ca2+ potentiates the phenylhydrazine-induced lipid peroxidation and hemoly- sis of erythrocytes significantly. (scirp.org)
Parameters1
- 0.0001)) after adjustment for lipid status parameters and traditional risk factors in this study population. (ajol.info)
Vascular2
- This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)
- An ever growing body of evidence shows that components of red grapes can have powerful effects on vascular health, reducing platelet aggregation and lipid peroxidation while improving endothelial function. (lifeextension.com)
Diseases3
- This is known as lipid peroxidation , a key driver of many serious diseases. (healthline.com)
- Many illnesses, but particularly degenerative diseases and organ injuries, exhibit lipid peroxidation (1). (canceractive.com)
- This decreased amount of lipid peroxidation is key to lowering heart risks and diseases. (earnestparenting.com)
Blood2
- Variants within APOE (rs7412, rs429358), PON1 (rs854560), ITGB3 (rs5918), and NOS3 (rs2070744) were found to be associated with one or more blood lipids in at least one race/ethnic group in crude and adjusted analyses. (cdc.gov)
- We report the significant associations of blood lipids with variants and haplotypes in APOE , ITGB3, NOS3 , and PON1 in the three main race/ethnic groups in the U.S. population using a large, nationally representative and population-based sample survey. (cdc.gov)
Status1
- We did not detect a difference in oxidation status between HDL isolated from uremic and healthy patients. (lww.com)