Brain tumors may be congenital in children younger than 3 years of age and range from benign complex lesions to highly malignant neoplasms. (medlink.com)
PPIs can cause hypergastrinemia at clinical doses, and hypergastrinemia has been reported to induce malignant neoplasms in the stomach in previous animal studies. (helicojournal.org)
Pituitary6
The MEN1 phenotype is inherited via an autosomal-dominant pattern and is associated with neoplasms of the pituitary gland, the parathyroid gland, and the pancreas (the 3 "P"s). (wikipedia.org)
In the last 30 years, an unprecedented production of new knowledge about the tumors of the pituitary gland has led to a series of new discoveries important for the understanding of how these neoplasms form and the management of our patients. (endocrine-abstracts.org)
Hyperparathyroidism is the most common feature, followed by tumors of the pituitary gland, additional endocrine glands, and other organs. (medlineplus.gov)
In MEN I, the neoplasms typically originate from the pancreas, the parathyroid gland, and the pituitary gland. (picmonic.com)
Spindle cell oncocytoma of the pituitary gland. (nih.gov)
The hypothalamic-pituitary-gonadal (HPG) axis plays a crucial and integrative role in the mammalian endocrine regulation to maintain homeostasis. (intechopen.com)
Thyroid15
The thyroid gland weighs, on average, 15 g, and is composed of two lateral lobes that extend to the sides of the larynx to very close to the midline of the thyroid cartilage, and that are joined by an isthmus that pass in front of the trachea. (teknon.es)
The most common sign of multiple endocrine neoplasia type 2 is a form of thyroid cancer called medullary thyroid carcinoma. (medlineplus.gov)
Multiple endocrine neoplasia type 2 is divided into three subtypes: type 2A, type 2B (formerly called type 3), and familial medullary thyroid carcinoma (FMTC). (medlineplus.gov)
Management of follicular and Hürthle cell neoplasms of the thyroid gland. (nih.gov)
Association between various thyroid gland diseases, TSH values and thyroid cancer: a case-control study. (nih.gov)
Diagnostic controversies in vascular proliferations of the thyroid gland. (nih.gov)
The steroid-producing endocrine cells of the adrenal cortex, ovary, and testis, as well as the thyroid hormone-producing follicular cells in the thyroid gland, do not form part of the DNS. (basicmedicalkey.com)
The multiple endocrine neoplasia type 2A (MEN2A) is a monogenic disorder characterized by an autosomal dominant pattern of inheritance which is characterized by high risk of medullary thyroid carcinoma in all mutation carriers. (repositoriosalud.es)
Overview of Thyroid Function The thyroid gland, located in the anterior neck just below the cricoid cartilage, consists of 2 lobes connected by an isthmus. (msdmanuals.com)
Follicular cells in the gland produce the 2 main thyroid hormones. (msdmanuals.com)
Thyroid gland medullary carcinoma that is resistant to treatment. (nih.gov)
Two pairs of small oval-shaped glands located in the front and the base of the Neck and adjacent to the two lobes of thyroid gland. (easyauscultation.com)
Ultrasonography showed masses in both lobes of the thyroid gland, and a 30-mm lobulated hypoechoic mass in the axilla with well-defined and rough borders, showing internal heterogeneity. (springeropen.com)
Whereas the thyroid gland showed faint FDG accumulation and multiple lung nodules showed no accumulation, FDG accumulation with a standardized uptake value maximum of 5.1 was observed in the right axillary tumor (Fig. 1 a-d). (springeropen.com)
Diseases3
CONCLUSION: Prominent corneal nerves have been described in some diseases, such as multiple endocrine neoplasia (MEN) type 1 and type 2A and 2B, congenital ichthyosis, Refsum's disease, leprosy, etc. (bvsalud.org)
Although the APUD concept provided a unifying theory for explaining some endocrine diseases and ectopic hormone productions, the hypothesis that the cells were all of neural crest origin, as postulated by Pearse, was later disproved by the experiments of LeDouarin ( 5 ) and others. (basicmedicalkey.com)
A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. (childrensmercy.org)
Tumor4
Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome) and has autosomal dominant inheritance. (wikipedia.org)
Although the term carcinoid tumor has been broadly used to refer to many neoplasms derived from the DNS ( 9 ), this term is being replaced by neuroendocrine neoplasms. (basicmedicalkey.com)
However, to communicate effectively with clinicians, the term carcinoid tumor can still be used in parenthesis for neoplasms of the gastrointestinal tract and lungs. (basicmedicalkey.com)
Recent advances in the molecular diagnosis and treatment of pineoblastoma, a rare embryonal tumor of the pineal gland with particular penetrance in infants and young children, are also highlighted in this review. (medlink.com)
MEN14
Mutations in the MEN1 , RET , and CDKN1B genes can cause multiple endocrine neoplasia. (medlineplus.gov)
Mutations in the MEN1 gene cause multiple endocrine neoplasia type 1. (medlineplus.gov)
Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism. (ox.ac.uk)
The disorder may represent either an early stage of multiple endocrine neoplasia type 1 (MEN1), or an allelic variant of MEN1, or a distinct entity involving another locus. (ox.ac.uk)
Syndromes2
Multiple endocrine neoplasia (MEN) syndromes are characterized by tumors involving multiple endocrine glands. (arupconsult.com)
Although pheochromocytoma has classically been associated with 3 syndromes-von Hippel-Lindau (VHL) syndrome, multiple endocrine neoplasia type 2 (MEN 2), and neurofibromatosis type 1 (NF1)-there are now 10 genes that have been identified as sites of mutations leading to pheochromocytoma. (medscape.com)
Vascular Neoplasm1
Epithelioid hemangioendothelioma (EHE) is a rare and slow-growing malignant vascular neoplasm composed of epithelioid endothelial cells within a distinctive myxohyaline stroma. (springeropen.com)
Exocrine1
The calcium ion is essential to any physiologic phenomena, including preservation of the integrity of cellular membranes, neuromuscular activity, regulation of endocrine and exocrine secretory activities, blood coagulation, activation of the complement system, and bone metabolism. (abdominalkey.com)
Mutation5
Autosomal dominant HEREDITARY CANCER SYNDROME in which a mutation most often in either BRCA1 or BRCA2 is associated with a significantly increased risk for breast and ovarian cancers. (umassmed.edu)
Mice homozygous for a dominant negative knock-in mutation in this gene exhibit partial prenatal lethality and abnormal afterhyperpolarization in the in the CA3 area of hippocampus. (jax.org)
Multiple endocrine neoplasm type one is a group of neoplasms occurring together due to a specific gene mutation. (picmonic.com)
This gene mutation is inherited in an autosomal dominant fashion which results in characteristic patient presentations. (picmonic.com)
Inheritance Chong-Hai and Rajagopalan (1977) suggested autosomal recessive inheritance of pachyonychia congenita in a 4-year-old Malaysian girl with first-cousin parents, although they recognized new dominant mutation as a possibility. (findzebra.com)
Disorders4
Multiple endocrine neoplasia is a group of disorders that affect the body's network of hormone-producing glands called the endocrine system. (medlineplus.gov)
A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. (lookformedical.com)
Chronic refractory diarrhoea: a manifestation of endocrine disorders. (nih.gov)
The pathological causes of short stature are diverse and include psychosocial circumstances as well as a variety of genetic, endocrine, and metabolic disorders, which may affect a child's development in other ways than longitudinal growth. (amboss.com)
Neoplasia16
Multiple Endocrine Neoplasia Type 2b" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "Multiple Endocrine Neoplasia Type 2b" by people in this website by year, and whether "Multiple Endocrine Neoplasia Type 2b" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Multiple Endocrine Neoplasia Type 2b" by people in Profiles. (umassmed.edu)
CT, therefore, is a novel form of multiple endocrine neoplasia (MEN). (endocrine-abstracts.org)
Background: Carney complex (CNC) is a rare multiple neoplasia syndrome, its commonest endocrine manifestation being ACTH-independent Cushing s syndrome, histologically characterized by primary pigmented nodular adrenocortical disease (PPNAD). (endocrine-abstracts.org)
The major forms of multiple endocrine neoplasia are called type 1, type 2, and type 4. (medlineplus.gov)
Many different types of tumors are associated with multiple endocrine neoplasia. (medlineplus.gov)
The most common sign of multiple endocrine neoplasia type 1 is overactivity of the parathyroid glands (hyperparathyroidism). (medlineplus.gov)
The signs and symptoms of multiple endocrine neoplasia type 2 are relatively consistent within any one family. (medlineplus.gov)
Multiple endocrine neoplasia type 4 appears to have signs and symptoms similar to those of type 1, although it is caused by mutations in a different gene. (medlineplus.gov)
multiple endocrine neoplasia type 2 affects an estimated 1 in 35,000 people. (medlineplus.gov)
The prevalence of multiple endocrine neoplasia type 4 is unknown, although the condition appears to be rare. (medlineplus.gov)
The loss of functional menin allows cells to divide too frequently, leading to the formation of tumors characteristic of multiple endocrine neoplasia type 1. (medlineplus.gov)
Mutations in the RET gene cause multiple endocrine neoplasia type 2. (medlineplus.gov)
BACKGROUND: Pure mucosal neuroma syndrome (MNS), an autosomal dominant neurocutaneous disorder, is a rare discrete subgroup in multiple endocrine neoplasia (MEN) type 2B, which present without associated endocrinopathies of MEN2B but with typical physical features such as prominent corneal nerves. (bvsalud.org)
Non-invasive prenatal diagnosis of multiple endocrine neoplasia type 2A using COLD-PCR combined with HRM genotyping analysis from maternal serum. (repositoriosalud.es)
Hyperparathyroidism3
However, a particular case can be frustrating and beguiling if the number of glands is abnormal or inconsistent, if the pathologic abnormality lies in an anomalous location, or if the hyperparathyroidism is based on heredity factors. (medscape.com)
Hyperparathyroidism is a condition caused by excessive, inappropriate, and uncontrolled secretion of PTH by one or more parathyroid glands. (medscape.com)
BACKGROUND: Familial isolated hyperparathyroidism (FIHP) is an autosomal dominant disorder characterized by uniglandular or multiglandular parathyroid tumours that occur in the absence of other endocrine tumours. (ox.ac.uk)
Epithelial2
and (b) those of epithelial type, which include neuroendocrine neoplasms from many sites. (basicmedicalkey.com)
This is followed by coverage of neoplasms in the more traditional categories of epithelial, mesenchymal, and other categories. (abdominalkey.com)
Adenoma1
adenoid t. adenoma , or neoplasm with glandlike spaces. (en-academic.com)
Nervous system2
The DNS consists of a wide variety of cells that are present in the central and peripheral nervous system and in many classic endocrine organs ( Table 11.1 ). (basicmedicalkey.com)
Wiedemann-Beckwith syndrome is related to abnormalities on chromosome 11p15 and characterized by multiple craniofacial anomalies, abdominal wall defects, and tumors of the genitourinary tract, liver, adrenal gland, and central nervous system among other abnormalities. (abdominalkey.com)
Clinical3
Many of these neoplasms have distinct clinicopathologic features, so precise classification by the pathologist is necessary for optimal clinical management. (basicmedicalkey.com)
Description Pachyonychia congenita (PC) is an autosomal dominant genodermatosis with the main clinical features of hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts. (findzebra.com)
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. (beds.ac.uk)
Diagnosis3
Methods of analysis of tumors of the DNS are also presented because some of these techniques are indispensable for the diagnosis of many neuroendocrine neoplasms. (basicmedicalkey.com)
Many broad-spectrum IHC markers are available to aid in the diagnosis of neuroendocrine neoplasms. (basicmedicalkey.com)
familial short stature (inherited short stature), constitutional delay of growth and puberty (an inherited pattern of short stature during childhood that is followed by a growth spurt during puberty , typically resulting in normal adult height), and idiopathic short stature (short stature in the absence of any metabolic, endocrine, or other diagnosis). (amboss.com)
Overactivity1
In Carney complex, medical care is restricted to the treatment of endocrine overactivity, which is commonly present. (medscape.com)
MEN2A1
While these neoplasias are often benign (in contrast to tumours occurring in MEN2A), they are adenomas and, therefore, produce endocrine phenotypes. (wikipedia.org)
Epithelioid1
Weiss and Enzinger first reported epithelioid hemangioendothelioma (EHE) in 1982 as a rare vascular endothelial neoplasm arising in soft tissues [ 1 ]. (springeropen.com)
Paracrine3
The cells and neoplasms of the neuroendocrine and paracrine systems make up the DNS. (basicmedicalkey.com)
Feyrter ( 2 ) considered the clear cells of the gastrointestinal tract to be peripheral endocrine or paracrine cells. (basicmedicalkey.com)
Skeletal muscle is regarded as an endocrine and paracrine organ. (e-enm.org)
Multiple1
Multiple adenomas can occur, and diffuse hyperplasia can develop in one or more glands. (medscape.com)
Pathogenesis1
The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
Inherited disease1
It is an autosomal dominant inherited disease. (umassmed.edu)
Neck1
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. (lookformedical.com)
Pancreatic1
An irregularly shaped gland, located behind the stomach, that secretes pancreatic juice into the duodenum and insulin, glucagon, and somatostatin into the bloodstream. (easyauscultation.com)
Tissues2
It is unclear why these tumors preferentially affect endocrine tissues. (medlineplus.gov)