• pathway
  • citation needed] A third medication that might help children with Costello syndrome is a MEK inhibitor that helps inhibit the pathway closer to the cell nucleus. (wikipedia.org)
  • pediatric
  • JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. (abcam.com)
  • common
  • Lack of postpubertal breast development is a common manifestation of this syndrome and may result in severe hypomastia and a masculine appearance of the female chest. (bireme.br)
  • tumor
  • The most frequent cancerous tumor associated with Costello syndrome is a soft tissue tumor called a rhabdomyosarcoma. (wikipedia.org)
  • However
  • However, there are syndromes which can affect the cranial structure and growth of the brain, severely impairing mental capacity. (wikipedia.org)