• pancreatic
  • Pancreatic cancer is an important health problem for which no simple screening test is available. (bmj.com)
  • All patients at increased inherited risk of pancreatic cancer should be referred to a specialist centre offering specialist clinical advice and genetic counselling and appropriate genetic testing (grade B). (bmj.com)
  • Secondary screening for pancreatic cancer in high risk cases should be carried out as part of an investigational programme coordinated through specialist centres (grade B). (bmj.com)
  • Most pancreatic cancers are of ductal origin and present at a stage when they are locally advanced, and exhibit vascular invasion and lymph node metastases. (bmj.com)
  • The diagnosis of pancreatic cancer should be considered in patients with adult onset diabetes who have no predisposing features or family history of diabetes (grade B). (bmj.com)
  • Pancreatic cancer should be excluded during the investigation of patients who have had an unexplained episode of acute pancreatitis (grade B). (bmj.com)
  • The workup of patients with suspected pancreatic cancer should logically focus initially on establishment of the diagnosis and an assessment of the patient's fitness to undergo potentially curative treatment. (bmj.com)
  • Other associated malignancies include ovarian cancer and pancreatic cancer. (wikipedia.org)
  • onset
  • Screening should include, at minimum, a personal cancer history and a first- and second-degree relative cancer history that includes a description of the type of primary cancer, the age of onset, and the lineage (paternal versus maternal) of the family member. (acog.org)
  • The classic features of Li Fraumeni syndrome include early-onset breast cancer, childhood leukemia, and teenage sarcoma. (cancernetwork.com)
  • There are associated conditions, such as late onset diabetes mellitus or an unexplained attack of acute pancreatitis, which may point to an underlying cancer. (bmj.com)
  • Genetic counseling can occur before conception (i.e. when one or two of the parents are carriers of a certain trait) through to adulthood (for adult onset genetic conditions, such as Huntington's disease or hereditary cancer syndromes). (wikipedia.org)
  • Another classification divides these into an early onset type (type B) which occurs in the first year of life and is usually benign and a type A tylosis which occurs between the ages of 5 and 15 years and is strongly associated with esophageal cancer. (wikipedia.org)
  • This form of acanthosis nigricans is more likely to involve mucous membranes (25-50% of cases) Malignant acanthosis nigricans that may either precede (18%), accompany (60%), or follow (22%) the onset of an internal cancer. (wikipedia.org)
  • clinical
  • Scientific understanding of cancer susceptibility syndromes is actively expanding: additional syndromes are being found, the underlying biology is becoming clearer, and commercialization of diagnostic genetics methodology is improving clinical access. (wikipedia.org)
  • Clinical presentation suggesting cancer of the pancreas should lead without delay to ultrasound of the liver, bile duct, and pancreas (grade B). (bmj.com)
  • This highlights the remaining challenges in surveillance and early-detection efforts for people with inherited genetic cancer syndromes, according to senior study author Sharon Savage, MD, branch chief of Clinical Genetics, Division of Cancer Epidemiology & Genetics at the NCI in Rockville, Maryland. (cancertherapyadvisor.com)
  • genetics
  • If a hereditary cancer risk assessment suggests an increased risk of a hereditary cancer syndrome, referral to a specialist in cancer genetics or a health care provider with expertise in genetics is recommended for expanded gathering of family history information, risk assessment, education, and counseling, which may lead to genetic testing. (acog.org)
  • A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment. (acog.org)
  • Recent advances in the field of genetics have led to improved understanding of the inherited cancer syndromes. (bmj.com)
  • benign
  • Acanthosis nigricans is conventionally divided into benign and malignant forms, although may be divided into syndromes according to cause: Benign This may include obesity-related, hereditary, and endocrine forms of acanthosis nigricans. (wikipedia.org)
  • It delineates acanthosis nigricans syndromes according to their associated syndromes, including benign and malignant forms, forms associated with obesity and drugs, acral acanthosis nigricans, unilateral acanthosis nigricans, and mixed and syndromic forms. (wikipedia.org)