• selective
  • Recently, considerable efforts have been made to find drugs that are selective agonists on DA autoreceptors which have been motivated by reports on clinical effects of low doses of APO, or other DA agonists, on schizophrenia and hyperkinetic disorders. (baillement.com)
  • nerve
  • with Ullrich Trendelenburg with whom he became lifelong friends.He spent two years (1967-1969) in Cambridge, England with de:Leslie Iversen and at the Institute of Animal Physiology with Marthe Vogt where he worked on norepinephrine(NE) uptake and the regulation of NE release elicited by nerve stimulation as well as the metabolic fate of the released neurotransmitter. (wikipedia.org)
  • mice
  • The original finding, which led to the formulation of the autoreceptor hypothesis (as defined in the introduction), was that APO inhibits tyrosine hydroxylation (dopa accumulation in NSD 1015 - treated mice) in the same doses as motor activity of mice is suppressed. (baillement.com)
  • possible
  • While RAT was also developed to support electrical stimulation for focally controlling neural activity, it should be possible to incorporate other methods for this purpose as well. (nih.gov)
  • fact
  • The fact that neurochemical and electrophysiological signs of DA autoreceptor stimulation can be induced in approximately the same dose range by DA agonists as the doses required to induce yawning and suppression of exploration has been interpreted as a causal connection. (baillement.com)