• There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
  • However, whether it can prevent cardiac hypertrophy is not known. (researchsquare.com)
  • The aim of this study was to investigate the effect and mechanism of Leonurine (Leo) against pressure-overload cardiac hypertrophy induced by abdominal aortic constriction (AAC) in rats. (researchsquare.com)
  • theβ-myosin heavy chain(β-MHC)and atrial natriuretic factor (ANF), which are recognized as a marker of cardiac hypertrophy, were determined by Real-time quantitative PCR (qRT-PCR), then another gene phospholipase C (PLC), inositol triphosphate (IP 3 ), which associated with RAS were determined by Western blot(WB). (researchsquare.com)
  • Therefore, Leonurine can inhibit cardiac hypertrophy induced by AAC and its effects may be associated with RAS. (researchsquare.com)
  • With time elapsing, the occurrence of cardiac hypertrophy can be divided into three stages: hypertrophy of the early, hypertrophy of the compensatory and the final decompensatory. (researchsquare.com)
  • Previous studies have shown that its development is closely related to cardiac overload[6], so abdominal aortic constriction(AAC) can use this principle to establish model of myocardial hypertrophy. (researchsquare.com)
  • If we allow this to continue, the results may lead to ventricular remodeling, decompensation of cardiac function and dilated cardiomyopathy, heart failure and even sudden cardiac death[7] Therefore, preventing the occurrence and development of cardiac hypertrophy is very important. (researchsquare.com)
  • AT 1 R is a member of the 7-fold transmembrane G-protein-coupled receptor (GPCR) family[12,13], mainly exists in the myocardial membrane and can mediate cardiac hypertrophy induced by pressure overload and mechanical stimulation after activation [14]. (researchsquare.com)
  • Ang II binds to AT 1 R, which can induce vasoconstriction, increase blood pressure, and further induce cardiac hypertrophy and proliferation of fibroblasts [15]. (researchsquare.com)
  • Human cardiomyocytes and mice treated with a uORF-enhancing ASO showed reduced cardiac GATA4 protein levels and increased resistance to cardiomyocyte hypertrophy. (bvsalud.org)
  • Regulation of autophagy is essential to prevent unwanted and escess activation, and several pathways and molecules, both stimulatory and inhibitory, are included. (helsinki.fi)
  • May also function as a paracrine antifibrotic factor in the heart. (cusabio.com)
  • Autophagy is a pathway for cells to degrade intracellular components that are no longer needed or are detrimental for the cells. (helsinki.fi)
  • Since rate of autophagy in cells was not detected, it is impossible to determine, if there were changes in autophagy that were not reflected as changes in colocalization of these two proteins. (helsinki.fi)
  • The intensity of Beclin 1 in the nuclei was stronger than in other parts of the cell in all samples, which could indicate a stronger activity of its nuclear tasks compared to autophagy. (helsinki.fi)
  • A trans-acting RNA helicase DDX3X inhibits the GATA4 uORF-dsRNA activity and modulates the translational balance of uORF and mORF. (bvsalud.org)
  • Thus, acetylation of histones is known to increase the expression of genes through transcription activation. (wikipedia.org)
  • After transcription, Pri-miRNA is cleaved by the enzymatic complex DROSHA into a micro-RNA precursor (pre-miRNA). (archivesofmedicalscience.com)
  • Autophagy is a complex process and there are still several unclear und unknown aspects to it. (helsinki.fi)
  • As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. (wikipedia.org)
  • Here, we data-mined human and mouse heart ribosome profiling analyses and identified a double-stranded RNA (dsRNA) structure within the GATA4 uORF that cooperates with the start codon to augment uORF translation and inhibits mORF translation. (bvsalud.org)
  • It is possible that even a small change in colocalization can affect the rate of autophagy or there might be subpopulations where the interaction is interrupted and these changes are so small that they are not detectable with the methods used in this experiment. (helsinki.fi)
  • Both Bcl-2 and Beclin 1 also have functions not related to autophagy, which could be one reason behind the results gained in this study. (helsinki.fi)
  • Chemerin/CMKLR1 ameliorates nonalcoholic steatohepatitis by promoting autophagy and alleviating oxidative stress through the JAK2-STAT3 pathway. (ac.ir)
  • 1. BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration. (nih.gov)
  • The aim of this study was to determine whether MS1 induces cellular hypertrophy and protects against apoptosis. (nih.gov)
  • Betulinic acid protects dox-triggered cardiomyocyte hypertrophy response through the GATA-4/Calcineurin/NFAT pathway. (ac.ir)
  • 18. BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility. (nih.gov)
  • Protective effect of Chushizi (Fructus Broussonetiae) on acetaminophen-induced rat hepatitis by inhibiting the Toll-like receptor 3/c-Jun N-terminal kinase/c-jun/c-fos/janus protein tyrosine kinase/activators of transcription 3 pathway. (ac.ir)
  • As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. (wikipedia.org)
  • Thus, acetylation of histones is known to increase the expression of genes through transcription activation. (wikipedia.org)
  • Over-expressed MS1 co-localized with actin in H9c2 cells and altered expression of genes of the myocardin-related transcription factor (MRTF)/serum response factor (SRF) transcriptional pathways and in addition the apoptosis repressor with caspase recruitment domain (Nol3) gene. (nih.gov)
  • Transcription of miR genes by RNA polymerase II form primary transcripts known as primary miR (pri-miR). (medscape.com)
  • To the best of our knowledge, this is the first study to demonstrate that PYGO2 uses a biphasic mechanism to promote cardiomyocyte formation from hUC-MSCs. (bvsalud.org)
  • 13. De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins. (nih.gov)
  • However, the regulatory mechanism underlying their ability to form mesodermal cells and differentiate into cardiomyocytes remains unclear. (bvsalud.org)