AutophagyLysosomesPhagosomesMicrotubule-Associated ProteinsProteasome Endopeptidase ComplexProteolysisLysosome-Associated Membrane GlycoproteinsUbiquitinVacuolesEndosomesLysosomal-Associated Membrane Protein 2Apoptosis Regulatory ProteinsUbiquitin-Activating EnzymesCell LineEndocytosisTOR Serine-Threonine KinasesUbiquitinationModels, BiologicalProtein TransportChloroquineSignal TransductionCathepsin DMembrane ProteinsApoptosisCell Line, TumorUbiquitin-Protein LigasesCells, CulturedClass III Phosphatidylinositol 3-KinasesMolecular Sequence DataBiodegradation, EnvironmentalAcid PhosphataseCysteine EndopeptidasesAdenineEndoplasmic ReticulumMutationHeLa CellsAmino Acid SequenceRNA, Small InterferingRNA InterferenceProteinsMicroscopy, ElectronMitochondrial DegradationFibroblastsProtein BindingCathepsinsCell SurvivalMicroscopy, FluorescenceMitochondriaProtein Processing, Post-TranslationalMicroscopy, Electron, TransmissionUbiquitinsKineticsOrganellesMultienzyme ComplexesCell DeathLiverBiological TransportSirolimusCarrier ProteinsCathepsin BCytoplasmHEK293 CellsGreen Fluorescent ProteinsSubcellular FractionsEndoplasmic Reticulum-Associated DegradationBlotting, Westernrab GTP-Binding ProteinsVesicular Transport ProteinsMultiprotein ComplexesMacrolidesHydrogen-Ion ConcentrationRecombinant Fusion ProteinsCell MembraneHydrolysisProteasome InhibitorsGolgi ApparatusTime FactorsSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiaeCysteine Proteinase InhibitorsGene Knockdown TechniquesPeptide HydrolasesPhosphorylationAdaptor Proteins, Signal TransducingMacrophagesIntracellular MembranesLysosomal Storage DiseasesProtein Structure, TertiaryEndoplasmic Reticulum StressMicroscopy, ConfocalCell FractionationReactive Oxygen SpeciesHydrolasesDown-RegulationUbiquitinated ProteinsCell CompartmentationMice, KnockoutMolecular Chaperonesbeta-N-AcetylhexosaminidasesCytosol