AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesNamed GroupsHealth Care
Skin TransplantationTransplantation, HomologousGraft RejectionTransplantation, AutologousGraft SurvivalLiver TransplantationMice, Inbred BALB CBone Marrow TransplantationKidney TransplantationMice, Inbred C57BLHematopoietic Stem Cell TransplantationSkinHeart TransplantationStem Cell TransplantationLung TransplantationTransplantation ConditioningOrgan TransplantationBlood Transfusion, AutologousCell TransplantationPancreas TransplantationIslets of Langerhans TransplantationTissue DonorsTransplantation ImmunologyTransplantationTreatment OutcomeTransplantation ChimeraSkin DiseasesSkin NeoplasmsSkin AgingGraft vs Host DiseaseImmunosuppressive AgentsPeripheral Blood Stem Cell TransplantationTransplantation, IsogeneicTime FactorsLiving DonorsTransplantation, HeterotopicCord Blood Stem Cell TransplantationRetrospective StudiesHeart-Lung Transplantation
TissueFibroblastsBone Marrow TransplaCell transplantationTherapiesSyngeneicTransplantsTissuesHSCTAllogeneic transplantationPeripheral bloodIPSCsChemotherapyJunctional epidermEfficacyPerson'sTransplantAutoimmune diseaseSclerodermaGraftOrganRejectionProcedureChronicIsletRegenerative MedicineCellsImmuneComplicationsSystemicPatientsInvolvesDiabetesTreatmentSevereClinicalCutaneousPigmentTreatmentsTherapy
Tissue25
  • http://www.researchandmarkets.com/research/f7thqr/organ_and_tissue ) has announced the addition of the "Organ and Tissue Transplantation - Global Strategic Business Report" report to their offering. (prnewswire.com)
  • This report analyzes the worldwide markets for Organ and Tissue Transplantation in Number of Procedures. (prnewswire.com)
  • The global and regional markets (except the US) for 'Organ and Tissue Transplantation' in this report are analyzed by the following Product Segments - Organ Tranplantation (Heart, Kidneys, Liver, Pancreas, and Lungs). (prnewswire.com)
  • and transplantation of in vitro grown organs and tissues (tissue engineering). (wikipedia.org)
  • Skin grafting, invented in the late 19th century, can be thought of as the earliest major attempt to recreate bodily tissue to restore structure and function. (wikipedia.org)
  • Scleroderma is a disease that involves the buildup of fibrous tissue in the skin and elsewhere in the body. (medlineplus.gov)
  • It affects the skin by causing hardened tissue or ulcers and may harm the internal organs. (mountsinai.org)
  • Embryonic stem cells are derived from embryos and have the ability to become any type of cell in the body, while adult stem cells are found in various tissues and can develop into different cell types within that tissue. (arthritistreatmentlab.com)
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
  • The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
  • Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • The term systemic sclerosis is used to describe a systemic autoimmune disease of unknown origin characterized by excessive deposition of collagen and other connective tissue macromolecules in skin and multiple internal organs, prominent and often severe fibroproliferative alterations in the microvasculature, and numerous humoral and cellular immunologic abnormalities. (medscape.com)
  • Such treatments include allogeneic and xenogeneic transplants and skin substitutes such as tissue-engineered skin, cultured cells, and stem cells. (biomedcentral.com)
  • The aim of this paper is to discuss the general overview of the quality assurance and quality control implemented in the manufacturing of cell and tissue product, with emphasis on our experience in the manufacturing of MyDerm ® , an autologous bilayered human skin substitute. (biomedcentral.com)
  • Manufacturing MyDerm ® requires multiple high-risk open manipulation steps, such as tissue processing, cell culture expansion, and skin construct formation. (biomedcentral.com)
  • In these situations, autologous skin transplantation in Daya Basti is the best alternative for preventing tissue rejection. (panaceaskinservices.com)
  • In order to avoid tissue rejection, they used autologous iPSCs-iPSCs that were created from the recipient's own skin cells. (neurosciencenews.com)
  • There are many genetic variations of MHCs, and after transplantation, if the MHCs of the transplanted cells are not recognized by the T cells of the host immune system, there is an immune response and the tissue is rejected. (neurosciencenews.com)
  • It has got huge breakthrough in many research areas such as biomaterials engineering, transplantation science, cell therapy and tissue engineering. (viezec.com)
  • Thus they can develop into cardiac muscle, kidney, liver, brain, fat and skin tissue assisting to heal the damaged/injured area. (viezec.com)
  • Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo. (medscape.com)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • A new technique has been presented that results in an acceleration of delayed primary healing with full thickness skin and subcutaneous tissue coverage. (who.int)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
Fibroblasts8
  • An alternative is a collagen matrix populated by allogeneic fibroblasts and overlaid with cultured autologous or allogeneic keratinocytes. (ox.ac.uk)
  • Induced pluripotent stem cells (iPSCs) generated from patient fibroblasts could potentially be used as a source of autologous cells for transplantation in retinal disease. (nature.com)
  • Through established protocols 2 , fibroblasts from a skin biopsy can be returned to a pluripotent state and serve as a renewable, autologous source of replacement cells that avoids the ethical complications of hESCs. (nature.com)
  • To generate iPSCs, dermal fibroblasts were cultured from the skin biopsy sample and transduced according to previously described protocols 5 . (nature.com)
  • In this open-label, single-arm phase IIa clinical trial, a total of 57 participants with wrinkles (n=37, 132 treatment sites) or acne scars (n=20, 36 treatment sites) who had an evaluator's assessment score of at least 2 out 7 (based on a standard photo-guide scoring) received 3 injections of autologous cultured fibroblasts administered at 4-6 week intervals. (celljournal.org)
  • To create iPSCs, mature cells, like skin fibroblasts, are taken from a patient and put into culture. (jove.com)
  • To create iPSCs, mature cells such as skin fibroblasts or blood cells from a person are grown in culture. (jove.com)
  • 2.Zhao Y, Wang J, Yan X, Li D, Xu J: Preliminary survival studies on autologous cultured skin fibroblasts transplantation by injection. (yasgmy.com)
Bone Marrow Transpla3
Cell transplantation53
Therapies6
  • This important proof-of-concept finding supports the development of personalized iPSC-based transplantation therapies for retinal disease. (nature.com)
  • The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)
  • ViaCyte is developing cell therapies to replace lost beta cells for people with type 1 diabetes (T1D). (ca.gov)
  • The therapies are derived from human embryonic stem cells, which are partially matured into becoming pancreatic tissues (the type destroyed in T1D). (ca.gov)
  • The recent emergence of cell-based therapies such as autologous bone marrow-derived mesenchymal stem cells (ABM-MSCs) and mononuclear cells (ABM-MNCs) seems to offer a pragmatic approach to augment β-cell function/mass. (drcalapai.com)
  • The time it takes to reach engraftment depends on several factors, including stem cell source, the type of transplant, and your pre-transplant therapies. (dana-farber.org)
Syngeneic1
Transplants4
  • Transplants from HLA-matched siblings are associated with a lower risk of GVHD and faster recovery of the recipient's immune system following transplantation. (medscape.com)
  • The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
  • Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
  • Learn more about the different types of stem cell transplants and stem cell transplant services at Dana-Farber. (dana-farber.org)
Tissues10
  • This is called autologous transplantation, and it reduces the risk of transplant rejection that can occur when tissues are transplanted between individuals. (jove.com)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • Thus, the availability of and access to human tissues for transplantation remains essential. (who.int)
  • In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
  • Total body irradiation can lower the relapse rate but has some fatal side effects such as irreversible damage to normal internal organs and graft-versus-host disease (a complication after transplantation in which donor's immune cells recognize the host as foreign and attack the recipient's tissues). (survivornet.com)
  • Notes lead author Sunao Sugita, "In order to make iPSC transplantation a practical reality, the current goal is to create banks of iPSC-derived tissues that can be transplanted into anyone as they are needed. (neurosciencenews.com)
  • While covering a broad range of applications, in practice the latter term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin). (coltsneckstemcells.com)
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
HSCT2
  • Patients who undergo HSCT experience a sequential suppression of host defenses, resulting in varying infectious risk at different phases of the transplantation process. (medscape.com)
  • GVHD, which is common among allogenic HSCT and rare in autologous HSCT, can be acute or chronic. (drugdiscoverynews.com)
Allogeneic transplantation4
Peripheral blood2
  • These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
  • After UMSC transplantation (UMSCT), the frequencies of Tregs and CD4 + memory T cells were significantly increased, and the frequencies of T helper (Th) 17 and CD4 + naive T cells were significantly decreased in peripheral blood (PB) of psoriasis patients. (nature.com)
IPSCs9
  • Using a patient's own cells for transplantation would avoid these pitfalls and is possible with induced pluripotent stem cells (iPSCs). (nature.com)
  • We tested whether CRISPR could precisely edit the pathogenic mutation and produce gene-corrected iPSCs for eventual use in autologous transplantation. (nature.com)
  • Induced pluripotent stem cells, iPSCs, are mature, differentiated cells, such as skin cells, that are reprogrammed in the laboratory to be similar to undifferentiated embryonic stem cells. (jove.com)
  • These cells are also pluripotent like embryonic stem cells-able to produce all cell types-and are therefore called induced pluripotent stem cells (iPSCs). (jove.com)
  • iPSCs are potentially valuable in medicine, because a patient who needs a particular cell type-for instance, someone with a damaged retina due to macular degeneration-could receive a transplant of the required cells, generated from another cell type in their own body. (jove.com)
  • As with other types of stem cells, scientists are learning how to promote the differentiation of specific cell types from iPSCs efficiently, so that the needed cell types can be produced in adequate quantities. (jove.com)
  • While this method is sound, producing autologous iPSCs is costly. (neurosciencenews.com)
  • Skin cells are taken from a patient, reprogrammed to induced pluripotent stem cells (iPSCs), differentiated into dopaminergic progenitors, and put back in the patient. (lu.se)
  • These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
Chemotherapy3
  • Children and young adults receiving chemotherapy for Ewing sarcoma may be at risk for developing neutropenia, which is an abnormally low level of a type of white blood cell called neutrophils. (zenonco.io)
  • Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)
  • Autologous transplantation involves extracting a person's stem cells from the bone marrow or blood and freezing them before a person has chemotherapy or radiation therapy. (medicalnewstoday.com)
Junctional epiderm2
  • Epidermolysis bullosa is classified into four major categories: (1) epidermolysis bullosa simplex (intraepidermal skin separation), (2) junctional epidermolysis bullosa (skin separation in lamina lucida or central BMZ), (3) dystrophic epidermolysis bullosa (sublamina densa BMZ separation, as in the images below), and (4) Kindler syndrome (extremely rare, blistering at any level). (medscape.com)
  • Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. (medscape.com)
Efficacy4
  • and (3) types of outcomes - the primary outcome was total efficacy rate, which was ≥ 50% repigmentation rate, and the secondary outcomes were cure rate (proportion of patients achieving 100% repigmentation of the lesion), serum cytokine levels, and blood ratio of CD4 + /CD8 + T cells. (medscape.com)
  • This randomized comparative study aimed to assess the efficacy of transplanting autologous melanocyte-keratinocyte suspension in patients with stable vitiligo and to compare site preparation using dermabrasion vs microneedling. (medscape.com)
  • We investigated the long-term safety and efficacy of autologous fibroblast transplantation for participants with mild to severe facial contour deformities. (celljournal.org)
  • This study aims to examine the efficacy and safety of ABM-MSC and ABM-MNC transplantation in T2DM and explores alterations in glucose-insulin homeostasis by metabolic studies. (drcalapai.com)
Person's1
  • Because a person's own (autologous) stem cells can be infused back into that individual without being rejected by the body's immune system, autologous cord blood stem cells have become an increasingly important focus of regenerative medicine research. (coltsneckstemcells.com)
Transplant6
  • Risks of infection also vary with the type of transplant, the indication for transplantation, and other host factors. (medscape.com)
  • A stem cell transplant is a procedure in which a person receives blood stem cells, which make any type of blood cell. (scdstudies.com)
  • This is an autologous transplant. (dana-farber.org)
  • When a patient is identified as a stem cell transplant candidate, the care team will create a treatment plan based on your type of cancer, the type of transplant, and your treatment history. (dana-farber.org)
  • 202. Autologous stem cell transplant within 6 weeks of planned KTE-X19 or axicabtagene ciloleucel infusion. (who.int)
  • Our findings support sun safety practices and skin screening for transplant recipients. (cdc.gov)
Autoimmune disease1
  • Diffuse systemic sclerosis is a rare chronic severe autoimmune disease affecting skin as well as inner organs such as the lung. (nordiclifescience.org)
Scleroderma12
  • Scleroderma is a type of autoimmune disorder . (medlineplus.gov)
  • Some types of scleroderma affect only the skin, while others affect the whole body. (medlineplus.gov)
  • Localized scleroderma (also called morphea) -- Often affects only the skin on the chest, abdomen, or limb but not usually on the hands and face. (medlineplus.gov)
  • Systemic scleroderma, or sclerosis -- May affect large areas of skin and organs such as the heart, lungs, or kidneys. (medlineplus.gov)
  • Several studies have demonstrated a reduction of new skin ulcers and accelerated healing of nondigital ulcers for certain scleroderma patients after taking Bosentan. (mountsinai.org)
  • The drug was approved in Europe in 2007 for the treatment of skin ulcers related to scleroderma. (mountsinai.org)
  • The name scleroderma comes from the Greek words skleros , which means hard, and derma , which means skin. (mountsinai.org)
  • Localized scleroderma usually affects only the skin on the hands and face. (mountsinai.org)
  • In morphea scleroderma, patches of hard skin form and can last for years. (mountsinai.org)
  • Linear scleroderma causes bands of hard skin across the face or on a single arm or leg. (mountsinai.org)
  • Rarely, if this type of scleroderma affects children or young adults, it may interfere with growth and cause severe deformities in the arms and legs. (mountsinai.org)
  • The term scleroderma is derived from the Greek words skleros (hard or indurated) and derma (skin) and it is used to describe a disease characterized by progressive skin hardening and induration. (medscape.com)
Graft1
  • En route to the patient we can also remove disease-associated genes that might compromise the transplanted cells and eventually the clinical benefit of the graft over time," described Fredrik. (lu.se)
Organ3
  • People with diffuse skin disease (rather than limited skin involvement) may be more prone to progressive and internal organ disease. (medlineplus.gov)
  • Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
  • Systemic sclerosis is a complex and heterogeneous disease with clinical forms ranging from limited skin involvement (limited cutaneous systemic sclerosis) to forms with diffuse skin sclerosis and severe and often progressive internal organ involvement (diffuse cutaneous systemic sclerosis), and occasionally a fulminant course (fulminant systemic sclerosis). (medscape.com)
Rejection1
  • Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
Procedure4
Chronic2
  • Autologous pancreas islet transplantation may be considered medically necessary as an adjunct to a total or near total pancreatectomy in individuals with chronic pancreatitis. (bcbsnd.com)
  • For chronic or acute liver failure, as well as some cardiorespiratory conditions, the only alternative to transplantation is death. (who.int)
Islet4
  • Allogeneic pancreas islet transplantation involves isolating islet cells from the pancreas of a cadaver donor, which are then purified and transplanted into the recipient via the portal vein or one of the tributaries of the liver where they take up residence and resume function. (bcbsnd.com)
  • Donislecel-jujn (Lantidra) is an allogeneic pancreatic islet cellular therapy for the treatment of adults with type 1 diabetes-related severe hypoglycemia who cannot attain target blood glucose levels despite intervention, also known as Brittle Type 1 Diabetes (T1D). (bcbsnd.com)
  • Autologous pancreas islet transplantation not meeting the criteria indicated in this policy is considered not medically necessary. (bcbsnd.com)
  • Proinflammatory islet antigen reactive CD4 T cells are linked with response to alefacept in type 1 diabetes. (immunetolerance.org)
Regenerative Medicine2
  • Stem cells are characterized by their ability to self-renew and differentiate into specialized cell types, making them ideal for use in regenerative medicine. (arthritistreatmentlab.com)
  • After more than 50 years of research, airway transplantation remains a major challenge in the fields of thoracic surgery and regenerative medicine. (biomedcentral.com)
Cells25
  • He recognized that these cells' unique ability to differentiate into all the cell types of the human body (pluripotency) had the potential to develop into a new kind of regenerative therapy. (wikipedia.org)
  • Unlike autologous cells, allogeneic keratinocytes are available immediately, although they survive for less than a week when applied to full-thickness skin defects. (ox.ac.uk)
  • While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
  • The cells can now divide, and ideally, be directed to produce a specific cell type in culture. (jove.com)
  • Stem cells are undifferentiated cells that divide and produce different types of cells. (jove.com)
  • Ordinarily, cells that have differentiated into a specific cell type are post-mitotic-that is, they no longer divide. (jove.com)
  • Stem Cells in Arthritis are unique cells with the potential to develop into different types of cells in the body. (arthritistreatmentlab.com)
  • There are several different types of stem cells, including embryonic stem cells and adult stem cells. (arthritistreatmentlab.com)
  • Stem cells have the ability to differentiate into various types of cells, including those needed for cartilage repair and regeneration. (arthritistreatmentlab.com)
  • Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)
  • Transplantation of beta cells, contained in donor pancreatic islets, can reverse the symptoms of diabetes. (ca.gov)
  • The cells are inserted into a small pouch that is transplanted under the patient's skin. (ca.gov)
  • if you do not exfoliate your skin properly, you can develop uneven skin tone because of the excessive buildup of dead skin cells. (panaceaskinservices.com)
  • In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
  • Currently, adult cells can be reprogrammed into stem cells, and then re-differentiated and grown into desired cell types. (neurosciencenews.com)
  • Transplantation of monkey iPS-RPE cells into the subretinal space in a control monkey (MHC mismatched) was performed without immunosuppression. (neurosciencenews.com)
  • B) Transplantation of monkey iPS-RPE cells into the subretinal space in an MHC-matched monkey. (neurosciencenews.com)
  • Mesenchymal stromal cells (MSCs) expanded in vitro have been proposed as a potential therapy for congenital or acquired skin defects in pediatrics. (biomedcentral.com)
  • The aim of this pre-clinical study was to investigate the effects of intradermal injections of MSC in experimental cutaneous wound repair comparing allogeneic and autologous adipose stem cells (ASCs) and autologous bone marrow-mesenchymal stromal cells (BM-MSCs). (biomedcentral.com)
  • When an adequate number of cells (ASCs 10 × 10 6 and BM-MSCs 3 × 10 6 , because of their low rate of proliferation) was reached, two skin wounds were surgically induced in each animal. (biomedcentral.com)
  • They are kind of like skin cells, but they are transparent unlike skin. (sciencefriday.com)
  • IRA FLATOW: But skin cells, some damage, when we damage our skin, the skin grows back. (sciencefriday.com)
  • The focus was on evaluating the potential of using patient-specific cells (i.e., autologous grafting). (lu.se)
  • My projects investigated whether patient-derived cells are more prone to develop disease phenotypes and what can be done to protect these cells after transplantation," explained Fredrik. (lu.se)
  • During a biology course, we had a guest speaker from Lund Stem Cell Center who talked about stem cells and their potential to become any type of cell in the body. (lu.se)
Immune1
  • Treatment involves a combination approach to treat the immune response, improve circulation, and stop the progression of skin symptoms. (mountsinai.org)
Complications2
  • There are complications of serial transfusions of either of these cell types, and a patient needs intense prophylactic treatments to protect from infections if his or her white counts are low. (drugdiscoverynews.com)
  • Children with type 1 diabetes (T1D) face lifelong struggles with controlling their blood sugar levels and, despite careful management, an increased risk of severe complications. (ca.gov)
Systemic2
  • Diffuse systemic sclerosis is a disease with a strong involvement of angiotensin II and an upregulation of the angiotensin II type 2 receptor (AT2R - the C21 target), which is known to mediate anti-fibrotic as well as vascular effects within a number of disease models. (nordiclifescience.org)
  • Diffuse cutaneous systemic sclerosis refers to skin thickening affecting the trunk and the skin of the extremities proximal to the elbows and knees besides involvement of the face. (medscape.com)
Patients8
  • Immediate resurfacing of skin defects is a challenging prospect, especially in patients with extensive full-thickness burns. (ox.ac.uk)
  • A cross-linked collagen and glycosaminoglycan dermal substitute, covered with thin split-skin grafts or cultured autologous keratinocytes, shows promise in burns patients. (ox.ac.uk)
  • Based on a better understanding of the basement membrane zone (BMZ) and the genes responsible for its components, newer treatments (eg, gene or protein therapy) may provide solutions to the skin fragility found in patients with epidermolysis bullosa. (medscape.com)
  • The most common adverse events were erythema and skin discomfort such as pruritus, burning sensation, and pain, which occurred only in patients who received phototherapy and laser therapy. (medscape.com)
  • Dermabrasion versus microneedling in transplantation of autologous noncultured melanocyte-keratinocyte cell suspension in patients with vitiligo. (medscape.com)
  • The excimer laser is another effective form of light therapy generally used for patients who do not have large patches of pigmented skin. (skinandhairacademy.in)
  • Does Transplantation Induce Aging In Patients? (medicaldaily.com)
  • Patients with a maculopapular drug rash without detachment of skin constituted the control group 1 (drug exposed). (e-ijd.org)
Involves1
  • Known as medical tattooing, it involves implanting small particles of pigments under the patient's skin. (skinandhairacademy.in)
Diabetes2
  • Type 1 Diabetes TrialNet Study Group. (immunetolerance.org)
  • 2023). Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial. . (immunetolerance.org)
Treatment7
  • If this type of lymphoma is completely removed by surgery, no additional treatment may be necessary. (dana-farber.org)
  • If you have any concerns with your skin or its treatment, see a dermatologist for advice. (dermnetnz.org)
  • Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
  • 1.Wang J, Zhao Z, Yu L, Li Q, Qi K: The extra-long artery-pedicled back fascia skin flap for treatment of cervical contractive scar. (yasgmy.com)
  • Treatment recommendations depend upon the size, grade and type of tumor, metastasis, possible side effects, and patient's preferences and overall health. (zenonco.io)
  • Since the laser doesn't touch the affected skin directly during the treatment, the risk of UV exposure reduces greatly. (skinandhairacademy.in)
  • Refractory ALL is a type of leukemia characterized by the failure to achieve complete remission or the recurrence of the disease after initial treatment. (medicalnewstoday.com)
Severe3
  • Prenatal diagnosis for severe inherited skin disorders: 25 years' experience. (medscape.com)
  • A brown 13-year-old boy with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia presented with severe oral mucositis (Oral Assessment Guide / OAG)6, namely, ulcerated skin and mucosa in the upper and lower lips ( Figure 1 ), and complaints of pain and much discomfort, especially when talking and eating. (bvsalud.org)
  • Decorative henna skin painting can provoke severe reactions in the skin. (who.int)
Clinical3
  • The clinical data after the transplantation will allow us to see if the iPS cell bank is truly useful or not. (neurosciencenews.com)
  • Pre-clinical studies are however necessary to validate the best skin regeneration technique, which could be used in pediatric surgical translational research. (biomedcentral.com)
  • Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
Cutaneous1
Pigment2
  • Melanin is a pigment that gives colour to the skin and hair and is produced by melanocytes. (skinandhairacademy.in)
  • Uneven skin tone is caused by uneven distribution of pigment, it can also be caused by extreme sun exposure and hormonal changes. (panaceaskinservices.com)
Treatments4
Therapy5
  • Since the FDA has warned about using calcineurin inhibitors because they are linked to skin cancer, many people opt for light therapy. (skinandhairacademy.in)
  • Many cases involve depigmentation therapy, where certain drugs are applied to the affected skin patches to match them to the rest of the areas that have turned white. (skinandhairacademy.in)
  • Learn more about the various types of radiation therapy. (medicalnewstoday.com)
  • Risk of localized tumors was stable over time after transplantation, but higher with azathioprine maintenance therapy (IRR=1.35, 95%CI 1.03-1.77). (cdc.gov)
  • The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)