• primary
  • The exact mechanism of the primary disease is unknown, but the fundamental mechanism of all vasculitides is auto-immune. (wikipedia.org)
  • Three or more of the following six criteria must be met: Age when disease starts is under 50 Decreased brachial artery pulse Systolic blood pressure differs by more than 10mmHg between arms Cramping caused by exercise in the extremities Abnormal sounds (through stethoscope) over subclavian arteries or abdominal aorta A narrowing or blockage in the aorta, its primary branches, or large arteries as seen through a radiograph of the arteries. (wikipedia.org)
  • Primary autoimmune neutropenia (AIN) is an autoimmune disease first reported in 1975 that primarily occurs in infancy. (wikipedia.org)
  • Primary autoimmune neutropenia has been reported as early as the second month of life although most cases are diagnosed in children between 5 and 15 months of age. (wikipedia.org)
  • platelet count
  • A normal platelet count is between 150,000-440,000, and this patient is thrombocytopenic at a count of below 150,000. (anaesthesiauk.com)
  • Signs include the spontaneous formation of bruises (purpura) and petechiae (tiny bruises), especially on the extremities, bleeding from the nostrils and/or gums, and menorrhagia (excessive menstrual bleeding), any of which may occur if the platelet count is below 20,000 per μl. (wikipedia.org)
  • Multiple Sclerosis
  • The Latin American Multiple Sclerosis Forum is an independent and supra-institutional group of experts that has assessed the latest scientific evidence regarding efficacy and safety of disease-modifying treatments. (scielo.br)
  • It is not known why this is the case, although hormone levels have been shown to affect the severity of some autoimmune diseases such as multiple sclerosis. (disabled-world.com)
  • infectious diseases
  • Infectious Diseases 10. (wikipedia.org)
  • Investigators in the laboratory of Dr. Michael Lenardo at National Institute of Allergy and Infectious Diseases, the National Institutes of Health and Dr. Michael Jordan at Cincinnati Children's Hospital Medical Center later described this condition and therapy in 2015. (wikipedia.org)
  • 1975
  • December 1997), "Subacute bacterial endocarditis masquerading as type III essential mixed", Journal of the American Society of Nephrology, 8 (12): 1971-6, PMID 9402102 Autoimmune Diseases at the US National Library of Medicine Medical Subject Headings (MeSH) Kárpáti F, Dénes L, Büttner K (1975). (wikipedia.org)
  • treatment
  • Recent advances in the area of stem cell research suggest that redirected differentiation of stem cells may prove useful for the treatment of a variety of diseases including diabetes and other systemic diseases. (clinicaltrials.gov)
  • The treatment of autoimmune diseases is typically with immuno-suppression - medication which decreases the immune response. (disabled-world.com)
  • Treatment depends on the disease, but in most cases one important goal is to reduce inflammation. (disabled-world.com)
  • Fostamatinib is an experimental drug candidate for the treatment of a variety of diseases, originally developed by Rigel Pharmaceuticals. (wikipedia.org)
  • The study is the second Phase 3, multi-center, randomized, double-blind, placebo controlled, study of fostamatinib disodium in the treatment of persistent/chronic immune thrombocytopenic purpura that Rigel has conducted. (wikipedia.org)
  • In January 2015, the FDA granted fast track status to Marathon Pharmaceuticals to pursue approval of deflazacort as a potential treatment for Duchenne muscular dystrophy, a rare, "progressive and fatal disease" that affects boys. (wikipedia.org)
  • When treatment with DMARDs fails, cyclophosphamide or steroid pulse therapy is often used to stabilise uncontrolled autoimmune disease. (wikipedia.org)
  • If disease remission is observed, regular NSAIDs or glucocorticoid treatment may no longer be needed. (wikipedia.org)
  • antibody
  • Autoimmune neutropenia is a form of neutropenia which is most common in infants and young children where the body identifies the neutrophils as enemies and makes antibody to destroy them. (wikipedia.org)
  • vaccination
  • Now, I believe that this is a very important distinction because it means that the MMR vaccination can, indeed, lead to at least one autoimmune condition. (sanevax.org)
  • syndrome
  • Evans syndrome is an autoimmune disease in which an individual's antibodies attack their own red blood cells and platelets. (wikipedia.org)
  • citation needed] It has been observed that there is a risk of developing other autoimmune problems and hypogammaglobulinemia, with recent research finding that 58% of children with Evans syndrome have CD4-/CD8- T cells which is a strong predictor for having autoimmune lymphoproliferative syndrome. (wikipedia.org)
  • 2002
  • 2002) demonstrated that self-MHC recognition (which, if too strong may contribute to autoimmune disease) maintains the responsiveness of CD4+ T cells when foreign antigens are absent. (wikipedia.org)
  • defects
  • Qualitative defects include aspirin or nonsteroidal use, ethanol use, cirrhosis, uremia, or inherited defects like von Willebrand disease. (anaesthesiauk.com)
  • Symptoms
  • Treatments your doctor suggests will depend on your disease and symptoms. (disabled-world.com)
  • The patient may have symptoms related to this, such as palpitations, angina (if pre-existing heart disease is present), intermittent claudication of the legs, and symptoms of heart failure. (wikipedia.org)
  • widely
  • These conditions are included here because: The disease was listed in the prior version of this table The disease is included in several widely used lists of autoimmune disease and is shown here to ensure that a person visiting this page does not conclude that the disease was not considered. (wikipedia.org)
  • blood
  • Volunteers with or without a blood disease may be eligible to donate stem cells for this study. (clinicaltrials.gov)
  • the Kell antigen system is a group of antigens on the human red blood cell surface that are important determinants of blood type and targets for autoimmune or alloimmune diseases that destroy red blood cells? (thefullwiki.org)
  • Kawasaki Disease is a serious illness characterized by inflammation of blood vessels throughout the body that primarily affects young children and infants. (cslbehring.com)
  • autoimmunity
  • At this time, there is not sufficient evidence - direct, indirect, or circumstantial - to indicate that these diseases are caused by autoimmunity. (wikipedia.org)
  • More recently it has become accepted that autoimmune responses are an integral part of vertebrate immune systems (sometimes termed "natural autoimmunity"), normally prevented from causing disease by the phenomenon of immunological tolerance to self-antigens. (wikipedia.org)
  • medication
  • Discontinuing a DMARD may reactivate disease or cause a "rebound flare", with no assurance that disease control will be reestablished upon resumption of the medication. (wikipedia.org)