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  • primary
  • 100 × 10 9 /L) caused by platelet destruction with an increased risk of mucocutaneous bleeding, is a primary autoimmune disease [ 1 ]. (ijbs.com)
  • The exact mechanism of the primary disease is unknown, but the fundamental mechanism of all vasculitides is auto-immune. (wikipedia.org)
  • Three or more of the following six criteria must be met: Age when disease starts is under 50 Decreased brachial artery pulse Systolic blood pressure differs by more than 10mmHg between arms Cramping caused by exercise in the extremities Abnormal sounds (through stethoscope) over subclavian arteries or abdominal aorta A narrowing or blockage in the aorta, its primary branches, or large arteries as seen through a radiograph of the arteries. (wikipedia.org)
  • Primary autoimmune neutropenia (AIN) is an autoimmune disease first reported in 1975 that primarily occurs in infancy. (wikipedia.org)
  • Primary autoimmune neutropenia has been reported as early as the second month of life although most cases are diagnosed in children between 5 and 15 months of age. (wikipedia.org)
  • antibody
  • Autoimmune neutropenia is a form of neutropenia which is most common in infants and young children where the body identifies the neutrophils as enemies and makes antibody to destroy them. (wikipedia.org)
  • Multiple Sclerosis
  • The Latin American Multiple Sclerosis Forum is an independent and supra-institutional group of experts that has assessed the latest scientific evidence regarding efficacy and safety of disease-modifying treatments. (scielo.br)
  • It is not known why this is the case, although hormone levels have been shown to affect the severity of some autoimmune diseases such as multiple sclerosis. (disabled-world.com)
  • Symptoms
  • Autoimmune disorders can also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. (disabled-world.com)
  • Treatments your doctor suggests will depend on your disease and symptoms. (disabled-world.com)
  • The patient may have symptoms related to this, such as palpitations, angina (if pre-existing heart disease is present), intermittent claudication of the legs, and symptoms of heart failure. (wikipedia.org)
  • Extensive collection of conditions currently considered to be autoimmune with symptoms of each, links to in-depth information about each, and support groups. (dmoztools.net)
  • Crohn's
  • This site explores these issues as well as looking at the personal story of a journey with atypical Crohn's Disease. (dmoztools.net)
  • petechiae
  • It is the failure to close those tiny holes that allows the blood to ooze out of a capillary to form the tiny hemorrhages called petechiae that constitute purpura. (healthsearchonline.com)
  • 1975
  • December 1997), "Subacute bacterial endocarditis masquerading as type III essential mixed", Journal of the American Society of Nephrology, 8 (12): 1971-6, PMID 9402102 Autoimmune Diseases at the US National Library of Medicine Medical Subject Headings (MeSH) Kárpáti F, Dénes L, Büttner K (1975). (wikipedia.org)
  • Infectious Diseases
  • Infectious Diseases 10. (wikipedia.org)
  • NIH resource, including disease examples, quick facts, and the latest research-from the US National Institute of Allergy and Infectious Diseases. (dmoztools.net)
  • Investigators in the laboratory of Dr. Michael Lenardo at National Institute of Allergy and Infectious Diseases, the National Institutes of Health and Dr. Michael Jordan at Cincinnati Children's Hospital Medical Center later described this condition and therapy in 2015. (wikipedia.org)
  • deficiency
  • There may be signs of specific causes of anemia, e.g., koilonychia (in iron deficiency), jaundice (when anemia results from abnormal break down of red blood cells - in hemolytic anemia), bone deformities (found in thalassemia major) or leg ulcers (seen in sickle-cell disease). (wikipedia.org)
  • liver
  • Progressive liver disease, as a result of chronic HCV infection, usually develops slowly over 20-50 years and may lead to cirrhosis, hepatocellular carcinoma, liver failure and eventual death. (clinicaltrials.gov)
  • Occurs
  • The disease occurs throughout the body, although some joints may be more affected than others. (encyclopedia.com)
  • The bruising often takes the form of purpura, while the most common site of bleeding, if it occurs, is from the nose or gums. (wikipedia.org)
  • treatment
  • Recent advances in the area of stem cell research suggest that redirected differentiation of stem cells may prove useful for the treatment of a variety of diseases including diabetes and other systemic diseases. (clinicaltrials.gov)
  • Treatment depends on the disease, but in most cases one important goal is to reduce inflammation. (disabled-world.com)
  • Fostamatinib is an experimental drug candidate for the treatment of a variety of diseases, originally developed by Rigel Pharmaceuticals. (wikipedia.org)
  • The study is the second Phase 3, multi-center, randomized, double-blind, placebo controlled, study of fostamatinib disodium in the treatment of persistent/chronic immune thrombocytopenic purpura that Rigel has conducted. (wikipedia.org)
  • In January 2015, the FDA granted fast track status to Marathon Pharmaceuticals to pursue approval of deflazacort as a potential treatment for Duchenne muscular dystrophy, a rare, "progressive and fatal disease" that affects boys. (wikipedia.org)
  • Research group at CHOC Children's Research Institute investigating new treatment and cures for pediatric inflammatory diseases, with educational references and links. (dmoztools.net)
  • Links to disease information, treatment and a network of people who want to share information and provide support. (dmoztools.net)
  • Research center dedicated towards the understanding and treatment of autoimmune diseases in Western New York. (dmoztools.net)
  • conditions
  • This list includes conditions that are not diseases but signs common to autoimmune disease. (wikipedia.org)
  • These conditions are included here because they are frequently listed as autoimmune diseases but should not be included in the list above until there is more consistent evidence. (wikipedia.org)
  • These conditions are included here because: The disease was listed in the prior version of this table The disease is included in several widely used lists of autoimmune disease and is shown here to ensure that a person visiting this page does not conclude that the disease was not considered. (wikipedia.org)
  • Synthetic pharmaceutical drugs with corticosteroid-like effects are used in a variety of conditions, ranging from brain tumors to skin diseases. (wikipedia.org)
  • During the following decades, a number of conditions could be linked to autoimmune responses. (wikipedia.org)
  • syndrome
  • citation needed] It has been observed that there is a risk of developing other autoimmune problems and hypogammaglobulinemia, with recent research finding that 58% of children with Evans syndrome have CD4-/CD8- T cells which is a strong predictor for having autoimmune lymphoproliferative syndrome. (wikipedia.org)
  • 2002
  • 2002) demonstrated that self-MHC recognition (which, if too strong may contribute to autoimmune disease) maintains the responsiveness of CD4+ T cells when foreign antigens are absent. (wikipedia.org)
  • disorders
  • In other disorders, like T1D, this allows a better control of the disease. (hindawi.com)
  • Children who have immunodeficiency syndromes may be subject to infection, diseases, disorders, or allergic reactions to a greater extent than individuals with fully functioning immune systems. (encyclopedia.com)
  • Secondary disorders occur in normally healthy people who are suffering from an underlying disease that weakens the immune system. (encyclopedia.com)
  • Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. (wikipedia.org)
  • An important use of plasmapheresis is in the therapy of autoimmune disorders, where the rapid removal of disease-causing autoantibodies from the circulation is required in addition to other medical therapy. (wikipedia.org)
  • Immunoglobulin therapy is also used for a number of other conditions, including in many autoimmune disorders such as dermatomyositis in an attempt to decrease the severity of symptoms. (wikipedia.org)
  • Immunoglobulin therapy is especially useful in some acute infection cases such as pediatric HIV infection and is also considered the standard of treatment for some autoimmune disorders such as Guillain-Barré syndrome. (wikipedia.org)
  • Extensive information on how to treat, diagnose, and live with autoimmune disorders and connect with others in blogs and forums-from EverydayHealth. (dmoztools.net)
  • Comorbidity is the presence of one or more diseases or disorders co-occurring with each other. (wikipedia.org)
  • lupus
  • Evidence suggests a relative undertreatment of SLE patients with end-stage renal disease (ESRD), because the extent of lupus activity may be underestimated. (livehopelupus.org)
  • There is some evidence for efficacy, but not necessarily safety, in a range of other autoimmune diseases, and rituximab is widely used off-label to treat difficult cases of multiple sclerosis, systemic lupus erythematosus, chronic inflammatory demyelinating polyneuropathy and autoimmune anemias. (wikipedia.org)
  • destroys
  • Rituximab destroys both normal and malignant B cells that have CD20 on their surfaces and is therefore used to treat diseases which are characterized by having too many B cells, overactive B cells, or dysfunctional B cells. (wikipedia.org)
  • complications
  • In several other complications and/or associated diseases, an adequate adherence to a GFD may slow down their evolution, especially if implemented during an early stage. (hindawi.com)
  • As measles and rubella cause upper respiratory disease that leads to complications of pneumonia and bronchitis which are also caused by varicella, MMR vaccine is beneficial to control exacerbations of chronic obstructive pulmonary disease (COPD) and asthma. (wikipedia.org)
  • adults
  • Heterogeneity among patients with latent autoimmune diabetes in adults. (jove.com)
  • The disease affects both children and adults and is characterized by systemic thrombotic microangiopathy (TMA), the formation of blood clots in small blood vessels throughout the body, which can lead to stroke, heart attack, kidney failure, and death. (wikipedia.org)
  • congenital
  • If your CBC comes back with high numbers of RBCs or a high hematocrit, it could indicate a number of other issues including lung disease, blood cancers, dehydration, kidney disease, congenital heart disease, and other heart problems. (livehopelupus.org)
  • In some cases, a combination of sepsis and a partial congenital defect in the protein C anticoagulant pathway initiates purpura fluminans. (wikipedia.org)
  • correlates
  • In early purpura fulminans, lesion progression correlates with the histological appearance of blockage of small skin blood vessels with blood clots causing capillary dilation and congestion with red blood cells. (wikipedia.org)
  • Although uncommonly used in North America and northern Europe, this test correlates better with disease status and predicts relapse more accurately than any other test. (wikipedia.org)
  • progression
  • Failure of neurologic, cardiac, kidney, and gastrointestinal (GI) organs, as well as death, can occur unpredictably at any time, either very quickly or following prolonged symptomatic or asymptomatic disease progression. (wikipedia.org)
  • vaccine
  • The MMR vaccine (also known as the MPR vaccine after the Latin names of the diseases) is an immunization vaccine against measles, mumps, and rubella (German measles). (wikipedia.org)
  • Nephrology
  • December 1997), "Subacute bacterial endocarditis masquerading as type III essential mixed", Journal of the American Society of Nephrology, 8 (12): 1971-6, PMID 9402102 Autoimmune Diseases at the US National Library of Medicine Medical Subject Headings (MeSH) Kárpáti F, Dénes L, Büttner K (1975). (wikipedia.org)
  • cases
  • Moreover, a significantly increased prevalence of other autoimmune diseases (AD) has been reported in individuals with CD and their first-degree relatives as compared to controls [ 3 - 7 ], with an estimated burden of AD in CD cases up to 15% [ 7 ]. (hindawi.com)
  • however only a very small number of cases have been recorded occurring in autoimmune diseases. (wikipedia.org)
  • In cases of severe inheritable protein C deficiency, purpura fulminans with disseminated intravascular coagulation manifests within a few hours or days after birth. (wikipedia.org)
  • Fewer than 200 cases have been reported each year between 1997 and 2013, and the disease is no longer considered endemic. (wikipedia.org)
  • The first 20 years of licensed measles vaccination in the U.S. prevented an estimated 52 million cases of the disease, 17,400 cases of intellectual disability, and 5,200 deaths. (wikipedia.org)
  • manifestations
  • In general, cutaneous manifestations, musculoskeletal manifestations, and serositis represent milder disease, which may wax and wane with disease activity. (livehopelupus.org)
  • General practitioners and other specialists must remember that CD may debut with extraintestinal manifestations, and associated illnesses may appear both at the time of diagnosis and throughout the evolution of the disease. (hindawi.com)
  • widely
  • These conditions are included here because: The disease was listed in the prior version of this table The disease is included in several widely used lists of autoimmune disease and is shown here to ensure that a person visiting this page does not conclude that the disease was not considered. (wikipedia.org)
  • uncommon
  • Our mission is both a journalistic and educational one: by reporting on common diseases affecting uncommon people, and including the medical facts behind the headlines, we provide a dynamic collection of Teachable Moments in Medicine™ to increase health awareness and medical knowledge. (celebritydiagnosis.com)
  • Examples
  • However, in many medical examples, such as comorbid diabetes mellitus and coronary artery disease, it makes little difference which word is used, as long as the medical complexity is duly recognized and addressed. (wikipedia.org)
  • Condition
  • People may also suffer from the opposite condition, an overactive immune system that attacks healthy cells as though they were foreign bodies, and that is called an autoimmune response. (cslbehring.com)
  • significantly
  • The disease was formally named leukemic reticuloendotheliosis and its characterization significantly advanced by Bertha Bouroncle and colleagues at The Ohio State University College of Medicine in 1958. (wikipedia.org)