Autoimmune disease apolipoproteins e. Medical search. Frequent questions

With the risk of coronary heart disease as a positive control, primary outcomes included the risk of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), myasthenia gravis (MG), multiple sclerosis (MS), asthma, Crohn's disease (CD), ulcerative colitis (UC), and type 1 diabetes (T1D). (biomedcentral.com)

β2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein that in humans is encoded by the APOH gene. (wikipedia.org)

Background and aim: Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease and it is in coexistence with many autoimmune disorders, especially celiac disease. (mattioli1885journals.com)
The results of the assay are to be used as an aid in the diagnosis of certain autoimmune disease thrombotic disorders, anti-phospholipid syndrome, SLE or lupus-like disorders. (rapidtest.com)
The determination of IgM antibodies is a valuable indicator in the diagnosis of beginning autoimmune disease, whereas IgG and/or IgA antibodies will be found in progressive stages of manifested autoimmune disorders. (rapidtest.com)
Liver fibrosis is a complex disease provoked by a range of chronic injuries to the liver, among which are viral hepatitis, (non-) alcoholic steatohepatitis and autoimmune disorders. (biomedcentral.com)
Genetic diseases can be classified as chromosomal abnormalities (for example, trisomy 21), Mendelian disorders (single gene alterations with typical inheritance patterns, like autosomal dominant/recessive or X-linked), and complex diseases that are influenced by many genetic and environmental components. (biomedcentral.com)
The genetic contributions to these disorders are not attributable to a single gene alteration, but rather to a host of genetic susceptibilities defined by single nucleotide polymorphisms (SNPs) that predispose an individual to a disease. (biomedcentral.com)
We know that it's important to be aware of our cholesterol levels - but now studies are providing even more information about the mechanisms that link cardiovascular disease (CVD) AND neurodegenerative disorders. (suzannegazdamd.com)
Also treats stress, auto immune disorders, painful joints and inflamed bowel diseases. (life-enthusiast.com)
Initially the phenomenon was classified as a series of false positive syphilis tests, before a more accurate analysis revealed, for this group of patients, a high prevalence of autoimmune disorders including SLE and Sjögrens syndrome. (diametra.com)
This group includes lysosomal storage disorders, various mitochondrial diseases, other neurometabolic disorders, and several other miscellaneous disorders. (medscape.com)

Walk-In Lab offers several discount heart disease tests and panels that check for signs of poor heart health such as inflammation of the arteries, homocysteine imbalances, and abnormal cholesterol and lipid levels. (walkinlab.com)
The Lipid Panel Blood Test measures the amount of cholesterol and specific fats in the blood to screen for cardiovascular disease. (walkinlab.com)
An apolipoprotein B blood test is useful in evaluating the risk of developing cardiovascular disease and monitoring treatment for high cholesterol. (walkinlab.com)
He also explains "Inflammation is the main cause of heart disease and is what makes cholesterol dangerous. (suzannegazdamd.com)
However, results from a number of studies have indicated that the biomarker apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), and ApoB/ApoA1 ratio could improve the prediction of CVD and mortality in comparison with total cholesterol, HDL-C, and LDL-C. ApoB has come to the forefront as being a better representation of the number of cholesterol-laden particles circulating in the bloodstream. (suzannegazdamd.com)
Lipids in MS. In MS higher total cholesterol and LDL-cholesterol levels have been linked to worsening disability, with greater ApoB levels at disease onset being linked to increased number of lesions on MRI brain scans over a two-year period. (suzannegazdamd.com)
Increases in HDL‐C (which ideally should be greater than 60) and ApoA‐I (should be greater than or equal to 14) have protective associations with magnetic resonance imaging (MRI) measures of neurodegeneration in MS. But, elevated levels of circulating low density lipoprotein cholesterol (LDL), total cholesterol, and particularly, apolipoprotein B and oxidized LDL are associated with adverse clinical and MRI outcomes. (suzannegazdamd.com)
Pantesin is a branded form of Pantethine, with 35+ years of research supporting its positive effect on cholesterol levels in high-risk cardiovascular disease (CVD) subjects. (life-enthusiast.com)
After two weeks, taking 600 mg of Pantesin a day, the subjects averaged a reduction of 3% in total cholesterol, 4% in LDL (bad) cholesterol, and 5% in Apolipoprotein B (main component of LDL). (life-enthusiast.com)
Low to moderate cardiovascular-disease-risk subjects, who were eligible for statin therapy, showed a significant decrease of 6% in total cholesterol, 11% in LDL (bad) cholesterol, and 7% in non-HDL cholesterol - significant. (life-enthusiast.com)
Emerging data show that high density lipoprotein cholesterol levels, an established negative risk factor for cardiovascular disease improves after bariatric surgery [ 9 ]. (biomedcentral.com)

6. List three common autoimmune conditions associated with Addison's disease? (familymedexamprep.com)

Cardiolipin autoantibodies (ACA) are described for various autoimmune diseases. (rapidtest.com)
This interaction results in conformational changes of ß2 GP-I and the creation of new epitopes apparently recognized by autoimmune phospholipid autoantibodies. (eaglebio.com)
We hypothesized that "autoimmune encephalitides" may result from any brain inflammation concurring with the presence of brain antigen-directed autoantibodies, e.g., against N-methyl-D-aspartate-receptor NR1 (NMDAR1-AB), which are not causal of, but may considerably shape the encephalitis phenotype. (nature.com)
apolipoprotein H) was identified as a natural and essential co-antigen for CL autoantibodies. (steffens-biotec.com)

Positivity for anti-cardiolipin antibodies in diagnostic tests for autoimmune antiphospholipid syndrome requires the presence of β2-GP1in the cardiolipin extract. (wikipedia.org)

The incidence of autoimmune diseases accounts for about 5-9% of the global population, and their treatment is still a thorny clinical problem that imposes a great burden on society and families [ 1 ]. (biomedcentral.com)
APAS is an autoimmune disorder comprising such clinical symptoms like arterial or venous thrombosis, thrombocytopenia and recurrent fetal loss. (eaglebio.com)
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. (acc.org)
Even though this disease is associated with adverse clinical outcomes, impaired physical function, and reduced physical activity, it has been understudied and underrecognized compared with other atherosclerotic diseases such as myocardial infarction. (encyclopedia.pub)
Anti-phospholipid syndrome (APS) as a systemic autoimmune disease that can include clinical conditions such as venous and arterial thrombosis, thrombocytopenia, and myocardial infarction. (steffens-biotec.com)
We believe with more validation and efforts from additional diversity cohorts, this model could be applied to a range of diseases to improve health care services for patients who may have been underrepresented in clinical research. (provaeducation.com)
The OCEAN(a) DOSE trial was a phase 2 clinical trial designed to assess the impact of olpasiran, a small interfering RNA (siRNA) on lipoprotein(a) (Lp(a)) concentrations in patients with established atherosclerotic cardiovascular disease (ASCVD). (mhmedical.com)
This chapter discusses the prevalence, genetics, pathophysiology, and management of lipoprotein abnormalities, which are interpreted in the context of the history of clinical cardiovascular events or subclinical cardiovascular disease (CVD) (see Fuster and Hurst's Central Illustration). (mhmedical.com)

Although previously referred to as apolipoprotein H, it is not present in appreciable quantities in the lipoprotein fractions, so ApoH is therefore thought to be a misnomer. (wikipedia.org)

Therefore, it is imperative to explore the underlying pathogenesis and identify novel therapeutic targets to more effectively prevent and treat autoimmune diseases [ 3 ]. (biomedcentral.com)
Consequently, dyslipidemia may be implicated in the pathogenesis and progression of autoimmune diseases, but the effects of various lipid-lowering drugs on autoimmune diseases warrant further investigation. (biomedcentral.com)
These findings suggest that PCSK9i may be involved in the pathogenesis of autoimmune diseases through pathways other than lipid-lowering. (biomedcentral.com)

Additionally, the fifth protein domain appears to resemble the other four in Apolipoprotein with the exception of three internal disulfide bonds and an extra C-terminal loop. (wikipedia.org)
The objective of this study was to develop an atheroprotective vaccine by targeting a peptide of the LDL protein constituent apolipoprotein B-100 (apoB-100) to the nasal mucosa to induce a protective mucosal immune response. (lu.se)
Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
The High Sensitivity C-Reactive Protein (hs-CRP) Blood Test, Cardiac Risk Assessment measures the hs-CRP levels in the blood to assess the risk of developing cardiovascular disease. (walkinlab.com)
Unlike phospholipid antibodies which occur in some patients having infectious disease, phospholipid antibodies of autoimmune disease patients seem to recognize the relevant phospholipids in association with a plasma protein cofactor. (eaglebio.com)
Methods In a population-based RA incident cohort (1987 American College of Rheumatology criteria first met between 1988 and 2007), details were collected of serum lipid measures, erythrocyte sedimentation rates (ESRs), C-reactive protein (CRP) measures and cardiovascular events, including ischaemic heart disease and heart failure. (bmj.com)
The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. (thermofisher.com)
Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). (thermofisher.com)

Objective To examine the impact of systemic inflammation and serum lipids on cardiovascular disease (CVD) in rheumatoid arthritis (RA). (bmj.com)
The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. (thermofisher.com)
Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile. (thermofisher.com)
Learned immunosuppressive placebo response attenuates disease progression in a rodent model of rheumatoid arthritis. (mdbioproducts.com)

This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
Apolipoprotein E: depressive illness, depressive symptoms, and Alzheimer's disease. (ox.ac.uk)
Depressive illness of late onset is also a risk factor for Alzheimer's disease (AD), and there is some evidence that the ApoE epsilon 2 allele is associated with depressive symptomatology in AD. (ox.ac.uk)
Alzheimer's disease is a pervasive neurodegenerative disorder, the molecular complexity of which remains poorly understood. (nature.com)
Here, we analysed 80,660 single-nucleus transcriptomes from the prefrontal cortex of 48 individuals with varying degrees of Alzheimer's disease pathology. (nature.com)
Overall, myelination-related processes were recurrently perturbed in multiple cell types, suggesting that myelination has a key role in Alzheimer's disease pathophysiology. (nature.com)
Our single-cell transcriptomic resource provides a blueprint for interrogating the molecular and cellular basis of Alzheimer's disease. (nature.com)
The snRNA-seq data are available on The Rush Alzheimer's Disease Center (RADC) Research Resource Sharing Hub at https://www.radc.rush.edu/docs/omics.htm (snRNA-seq PFC) or at Synapse ( https://www.synapse.org/#!Synapse:syn18485175 ) under the doi 10.7303/syn18485175. (nature.com)
Alzheimer's disease. (nature.com)
Hardy, J. & Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. (nature.com)
Philadelphia, July 20, 2023 - Using data from diverse populations around the world, researchers from Children's Hospital of Philadelphia (CHOP) have developed an algorithm to help predict the risk of developing Alzheimer's disease based on genetic information in patients with a wide variety of ethnic backgrounds. (provaeducation.com)
Alzheimer's disease affects approximately one in 10 patients aged 65 or older, according to the U.S. Centers for Disease Control. (provaeducation.com)
Researchers had previously developed genomic informed risk assessment (GIRA) algorithms using known genomic information about Alzheimer's disease. (provaeducation.com)
We were able to demonstrate the feasibility of developing a GIRA algorithm for Alzheimer's disease that predicts disease predisposition across diverse populations around the globe. (provaeducation.com)
The researchers developed their GIRA algorithm to assess Alzheimer's risk based on variants of the apolipoprotein E (APOE) gene - which has been implicated in Alzheimer's risk - as well as polygenic risk scores by other genomic markers and other variables including age, sex and ethnicity. (provaeducation.com)
Using this GIRA algorithm, which was tested in different ethnic populations, the researchers were able to identify certain proteins related to female infertility and autoimmune thyroiditis as contributors to the risk of developing Alzheimer's disease. (provaeducation.com)
The study lacked a well-phenotyped Alzheimer's disease cohort of African origin, but the current polygenic risk score system was additionally validated in people from different regions of Africa. (provaeducation.com)
Sleiman et al, "Trans-ethnic Genomic Informed Risk Assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium Study. (provaeducation.com)

Autoimmune responses to low-density lipoproteins (LDL) contribute to its progression, whereas immunization with LDL may induce atheroprotective or proatherogenic responses. (lu.se)
For those aged 20-39 years, it is reasonable to measure traditional risk factors every 4-6 years to identify major factors (e.g., tobacco, dyslipidemia, family history of premature ASCVD, chronic inflammatory diseases, hypertension, or type 2 diabetes mellitus [T2DM]) that provide rationale for optimizing lifestyle and tracking risk factor progression and need for treatment. (acc.org)
It is vital to establish accurate tools to identify those patients at highest risk for disease severity or progression in order to determine who are in need of immediate therapies. (biomedcentral.com)
Ideally, biomarkers can be used to predict disease progression and treatment response, but these studies will take many years due to the requirement for lengthy follow-up periods to assess outcomes. (biomedcentral.com)
This review will focus on the contribution of high-throughput genomic and proteomic approaches to the study of fibrogenesis and fibrosis progression, concentrating on the most prevalent human chronic liver diseases and findings from animal models in liver tissue, isolated liver cells, cell lines and serum. (biomedcentral.com)
The strongest disease-associated changes appeared early in pathological progression and were highly cell-type specific, whereas genes upregulated at late stages were common across cell types and primarily involved in the global stress response. (nature.com)

Understanding the mutations in APOE, their structural properties, and their isoforms is important to determine its role in various diseases and to advance the development of therapeutic strategies. (dovepress.com)
Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans. (dovepress.com)
The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
BACKGROUND: The apolipoprotein E (ApoE) epsilon 4 and epsilon 2 alleles may influence the age of onset of depressive illness. (ox.ac.uk)
METHODS: The frequency of the epsilon 2 and epsilon 4 alleles of ApoE and their effects on age of onset of disease in three independent groups of subjects, with depressive illness, with AD, and controls, were compared in a defined population from Southeast London. (ox.ac.uk)

The group has defined epitopes on apolipoprotein B-containing lipoproteins targeted by immunoglobulins, and have shown that plasma levels of these immunoglobulins can predict future cardiovascular disease. (lu.se)

Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) among Indian Asians in high-income countries is not well studied, but appears to be different from that for Western populatio. (researcher.life)
The Centers for Disease Control and Prevention (CDC) uses the Behavioral Risk Factor Surveillance System (BRFSS) to compile chronic disease prevalence data for the US population, but data specific to people with MS are unavailable. (cdc.gov)
Page 2 of 10 epidemiologic data on chronic disease prevalence in men with MS. Our objective was to identify chronic diseases that may disproportionately affect male veterans with MS. Diabetes, hypertension, hypercholesterolemia, coronary heart disease (CHD), and stroke were assessed because they are associated with the leading causes of illness and death in the United States (5). (cdc.gov)
Care Questionnaire (MS-HCQ) (survey instrument available on request from the corresponding author) to collect primary data on sociodemographics, health behaviors, and chronic disease prevalence in veterans with MS. We included additional questions to assess MS duration and age at diagnosis. (cdc.gov)
Multiple sclerosis is a common, chronic demyelinating neurological disease primarily affecting young adults, with a prevalence of ~0.1% in the Caucasian population (Miller and Leary, 2007). (medscape.com)

Anti-β2-GP1 antibodies are found in both infectious and some systemic autoimmune diseases (eg. (wikipedia.org)
An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system. (mcw.edu)

Spinal cord injury is a destructive disease characterized by motor/sensory dysfunction and severe inflammation. (en-journal.org)
To conclude, genetic brain inflammation may explain an encephalitic component underlying autoimmune conditions. (nature.com)
11 13 , - , 15 The implications of these changes on cardiovascular risk are unclear, and the relative impact of systemic autoimmune inflammation and dyslipidaemia on cardiovascular risk in RA is not fully understood. (bmj.com)
Inflammation can arise from poor diet (too much sugar and trans and saturated fats), a sedentary lifestyle, stress, autoimmune disease, food allergies, or hidden infections such as gum disease, or even toxins such as mercury. (suzannegazdamd.com)
Cardiovascular disease is mainly caused by atherosclerosis, which is characterized by lipid deposition, chronic inflammation, immune cell accumulation, and fibrosis of the vessel wall of large and medium sized arteries. (lu.se)
It has been suggested that increased low-grade inflammation and impaired fibrotic repair explain why people with diabetes are more likely to suffer from cardiovascular disease. (lu.se)

HIV infection, chronic inflammatory or autoimmune disease, and low socioeconomic levels). (acc.org)
Thus, great opportunities and challenges lie ahead in the field of genomics and proteomics, which, if successful, could transform the diagnosis and treatment of chronic fibrosing liver diseases. (biomedcentral.com)
Fibrosis is prominent in chronic liver diseases, including viral hepatitis, alcoholic and non-alcoholic steatohepatitis, toxic liver injury, auto-immune diseases and several genetic diseases. (biomedcentral.com)
Atherosclerosis is a lipid-driven chronic inflammatory disease characterized by progressive atherosclerotic plaque growth. (hindawi.com)
It is well known that Tregs play a significant role in maintaining peripheral tolerance, preventing autoimmune diseases, and restraining chronic inflammatory diseases. (hindawi.com)
Vascular Cognitive Impairment and Dementia Vascular cognitive impairment and dementia is acute or chronic cognitive deterioration due to diffuse or focal cerebral infarction that is most often related to cerebrovascular disease. (msdmanuals.com)
Cervical vertebrae 1,2, …?Ca: Calcium?Ca: Cancer?Ca: Carcinoma?Ca: Cardiac arrest?Ca: Coronary artery?CA-125: A tumor marker for ovarian cancer?CAB: Cellulose acetate butyrate?CABG: Coronary artery bypass graft?CACI: Computer-Assisted Continuous Infusion?CAD: Coronary artery disease?CAG: ?CAH: Chronic active hepatitis?CAH: Congenital adrenal hyperplasia?calid. (kuwaitpharmacy.com)
Explanatory variables (eg, age, education, race) and dynamic associations between conditions (higher odds for each when 1 of the other conditions were present) for chronic disease in men with MS were similar to findings in the general population literature for select conditions. (cdc.gov)
These findings raise awareness of chronic disease in a veteran cohort and help bridge a gap in the literature on chronic disease epidemiology in men with MS. We identified chronic disease priorities that may benefit from focused interventions to reduce disparities. (cdc.gov)
Research suggests that people with MS experience more premature illness (1,2), which may result in the presence of more chronic diseases at a younger age, compared with the general population. (cdc.gov)
Factors such as inactivity and immobility may place people with MS at increased risk of developing disabilities, and they may be disproportionately affected by chronic diseases (1,2). (cdc.gov)

Product inserts for all Autoimmune ELISA kits follow a similar method. (rapidtest.com)
Diagnostic Automation Inc. also provides other Autoimmune Disease ELISA Kits. (rapidtest.com)

Although significance and pathological relevance of phospholipid anti-bodies are not completely revealed yet, the detection of several autoantibody specificities is usually applied to the differential diagnosis and follow-up of systemic rheumatic inflammatory diseases. (eaglebio.com)
Despite the overlap, the causes of atherosclerotic diseases are not the same and the need for the appropriate diagnosis and treatment remains a major concern for medicine. (encyclopedia.pub)
While additional ethnicities should be included in future studies, this work aims to eliminate disparities in diagnosis of the disease. (provaeducation.com)
We then aim to define biomarkers and to develop interventions that are specifically targeted towards these mechanisms to improve diagnosis, prognosis, and treatment of atherosclerotic cardiovascular disease. (lu.se)

I have exhibited zero markers for a rheumatological disease and only a low normal for thyroid disease. (mayoclinic.org)

Antiphospholipid syndrome (APS) is an acquired autoimmune disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. (medscape.com)

Overt and subclinical hypothyroidism have an adverse effect on the serum lipid profile that may predispose to the development of atherosclerotic disease. (hormones.gr)
Notably, numerous brain-directed AB-apart from NMDAR1-AB-have been reported in serum of healthy humans and of various other mammalian species, likely constituting the preexisting physiological "autoimmune repertoire. (nature.com)
Some years later the role of a cofactor was investigated, the β2-glycoprotein I (apolipoprotein H) also called β2GPI and its interactions with anionic phospholipids in human serum / plasma. (diametra.com)

In other patients, APS occurs in association with systemic lupus erythematous (SLE) or another rheumatic or autoimmune disorder. (medscape.com)

article{810b2d7a-9a83-4e7e-8653-77f8f1470a30, abstract = {{Objective-Atherosclerosis is an inflammatory disease. (lu.se)

Latter has lead to recommendations to osteopaths, chiropractors, body workers and their patients to look for underlying celiac disease seen in an inflamed, bloated gut, overall puffiness and fluid retention whenever low back, [12] sacroiliitis, [13] and pelvic alignments "don't hold" after repeat treatments. (greenmedinfo.com)

Objective-Atherosclerosis is an inflammatory disease. (lu.se)

The focus is primary prevention in adults to reduce the risk of ASCVD (acute coronary syndromes, myocardial infarction, stable or unstable angina, arterial revascularization, stroke/transient ischemic attack, peripheral arterial disease), as well as heart failure and atrial fibrillation. (acc.org)
More than 200 million adults suffer from peripheral artery disease in their lower extremities, which increases their risk of cardiovascular events (such as coronary heart disease, strokes, and leg amputations). (encyclopedia.pub)
Clinically, peripheral artery disease and coronary artery disease overlap due to their shared risk factors. (encyclopedia.pub)
Many studies have found that coronary artery disease and peripheral artery disease are frequently coexisting conditions. (encyclopedia.pub)
During 2.79 million person-years of follow-up, there were 8857 nonfatal myocardial infarctions, 3928 coronary heart disease [CHD] deaths, 2534 ischemic strokes, 513 hemorrhagic strokes, and 2536 unclassified strokes. (ox.ac.uk)
Overall and for the subset of people aged 50 years or older, diabetes, hypertension, hypercholesterolemia, coronary heart disease, and stroke were significantly more prevalent among male veterans with MS than among the general population. (cdc.gov)

An adverse lipid profile or dyslipidaemia is an important risk factor for cardiovascular disease (CVD) in the general population. (bmj.com)
The INTERHEART study (15,152 cases and 14,820 controls, from 52 countries) [1] reported that among modifiable cardiovascular disease (CVD) predictors, dyslipidaemia is the main risk factor [1]. (researcher.life)

He diagnosed me with what he termed an immune deficiency which he felt was manifesting as an auto-immune disease, even though all my blood work never revealed any markers for any known auto-immune diseases and I don't exhibit any symptoms from the neck down. (mayoclinic.org)
Approximately 15% of patients follow a primary progressive or progressive relapsing course from disease onset, usually characterized by symptoms of progressive myelopathy (gait instability, spasticity, bladder symptoms) and cognitive impairment. (medscape.com)

Lymes disease, infections etc… The doctor could clearly see my facial swelling and she recommended that I go back to a rheumatologist, which I did. (mayoclinic.org)

They affect the body's nutrient and mineral absorption, auto-immune defense capability, toxin drainage ability, pH balance and anti-parasitic properties, defense from non-communicable and communicable diseases. (greenmedinfo.com)
Recent evidence indicated that interleukin (IL)-27 showed pleiotropic properties in immune diseases. (hindawi.com)
The experimental cardiovascular research group has a long history of studying immune mechanisms in atherosclerosis, diabetes, and cardiovascular disease. (lu.se)

We collected single nucleotide polymorphisms (SNPs) of PCSK9 from published genome-wide association studies statistics and conducted drug target MR analysis to detect the causal relationship between PCSK9 inhibitor and the risk of autoimmune diseases. (biomedcentral.com)
A Lipoprotein (a) Blood Test measures the level of a particular type of lipoprotein which can increase a person's risk for cardiovascular disease. (walkinlab.com)
The susceptibility to an accumulation of environmental influences is either enhanced or reduced by genetic factors, thereby defining an individual's disease risk. (biomedcentral.com)
Studies investigating these genetic traits are complicated, because there are many genes that influence the risk for complex diseases, yet the impact of each single genetic variant by itself is small. (biomedcentral.com)
Inheritance of the TNF-α (−863) C allele has been associated with an elevated risk of Alzheimer disease. (molvis.org)
In recent years, there has been mounting evidence that peripheral artery disease is significantly linked to mortality, primarily as a risk factor for future myocardial infarctions and strokes. (encyclopedia.pub)
Major lipids, apolipoproteins, and risk of vascular disease. (ox.ac.uk)
CONTEXT: Associations of major lipids and apolipoproteins with the risk of vascular disease have not been reliably quantified. (ox.ac.uk)
OBJECTIVE: To assess major lipids and apolipoproteins in vascular risk. (ox.ac.uk)
Helps reduce your risk of heart disease, cardiovascular disease and blood clots. (life-enthusiast.com)
Bariatric surgery can alleviate cardiovascular risk via effects on cardiovascular disease (CVD) risk factors such as diabetes mellitus, hypertension, and dyslipidemia. (biomedcentral.com)
The BRFSS survey is a standardized instrument used to monitor disease, health, and risk behaviors in the US population (50 states, the District of Columbia, Puerto Rico, Guam, and the US Virgin Islands). (cdc.gov)
Therapies targeting atherosclerotic disease mechanisms will play a critical role in reducing the risk of cardiovascular complications in diabetes beyond what can be achieved by managing risk factors and doing life style interventions. (lu.se)

Autoantibody to apolipoprotein A-1 in hepatitis C virus infection: a role in atherosclerosis? (northumbria.ac.uk)
One way to ease the burden is to identify interventions that specifically target disease mechanisms in atherosclerosis. (lu.se)
The group has also studied the role of regulatory T cells in atherosclerosis development and revealed associations between monocytes and T cell subsets and future cardiovascular disease. (lu.se)

Both genetic and environmental factors are thought to contribute to the pathophysiology of the disease. (molvis.org)
Pathophysiology and Mortality with Peripheral Artery Disease" Encyclopedia , https://encyclopedia.pub/entry/45479 (accessed December 08, 2023). (encyclopedia.pub)

Diagnostic criteria and classification of multiple sclerosis subtypes have evolved in recent decades, and, although successive versions have differed in emphasis, all have required dissemination of disease in space (requiring involvement of multiple areas of the CNS) and in time (requiring ongoing disease activity over time). (medscape.com)

Degenerative diseases like liver fibrosis are complex illnesses [ 3 ]. (biomedcentral.com)
T2DM and MetS are associated with abnormal liver enzyme levels, which can be the result of non-alcoholic fatty liver disease, cirrhosis, hepatocellular carcinoma or acute liver failure. (researcher.life)

It is unclear how the atherosclerotic disease process is different in people with diabetes. (lu.se)

Centers for Disease Control and Prevention. (cdc.gov)

Amyloidoses are a group of diseases resulting from deposition of amyloid, insoluble fibrils derived from various precursor proteins, into extracellular tissues. (renalfellow.org)
Distinguishing characteristics - AL amyloidosis is the most prevalent type of amyloid disease in most parts of the United States (US). (renalfellow.org)

This variety can be caused by disease-related factors (for example, viral genotype) or host-factors (genetic/epigenetic). (biomedcentral.com)
However, studies using GIRA to identify genetic variants associated with the disease have largely been carried out in white patients of European ancestry. (provaeducation.com)

The Lipid Panel Blood Test Plus Hemoglobin (HB) A1c measures fats in the blood, and the average glucose level from over 12 weeks, to screen for cardiovascular disease in individuals with diabetes. (walkinlab.com)
Although patients with diabetes mellitus benefit from medical and endovascular procedures to manage atherosclerotic cardiovascular diseases, restenosis is a significant factor that may worsen the prognosis and may be associated with the necessity of reintervention [ 7 ] . (encyclopedia.pub)
Cardiovascular disease is the number one cause of death in people living with diabetes, and people with diabetes are twice as likely to have heart disease or suffer a stroke than people without diabetes. (lu.se)

Kidney disease usually presents as reduced glomerular filtration rate (GFR) and/or proteinuria which may progress to nephrotic syndrome. (renalfellow.org)

Anatomy18

Organisms11

Diseases43

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes25

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Health Care2

Systemic lupus erythem1

Beta-2 glycoprotein1

Disorders10

Cholesterol11

Common autoimmune1

Autoantibodies4

Anti-cardiolipi1

Clinical8

Apoh1

Pathogenesis3

Protein8

Rheumatoid arthritis4

Alzheimer's19

Progression6

APOE5

Epitopes1

Prevalence5

Antibodies2

Inflammation6

Chronic11

ELISA2

Diagnosis4

Thyroid disease1

Antiphospholipid1

Serum3

Disorder1

Abstract1

Celiac disease1

Inflammatory disease1

Coronary6

Dyslipidaemia2

Symptoms2

Infections1

Immune3

Risk13

Atherosclerosis3

Pathophysiology2

Multiple sclerosis1

Liver2

Atherosclerotic disease1

Centers1

Amyloid2

Genetic2

Diabetes3

Syndrome1