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  • chronic
  • MG is a debilitating, chronic and progressive autoimmune neuromuscular disease that typically begins with weakness in the muscles that control the movements of the eyes and eyelids, and often progresses to the more severe and generalized form, known as gMG, with weakness of the head, neck, trunk, limb and respiratory muscles. (alxn.com)
  • interstitial
  • Genetic knock-out of the gene encoding the astroglial water channel aquaporin-4, which is importantly involved in paravascular interstitial solute clearance, exacerbated glymphatic pathway dysfunction after TBI and promoted the development of neurofibrillary pathology and neurodegeneration in the post-traumatic brain. (blogspot.com)
  • Interstitial cystitis=autoimmune cyatitis? (wikipedia.org)
  • demyelination
  • These findings suggest several distinct mechanisms of demyelination in early MS. Whether these patterns reflect different causes, such as autoimmune viral causes, or different host genetic factors is an area of ongoing research. (mayo.edu)
  • water
  • The cell membranes of a variety of different bacteria, fungi, animal and plant cells contain aquaporins through which water can flow more rapidly into and out of the cell than by diffusing through the phospholipid bilayer. (wikipedia.org)
  • mechanisms
  • The patient did not respond to prednisone, but eventually recovered, leading Brain to suggest that autoimmune mechanisms might be responsible. (wikipedia.org)
  • abnormal
  • Astrogliosis (also known as astrocytosis or referred to as reactive astrocytosis) is an abnormal increase in the number of astrocytes due to the destruction of nearby neurons from CNS trauma, infection, ischemia, stroke, autoimmune responses, and neurodegenerative disease. (wikipedia.org)
  • brain
  • Aquaporin 4 is found in the astrocytes that surround the blood-brain barrier (BBB), a system responsible for preventing substances in the blood from crossing into the brain. (wikipedia.org)
  • known
  • It was not until 1992 that the first aquaporin, 'aquaporin-1' (originally known as CHIP 28), was reported by Peter Agre, of Johns Hopkins University. (wikipedia.org)
  • CRION has been classified as an autoimmune process but this description is not established with certainty and there is no known associated autoimmune antibody Some research points to CRION belonging to the antiMOG associated encephalomyelitis spectrum. (wikipedia.org)
  • cell
  • The aquaporin-4 tetramers accumulate to transform into orthogonal arrays of particle (OAPs) in the cell plasma membrane. (wikipedia.org)
  • They are called pre-active lesions in its initial stage and they do not show autoimmune infiltrates at this stage They show microglia activation and degeneration of the neuron axons without T-cell infiltration. (wikipedia.org)
  • target
  • In Anti-AQP positive variants, CNS astrocytes, which are the basis for the glymphatic system are the target of the autoimmune attack. (wikipedia.org)
  • disease
  • Backgroundï¼ The discovery of aquaporin-4 (AQP4) antibody was a major advance since it indicated that neuromyelitis optica (NMO) is an independent disease distinct from multiplesclerosis. (jneuropsychiatry.org)
  • Around one-third of people with this subtype will develop MS-like disease within about 4 and a half years. (livewisems.org)
  • These conditions are included here because: The disease was listed in the prior version of this table The disease is included in several widely used lists of autoimmune disease and is shown here to ensure that a person visiting this page does not conclude that the disease was not considered. (wikipedia.org)