• pathology
  • Genetic knock-out of the gene encoding the astroglial water channel aquaporin-4, which is importantly involved in paravascular interstitial solute clearance, exacerbated glymphatic pathway dysfunction after TBI and promoted the development of neurofibrillary pathology and neurodegeneration in the post-traumatic brain. (blogspot.com)
  • syndrome
  • Caselli RJ in 1999 reported five patients, age 54 to 80 years, presented between 3 weeks and 18 months after symptomatic onset of progressive cognitive decline, psychosis, and unsteady gait that proved to be due to a steroid-responsive nonvasculitic autoimmune inflammatory meningoencephalitic syndrome. (wikipedia.org)
  • pore
  • For example, the aquaporin 3 channel has a pore width of 8-10 Ångströms and allows the passage of hydrophilic molecules ranging between 150 and 200 Da. (wikipedia.org)
  • patients
  • therefore, a careful neurological evaluation is usually recommended in the global assessment of SS patients [ 4 ]. (hindawi.com)
  • cells
  • HEK293 cells were used as antigenic substrate after transfected with full-length human AQP4 and mocktransfected cells were used as control substrate [ 4 ]. (jneuropsychiatry.org)
  • The cell membranes of a variety of different bacteria, fungi, animal and plant cells contain aquaporins through which water can flow more rapidly into and out of the cell than by diffusing through the phospholipid bilayer. (wikipedia.org)
  • mainly
  • While the former consists mainly of drugs that enhance the GABA activity, the latter is aimed at altering the autoimmune attack. (hindawi.com)
  • brain
  • The patient did not respond to prednisone, but eventually recovered, leading Brain to suggest that autoimmune mechanisms might be responsible. (wikipedia.org)
  • known
  • It was not until 1992 that the first aquaporin, 'aquaporin-1' (originally known as CHIP 28), was reported by Peter Agre, of Johns Hopkins University. (wikipedia.org)
  • CRION has been classified as an autoimmune process but this description is not established with certainty and there is no known associated autoimmune antibody Some research points to CRION belonging to the antiMOG associated encephalomyelitis spectrum. (wikipedia.org)
  • mechanism
  • The 2003 Nobel Prize in Chemistry was awarded jointly to Peter Agre for the discovery of aquaporins, and Roderick MacKinnon for his work on the structure and mechanism of potassium channels. (wikipedia.org)
  • disease
  • The discovery of aquaporin-4 (AQP4) antibody in 2004 was a major advance since it indicated that NMO is an antibody-mediated disease, distinct from multiple sclerosis. (jneuropsychiatry.org)
  • Around one-third of people with this subtype will develop MS-like disease within about 4 and a half years. (livewisems.org)
  • These conditions are included here because: The disease was listed in the prior version of this table The disease is included in several widely used lists of autoimmune disease and is shown here to ensure that a person visiting this page does not conclude that the disease was not considered. (wikipedia.org)
  • human
  • The human inner ear develops during week 4 of embryonic development from the auditory placode, a thickening of the ectoderm which gives rise to the bipolar neurons of the cochlear and vestibular ganglions. (wikipedia.org)