Arthritis, RheumatoidAutoantibodiesArthritisDisease SusceptibilityGenotypeGenetic Predisposition to DiseaseArthritis, ExperimentalArthritis, InfectiousSynovial MembraneArthritis, JuvenileRheumatoid FactorAntirheumatic AgentsPolymorphism, Single NucleotideAllelesSynovial FluidPolymorphism, GeneticAutoimmune DiseasesArthritis, PsoriaticAutoantigensLupus Erythematosus, SystemicJointsHaplotypesCase-Control StudiesGene FrequencyImmunoglobulin GGeneticsHLA-DRB1 ChainsArthritis, ReactiveAntibodies, AntinuclearGenetic VariationGenome-Wide Association StudyHLA-DR AntigensSynovitisOsteoarthritisPhenotypeMethotrexateLinkage DisequilibriumSeverity of Illness IndexGenetic MarkersGenetics, PopulationGenetic LinkageAutoimmunityChromosome MappingBlood SedimentationMolecular Sequence DataMice, Inbred DBATumor Necrosis Factor-alphaHLA-DQ AntigensPeptides, CyclicEnzyme-Linked Immunosorbent AssayAntibodies, MonoclonalRheumatic DiseasesRheumatoid NoduleSulfasalazineMetacarpophalangeal JointPolymerase Chain ReactionHLA-DQ beta-ChainsSpondylitis, AnkylosingArthrographyMutationGold Sodium ThiomalateDisease Models, AnimalMicrobial Sensitivity TestsModels, GeneticDiabetes Mellitus, Type 1Risk FactorsBiological MarkersRheumatologyHLA-DR3 AntigenEpistasis, GeneticGenome, HumanHLA-DR4 AntigenCohort StudiesMice, Inbred C57BLAntibody SpecificityImmunoglobulin MCitrullineSjogren's SyndromeWrist JointGenetic Association StudiesGenetic LociTreatment OutcomeHLA AntigensSequence Analysis, DNACrohn DiseaseCells, CulturedT-LymphocytesImmunity, InnateCytokinesMicrosatellite RepeatsBase SequenceCollagen Type IIQuantitative Trait LociFinger JointTime FactorsGenetic TestingEpitopesEuropean Continental Ancestry GroupAmino Acid SequenceNod2 Signaling Adaptor Protein