• antigen
  • Subsequently, it was demonstrated that many new-onset type 1 diabetic patients had insulin autoantibodies (IAAs), and further analysis of islet autoantigens resulted in the discovery of the insulinoma-antigen 2 (IA-2), which was co-precipitated with GAD65 in many 64K + patient sera. (diabetesjournals.org)
  • In females with nonallergic versus allergic asthma, autoantibody levels to TPO and cytokeratin (CK), a bronchial epithelial antigen, were higher in the former. (thefreedictionary.com)
  • Anti-SSA autoantibodies (Anti-Sjögren's-syndrome-related antigen A, also called anti-Ro, or the combination anti-SSA/Ro or anti Ro/SSA autoantibodies) are anti-nuclear autoantibodies that are associated with many autoimmune diseases, such as systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous LE (SCLE), neonatal lupus and primary biliary cirrhosis. (wikipedia.org)
  • tissue
  • Autoantibodies and their corresponding autoantigens are intensively studied to provide clues to the understanding of disease initiation, tissue specificity, and propagation of hepatic autoimmune diseases. (omicsonline.org)
  • Tests may include: blood tests to detect inflammation, autoantibodies, and organ involvement x-rays and other imaging scans to detect changes in bones, joints, and organs biopsies to look for pathologic changes in tissue specimens Autoantibody tests may be ordered as part of an investigation of chronic progressive arthritis type symptoms and/or unexplained fevers, fatigue, muscle weakness and rashes. (wikipedia.org)
  • Some disorders, such as SLE may be more likely if several autoantibodies are present, while others, such as MCTD (mixed connective tissue disease) may be more likely if a single autoantibody, RNP - ribonucleic protein is the only one present. (wikipedia.org)
  • receptors
  • Adrenergic receptor autoantibodies The adrenergic receptors (or adrenoreceptors) are a class of cell membrane-bound protein receptors throughout the body that are targets of the catecholamines, especially norepinephrine(or noradrenaline) and epinephrine (or adrenaline). (wikipedia.org)
  • Associated pathologies: Cardiovascular diseases and events: Circulating autoantibodies to adrenergic receptors have been identified in numerous heart diseases and cardiac symptoms. (wikipedia.org)
  • Beta-1 adrenergic receptors are the primary receptor of the heart and, therefore, autoantibodies to these receptors have been tied to many different heart diseases. (wikipedia.org)
  • Autoantibodies to beta1-adrenergic receptors are linked to chronic heart failure. (wikipedia.org)
  • The work of endocrinology labs have correlated autoantibodies to the beta-adrenergic receptors with Postural Orthostatic Tachycardia Syndrome (POTS). (wikipedia.org)
  • Future research solidifying this correlation of CFS with autoantibodies to adrenergic receptors would be useful to clinicians tackling this difficult-to-treat condition that affects 200,000 people per year in the US. (wikipedia.org)
  • Other: Experimental studies observed that activating autoantibodies to the beta1/2-adrenergic and M2 muscarinic receptors are associated with atrial tachyarrhythmias in patients with hyperthyroidism. (wikipedia.org)
  • pemphigoid
  • Paraneoplastic pemphigoid is suggested to be a distinct entity from the group of bullous pemphigoid in view of the linear C3 deposits along the basement membrane of the perilesional skin and the "ladder" configuration of autoantibodies demonstrated by western blot analysis. (hindawi.com)
  • Pathogenicity of autoantibodies in anti-p200 pemphigoid. (sigmaaldrich.com)
  • serum
  • Objectives: To investigate the relationship between serum carbonic anhydrase I-II (CA-I and II) autoantibody levels and diabetic retinopathy (DRP) in cases with type 1 diabetes. (thefreedictionary.com)
  • clinical
  • Although there are few clinical implications resulting from this classification, autoantibody profiles indicate that AIH is a heterogenous group of entities. (omicsonline.org)
  • primarily
  • Disorders caused by autoantibodies that primarily affect a single organ, such as the thyroid in Graves disease or Hashimoto thyroiditis, are often easier to diagnose. (labcorp.com)
  • drug-induced
  • Many cases of encephalitis can be traced to infectious or drug-induced etiologies, but increasingly researchers have found that autoantibodies are involved. (aacc.org)
  • radioimmunoassay
  • 6. Greenbaum CJ, Palmer JP, Kuglin B, Kolb H. Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: Results of the Fourth International Workshop on the Standardization of Insulin Autoantibody Measurement. (labcorp.com)
  • production
  • While there is not a direct link, it is thought that many cases of autoantibody production are due to a genetic predisposition combined with an environmental trigger, such as a viral illness or prolonged exposure to certain toxic chemicals. (labcorp.com)
  • The causes of autoantibody production are varied and not well understood. (wikipedia.org)
  • It is thought that some autoantibody production is due to a genetic predisposition combined with an environmental trigger, such as a viral illness or a prolonged exposure to certain toxic chemicals. (wikipedia.org)
  • While the initial event that leads to the production of autoantibodies is still unknown, there is a body of evidence that autoantibodies may have the capacity to maintain their production. (wikipedia.org)
  • found
  • Autoantibodies to IA 2 , a tyrosine phosphatase-like protein, are found in 50% to 75% of type 1 diabetics at and prior to disease onset. (labcorp.com)
  • Desmoglein 1, the protein that is destroyed by the autoantibody, is found in only the top dry layer of the skin. (wikipedia.org)