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Staphylococcus aureusStaphylococcusStaphylococcal InfectionsMethicillin-Resistant Staphylococcus aureusStaphylococcus epidermidisAnti-Bacterial AgentsMethicillin ResistanceStaphylococcus PhagesMicrobial Sensitivity TestsBacterial ProteinsCoagulaseMethicillinVirulence FactorsDNA, BacterialMolecular Sequence DataStaphylococcal Protein ACross InfectionDrug Resistance, BacterialVancomycinOxacillinBacteriaBiofilmsStaphylococcal Skin InfectionsBacterial Typing TechniquesVirulenceCarrier StateAnti-Infective AgentsPhylogenyGene Expression Regulation, BacterialBacterial ToxinsSequence Analysis, DNAStaphylococcus haemolyticusPolymerase Chain ReactionGenes, BacterialPlant DiseasesLysostaphinHost-Pathogen InteractionsBacteremiaNoseBacterial AdhesionGenome, BacterialGram-Positive BacteriaStreptococcus suisDrug Resistance, Multiple, BacterialCommunity-Acquired InfectionsAmino Acid SequenceColony Count, MicrobialVancomycin ResistanceBase SequenceExotoxinsMupirocinPseudomonas aeruginosaMastitis, BovineDrug Resistance, MicrobialPenicillin ResistanceDaptomycinEndocarditis, BacterialMolecular EpidemiologyElectrophoresis, Gel, Pulsed-FieldOxazolidinonesAcetamidesDNA FingerprintingCulture MediaBacteriological TechniquesEscherichia coliMutationSpecies SpecificityStaphylococcus lugdunensisAbscessStaphylococcal VaccinesStreptococcal InfectionsBacteriophage TypingGram-Negative BacteriaGenotypeNasal CavityCattleBacterial InfectionsGenetic VariationStaphylococcus hominisOsteomyelitisTeicoplaninPneumonia, StaphylococcalMicrobial ViabilityTeichoic AcidsExfoliatinsCell WallEnterotoxinsLeukocidinsPlasmidsRhodococcus equiPenicillinsSoft Tissue InfectionsStreptococcus pneumoniaeFish DiseasesSwine DiseasesPenicillin-Binding ProteinsBurkholderia InfectionsCattle DiseasesNafcillinPeptidoglycan
StreptococcusMRSABacteriaPseudomonasStrainsResistantCenters for DiseasEpidermidisEscherichiaCommon pathogenResistanceClostridiumOrganismVirulence factorsInfectionIsolated From Clinical SpecimensPresence of pathogensCoagulase-negative StapFoodborneNosocomial pathogensListeriaBacterial pathogenDifferent pathogensBacillusGenomesEnterococcusMastitisGram-negativFacultativeStaphInfectiousExpressed genes2019MultiresistantNeonatalBiofilmsColiOxacillinHumanPrevalentIsolates2002PathogenicityChromosomeSpeciesPrevalenceNasalSequencesInhibitsDiseasesMortalityPathogenicClinicalPotent
Streptococcus10
MRSA17
  • The current study aimed to use Coagulase gene polymorphism to identify methicillin-resistant Staphylococcus aureus (MRSA) subtypes isolated from nasal carriers in Minia governorate, Egypt, evaluate the efficiency of these methods in discriminating variable strains, and compare these subtypes with antibiotypes. (hindawi.com)
  • MRSA was identified as a hospital acquired pathogen in the 1960s. (hindawi.com)
  • The increasing rate of CA-MRSA infections in many areas, coupled with the organism's unique pattern of virulence, clinical picture, and antimicrobial resistance, has important implications for treatment and infection control measures and acts as a serious challenge for the clinician [ 3 ]. (hindawi.com)
  • IntroductionMethicillin resistant Staphylococcus aureus (MRSA) is a major human pathogen associated with nosocomial and community infections. (ox.ac.uk)
  • In this work, using diverse sequence analysis, we evaluated the repertoire of TFs and sigma factors in the community-associated methicillin resistant S. aureus (CA-MRSA) strain USA300-FPR3757. (biomedcentral.com)
  • Hospital associated (HA) and community associated (CA) infections caused by methicillin-resistant S. aureus (MRSA) have become a major public health concern, particularly for CA-MRSA infections as they cause life threatening disease in otherwise healthy individuals with no pre-existing risk factors [ 1 ]. (biomedcentral.com)
  • An investigation carried out by the Association for Environmental Protection and Nature Conservation (BUND) has caused a stir: on 10 out of 20 bought meat samples, ESBL producing bacteria were found, while two samples were contaminated with MRSA pathogens. (bund.de)
  • Methicillin-resistant Staphylococcus aureus (MRSA) are bacteria which in humans can cause wound infections, inflammation of the respiratory tract and other infections. (bund.de)
  • For example, methicillin-resistant Staphylococcus aureus (MRSA) is responsible for difficult-to-treat infections in humans and caused more than 100,000 deaths attributable to antimicrobial resistance in 2019. (fems-microbiology.org)
  • E. coli , C. diff and other standard organisms like MRSA (methicillin- resistant Staphylococcus aureus ) and VRE (vancomycin-resistant Enterococci ) may linger and multiply on shared items. (beckershospitalreview.com)
  • Multi-resistant and virulent strains of MRSA have spread in many hospitals around the world and there are few therapies available to treat infections caused by this pathogen. (fapesp.br)
  • Recent reports show that the prevalence of Methicillin-Resistant S. aureus (MRSA) infections in cystic fibrosis (CF) patients is increasing. (biomedcentral.com)
  • EVS staff are crucial when it comes to controlling pHAIs, which include superbugs such as Methicillin-resistant Staphylococcus aureus (MRSA), Clostridioides difficile (C. diff), Vancomycin-resistant Enterococcus (VRE), and COVID-19. (cleanlink.com)
  • Methicillin-resistant Staphylococcus aureus (MRSA) are important pathogens in neonatal and pediatric intensive care units, which can cause severe infections in hospitalized children. (biomedcentral.com)
  • What is methicillin-resistant Staphylococcus aureus, more commonly known as MRSA? (cdc.gov)
  • So, MRSA refers to Staph aureus strains that have become resistant to methicillin. (cdc.gov)
  • And MRSA actually accounts for 9,000 deaths in the U.S. and 7,000 deaths in Europe, so it's definitely an important pathogen. (cdc.gov)
Bacteria17
  • medical citation needed] Cefepime is a broad-spectrum cephalosporin antibiotic and has been used to treat bacteria responsible for causing pneumonia and infections of the skin and urinary tract. (wikipedia.org)
  • Bacteria and parasites continue to be recognized as important causes of diarrhea worldwide. (cdc.gov)
  • Although uterine bacteria are likely to be introduced via the vaginal route, it has also been suggested that pathogens can be transferred to the uterus via a hematogenous route. (bvsalud.org)
  • This study focused on the changes in biofilm activity and related metabolic pathways of S. aureus treated with lactic acid bacteria planktonic CFS (LAB-pk-CFS) and biofilm state (LAB-bf-CFS). (frontiersin.org)
  • Here, we used untargeted metabolomics to investigate the potential impacts of planktonic bacteria (LAB-pk-CFS) and biofilm colonies (LAB-bf-CFS) on the metabolism of S. aureus biofilms. (frontiersin.org)
  • analysed the resistance situation for zoonotic pathogens and commensal bacteria. (bund.de)
  • Firmicutes, a group of Gram-positive bacteria that includes several important human pathogens, make exceptional use of the stringent response. (fems-microbiology.org)
  • In abdominal surgery, on the other hand, intestinal bacteria play a particularly important role for SSI. (hartmann-science-center.com)
  • Since the material properties of the implants favour the adhesion of bacteria (biofilm formation) fewer pathogens may be needed to cause an infection. (hartmann-science-center.com)
  • It received attention due to its antibiotic potency against several strains of bacteria including pathogens such as Staphylococcus aureus. (cipsm.de)
  • The use of antibiotics may also result in the emergence of strains of both helpful and harmful bacteria with genetic mutations that allow them to survive antibiotics," explains lead author David Smith, a PhD student at the Institut Pasteur and the CESP laboratory (Inserm/University of Versailles Saint-Quentin-en-Yvelines (USVQ)), France. (elifesciences.org)
  • By modelling how harmful, antibiotic-resistant bacteria interact with the microbiome and how antibiotic use changes those interactions, Smith and his colleagues show that antibiotic use plays an outsized role in increasing the abundance of drug-resistant pathogens. (elifesciences.org)
  • Next, the team simulated how well different prevention strategies might work to stop the spread of drug-resistant bacteria, including Clostridioides difficile , methicillin-resistant Staphylococcus aureus , and multidrug-resistant Enterobacteriaceae. (elifesciences.org)
  • Our study reveals how important it is to consider the protective effects of a healthy microbiome when designing strategies to reduce the dissemination of drug-resistant strains of bacteria," concludes co-senior author Lulla Opatowski, Professor in Mathematical Epidemiology at UVSQ, and senior researcher in the Epidemiology and Modeling of Antibiotic Evasion group at the Institut Pasteur. (elifesciences.org)
  • Bacteria inhabiting the digestive tract are responsible for our health. (mdpi.com)
  • Staphylococcus epidermidis was the most common isolate in 2001 followed by Pseudomonas aeruginosa, whereas in 2002 coliform bacteria were the highest, fol- lowed by P. aeruginosa. (who.int)
  • Other important pathogens include enteric gram-negative bacteria (mainly Enterobacter species, Klebsiella pneumoniae , Escherichia coli , Serratia marcescens , Proteus species, and Acinetobacter species). (msdmanuals.com)
Pseudomonas4
Strains11
  • Identification and subtyping of such strains is very important to apply suitable infection control programs tocontrol MRSAspread [ 6 ]. (hindawi.com)
  • All strains of S. aureus produce coagulase enzyme, and its production can identify S. aureus infections [ 9 ]. (hindawi.com)
  • was conducted to study the phenotypic and genotypic characterization of antibiotic resistance in the methicillin-resistant Staphylococcus aureus strains isolated from hospital cockroaches. (infectioncontroltoday.com)
  • Phenotypic and genotypic characterization of antibiotic resistance in the methicillin-resistant Staphylococcus aureus strains isolated from hospital cockroaches. (infectioncontroltoday.com)
  • Here, using a population-genomic approach, we identify humans as a major hub for ancient and recent S. aureus host-switching events linked to the emergence of endemic livestock strains, and cows as the main animal reservoir for the emergence of human epidemic clones. (st-andrews.ac.uk)
  • The analysis presented herein highlights the complexity of regulatory networks in S. aureus strains, identifies key conserved TFs among the Staphylococacceae , and offers unique insights into several as yet uncharacterized TFs. (biomedcentral.com)
  • S. aureus has obtained notoriety in recent years due to the appearance and worldwide spread of antibiotic resistant strains. (biomedcentral.com)
  • Even though diverse strains of S. aureus have been extensively studied, and subjected to genome sequencing, the function of a large proportion of their genes remains unidentified. (biomedcentral.com)
  • Finally, we examine the conservation of 135 USA300 TFs amongst 11 other S. aureus strains, identifying a key group of regulators that display a high degree of conservation, including many that have previously been demonstrated to play a role in virulence gene regulation. (biomedcentral.com)
  • A total of 119S S. aureus strains were isolated from clinical specimens and the mec A gene was detected by PCR. (biomedcentral.com)
  • SCC mec type III encodes the largest number of resistance genes and strains harboring this type are important pathogens in hospitals where they cause severe infections [ 11 ]. (biomedcentral.com)
Resistant11
  • and infection or colonization with methicillin-resistant Staphylococcus aureus or Clostridium difficile within the past year (independent of vancomycin treatment). (cdc.gov)
  • Further, the chemically synthesized antibiotics and their injudicious usage have resulted in emerging multidrug resistant pathogens and their devastating damage thereafter. (researchsquare.com)
  • 2016) Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011-2014. (hartmann-science-center.com)
  • CF-Marseille is multidrug resistant, has a hetero-Glycopeptide-Intermediate resistance S. aureus phenotype, grows on Cepacia agar with intense orange pigmentation and has a thickened cell wall. (biomedcentral.com)
  • Phylogenetic analyses using Complete Genome Hybridization and Multi Locus VNTR Assay showed that CF-Marseille was closely related to strain Mu50, representing vancomycin-resistant S. aureus . (biomedcentral.com)
  • Resistance in gram positive organism is important to consider, and due to organisms such as penicillin resistant VGS, Methicillin Resistant Staphylococcus Aureus and Vancomycin Resistant Enterococcus . (pedsoncologyeducation.com)
  • Our approach can be divided into five broad components: number of deaths where infection played a role, proportion of infectious deaths attributable to a given infectious syndrome, proportion of infectious syndrome deaths attributable to a given pathogen, the percentage of a given pathogen resistant to an antibiotic of interest, and the excess risk of death or duration of an infection associated with this resistance. (ox.ac.uk)
  • One pathogen-drug combination, meticillin-resistant S aureus, caused more than 100 000 deaths attributable to AMR in 2019, while six more each caused 50 000-100 000 deaths: multidrug-resistant excluding extensively drug-resistant tuberculosis, third-generation cephalosporin-resistant E coli, carbapenem-resistant A baumannii, fluoroquinolone-resistant E coli, carbapenem-resistant K pneumoniae, and third-generation cephalosporin-resistant K pneumoniae. (ox.ac.uk)
  • As Science 's editors predicted, pathogen genome sequences are being used to "determine quickly where newly emerging diseases come from, whether microbes are resistant to antibiotics, and how they are moving through a population. (cdc.gov)
  • antibiotic-resistant organisms are an important concern. (msdmanuals.com)
  • VAP often involves more resistant pathogens and poorer outcomes than other forms of hospital-acquired pneumonia. (msdmanuals.com)
Centers for Diseas1
  • Also, in data from the US, captured in the National Healthcare Safety Network (NHSN) of the Centers for Disease Control and Prevention (CDC), S. aureus was identified in 20.7% of all SSI cases [2]. (hartmann-science-center.com)
Epidermidis3
Escherichia1
  • The log counts population per million reads for all investigated pathogens (Salmonella enterica, Listeria monocytogenes, generic Escherichia coli, Staphylococcus aureus, Clostridium (C. botulinum, C. perfringens), and Campylobacter (C.jejuni, C.coli, C.fetus)) were reduced from Arrival to Market-Ready samples mainly due to reduced diversity within the microbiome. (cdc.gov)
Common pathogen2
Resistance17
  • S. aureus produces large biofilm formations that support its pathogenicity and confer protection and subsequently drug resistance ( 5 ). (frontiersin.org)
  • mecA gene is considered one of the important virulence factors of S. aureus responsible for acquiring resistance against methicillin. (ox.ac.uk)
  • The prevalence of methicillin resistance was 46% (18/39) of which 72.2% (13/18) were positive for mecA gene in PCR assay.ConclusionOne in 4 culture positive isolates from the clinical specimens were S. aureus, of which almost two-thirds were MDR. (ox.ac.uk)
  • This study concludes that the mecA gene is solely dependent for methicillin resistance in S. aureus but the presence of gene is not obligatory. (ox.ac.uk)
  • However, as Wilson explains: "The genes necessary for resistance are often activated only when required (i.e., when the antibiotic is present in the environment), and so-called leader or signal peptides play an important role in this process. (uni-muenchen.de)
  • IRGs and GBPs belong to a family of GTPases that confer host cell resistance during infection by pathogens ( 22 - 24 ). (frontiersin.org)
  • A special problem is the transferability of the genes responsible for the antimicrobial resistance between different bacterial groups. (bund.de)
  • However, resistance and therapeutic failure have already been observed and genes with mutations, such as liaFSR and yycFGHIJ have been suggested as responsible. (fapesp.br)
  • Staphylococcus aureus is an opportunistic pathogen related to a variety of life-threatening infections but for which antimicrobial resistance is liming the treatment options. (nature.com)
  • Intrinsic resistance of S. aureus to oxacillin is mediated by the production of a supplemental penicillin-binding protein (PBP 2a), which is encoded by the mec A gene [ 7 ]. (biomedcentral.com)
  • And it's actually very important because methicillin resistance. (cdc.gov)
  • And furthermore, if you have to use other antibiotics, that leads to increased use of broad-spectrum antibiotics which can actually cause resistance to emerge in Staph aureus , but also in. (cdc.gov)
  • Mechanisms of resistance in Gram negative organisms, mostly due to the production of ß-lactamases, are important to understand. (pedsoncologyeducation.com)
  • Pathogens and antibiotic resistance patterns vary significantly among institutions and can vary within institutions over short periods (eg, month to month). (msdmanuals.com)
  • The Public Health Agency of Sweden is responsible for national monitoring of antibiotic resistance and sales of antibiotics in human medicine, with support from local and regional experts. (folkhalsomyndigheten.se)
  • European resistance monitoring of invasive infections, coordinated by ECDC, a programme that has an important role in informing about the occurrence and spread of antibiotic resistance in Europe. (folkhalsomyndigheten.se)
  • This resistance to antimicrobial medicines is happening in all parts of the world for a broad range of pathogens, with an increasing prevalence that threatens human and animal health. (who.int)
Clostridium1
  • 10 kDa in size with 37-48 amino acids that inhibit growth of food spoilage organisms such as Listeria monocytogenes, Bacillus cereus, Clostridium perfringens, Staphylococcus aureus and E. coli (Rodrigues et al. (researchsquare.com)
Organism3
  • An understanding of the diverse nature of infectious disease complications attributable to this organism is an important cornerstone of pediatric medicine. (medscape.com)
  • Bloodstream in- pling date, organism identified and results fections are important causes of morbidity of antimicrobial susceptibility testing. (who.int)
  • An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens and tumor cells. (absoluteastronomy.com)
Virulence factors1
  • We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. (nature.com)
Infection11
  • Infection with this pathogen is also causally linked to 2 potentially serious nonsuppurative complications: acute rheumatic fever (ARF) and acute glomerulonephritis . (medscape.com)
  • In addition, infection with S pyogenes has reemerged as an important cause of toxic shock syndrome (TSS) and of life-threatening skin and soft-tissue infections, especially necrotizing fasciitis. (medscape.com)
  • Therefore, this assay is considered a simple and accurate subtyping method of S. aureus [ 11 ] and can be included in epidemiological studies and routine infection control programs [ 8 ]. (hindawi.com)
  • How important the contribution of the infection sources food, production and domestic animals as well as livestock in agriculture is for the ESBL associated illness in humans cannot be evaluated on the basis of the currently available data. (bund.de)
  • In this manner, S. aureus is responsible for a variety of diseases ranging from mild food poisoning to deadly infection [3]. (vanderbilt.edu)
  • The identification of genes important to the growth of Staphylococcus aureus in in vitro models mimicking infection. (whiterose.ac.uk)
  • Finally, in addition to the development of a model mimicking infection, and the identification of genes with a potentially important role in vivo, this thesis has enhanced our understanding of both methionine and lysine biosynthesis in S. aureus. (whiterose.ac.uk)
  • Data collected by the National Reference Center for Nosocomial Infections (Nationales Referenzzentrum für nosokomiale Infektionen, NRZ) in the hospital infection surveillance system 'KISS' show that S. aureus can be found in 20% of all SSI isolates [1]. (hartmann-science-center.com)
  • Orthopaedic surgeries carry a particularly high risk of osteomyelitis (bone infection due to spread from surrounding tissue, systemic bacteraemia, or direct bone trauma), which is mostly caused by S. aureus or coagulase-negative Staphylococci from the normal skin flora [3]. (hartmann-science-center.com)
  • Adds Clarke, "Responsible for cleaning and disinfecting patient rooms, operating rooms, and common areas throughout hospitals, hygiene specialists are integral to enterprise-wide multimodal infection prevention and control. (cleanlink.com)
  • Understanding the burden of AMR and the leading pathogen-drug combinations contributing to it is crucial to making informed and location-specific policy decisions, particularly about infection prevention and control programmes, access to essential antibiotics, and research and development of new vaccines and antibiotics. (ox.ac.uk)
Isolated From Clinical Specimens1
Presence of pathogens2
  • The Center for Disease Control and Prevention ( CDC ) recommends that, to keep patients safe, healthcare facilities must maintain a clean environment and minimize the presence of pathogens. (cleanlink.com)
  • Our investigation demonstrates that although the metagenomic approach has promise, further refinement is needed before it can be used to confirm the presence of pathogens in environmental samples. (cdc.gov)
Coagulase-negative Stap1
  • All blood cultures cluding coagulase-negative staphylococci, are incubated at 35 °C for at least 2 weeks. (who.int)
Foodborne2
  • One of the most prevalent foodborne infections, Staphylococcus aureus ( S. aureus ), is highly dangerous and endangers both human and animal health ( 1 ). (frontiersin.org)
  • Understanding the ecology of foodborne pathogens within the meat industry is critical to mitigating this challenge. (cdc.gov)
Nosocomial pathogens2
  • F enterococci (VRE) have rapidly become established as and other antibiotic agents, including cephalosporins, quinolo- important nosocomial pathogens in the United States. (cdc.gov)
  • In several nosocomial pathogens, mutations leading to elevated (p)ppGpp levels have been associated with persistent infections. (fems-microbiology.org)
Listeria1
  • In contrast, some bacterial pathogens (including Listeria monocytogenes and Shigella flexneri ) have mechanisms to escape from the phagosome and proliferate in the cytosol ( 13 ). (frontiersin.org)
Bacterial pathogen2
  • Staphylococcus aureus is a multi-host bacterial pathogen responsible for important human and livestock diseases. (st-andrews.ac.uk)
  • Overall, our findings highlight the influence of human activities on the multi-host ecology of a major bacterial pathogen, underpinned by horizontal gene transfer and core genome diversification. (st-andrews.ac.uk)
Different pathogens1
Bacillus3
  • Here, we observed that a Bacillus strain from the teat apex of lactating cows was associated to reduce colonization by S. aureus. (bvsalud.org)
  • When exploring the metabolite responsible for this activity, we found that a widespread class of Bacillus exopolysaccharide, levan, eliminated the pathogenic biofilm under evaluated conditions. (bvsalud.org)
  • Our results indicate that commensal Bacillus may counteract S. aureus-induced mastitis, and could therefore be used in novel biotechnological strategies to prevent and/or treat this disease. (bvsalud.org)
Genomes2
  • A comparison of the TF repertoire of S. aureus against 1209 sequenced bacterial genomes was carried out allowing us to identify a core set of orthologous TFs for the Staphylococacceae , and also allowing us to assign potential functions to previously uncharacterized TFs. (biomedcentral.com)
  • correctly point out, a continuously updated and annotated database of pathogen genomes is crucial. (cdc.gov)
Enterococcus1
Mastitis4
  • Staphylococcus aureus is the most frequent causal agent of bovine mastitis, which is largely responsible for milk production losses worldwide. (bvsalud.org)
  • Since udder microbiota have important implications in mastitis pathogenesis, they offer opportunities to develop alternative prophylactic and therapeutic strategies. (bvsalud.org)
  • Additionally, it is the primary pathogen responsible for mastitis in ruminants ( 2 ), which has a significant negative impact on milk supply and quality and results in significant financial losses for the dairy industry. (frontiersin.org)
  • Equitably, it is a relevant pathogen in animal health, with mastitis being the main source of economic losses in dairy herds of regions without control strategies. (fapesp.br)
Gram-negativ2
  • The stomach appears to be an important reservoir of gram-negative bacilli that can ascend and colonize the respiratory tract. (medscape.com)
  • [ 9 ] Alternatively, other non-necrotizing gram-negative bacilli (eg, Serratia marcescens) may be responsible for nosocomial pneumonia. (medscape.com)
Facultative2
  • Staphylococcus aureus is a facultative human pathogen and the casual agent of a diverse array of diseases, including superficial skin and wound-related tissue infections, food poisoning, bacteremia, endocarditis and pneumonia. (biomedcentral.com)
  • For example, facultative pathogens only become problematic in combination with other factors such as the insertion of an implant [1]. (hartmann-science-center.com)
Staph3
  • And Staph aureus (the sensitive one) is actually part of our normal skin and nose flora, and around 30-50% of all people in the world actually carry Staph aureus . (cdc.gov)
  • And Staph aureus probably acquired SCC mec multiple times from other staph species. (cdc.gov)
  • Cistus villosus and Cistus monspeliensis, two species native to Morocco, have been shown to be antibacterial against Staphylococcus aureus, which is the bacterium responsible for causing Staph infections. (theorganicskincare.com)
Infectious4
  • Recent discoveries have implicated a number of 'new' (i.e., previously unrecognized) infectious agents as important causes of outbreaks of gastroenteritis. (cdc.gov)
  • Consequently, the need for new strategies and methodologies to control infectious pathogens is increasing. (researchsquare.com)
  • S. aureus is exceptionally infectious partially because it can withdraw iron from hemoglobin [3]. (vanderbilt.edu)
  • The goal of the draft global action plan is to ensure, for as long as possible, continuity of successful treatment and prevention of infectious diseases with effective and safe medicines that are quality-assured, used in a responsible way, and accessible to all who need them. (who.int)
Expressed genes1
  • The differentially expressed genes and proteins linked to S. aureus biofilms have been identified using transcriptomic and proteomic investigations ( 14 - 17 ). (frontiersin.org)
20191
  • METHODS: We estimated deaths and disability-adjusted life-years (DALYs) attributable to and associated with bacterial AMR for 23 pathogens and 88 pathogen-drug combinations in 204 countries and territories in 2019. (ox.ac.uk)
Multiresistant1
  • Multiresistant bacterial pathogens that are insensitive to virtually all available antibiotics are one of the major public-health challenges of our time. (uni-muenchen.de)
Neonatal1
  • More than 20 serologic groups have been identified and designated by letters (eg, A, B, C). Of the non-group A streptococci, group B is the most important human pathogen (the most common cause of neonatal sepsis and bacteremia ), although other groups (particularly group G) have occasionally been implicated as causes of pharyngitis . (medscape.com)
Biofilms4
  • H21, was able to antagonize in-formation or mature S. aureus biofilms associated to intramammary infections without affecting cell viability. (bvsalud.org)
  • The findings demonstrated that the LAB-CFS treatment considerably slowed Staphylococcus aureus ( S. aureus ) growth and prevented it from forming biofilms. (frontiersin.org)
  • The capacity of S. aureus to build biofilms is correlated with the severity of infections ( 4 ). (frontiersin.org)
  • Because of this, it is crucial to understand how LAB-CFS affects the makeup and function of metabolites in S. aureus biofilms. (frontiersin.org)
Coli1
  • Here, E. coli is the leading pathogen with 30% (NRZ) and 19.6% (NHSN) of SSI cases, followed by enterococci (NRZ 29%, NHSN 13.9%) [1, 2]. (hartmann-science-center.com)
Oxacillin1
Human8
  • Cockroaches are one of the most important and frequent insects responsible for harboring, transmission and dissemination of human pathogens in the hospital environment. (infectioncontroltoday.com)
  • Staphylococcus aureus is a widely distributed human pathogen capable of infecting almost every ecological niche of the host. (biomedcentral.com)
  • Because variations in human hemoglobin may affect IsdB's efficiency in binding hemoglobin, it is important to understand the specificity of IsdB to hemoglobin variants. (vanderbilt.edu)
  • Staphylococcus aureus is a major human pathogen responsible for a variety of nosocomial and community-acquired infections. (biomedcentral.com)
  • Staphylococcus aureus is a major human pathogen responsible for a variety of nosocomial and community-acquired infections ranging from mild to life -threatening diseases [ 1 ]. (biomedcentral.com)
  • Staphylococcus aureus is an important human opportunistic pathogen involved in a wide range of human infections. (nature.com)
  • There are serious data gaps in many low-income settings, emphasising the need to expand microbiology laboratory capacity and data collection systems to improve our understanding of this important human health threat. (ox.ac.uk)
  • Plants in the Cistus genus exert a number of powerful antibacterial and antifungal properties against pathogens that can cause serious human health problems. (theorganicskincare.com)
Prevalent1
Isolates2
  • The main objective of this study was to explore the prevalence, antibiotic susceptibility pattern, and mec A gene.MethodsA total of 39 isolates of S. aureus were isolated from 954 clinical specimens processed in Microbiology laboratory of Himal Hospital, Kathmandu. (ox.ac.uk)
  • Among 153 culture positive isolates, 25.5% (39/153) were positive for S. aureus. (ox.ac.uk)
20022
  • We also conducted a retrospective epidemiological analysis on all S. aureus isolated from 2002 to 2007 in CF patients from our institution. (biomedcentral.com)
  • Sur 1 216 prélèvements recueillis sur les surfaces, matériel et solutions antiseptiques de différentes salles d'opération en 2001 et 2002, le taux de cultures positives était de 3,7 % en 2001 et de 4,0 % en 2002. (who.int)
Pathogenicity2
  • However, these genes were not found to be important in three murine pathogenicity models. (whiterose.ac.uk)
  • The present findings reveal the potential of Myr as an alternative multi-target antivirulence candidate to control S. aureus pathogenicity. (nature.com)
Chromosome2
  • Several genes encoding methionine biosynthetic enzymes were found clustered on the S. aureus chromosome. (whiterose.ac.uk)
  • The ccr gene complex is responsible for the integration and excision of SCC mec in the chromosome. (biomedcentral.com)
Species5
  • The capacity for some pathogens to jump into different host-species populations is a major threat to public health and food security. (st-andrews.ac.uk)
  • Pathogen restriction is enhanced by the nutrient-limiting ability of the phagolysosome and the input of antimicrobial agents into the lumen, such as reactive oxygen/nitrogen species (ROS/RNS) ( 10 ). (frontiersin.org)
  • Staphylococcus aureus is a bacterial species that colonizes over 30% of the American population [1]. (vanderbilt.edu)
  • Staphylococcus aureus is the most important species of this genus and the causative agent of a range of infections, such as furuncles, cellulitis, impetigo, and wound infections. (biomedcentral.com)
  • Specifically, identifying the origin of reads assigned to specific pathogen from a diverse environmental sample containing thousands other bacterial species can be difficult. (cdc.gov)
Prevalence1
Nasal2
  • One major risk factor is nasal colonisation of the patient with S. aureus , which can be tackled by preoperative screening and decolonisation [1]. (hartmann-science-center.com)
  • Those patients often have nasal polyps with tissue eosinophilia, S. aureus -dominant mucosal biofilm, comorbid asthma, and a severely compromised quality of life. (encyclopedia.pub)
Sequences2
  • Erythromycin targets bacterial ribosomes - the nanomachine responsible for the translation of messenger RNA (mRNA) sequences into protein - thus preventing synthesis of the proteins required for continued growth and survival. (uni-muenchen.de)
  • The Mubende variant exhibited 96% amino acid similarity with historic SUDV sequences from the 1970s and a high degree of conservation throughout the outbreak, which was important for ongoing diagnostics and highly promising for future therapy development. (cdc.gov)
Inhibits1
  • Additionally, it inhibits the physiological traits of the S. aureus biofilm, including hydrophobicity, motility, eDNA, and PIA associated to the biofilm. (frontiersin.org)
Diseases2
  • As a result, it is responsible for causing many different diseases. (biomedcentral.com)
  • Through such diseases, S. aureus caused 300,000 hospitalizations and 40,000 deaths in 2005 [4]. (vanderbilt.edu)
Mortality2
Pathogenic2
  • As virulence determinant production is very tightly regulated in S. aureus , a thorough understanding of its regulatory network is necessary to fully comprehend the pathogenic processes of this bacterium. (biomedcentral.com)
  • The diversity of microorganisms (pathogenic and nonpathogenic) that exists within the food and meat industries complicates efforts to understand pathogen ecology. (cdc.gov)
Clinical4
  • This information is crucial for the clinical diagnosis, care, and prevention of S. aureus . (frontiersin.org)
  • Recognition of the clinical features of endocarditis, such as distant embolisation, and adequate treatment should be initiated promptly given the grim perspective of upcoming virulent pathogens. (springer.com)
  • With regard to the occurrence of distant embolisation, there are three important aspects: it may establish the diagnosis of endocarditis, impact clinical decision-making and affect the clinical and inflammatory course of the disease. (springer.com)
  • Diagnosis is suspected on the basis of clinical presentation and chest x-ray and is sometimes confirmed by a positive blood culture for the same pathogen found in respiratory secretions or bronchoscopic sampling of the lower respiratory tract with quantitative Gram stain and cultures. (msdmanuals.com)
Potent1
  • A better understanding of this mechanism is an important step towards the development of new and more potent antibiotics," Wilson says. (uni-muenchen.de)