• infarct size
  • CD11c-DTR mice showed decreased infiltration of CD11c + dendritic cells and CD11c + F4/80 + macrophages in the I/R heart, reduced infarct size, attenuated myocardium apoptosis and improved cardiac function compared with those in WT mice. (ahajournals.org)
  • 2 Despite inferences from the analysis of surrogate end points in clinical studies, eg, biomarker elevation, ST-segment shift, anginal discomfort (either preceding or accompanying ischemia), there are as yet no clinical studies directly assessing infarct size reduction consequent to preconditioning, as originally described by Murry et al 3 in a canine model. (ahajournals.org)
  • acute
  • Acute pain is typically defined as pain associated with an injury and pain that is relatively short in duration. (frontiersin.org)
  • Physical: Burns Frostbite Physical injury, blunt or penetrating Foreign bodies, including splinters, dirt and debris Trauma Ionizing radiation Biological: Infection by pathogens Immune reactions due to hypersensitivity Stress Chemical: Chemical irritants Toxins Alcohol Psychological: Excitement Acute inflammation is a short-term process, usually appearing within a few minutes or hours and begins to cease upon the removal of the injurious stimulus. (wikipedia.org)
  • rats
  • To identify the potential target proteins of XST, two-dimensional gel electrophoresis (2-DE)-based proteomics was utilized to analyze the protein profile of myocardium in rats with myocardial ischemia/reperfusion (I/R) injury. (rsc.org)
  • Methods and Results- Immediately after hindlimb ischemia was created, rats were randomized to receive AM infusion plus bone marrow-derived mononuclear cell (MNC) transplantation (AM+MNC group), AM infusion alone (AM group), MNC transplantation alone (MNC group), or vehicle infusion (control group). (ahajournals.org)
  • Transplantation of bone marrow-derived MNCs and infusion of AM were performed in 40 rats immediately after hindlimb ischemia was created. (ahajournals.org)
  • myocardium
  • We tested the hypothesis that conditional depletion of pro-inflammatory macrophages and dendritic cells may dampen excessive inflammatory response in the infarct myocardium, and thus attenuate MI/R injury. (ahajournals.org)
  • Moreover, inflammatory cytokines, such as TNF-α, MCP-1 and IFN-γ in the infracted myocardium as well as myocardial nitrotyrosine level, an index of oxidative and nitrative stresses, were dramatically decreased in CD11c-DTR mice than those in WT mice. (ahajournals.org)
  • This is the first study on the proteomic expression of XST-treated myocardium with I/R injury to reveal that the cardioprotective effects of XST may be attributed to the PDH-mediated restoration of aerobic glucose oxidation. (rsc.org)
  • After MI, the myocardium suffers from reperfusion injury which leads to death of cardiomyocytes and detrimental remodelling of the heart, consequently reducing proper cardiac function. (wikipedia.org)
  • inhibition
  • It was shown that PKCε translocates from the cytosolic to the particulate fraction upon RIPC induction and that the protection conferred by RIPC can be inhibited with the PKC inhibitor chelerythrine Similarly, in models of local PostC, phosphorylation and activation of PKCε has been shown to be induced and PKCε inhibition attenuated the beneficial effects of these regimens. (wikipedia.org)
  • limb
  • 1 Despite recent advances in medical intervention, the symptoms of some patients with critical limb ischemia fail to be controlled. (ahajournals.org)
  • The procedure involves repeated, temporary cessation of blood flow to a limb to create ischemia (lack of oxygen and glucose) in the tissue. (wikipedia.org)
  • Physiology
  • This "conditioning" activates the body's natural protective physiology against reperfusion injury and the tissue damage caused by low oxygen levels-a protection present in many mammals. (wikipedia.org)
  • deposition
  • Transfection with HGF plasmids in damaged cardiac tissue also promotes angiogenesis (increased capillary density compared to control subjects), as well as decreasing detrimental remodelling of the tissue at the site of injury (decreased fibrotic deposition). (wikipedia.org)
  • protein
  • In animal models of disease and injury, CARP has been characterized to be a stress-inducible myofibrillar protein. (wikipedia.org)
  • salvage
  • A second wave of clinical studies, building on the momentum of these initial sanguine reports and using more sophisticated measures of myocardial salvage, eg, single-photon emission computed tomography, cardiac magnetic resonance, introduced an element of uncertainty into the mix, not only with respect to the correct methodology for the assessment of myocardial salvage, 10 but also with respect to the possibility of harm consequent to postconditioning. (ahajournals.org)
  • Further analysis of a Danish study (CONDI-1), in which patients were treated in the ambulance, showed that those who received RIC did not show a decline in myocardial salvage index (a measure of a healthy heart) when they experienced a delay in treatment, while the control group experienced a significant decline in salvage index. (wikipedia.org)
  • effects
  • The present experiment evaluated the effects of carvedilol, a new beta adrenoreceptor blocker with potent free radical-scavenging activity, on myocardial ischemia and reperfusion injury in a hypercholesterolemic rabbit model. (aspetjournals.org)
  • These results indicate that in addition to its beta blocking activity, the antioxidant and endothelial protective activities of carvedilol contributed significantly to its cardiac protective effects after ischemia and reperfusion. (aspetjournals.org)
  • Based on the number of human-specific cells relative to overall increases in capillary density and myocardial viability, direct differentiation quantitatively accounted for 20% to 50% of the observed effects. (ahajournals.org)
  • Thus, the purposes of the present study were (1) to investigate whether local infusion of AM enhances the angiogenic potency of MNC transplantation in a rat model of hindlimb ischemia and (2) to investigate the effects of AM on the survival, adhesion, and differentiation of transplanted MNCs. (ahajournals.org)
  • Clinically, sulodexide is used for the prophylaxis and treatment of thromboembolic diseases however recent research has also demonstrated the beneficial effects of sulodexide in animal models of reperfusion injury and the treatment of diabetic nephropathy. (wikipedia.org)
  • Other BKCa++ channel openers (NS1619, NS11021 and DiCl-DHAA) have been reported to have cardio-protective effects after ischemic-reperfusion injury. (wikipedia.org)
  • Midiv-1 has been demonstrated to attenuate the effects of ischemia reperfusion injury after cardiac arrest. (wikipedia.org)
  • significantly
  • Objectives type 2 diabetes (T2DM) exacerbated myocardial ischemia/reperfusion (MI/R) injury, accompanied by significantly lower adiponectin (APN) level and diminished APN multimerisation. (bmj.com)
  • Moreover, carvedilol treatment significantly preserved aortic endothelial function and markedly reduced neutrophil accumulation in ischemic-reperfused myocardial tissue. (aspetjournals.org)
  • Conclusions- A combination of AM infusion and MNC transplantation caused significantly greater improvement in hindlimb ischemia than MNC transplantation alone. (ahajournals.org)
  • injection
  • Compound C (an AMPK inhibitor) was administrated by intraperitoneal injection with 20 ug/g one h before MI/R. Mice were subjected to 30 min of ischemia and three h or 24 h of reperfusion. (bmj.com)
  • heart
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation. (wikipedia.org)
  • In 1993, Karin Przyklenk and colleagues began using the term "remote" when they observed that cross-clamping on the right side of the heart (right circumflex artery) protected the left side of the heart (LAD territory) from ischemia: that is, the protective trigger was remote from the observed effect. (wikipedia.org)
  • vascular
  • Muscle-derived Fstl1 modulates vascular remodelling in response to injury. (wikipedia.org)
  • CARP has been shown to play a role in skeletal muscle structure remodeling, and repair, being expressed in skeletal muscle near myotendinous junctions, and in vascular smooth muscle cells, as a downstream target of TGF-beta/Smad sigmaling in response to balloon injury and atherosclerotic plaques. (wikipedia.org)
  • blood vessels
  • VEGF's normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels. (wikipedia.org)
  • treatment
  • 001). Treatment with propranolol neither preserved endothelial function after cholesterol feeding nor reduced neutrophil accumulation in ischemic-reperfused myocardial tissue. (aspetjournals.org)
  • It is unclear what the specific role of Akt may play in modulating of myocardial function after rottlerin treatment of cardioplegia. (wikipedia.org)
  • mechanisms
  • Therefore, the present study aimed to observe whether RSV attenuates MI/R injury in T2DM, and if so, to further investigate the underlying mechanisms. (bmj.com)