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  • Circulation
  • Another school of thought focuses on hypothermia's ability to prevent the injuries that occur after circulation returns to the brain, or what is termed reperfusion injuries. (wikipedia.org)
  • In fact an individual suffering from an ischemic insult continues suffering injuries well after circulation is restored. (wikipedia.org)
  • VEGF's normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels. (wikipedia.org)
  • deposition
  • Transfection with HGF plasmids in damaged cardiac tissue also promotes angiogenesis (increased capillary density compared to control subjects), as well as decreasing detrimental remodelling of the tissue at the site of injury (decreased fibrotic deposition). (wikipedia.org)
  • protein
  • In animal models of disease and injury, CARP has been characterized to be a stress-inducible myofibrillar protein. (wikipedia.org)
  • vascular
  • Muscle-derived Fstl1 modulates vascular remodelling in response to injury. (wikipedia.org)
  • PKCδ has been implicated in depressing cardiac function and cell death after ischemia-reperfusion injury as well as promoting vascular smooth muscle contraction and decreasing perfusion. (wikipedia.org)
  • CARP has been shown to play a role in skeletal muscle structure remodeling, and repair, being expressed in skeletal muscle near myotendinous junctions, and in vascular smooth muscle cells, as a downstream target of TGF-beta/Smad sigmaling in response to balloon injury and atherosclerotic plaques. (wikipedia.org)
  • heart
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation. (wikipedia.org)
  • In 1993, Karin Przyklenk and colleagues began using the term "remote" when they observed that cross-clamping on the right side of the heart (right circumflex artery) protected the left side of the heart (LAD territory) from ischemia: that is, the protective trigger was remote from the observed effect. (wikipedia.org)
  • Further analysis of a Danish study (CONDI-1), in which patients were treated in the ambulance, showed that those who received RIC did not show a decline in myocardial salvage index (a measure of a healthy heart) when they experienced a delay in treatment, while the control group experienced a significant decline in salvage index. (wikipedia.org)
  • mechanisms
  • Therefore, the present study aimed to observe whether RSV attenuates MI/R injury in T2DM, and if so, to further investigate the underlying mechanisms. (bmj.com)