• infarct size
  • CD11c-DTR mice showed decreased infiltration of CD11c + dendritic cells and CD11c + F4/80 + macrophages in the I/R heart, reduced infarct size, attenuated myocardium apoptosis and improved cardiac function compared with those in WT mice. (ahajournals.org)
  • 2 Despite inferences from the analysis of surrogate end points in clinical studies, eg, biomarker elevation, ST-segment shift, anginal discomfort (either preceding or accompanying ischemia), there are as yet no clinical studies directly assessing infarct size reduction consequent to preconditioning, as originally described by Murry et al 3 in a canine model. (ahajournals.org)
  • remote ischemic conditioning reduced infarct size in ST-elevation myocardial infarction (STEMI) patients when used in the ambulance or emergency department as an adjunct therapy to primary percutaneous coronary intervention (PCI), or when used with thrombolytic drugs. (wikipedia.org)
  • inhibition
  • Recently, selective inhibition of classes I and II HDACs with an inhibitor, trichostatin A (TSA), showed protective effects against MI/R injury [ 15 ]. (hindawi.com)
  • This is in line with the observations that inhibition of HDACs in cardiac myocytes silences fetal gene activation, attenuates cardiac hypertrophy, and prevents cardiac remodeling [ 16 , 17 ]. (hindawi.com)
  • Furthermore, HDACs inhibition was recently reported to improve myocardial function and prevent cardiac remodeling in diabetic mice [ 18 ]. (hindawi.com)
  • Moreover, inhibition of AMPK activation with compound C or alleviation of ER stress with chemical chaperone 4-PBA obviously attenuated H 2 O 2 -induced changes in autophagy-related proteins. (medsci.org)
  • It was shown that PKCε translocates from the cytosolic to the particulate fraction upon RIPC induction and that the protection conferred by RIPC can be inhibited with the PKC inhibitor chelerythrine Similarly, in models of local PostC, phosphorylation and activation of PKCε has been shown to be induced and PKCε inhibition attenuated the beneficial effects of these regimens. (wikipedia.org)
  • myocardium
  • Both MI/R injury and diabetes mellitus elevated myocardium HDACs activity. (hindawi.com)
  • We tested the hypothesis that conditional depletion of pro-inflammatory macrophages and dendritic cells may dampen excessive inflammatory response in the infarct myocardium, and thus attenuate MI/R injury. (ahajournals.org)
  • Moreover, inflammatory cytokines, such as TNF-α, MCP-1 and IFN-γ in the infracted myocardium as well as myocardial nitrotyrosine level, an index of oxidative and nitrative stresses, were dramatically decreased in CD11c-DTR mice than those in WT mice. (ahajournals.org)
  • This is the first study on the proteomic expression of XST-treated myocardium with I/R injury to reveal that the cardioprotective effects of XST may be attributed to the PDH-mediated restoration of aerobic glucose oxidation. (rsc.org)
  • significantly
  • Objectives type 2 diabetes (T2DM) exacerbated myocardial ischemia/reperfusion (MI/R) injury, accompanied by significantly lower adiponectin (APN) level and diminished APN multimerisation. (bmj.com)
  • Moreover, carvedilol treatment significantly preserved aortic endothelial function and markedly reduced neutrophil accumulation in ischemic-reperfused myocardial tissue. (aspetjournals.org)
  • These results indicate that in addition to its beta blocking activity, the antioxidant and endothelial protective activities of carvedilol contributed significantly to its cardiac protective effects after ischemia and reperfusion. (aspetjournals.org)
  • KMP pretreatment significantly ameliorated IR injury by maintaining cardiac function, normalizing oxidative stress, and preserving morphological alterations. (hindawi.com)
  • Our results showed that STZ administration following high-fat diet significantly worsened the readings of LVP , LVEDP, +dp/dt and -dp/dt, while Zn supplementation effectively attenuated the detrimental effects of high-fat diet and STZ on +dP/dt and -dP/dt but not on LVP and LVEDP (Table 3). (thefreedictionary.com)
  • Conclusions- A combination of AM infusion and MNC transplantation caused significantly greater improvement in hindlimb ischemia than MNC transplantation alone. (ahajournals.org)
  • model
  • The present experiment evaluated the effects of carvedilol, a new beta adrenoreceptor blocker with potent free radical-scavenging activity, on myocardial ischemia and reperfusion injury in a hypercholesterolemic rabbit model. (aspetjournals.org)
  • Thus, the purposes of the present study were (1) to investigate whether local infusion of AM enhances the angiogenic potency of MNC transplantation in a rat model of hindlimb ischemia and (2) to investigate the effects of AM on the survival, adhesion, and differentiation of transplanted MNCs. (ahajournals.org)
  • deposition
  • Transfection with HGF plasmids in damaged cardiac tissue also promotes angiogenesis (increased capillary density compared to control subjects), as well as decreasing detrimental remodelling of the tissue at the site of injury (decreased fibrotic deposition). (wikipedia.org)
  • protein
  • In animal models of disease and injury, CARP has been characterized to be a stress-inducible myofibrillar protein. (wikipedia.org)
  • salvage
  • A second wave of clinical studies, building on the momentum of these initial sanguine reports and using more sophisticated measures of myocardial salvage, eg, single-photon emission computed tomography, cardiac magnetic resonance, introduced an element of uncertainty into the mix, not only with respect to the correct methodology for the assessment of myocardial salvage, 10 but also with respect to the possibility of harm consequent to postconditioning. (ahajournals.org)
  • Further analysis of a Danish study (CONDI-1), in which patients were treated in the ambulance, showed that those who received RIC did not show a decline in myocardial salvage index (a measure of a healthy heart) when they experienced a delay in treatment, while the control group experienced a significant decline in salvage index. (wikipedia.org)
  • injection
  • Compound C (an AMPK inhibitor) was administrated by intraperitoneal injection with 20 ug/g one h before MI/R. Mice were subjected to 30 min of ischemia and three h or 24 h of reperfusion. (bmj.com)
  • vascular
  • Muscle-derived Fstl1 modulates vascular remodelling in response to injury. (wikipedia.org)
  • CARP has been shown to play a role in skeletal muscle structure remodeling, and repair, being expressed in skeletal muscle near myotendinous junctions, and in vascular smooth muscle cells, as a downstream target of TGF-beta/Smad sigmaling in response to balloon injury and atherosclerotic plaques. (wikipedia.org)
  • pathological
  • Accumulating evidences demonstrate that autophagy is involved in the pathological process of brain damage caused by hypoxic-ischemia, head trauma, and transient focal ischemia [ 6 - 8 ]. (medsci.org)
  • blood vessels
  • VEGF's normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels. (wikipedia.org)
  • heart
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation. (wikipedia.org)
  • In 1993, Karin Przyklenk and colleagues began using the term "remote" when they observed that cross-clamping on the right side of the heart (right circumflex artery) protected the left side of the heart (LAD territory) from ischemia: that is, the protective trigger was remote from the observed effect. (wikipedia.org)
  • mechanisms
  • Therefore, the present study aimed to observe whether RSV attenuates MI/R injury in T2DM, and if so, to further investigate the underlying mechanisms. (bmj.com)