Loading...



  • form
  • The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. (curehunter.com)
  • History
  • I read with interest the article by Dr. Cohn, et al regarding the natural history of autosomal dominant optic atrophy (DOA). (bmj.com)
  • multiple system
  • What is multiple system atrophy? (nih.gov)
  • Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by a combination of symptoms that affect both the autonomic nervous system (the part of the nervous system that controls involuntary action such as blood pressure or digestion) and movement. (nih.gov)
  • MSA INFO - Multiple System Atrophy is a Public Group with 110 members. (yahoo.com)
  • The fundamental cause of multiple system atrophy (MSA) is a loss of oligodendroglial and neuronal cells in the brain and central nervous system. (news-medical.net)
  • OPCA is present in several neurodegenerative syndromes, including inherited and non-inherited forms of ataxia (such as the hereditary spinocerebellar ataxia known as Machado-Joseph disease) and multiple system atrophy (MSA), with which it is primarily associated. (wikipedia.org)
  • There are two forms: A few non-hereditary diseases formerly categorized as olivopontocerebellar atrophy have been reclassified as forms of multiple system atrophy as well as to four hereditary types, that have been currently reclassified as four different forms of spinocerebellar ataxia: Physiotherapy intervention aims to improve balance and gait of OPCA patients, by stimulating neuroplastic changes in the atrophied neural structure. (wikipedia.org)
  • Multiple system atrophy (MSA), also known as Shy-Drager syndrome, is a rare neurodegenerative disorder characterized by tremors, slow movement, muscle rigidity, and postural instability (collectively known as parkinsonism) due to dysfunction of the autonomic nervous system, and ataxia. (wikipedia.org)
  • Many people affected by multiple system atrophy experience dysfunction of the autonomic nervous system, which commonly manifests as orthostatic hypotension, impotence, loss of sweating, dry mouth and urinary retention and incontinence. (wikipedia.org)
  • These terms and their distinctions have been dropped in recent (1996 onwards) medical usage and replaced with MSA and its subtypes, but are helpful to understanding the older literature about this disease: The current terminology and diagnostic criteria for the disease were established at a 2007 conference of experts on the disease and set forth in the "Second consensus statement on the diagnosis of multiple system atrophy. (wikipedia.org)
  • Posterior Cortica
  • Posterior Cortical Atrophy A topic in the Alzheimer's Association series on understanding dementia. (alz.org)
  • Posterior cortical atrophy (PCA) refers to gradual and progressive degeneration of the outer layer of the brain (the cortex) in the part of the brain located in the back of the head (posterior). (alz.org)
  • however it's not verified whether the episodes cause brain tissue loss or vice versa Schizophrenia Mitochondrial encephalomyopathies, such as Kearns-Sayre syndrome, which interfere with the basic functions of neurons Posterior cortical atrophy: In the most posterior area of the brain lies the visual cortex, the area of the brain where visual information is received and processed. (wikipedia.org)
  • A common vision impairment seen in patients with posterior cortical atrophy is simultanagnosia, where a person is unable to see multiple locations at once or to quickly shift attention between these locations. (wikipedia.org)
  • When looking at images of a brain suffering from posterior cortical atrophy, one can see a loss in volume of the dorsal and ventral visual pathways, where visual stimuli is brought to the visual cortex and integrated information is sent back out to other areas of the brain. (wikipedia.org)
  • Posterior cortical atrophy (PCA), also called Benson's syndrome, is a form of dementia which is usually considered an atypical variant of Alzheimer's disease (AD). (wikipedia.org)
  • Testicular
  • Testicular atrophy can occur with prolonged use of enough exogenous sex steroids (either androgen or estrogen ) to reduce gonadotropin secretion. (wikipedia.org)
  • Testicular atrophy is a medical condition in which the male reproductive organs (the testes, which in humans are located in the scrotum) diminish in size and may be accompanied by loss of function. (wikipedia.org)
  • disuse atrophy
  • Disuse atrophy of muscles and bones, with loss of mass and strength, can occur after prolonged immobility, such as extended bedrest , or having a body part in a cast (living in darkness for the eye, bedridden for the legs etc. (wikipedia.org)
  • Disuse of the muscles, such as when muscle tissue is immobilized for even a few days of unuse - when the patient has a primary injury such as an immobilized broken bone (set in a cast or immobilized in traction), for example - will also lead rapidly to disuse atrophy. (wikipedia.org)
  • geographic atrophy
  • With no FDA-approved therapies yet for the treatment of geographic atrophy (GA), some companies and institutions, eager to change that fact, are initiating or resurrecting past research approaches to discern effective methods of combating this advanced form of dry AMD. (wabi.tv)
  • Almost a decade ago, Allergan (Dublin) began to study its glaucoma drug brimonidine (now known as Alphagan) as a potential treatment for Geographic Atrophy because it had demonstrated neuroprotective qualities in the company's animal studies. (wabi.tv)
  • His conclusion: Inhibiting the FAS-pathway through medical intervention is key to stopping unwanted photoreceptor cell death (apoptosis) in retinal detachment, wet and dry AMD, geographic atrophy, and diabetic retinopathy. (wabi.tv)
  • Dr. Zacks says ONL1204 should also be able to provide neuroprotection in geographic atrophy, treating the root cause of vision loss which is photoreceptor cell death. (wabi.tv)
  • The Janssen (Beerse, Belgium) drug development division of Johnson & Johnson has for several years been pursuing an initiative using cell therapy in an attempt to reverse the vision loss associated with geographic atrophy. (wabi.tv)
  • Geographic Atrophy (GA), also known as atrophic age-related macular degeneration (AMD) or advanced dry AMD, is an advanced form of age-related macular degeneration that can result in the progressive and irreversible loss of retina (photoreceptors, retinal pigment epithelium, choriocappillaris) which can lead to a loss of visual function over time. (wikipedia.org)
  • The incidence of advanced AMD, both geographic atrophy and neovascular AMD, increases exponentially with age and while there are therapies for wet AMD, GA currently has no approved treatment options. (wikipedia.org)
  • Geographic atrophy (GA) is a chronic disease, which leads to visual function loss. (wikipedia.org)
  • induce
  • For example, diseases such as cancer and AIDS induce a body wasting syndrome called cachexia , which is notable for the severe muscle atrophy seen. (wikipedia.org)
  • Other syndromes or conditions which can induce skeletal muscle atrophy are congestive heart failure and liver disease. (wikipedia.org)
  • Glucocorticoids, a class of medications used to treat allergic and other inflammatory conditions can induce muscle atrophy by increasing break-down of muscle proteins. (wikipedia.org)
  • Other syndromes or conditions which can induce skeletal muscle atrophy are liver disease, and starvation. (wikipedia.org)
  • menopause
  • Atrophy of the breasts can occur with prolonged estrogen reduction, as with anorexia nervosa or menopause . (wikipedia.org)
  • Atrophy also happens in the normal course of events to cells or tissues which have fulfilled their useful life (such as umbilical blood vessels after birth or ovaries after the menopause) or as cells die off progressively with age (as in kidneys and brain). (encyclopedia.com)
  • This atrophy, and that of the breasts concurrently, is consistent with the homeostatic (normal development) role of atrophy in general, as after menopause the body has no further functional biological need to maintain the reproductive system which it has permanently shut down. (wikipedia.org)
  • decreases
  • Muscular atrophy decreases qualities of life as the sufferer becomes unable to perform certain tasks or worsen the risks of accidents while performing those (like walking). (wikipedia.org)
  • Causes
  • Causes of atrophy include mutations (which can destroy the gene to build up the organ), poor nourishment, poor circulation , loss of hormonal support, loss of nerve supply to the target organ , excessive amount of apoptosis of cells, and disuse or lack of exercise or disease intrinsic to the tissue itself. (wikipedia.org)
  • Spinal muscular atrophy, or SMA, is an inherited condition that causes nerve cells in the lower part of the brain and spinal cord to break down and die. (kidshealth.org)
  • Long-term use of steroids causes irreversible atrophy, while atrophy induced by short-term use may to some extent be reversible except for striae. (wikipedia.org)
  • Generalized PRA is the most common type and causes atrophy of all the neural retinal structures. (wikipedia.org)
  • Atrophic
  • There is inhibition of the mitotic activity of fibroblasts resulting in reduction of collagen and glycosaminoglycan synthesis but probably the earliest evidence of dermal atrophy is a reduction in the diameter of the fibrils and then the collagen bundles become atrophic and separated. (wikipedia.org)
  • dementia
  • Many diseases that cause cerebral atrophy are associated with dementia, seizures, and a group of language disorders called the aphasias. (wikipedia.org)
  • cerebral
  • Studies have shown that biomarkers in the CSF and plasma can be tracked for their presence in different parts of the brain-and their presence can tell us about cerebral atrophy. (wikipedia.org)
  • better source needed] CT and MRI are most commonly used to observe the brain for cerebral atrophy. (wikipedia.org)
  • onset
  • Modern medicine's understanding of the quick onset of muscle atrophy is a major factor behind the practice of getting hospitalized patients out of bed and moving about as active as possible as soon as is feasible, despite sutures, wounds, broken bones and pain. (wikipedia.org)
  • mild
  • While mild atrophy and telangiectasia might be reversible upon discontinuation of corticosteroids, overtly visible changes in skin texture and striae are considered permanent manifestations of corticosteroid-induced atrophy and are resistant to treatment. (wikipedia.org)
  • slight
  • I am 48 years old and I was diagnosed with slight brain atrophy and my neurologist said that it can be caused by many things. (medhelp.org)
  • Even low-potency topical steroids can cause slight skin atrophy that often reverses upon discontinuation of the drugs. (wikipedia.org)
  • include
  • Examples of atrophy as part of normal development include shrinking and the involution of the thymus in early childhood, and the tonsils in adolescence. (wikipedia.org)
  • Examples of treatment options for breast atrophy, depending on the situation/when appropriate, can include estrogens, antiandrogens, and proper nutrition or weight gain. (wikipedia.org)
  • Other types of brown atrophy include brown atrophy of neuronia and brown atrophy of the liver. (wikipedia.org)
  • brain
  • citation needed] Brain atrophy does not affect all regions with the same intensity as shown by neuroimaging. (wikipedia.org)
  • Other biomarkers like Ng-a protein important in long-term potentiation and memory-have been tracked for their associations with brain atrophy as well, but NFL had the greatest association. (wikipedia.org)
  • DRPLA is characterized by marked, generalized brain atrophy and the accumulation of atrophin-1 with expanded glutamine stretches. (wikipedia.org)
  • PCA patients with significant atrophy in one hemisphere of the brain may experience hemispatial neglect, the inability to see stimuli on one half of the visual field. (wikipedia.org)
  • At this early stage PCA patients will show brain atrophy more centrally located in the right posterior lobe and occipital gyrus, while AD brain images show the majority of atrophy in the medial temporal cortex. (wikipedia.org)
  • however, as the years go on the images will become increasingly similar, due to the majority of PCA patients also having AD later in life because of continued brain atrophy. (wikipedia.org)