• vaginal
  • Cardiovascular side effects have included edema and congestive heart failure.Endocrine side effects have included the inhibition of estrogen synthesis, resulting in flushing, sweating, vaginal dryness and irritation, and reduction in breast size. (coremedicalgrp.com)
  • tumors
  • For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors. (drugbank.ca)
  • These mutations lead to characteristic features including macrocephaly, intestinal hamartomatous polyps, benign skin tumors (multiple trichilemmomas, papillomatous papules, and acral keratoses) and dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease). (wikipedia.org)
  • immune
  • 2. A method of ablating normal cells in the spleen in immune disease by parenterally administering an unconjugated monoclonal antibody which targets normal cells in the spleen and is directed against normal and malignant B-cells. (google.com)
  • uterus
  • Like lignans, many bioflavonoids are estrogenic and can help to regulate the effects of our own body's estrogen on sensitive target tissue like the breast and uterus. (healthy.net)
  • While the hamartomas are benign, people with Cowden syndrome are at increased risk of certain forms of cancer, including breast, thyroid, uterus (endometrial), and kidney cancers. (wikipedia.org)
  • however, people with Cowden syndrome are at increased risk of developing several types of cancer, including cancers of the breast, thyroid, uterus (endometrial), and kidney cancers. (wikipedia.org)
  • bone
  • At the sides of the chest, the breast tissue can extend into the axilla (armpit), and can reach as far to the back as the latissimus dorsi muscle, extending from the lower back to the humerus bone (the longest bone of the upper arm). (wikipedia.org)
  • liver
  • Since danazol is metabolized by the liver, it cannot be used by patients with liver disease, and in patients receiving long-term therapy, liver function must be monitored on a periodic basis. (wikipedia.org)
  • Pregnancy
  • During pregnancy, the breast responds to a complex interaction of hormones, including estrogens, progesterone, and prolactin, that mediate the completion of its development, namely lobuloalveolar maturation, in preparation of lactation and breastfeeding. (wikipedia.org)
  • routine
  • Assessment of the external genitalia and breast development are often part of routine physical examinations. (wikipedia.org)
  • characteristic
  • People with Cowden syndrome develop characteristic lesions called hamartomas, which are small, noncancerous growths that are most commonly found on the skin and mucous membranes (such as the lining of the mouth, nose, and intestines), but can also occur other parts of the body, such as the thyroid and breast. (wikipedia.org)
  • children
  • Has your daughter considered the impact this may have should she have children and want to breast feed? (healthlinkusa.com)
  • Alpers' disease a rare disease of young children, characterized by neuronal deterioration of the cerebral cortex and elsewhere, progressive mental deterioration, motor disturbances, seizures, and early death. (thefreedictionary.com)
  • brain
  • Additional signs and symptoms of Cowden syndrome can include an enlarged head (macrocephaly), a rare noncancerous brain tumor called Lhermitte-Duclos disease, and glycogenic acanthosis of the esophagus. (wikipedia.org)
  • activity
  • Following an initial favorable response (amenorrhea develops), the dosage should be titrated to the minimum dose that suppresses disease activity. (coremedicalgrp.com)
  • patients
  • Danazol should be used with caution, if at all, in patients with milder grades of hepatic disease. (pdr.net)
  • A dosage of 800 mg/day danazol was found to increase telomere length in patients with telomere diseases in a phase I/II clinical trial. (wikipedia.org)
  • skin
  • Milk exits the breast through the nipple, which is surrounded by a pigmented area of skin called the areola. (wikipedia.org)
  • heavy
  • alpha chain disease heavy chain disease characterized by plasma cell infiltration of the lamina propria of the small intestine resulting in malabsorption with diarrhea, abdominal pain, and weight loss, possibly accompanied by pulmonary involvement. (thefreedictionary.com)