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  • cGMP
  • Human atrial natriuretic polypeptide, which stimulates cGMP accumulation in vascular smooth muscle cells, also enhanced interleukin-1-induced nitric oxide release at a concentration of 100 nmol/L. In contrast, coincubation with 10 μmol/L methylene blue, an inhibitor of soluble guanylate cyclase, inhibited interleukin-1-induced nitric oxide release from vascular smooth muscle cells. (ahajournals.org)
  • Human recombinant IL-1β was provided by Otsuka Pharmaceutical Co Inc. N G -Monomethyl- l -arginine (L-NMMA), 8-bromo-guanosine 3′:5′-cyclic monophosphate (8-Br-cGMP), and methylene blue were from Sigma Chemical Co. Human atrial natriuretic polypeptide (ANP) was purchased from Peptide Institute. (ahajournals.org)
  • Reduction in type C receptor density was accompanied by modest increases in the stability of ANP in the culture medium and enhancement of the cellular cGMP response to the peptide, particularly at low ligand concentrations. (ahajournals.org)
  • In explaining the trophic actions of the natriuretic peptides, attention has focused on guanylate cyclase-coupled NPRs 2 6 7 8 because cGMP powerfully inhibits VSM hyperplasia and hypertrophy. (ahajournals.org)
  • 11 However, recent work suggests that the antiproliferative effect of natriuretic peptides on cultured VSM may not correlate with their power to stimulate cGMP production. (ahajournals.org)
  • gene
  • 1997) studied an insertion/deletion (I/D) dimorphism located in the second intron of the human atrial natriuretic factor (ANF) gene among 232 UAE nationals (112 normotensives and 120 hypertensives) from the Abu Dhabi Emirate, with a view to evaluating the value of this marker in relation to hypertension. (cags.org.ae)
  • 2002) carried out a case-controlled study on a group of 151 UAE nationals (62 normotensives with and without left ventricular hypertrophy and 89 hypertensives, also with and without left ventricular hypertrophy) with a view to evaluate the value of an insertion/deletion (I/D) dimorphism located in the second intron of the human atrial natriuretic factor gene in relation to left ventricular hypertrophy. (cags.org.ae)
  • The gene is expressed primarily in atrial myocytes. (wikipedia.org)
  • Corin, also called atrial natriuretic peptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene. (wikipedia.org)
  • cardiac
  • A method of diagnosing cardiac transplant rejection within a patient comprising, obtaining a sample of a biological fluid from the patient, and determining the level of a brain natriuretic peptide (BNP) or a fragment thereof, within the sample of body fluid. (google.com.au)
  • 1. A method of diagnosing cardiac transplant rejection episode within a patient comprising, obtaining a sample of a biological fluid from said patient, and determining the level of a brain natriuretic peptide (BNP) or a fragment thereof, within said sample of body fluid, wherein an increase in said level of BNP or fragment thereof is an indication of a rejection episode. (google.com.au)
  • Plasma atrial natriuretic peptide (ANP) values in cardiac disease. (springer.com)
  • We also determined cardiac levels of ghrelin and whether the heart is a source of the circulating peptide. (physiology.org)
  • pancreatic
  • Amylin (islet amyloid polypeptide) is the chief component of the islet amyloid found in type 2 diabetes, and amylin fibril precursors may be cytotoxic to pancreatic β-cells. (diabetesjournals.org)
  • 1981
  • The discovery of ANP was reported in 1981, when rat atrial extracts were found to contain a substance that increased salt and urine output in the kidney. (wikipedia.org)
  • known
  • Atrial fibrillation is not uncommon in patients presenting with acute dyspnea, but it is not known whether permanent/paroxysmal AF significantly affects circulating levels of BNP in dyspneic patients with and without HF. (onlinejacc.org)
  • Clinical
  • The BNP levels are also increased in patients with atrial fibrillation (AF) ( 11 ), even after controlling for demographic and clinical variables ( 12 ). (onlinejacc.org)
  • levels
  • Therefore, IDE may be involved in controlling the levels of amylin by degradation, similar to its role in regulating the levels of the Alzheimer's-related β-amyloid peptide ( 14 ). (diabetesjournals.org)
  • heart
  • Objectives This study was designed to assess the diagnostic performance of B-type natriuretic peptide (BNP) in the diagnosis of acute congestive heart failure (CHF) in patients with permanent/paroxysmal atrial fibrillation (AF) presenting with acute dyspnea. (onlinejacc.org)