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  • function
  • The present research investigated the function of eIF4G in the level of resistance of MCF-7/ADR cells to anticancer medications, and unravelled the feasible association between eIF4G and ABC transporters. (paft-phil.com)
  • transmembrane
  • The involvement hydrolyze ATP, as well as two transmembrane domains (TMDs), of ABC transporters in xenobiotic resistance for arthropods was his- which are involved in the translocation of their respective substrates torically not well documented, but an increasing number of studies (Rees et al. (deepdyve.com)
  • ABCG1
  • Specifically, we expressed murine ABCG1 (mABCG1) in yeast and assessed how changes in the intracellular sterol environment affect movement of sterols by this transporter. (columbia.edu)
  • utilize
  • Although most organisms utilize these ABC transporters during embryonic development, many of these transporters have broad substrate specificity, and their developmental functions remain incompletely understood. (ucsd.edu)
  • translocate
  • Cultivated on inserts ECs bind, internalize, and translocate HDL from the apical to the basolateral compartment in a specific and temperature-dependent manner. (ahajournals.org)
  • Deletion
  • Deletion of either ABC transporter resulted in Are2p re-localization from DRMs to a detergent soluble fraction as well as a significant decrease in the percent of sterol esterified. (columbia.edu)

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  • transport
  • While it is well appreciated that membrane transport is critical for development, the specific roles of many transporters have remained cryptic, in part because of their abundance and the diversity of their substrates. (ucsd.edu)
  • In Saccharomyces cerevisiae, we have demonstrated that the opposite (i.e inward) transport of sterol in yeast is also dependent on two ABC transporters (Aus1p and Pdr11p). (columbia.edu)
  • This prompts the question what dictates directionality of sterol transport by ABC transporters. (columbia.edu)
  • This is the first example of an ABC transporter mediating bi-directional transport. (columbia.edu)
  • These data suggest that direction of transport is not a static property of the transporter but rather can adapt in response to changes in the intracellular microenvironment. (columbia.edu)
  • 8 Recently, we have shown that ECs bind, internalize, and transport lipid-free apoA-I in a specific manner. (ahajournals.org)
  • (ahajournals.org)
  • There are two types of active transport - primary active transport that uses ATP, and secondary active transport that uses an electrochemical gradient. (wikipedia.org)
  • reveal
  • These studies reveal that multifunctional transporters are required for signaling, homeostasis, and protection of the embryo, and shed light on how they are integrated into ancestral developmental pathways recapitulated in disease. (ucsd.edu)
  • function
  • The present research investigated the function of eIF4G in the level of resistance of MCF-7/ADR cells to anticancer medications, and unravelled the feasible association between eIF4G and ABC transporters. (paft-phil.com)
  • ATPase
  • In enzymology, a xenobiotic-transporting ATPase (EC 3.6.3.44) is an enzyme that catalyzes the chemical reaction ATP + H2O + xenobioticin ⇌ {\displaystyle \rightleftharpoons } ADP + phosphate + xenobioticout The 3 substrates of this enzyme are ATP, H2O, and xenobiotic, whereas its 3 products are ADP, phosphate, and xenobiotic. (wikipedia.org)
  • uptake
  • It also stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. (abcam.com)
  • function
  • Class 3 contains all known BPD transporters and systems with ill-characterized function or transport mechanism, some of the latter being considered as exporters. (antoniosonnessa.com)
  • The heart utilizes a lot of energy in the form of ATP to properly pump blood and maintain physiological requirements in order to live, and 17βE2 helps by increasing these myocardial ATP levels and respiratory function. (wikipedia.org)
  • it carries out this function by binding to a trimethylated lysine 27 on histone 3 (H3K27me3) and subsequently marking lysine 119 of histone H2A with a single ubiquitin group (H2AK119ub). (wikipedia.org)
  • bacterial
  • The persistence of B. longum in the gut is attributed to the glycoprotein-binding fimbriae structures and bacterial polysaccharides, the latter of which possess strong electrostatic charges that aid in the adhesion of B. longum to intestinal endothelial cells. (wikipedia.org)