• arterial
  • IRVINE, Calif., July 9, 2012 /PRNewswire/ -- AtheroNova Inc. (OTCBB: AHRO), a biotech company focused on the research and development of compounds to regress atherosclerotic plaque, announced that it has received a Notice of Allowance for its patent application for Dissolution of Arterial Plaque. (bio-medicine.org)
  • The current methodology for quantification of FDG uptake in atherosclerotic plaque involves measurement of the standardized uptake value (SUV) of an artery of interest and of the venous blood pool in order to calculate a target to background ratio (TBR), which is calculated by dividing the arterial SUV by the venous blood pool SUV. (jove.com)
  • Play media The lesions of arteriosclerosis begin as the intima (innermost layer of blood vessel wall) of the arterial wall start to fill up with the deposition of cellular wastes. (wikipedia.org)
  • Hyaline type: Hyaline arteriosclerosis, also referred to as arterial hyalinosis and arteriolar hyalinosis, refers to lesions that are caused by the deposition of homogenous hyaline in the small arteries and arterioles. (wikipedia.org)
  • While many cases have been observed and recorded, the term arteriosclerosis was not used until Jean Fréderic Martin Lobstein coined it while he was analyzing the composition of calcified arterial lesions. (wikipedia.org)
  • artery
  • Pretreatment anteroposterior (AP) pelvic image shows severe atherosclerotic disease with attenuated flow through the left superficial femoral artery (SFA), which suggests a distal occlusion. (medscape.com)
  • Delipidization dissolves plaques in artery walls, which are then removed by natural body processes. (bio-medicine.org)
  • Even most plaque ruptures do not produce symptoms until enough narrowing or closure of an artery, due to clots, occurs. (wikipedia.org)
  • In the context of heart or artery matters, atheromata are commonly referred to as atheromatous plaques. (wikipedia.org)
  • If the muscular wall enlargement eventually fails to keep up with the enlargement of the atheroma volume, or a clot forms and organizes over the plaque, then the lumen of the artery becomes narrowed as a result of repeated ruptures, clots & fibrosis over the tissues separating the atheroma from the blood stream. (wikipedia.org)
  • Endarterectomy: This is the general procedure for the surgical removal of plaque from the artery that has become narrowed, or blocked. (wikipedia.org)
  • aortic
  • The condition is often associated with thickening of the aortic wall, and can be differentiated from similar conditions (atherosclerotic plaque and a thrombus) through the use of computed tomography and magnetic resonance imaging, though the latter is superior. (wikipedia.org)
  • mice
  • Recent studies on LDL receptor-deficient mice that are hyperglycemic, but exhibit no marked dyslipidemia compared with nondiabetic controls, show that diabetes in the absence of diabetes-induced hyperlipidemia is associated with an accelerated formation of atherosclerotic lesions, similar to what is seen in fat-fed nondiabetic mice. (ahajournals.org)
  • These effects of diabetes are masked in severely dyslipidemic mice, suggesting that the effects of glucose and lipids on lesion initiation might be mediated by similar mechanisms. (ahajournals.org)
  • Immunostaining showed a 50% ( P =0.004) decrease in the MOMA-2-stained lesion area of Serp-1-treated mice. (ahajournals.org)
  • In both studies, a higher cellularity of the plaque and increased collagen content was observed in Serp-1-treated mice. (ahajournals.org)
  • Here we placed Apoe/ mice deficient in macrophage p38α MAPK on a Western diet and found that they had a marked increase in macrophage apoptosis and plaque necrosis. (uantwerpen.be)
  • ischemic
  • The low-grade disease of an atherosclerotic carotid can also result in cerebrovascular ischemic events [ 3 ]. (pubmedcentralcanada.ca)
  • A study was carried out in seven of the centers participating in ICSS to assess the incidence of ischemic brain lesions (silent infarcts) detected by diffusion-weighted MRI. (wikipedia.org)
  • They found that 73% of patients undergoing CAS with distal filter protection showed new ischemic lesions after the procedure versus 17% of those undergoing CEA. (wikipedia.org)
  • clots
  • It is plaque ruptures, producing debris and clots which obstruct blood flow downstream, sometimes also locally (as seen on angiograms), which reduce/stop blood flow. (wikipedia.org)
  • macrophage
  • High-resolution contrast-enhanced MRI (CEMRI) is an optimal noninvasive imaging technique that allows the discrimination of large lipid cores with macrophage infiltration, thin and fragile fibrous caps, calcific nodules and adventitia in human atheromatous vulnerable plaques both in vivo and ex vivo [ 5 ]. (pubmedcentralcanada.ca)
  • He began his independent scientific career as a Columbia faculty in 1985, and currently serves as Vice-Chair of Research in the Department of Medicine A major research focus of Tabas is the molecular and cellular mechanisms and consequences resulting from macrophage apoptosis and from phagocytic clearance of apoptotic cells in advanced atherosclerotic lesions. (wikipedia.org)
  • In some regions of increased macrophage activity, macrophage-induced-enzymes erode away the fibrous membrane beneath the endothelium so that the cover separating the plaque from blood flow in the lumen becomes thin and fragile. (wikipedia.org)
  • human
  • Finally, it has also shown that GPR84 expression is increased in both the normal appearing white matter and plaque in brains from human Multiple Sclerosis patients. (wikipedia.org)
  • cholesterol
  • Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. (wikipedia.org)
  • At this point, foam cells can either be degraded though the de-esterification and secretion of cholesterol, or can further promote foam cell development and plaque formation - a process that is dependent on the balance of free cholesterol and esterified cholesterol. (wikipedia.org)
  • deposits
  • AHRO-001 uses certain pharmacological compounds to regress atherosclerotic plaque deposits through a process known as delipidization. (bio-medicine.org)
  • AtheroNova Inc., through its wholly-owned subsidiary, AtheroNova Operations, Inc., is an early stage biotech company focused on discovery, research, development and licensing of novel compounds to reduce or regress atherosclerotic plaque deposits. (bio-medicine.org)
  • biomarkers
  • The analytical power of modern proteomic technologies could facilitate our understanding of vulnerable plaques and lead to the discovery of novel therapeutic targets and diagnostic biomarkers. (springer.com)
  • occurs
  • Amaurosis (Greek meaning darkening, dark, or obscure) is vision loss or weakness that occurs without an apparent lesion affecting the eye. (wikipedia.org)
  • cellular
  • In addition to the cellular constituents of the atherosclerotic plaque, which are primarily of smooth muscle cell, monocytic, and lymphocytic origin, a plethora of paracrine and autocrine mediators have been found to be instrumental in atherogenesis. (ahajournals.org)