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  • obesity
  • Interestingly, this prediction appears to be independent of traditional risk factors for cardiovascular disease such as high cholesterol levels, high blood pressure, obesity, smoking, and diabetes mellitus. (wikipedia.org)
  • Elevated levels of non-HDL cholesterol and LDL in the blood may be a consequence of diet, obesity, inherited (genetic) diseases (such as LDL receptor mutations in familial hypercholesterolemia), or the presence of other diseases such as diabetes and an underactive thyroid. (wikipedia.org)
  • He is known for his work in the fields of atherosclerosis, common metabolic disorders such as obesity, insulin resistance and type-2 diabetes and neurodegenerative disorders. (wikipedia.org)
  • Other genetic factors with relevance for obesity, type 2 diabetes and the metabolic syndrome also were studied in collaboration with H. Esterbauer, H. Oberkofler, T. Felder and F. Krempler. (wikipedia.org)
  • PMID
  • PMID 17609583 Pietraszek MH, Takada Y, Taminato A, Yoshimi T, Watanabe I, Takada A. The effect of MCI-9042 on serotonin-induced platelet aggregation in type 2 diabetes mellitus. (wikipedia.org)
  • PMID 8322284 Ogawa S, Takeuchi K, Sugimura K, Sato C, Fukuda M, Lee R, Ito S, Sato T. The 5-HT2 receptor antagonist sarpogrelate reduces urinary and plasma levels of thromboxane A2 and urinary albumin excretion in non-insulin-dependent diabetes mellitus patients. (wikipedia.org)
  • PMID 8987165 Igarashi M, Okuda T, Oh-i T, Koga M. Changes in plasma serotonin concentration and acceleration plethysmograms in patients with Raynaud's phenomenon after long-term treatment with a 5-HT2 receptor antagonist. (wikipedia.org)
  • 1993
  • From 1982 to 93 he was director of the Atherosclerosis Laboratory at Baylor College of Medicine and Houston Methodist Hospital and from 1987 to 1993 also director of the CDC-Cholesterol Reference Laboratory. (wikipedia.org)
  • methods
  • Methods of treating diabetes in mammals, particularly humans, by blocking or inhibiting VEGF-mediated activity. (patents.com)
  • The subject invention provides compositions and methods for treating diabetes in patients. (google.com)
  • In a preferred embodiment, the invention provides compositions methods for treating diabetes and/or preventing or alleviating complications associated with diabetes. (google.com)
  • COMPOSITIONS AND METHODS FOR TREATING DIABETES Cross-Reference to a Related Application This application claims the benefit of U.S. provisional applications Serial Nos. (google.com)
  • 2002
  • Data came from the U.S. Mexico Border Diabetes Prevention and Control Project survey (2001 2002), a stratified, multistage sample representative of the border population. (scielosp.org)
  • Los datos procedieron de la encuesta del Proyecto de Prevención y Control de la Diabetes en la Frontera México-Estados Unidos (2001 2002), llevada a cabo en una muestra estratificada polietápica, representativa de la población fronteriza. (scielosp.org)
  • Also in support is another study where the incidence of retinopathy in a group of adolescents with type 1 diabetes appeared to fall substantially between 1990 and 2002, despite A1C levels changing little throughout the study period ( 6 ). (diabetesjournals.org)
  • 2002 Jan;25(1):28-32. (wikipedia.org)
  • hyperlipoproteinemia
  • For example, familial hypercholesterolemia (Type IIa hyperlipoproteinemia) may be associated with xanthelasma palpebrarum (yellowish patches underneath the skin around the eyelids), arcus senilis (white or gray discoloration of the peripheral cornea), and xanthomata (deposition of yellowish cholesterol-rich material) of the tendons, especially of the fingers. (wikipedia.org)
  • genetic
  • This pharmacogenetic effect is consistent with models of HNF-1α deficiency, and the genetic basis of hyperglycemia may have implications for patient management. (wikipedia.org)
  • mechanism
  • Binding of transcription factors such as Sp1, Sp3, Ets-1, Elf-1, and YY1 to the NOS3 promoter and DNA methylation represents an important mechanism of transcriptional regulation. (wikipedia.org)
  • gene
  • The IL-1 gene cluster contains the genes encoding the proinflammatory cytokines IL-1α and -1β and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1ra). (diabetesjournals.org)
  • The human CYBA gene (OMIM number 233690) encoding the p22phox protein is located on the long arm of chromosome 16 at position 24 (16q24: 88,643,288 to 88,651,084, OMIM 608508), containing 6 exons, 5 introns and spanning 8.5kb (Fig. 1). (wikipedia.org)
  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 is an enzyme that in humans is encoded by the ENPP1 gene. (wikipedia.org)
  • Lipid phosphate phosphohydrolase 3 (LPP3), also known as phospholipid phosphatase 3 (PLPP3) and phosphatidic acid phosphatase type 2B (PAP-2b or PPAP2B), is an enzyme that in humans is encoded by the PPAP2B gene on chromosome 1. (wikipedia.org)
  • The PPAP2B gene resides on chromosome 1 at the band 1p32.2 and includes 6 exons. (wikipedia.org)
  • Mutations to the p53 gene are often found in many types of cancers. (wikipedia.org)
  • HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. (wikipedia.org)
  • Mutations in the HNF1A gene have been known to cause diabetes. (wikipedia.org)
  • Likewise, patients with diabetes caused by mutations in the HNF1A gene have been described as sensitive to the hypoglycemic effects of sulphonylureas. (wikipedia.org)
  • triglyceride levels
  • The most typical lipoprotein pattern in diabetes, also known as diabetic dyslipidemia or atherogenic dyslipidemia, consists of moderate elevation in triglyceride levels, low HDL cholesterol values, and small dense LDL particles. (diabetesjournals.org)
  • 5 However, in the U.K. Prospective Diabetes Study, despite a high frequency of modestly elevated baseline triglyceride levels (mean baseline 159 mg/dl), a multivariate analysis showed that triglyceride levels did not predict CHD events. (diabetesjournals.org)
  • Expression
  • P22phox human mRNA is 0.8 kb and has a constitutive expression in a variety of cell types. (wikipedia.org)
  • It associates with NOX2 and with NOX1, NOX3 and NOX4 in a 1:1 complex and has a ubiquitous expression. (wikipedia.org)
  • Expression of the murine plasma cell nucleotide pyrophosphohydrolase PC-1 is shared by human liver, bone, and cartilage cells. (wikipedia.org)
  • To date, MAP4K4 has been found to be expressed in all tissue types with a relatively more pronounced expression in the brain and testes. (wikipedia.org)
  • levels
  • Enzyme-linked immunosorbent assays showed decreased baseline plasma levels of IL-1ra in patients with type 2 diabetes, which may in part explain the role of the IL1RN VNTR in these patients. (diabetesjournals.org)
  • Therefore, in this study, we determined the relationship between MPO levels and the incidence of CAD in patients with type 2 diabetes. (hindawi.com)
  • 1 Belli R, Amerio P, Brunetti L, Orlando G, Toto P, Proietto G, Vacca M, Tulli A. Elevated 8-isoprostane levels in basal cell carcinoma and in UVA irradiated skin. (biology-online.org)
  • Moreover, significantly lower levels of HNF-1α in pancreatic tumors and hepatocellular adenomas than in normal adjacent tissues was observed, suggesting that HNF-1α might play a possible tumor suppressor role. (wikipedia.org)
  • onset
  • Severe nocturnal enuresis secondary to polyuria can be an indication of onset of diabetes in young children. (medscape.com)
  • An explosive onset of symptoms in a young lean patient with ketoacidosis always has been considered diagnostic of type 1 DM. (medscape.com)
  • Over time, patients with new-onset type 1 DM will lose weight, despite normal or increased appetite, because of depletion of water and a catabolic state with reduced glycogen, proteins, and triglycerides. (medscape.com)
  • This lipoprotein pattern is associated with insulin rsistance and is present even before the onset of diabetes. (diabetesjournals.org)
  • disease
  • The chronic complications of diabetes are related to the length of time the patient has had the disease. (medscape.com)
  • Coffee is also used to prevent Parkinson's disease , gallstones , type 2 diabetes , gastrointestinal cancer , lung cancer , and breast cancer . (webmd.com)
  • But drinking even 1 or 2 cups of coffee cuts their Parkinson's disease risk significantly. (webmd.com)
  • 100 mg/dl and provided an optional lower target of 70 mg/dl for very-high-risk patients, such as those with diabetes and heart disease. (diabetesjournals.org)
  • Behavioural and Generational Change: What physical activity, diet and other behavioural patterns are optimal at different life stages in preventing diabetes and cardiovascular disease, and how can behavioural and generational change best be addressed? (wikipedia.org)
  • Other goals of diabetes management are to prevent or treat the many complications that can result from the disease itself and from its treatment. (wikipedia.org)
  • These changes are accompanied by a variety of electrocardiographic changes that may be associated with diabetic cardiomyopathy in 60% of patients without structural heart disease, although usually not in the early asymptomatic phase. (wikipedia.org)