• obesity
  • Interestingly, this prediction appears to be independent of traditional risk factors for cardiovascular disease such as high cholesterol levels, high blood pressure, obesity, smoking, and diabetes mellitus. (wikipedia.org)
  • Elevated levels of non-HDL cholesterol and LDL in the blood may be a consequence of diet, obesity, inherited (genetic) diseases (such as LDL receptor mutations in familial hypercholesterolemia), or the presence of other diseases such as diabetes and an underactive thyroid. (wikipedia.org)
  • He is known for his work in the fields of atherosclerosis, common metabolic disorders such as obesity, insulin resistance and type-2 diabetes and neurodegenerative disorders. (wikipedia.org)
  • Other genetic factors with relevance for obesity, type 2 diabetes and the metabolic syndrome also were studied in collaboration with H. Esterbauer, H. Oberkofler, T. Felder and F. Krempler. (wikipedia.org)

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  • PMID
  • PMID 17609583 Pietraszek MH, Takada Y, Taminato A, Yoshimi T, Watanabe I, Takada A. The effect of MCI-9042 on serotonin-induced platelet aggregation in type 2 diabetes mellitus. (wikipedia.org)
  • PMID 8322284 Ogawa S, Takeuchi K, Sugimura K, Sato C, Fukuda M, Lee R, Ito S, Sato T. The 5-HT2 receptor antagonist sarpogrelate reduces urinary and plasma levels of thromboxane A2 and urinary albumin excretion in non-insulin-dependent diabetes mellitus patients. (wikipedia.org)
  • PMID 8987165 Igarashi M, Okuda T, Oh-i T, Koga M. Changes in plasma serotonin concentration and acceleration plethysmograms in patients with Raynaud's phenomenon after long-term treatment with a 5-HT2 receptor antagonist. (wikipedia.org)
  • oxidative stress
  • In the present study to investigate cardiac oxidative stress and evaluate the role of oxidant we measured lipid peroxides in terms of Malondialdehye and antioxidants namely total antioxidant capacity (TAC), vitamin C, glutathione peroxidase (GPx) and superoxide dismutase (SOD) in normal controls and different groups of Coronary artery disease patients, before and after treatment and after supplementation of oral dose of A - Z antioxidant tablets along with regular treatment. (alliedacademies.org)
  • glucose
  • Patients using a pump or a multiple-injection regimen have a basal insulin (taken through the pump or with the injection of a long-acting insulin analogue) and a premeal rapid-acting insulin, the dose of which may be determined as a function of the carbohydrate count plus the correction (to adjust for how high the premeal glucose level is). (medscape.com)
  • Is the patient's diabetes generally well controlled, with near-normal blood glucose levels? (medscape.com)
  • This study has analyzed data from the Diabetes Control and Complications Trial (DCCT) to assess the effect of glucose variability on the risk of retinopathy and nephropathy in patients with type 1 diabetes. (diabetesjournals.org)
  • Also, pre- and postprandial glucose values are equally predictive of the small-vessel complications of type 1 diabetes. (diabetesjournals.org)
  • It has therefore been proposed that beyond simply avoiding short-term complications such as hypoglycemia and diabetic ketoacidosis, minimizing variability in blood glucose control should be a therapeutic goal for patients to help avoid any excess risk of long-term complications as well ( 7 ). (diabetesjournals.org)
  • More recently, however, it has been shown that the variability of blood glucose seems to have little influence on the A1C of a patient over the mean glucose value, but it is not known if this translates to a similar risk of complications ( 8 ). (diabetesjournals.org)
  • In a preferred embodiment, oral administration of cysteamine hydrochloride with Metformin to a patient diagnosed with diabetes can substantially regulate the patient's glucose metabolism and insulin sensitivity. (google.com)
  • The term diabetes includes several different metabolic disorders that all, if left untreated, result in abnormally high concentration of a sugar called glucose in the blood. (wikipedia.org)
  • The treatment goals are related to effective control of blood glucose, blood pressure and lipids, to minimize the risk of long-term consequences associated with diabetes. (wikipedia.org)
  • Impaired fasting glycaemia or impaired fasting glucose (IFG) refers to a condition in which the fasting blood glucose or the 3-month average blood glucose (A1C) is elevated above what is considered normal levels but is not high enough to be classified as diabetes mellitus. (wikipedia.org)
  • Impaired fasting glucose is defined as a fasting glucose that is higher than the upper limit of normal, but not high enough to be classified as diabetes mellitus. (wikipedia.org)
  • Some patients with impaired fasting glucose also may be diagnosed with impaired glucose tolerance, but many have normal responses to a glucose tolerance test. (wikipedia.org)
  • World Health Organization (WHO) criteria for impaired fasting glucose differs from the American Diabetes Association (ADA) criteria, because the normal range of glucose is defined differently by each. (wikipedia.org)
  • The consequences of increased intracellular glucose concentration are fourfold, all resulting from increasing concentration of glycolytic intermediates upstream of the rate-limiting glyceraldehyde-3-phosphate reaction which is inhibited by mechanisms activated by increased free radical formation, common in diabetes. (wikipedia.org)
  • The participation of HNF-1α in glucose metabolism and diabetes has been reported, including the involvement in GLUT1 and GLUT2 transporter expression in pancreatic β-cells and angiotensin-converting enzyme 2 gene expression in pancreatic islets. (wikipedia.org)
  • 1993
  • From 1982 to 93 he was director of the Atherosclerosis Laboratory at Baylor College of Medicine and Houston Methodist Hospital and from 1987 to 1993 also director of the CDC-Cholesterol Reference Laboratory. (wikipedia.org)
  • 2002
  • Data came from the U.S. Mexico Border Diabetes Prevention and Control Project survey (2001 2002), a stratified, multistage sample representative of the border population. (scielosp.org)
  • Los datos procedieron de la encuesta del Proyecto de Prevención y Control de la Diabetes en la Frontera México-Estados Unidos (2001 2002), llevada a cabo en una muestra estratificada polietápica, representativa de la población fronteriza. (scielosp.org)
  • Also in support is another study where the incidence of retinopathy in a group of adolescents with type 1 diabetes appeared to fall substantially between 1990 and 2002, despite A1C levels changing little throughout the study period ( 6 ). (diabetesjournals.org)
  • 2002 Jan;25(1):28-32. (wikipedia.org)
  • hyperlipoproteinemia
  • For example, familial hypercholesterolemia (Type IIa hyperlipoproteinemia) may be associated with xanthelasma palpebrarum (yellowish patches underneath the skin around the eyelids), arcus senilis (white or gray discoloration of the peripheral cornea), and xanthomata (deposition of yellowish cholesterol-rich material) of the tendons, especially of the fingers. (wikipedia.org)
  • concomitant
  • A significant increase in levels of serum lipid peroxide was observed in various groups of CAD patients when compared to control with concomitant fall in TAC, Vit C, GPx and SOD levels. (alliedacademies.org)
  • mechanism
  • Binding of transcription factors such as Sp1, Sp3, Ets-1, Elf-1, and YY1 to the NOS3 promoter and DNA methylation represents an important mechanism of transcriptional regulation. (wikipedia.org)
  • methods
  • Methods of treating diabetes in mammals, particularly humans, by blocking or inhibiting VEGF-mediated activity. (patents.com)
  • The subject invention provides compositions and methods for treating diabetes in patients. (google.com)
  • In a preferred embodiment, the invention provides compositions methods for treating diabetes and/or preventing or alleviating complications associated with diabetes. (google.com)
  • COMPOSITIONS AND METHODS FOR TREATING DIABETES Cross-Reference to a Related Application This application claims the benefit of U.S. provisional applications Serial Nos. (google.com)
  • gene
  • We studied the relationship between a variable number tandem repeat (VNTR) polymorphism in intron 2 of the IL-1ra gene (IL1RN) and coronary artery disease (CAD) in patients with and without type 2 diabetes, following 787 consecutive patients admitted for suspected CAD. (diabetesjournals.org)
  • The IL-1 gene cluster contains the genes encoding the proinflammatory cytokines IL-1α and -1β and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1ra). (diabetesjournals.org)
  • The human CYBA gene (OMIM number 233690) encoding the p22phox protein is located on the long arm of chromosome 16 at position 24 (16q24: 88,643,288 to 88,651,084, OMIM 608508), containing 6 exons, 5 introns and spanning 8.5kb (Fig. 1). (wikipedia.org)
  • Lipid phosphate phosphohydrolase 3 (LPP3), also known as phospholipid phosphatase 3 (PLPP3) and phosphatidic acid phosphatase type 2B (PAP-2b or PPAP2B), is an enzyme that in humans is encoded by the PPAP2B gene on chromosome 1. (wikipedia.org)
  • The PPAP2B gene resides on chromosome 1 at the band 1p32.2 and includes 6 exons. (wikipedia.org)
  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 is an enzyme that in humans is encoded by the ENPP1 gene. (wikipedia.org)
  • Mutations to the p53 gene are often found in many types of cancers. (wikipedia.org)
  • HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. (wikipedia.org)
  • Mutations in the HNF1A gene have been known to cause diabetes. (wikipedia.org)
  • Likewise, patients with diabetes caused by mutations in the HNF1A gene have been described as sensitive to the hypoglycemic effects of sulphonylureas. (wikipedia.org)
  • triglyceride levels
  • 5 However, in the U.K. Prospective Diabetes Study, despite a high frequency of modestly elevated baseline triglyceride levels (mean baseline 159 mg/dl), a multivariate analysis showed that triglyceride levels did not predict CHD events. (diabetesjournals.org)
  • levels
  • Enzyme-linked immunosorbent assays showed decreased baseline plasma levels of IL-1ra in patients with type 2 diabetes, which may in part explain the role of the IL1RN VNTR in these patients. (diabetesjournals.org)
  • However decrease in serum lipid peroxide and increase in the levels of TAC, Vit C, GPx and SOD up to control levels were found in patients subjected to oral dose of A - Z antioxidant tablets along with regular treatment. (alliedacademies.org)
  • Therefore, in this study, we determined the relationship between MPO levels and the incidence of CAD in patients with type 2 diabetes. (hindawi.com)
  • Likewise, plasma LPA levels are significantly elevated in patients with acute coronary syndromes. (wikipedia.org)
  • All the lipoproteins carry cholesterol, but elevated levels of the lipoproteins other than HDL (termed non-HDL cholesterol), particularly LDL-cholesterol, are associated with an increased risk of atherosclerosis and coronary heart disease. (wikipedia.org)
  • Moreover, significantly lower levels of HNF-1α in pancreatic tumors and hepatocellular adenomas than in normal adjacent tissues was observed, suggesting that HNF-1α might play a possible tumor suppressor role. (wikipedia.org)
  • Expression
  • P22phox human mRNA is 0.8 kb and has a constitutive expression in a variety of cell types. (wikipedia.org)
  • It associates with NOX2 and with NOX1, NOX3 and NOX4 in a 1:1 complex and has a ubiquitous expression. (wikipedia.org)
  • Expression of the murine plasma cell nucleotide pyrophosphohydrolase PC-1 is shared by human liver, bone, and cartilage cells. (wikipedia.org)
  • To date, MAP4K4 has been found to be expressed in all tissue types with a relatively more pronounced expression in the brain and testes. (wikipedia.org)
  • metabolic
  • A series of metabolic risk factors have been proposed to account for the accelerated development of atherosclerosis in patients with this disease. (diabetesjournals.org)
  • A lot of metabolic functions can be affected by cellular magnesium level [ 1 ] as it acts as a cofactor for more than 300 biochemical reactions. (omicsonline.org)
  • To this end, he has identified seven types of molecular and cellular damage caused by essential metabolic processes. (wikipedia.org)
  • HNF-1α is also involved in various metabolic pathways of other organs, such as being a transcriptional regulator of bile acid transporters in the intestine and kidneys. (wikipedia.org)