• Since changes in cerebral hemodynamics underlie a broad spectrum of ischemic cerebrovascular disorders, more and more studies have proved that intracranial hemodynamics played an essential role in predicting stroke. (highwire.org)
  • This group includes lysosomal storage disorders, various mitochondrial diseases, other neurometabolic disorders, and several other miscellaneous disorders. (medscape.com)
  • Depressive disorders do not exhibit manic or hypomanic components characteristic of bipolar disease. (pharmacology2000.com)
  • 3. Steinlin M. Cerebrovascular disorders in childhood. (acr.org)
  • The "Surprise Question" for Prognostication in People with Parkinson's Disease & Related Disorders. (cuanschutz.edu)
  • Multiple sclerosis is a common, chronic demyelinating neurological disease primarily affecting young adults, with a prevalence of ~0.1% in the Caucasian population (Miller and Leary, 2007). (medscape.com)
  • Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes. (biomedcentral.com)
  • CONCLUSIONS: Severe patients with CNSI can be efficiently and effectively treated in an ICU specialized in infectious diseases when compared to mixed medical/surgical and neurological ICUs from the public health system. (cdc.gov)
  • RESULTS: Compared to SARS-CoV-2 infections of the original strain, COVID-19 cases hospitalized during the Omicron surge (B.1.1.529) were associated with incidental and/or asymptomatic COVID-19 cases (96, 53.9%) and an increased incidence of pre-existing neurological and immunocompromising conditions. (cdc.gov)
  • INTERPRETATION: In our cohort of 178 admitted SARS-CoV-2-positive patients with select neurological conditions during the Omicron B.1.1.529 surge, 54% of COVID-19 cases were considered incidental and/or asymptomatic, and the identified neurological conditions resembled those associated with the original SARS-CoV-2 strain. (cdc.gov)
  • This study assessed WMH in patients with migraine using a modified version of the Scheltens visual rating scale, a semiquantitative scale for categorizing WMH in periventricular, lobar, basal ganglia, and infratentorial regions. (frontiersin.org)
  • The goal of this study was to assess WMHs in patients with migraine using a modified version of the Scheltens visual rating scale ( 13 ), a well-known semi-quantitative rating scale for assessing WMHs in the following brain regions: periventricular, lobar, basal ganglia, and infratentorial (as shown in Figure 1 ). (frontiersin.org)
  • 7 Nodular white matter lesions are seen on imaging and most ischaemic changes occur in the basal ganglia, periventricular white matter and temporal lobes, 1 , 8 and a family with spinal cord lesions in the presence of a novel NOTCH 3 mutation has been described. (bmj.com)
  • Genetic and acquired hypercoagulable states, such as factor V Leiden deficiency, prothrombin G20210A mutation, and antiphospholipid syndrome, are associated with cerebrovascular events, including cerebral venous thrombosis and ischemic stroke. (medlink.com)
  • Cerebrovascular manifestations of a hypercoagulable state are arterial ischemic stroke and cerebral venous thrombosis. (medlink.com)
  • 1 Since carotid artery atherosclerosis can progress quietly during an asymptomatic phase, asymptomatic carotid stenosis (ACS) is a silent harbinger of fatal stroke as the first clinical manifestation. (highwire.org)
  • Identifying high-risk patients with asymptomatic carotid stenosis (ACS) is necessary regardless of whether intensive medical therapy or aggressive treatment is applied. (highwire.org)
  • Carotid stenosis is a recognized risk factor for the development of ischemic cerebrovascular disease. (highwire.org)
  • Identifying high-risk patients with asymptomatic carotid stenosis (ACS) is necessary. (highwire.org)
  • Identification of carotid stenosis in an asymptomatic population can significantly prevent the occurrence of cerebrovascular diseases. (highwire.org)
  • Hypertension, carotid stenosis, chronic kidney disease and metabolic syndrome all showed a strong association with SBI. (biomedcentral.com)
  • Ischemic cerebrovascular disease, characterized by high morbidity and mortality, has increasingly endangered human health and inflicted great financial burden on the society. (highwire.org)
  • 5 Cerebrovascular reserve (CVR), defined as the increase in cerebral blood flow in response to a vasodilatory stimulus, is known to reflect the capacity of the brain to maintain adequate blood flow by compensatory vasoconstricition or vasodilatation in the face of decreased perfusion due to arterial stenosis. (highwire.org)
  • Described by Joutel et al , 3 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a Mendelian form of hereditary small-vessel disease and vascular dementia. (bmj.com)
  • Basal ganglionic hemorrhage strongly affects clinical outcome and is distinctively related to late reperfusion. (ajnr.org)
  • This review highlights new information regarding the virology, clinical manifestations, and pathology of WNV disease, which will provide a new platform for further research into diagnosis, treatment, and possible prevention of WNV through vaccination. (cdc.gov)
  • Inherited Neuropathies Consortium-Rare Disease Clinical Research Network. (cuanschutz.edu)
  • Microfibrillar-associated protein 4 as a potential marker of acute relapse in inflammatory demyelinating diseases of the central nervous system: Pathological and clinical aspects. (cuanschutz.edu)
  • They've also revealed latent disease-modifying factors, helped develop clinical trial stratification models and served as matched control groups in clinical trials. (neurosurgery.directory)
  • In the era of newborn screening (NBS), the prompt initiation of treatment of asymptomatic infants detected by NBS means that most individuals who would have developed neonatal manifestations of MSUD remain asymptomatic with continued treatment compliance. (nih.gov)
  • For asymptomatic patients with uncomplicated coronary disease resumption of activity was recommended by some following six weeks of convalescence. (pharmacology2000.com)
  • OBJECTIVE: Emerging variants and sublineages of SARS-CoV-2 have differing disease severity, transmissibility, and immune evasion. (cdc.gov)
  • Genetic analysis and natural history of Charcot-Marie-Tooth disease CMTX1 due to GJB1 variants. (cuanschutz.edu)
  • Ornithine transcarbamylase (OTC) deficiency can occur as a severe neonatal-onset disease in males (but rarely in females) and as a post-neonatal-onset (also known as "late-onset" or partial deficiency) disease in males and females. (beds.ac.uk)
  • Males with severe neonatal-onset OTC deficiency are asymptomatic at birth but become symptomatic from hyperammonemia in the first week of life, most often on day two to three of life, and are usually catastrophically ill by the time they come to medical attention. (beds.ac.uk)
  • View of the base of the brain arteries, blockage which can lead to lacunar infarcts (lacunar disease of the brain). (minclinic.ru)
  • Characteristic to the disease is the profound atrophy of the brain accompanied by amyloid-beta (Aβ) plaques and the presence of tau neurofibrillary tangles (NFTs). (frontiersin.org)
  • Effects of deep brain stimulation on quantitative sleep electroencephalogram during non-rapid eye movement in Parkinson's disease. (cuanschutz.edu)
  • cerebrovascular disease and brain space-occupying lesions are the main causes in adults. (medlink.com)
  • Three-dimensional constructive interference in steady state (3D CISS) is a steady-state gradient-echo sequence in magnetic resonance imaging (MRI) that has been used in an increasing number of applications in the study of brain disease in recent years. (mdpi.com)
  • APOE4 Alzheimer's gene: a variant of the APOE gene that has been strongly associated with a higher risk of developing Alzheimer's disease, a progressive brain disorder that affects memory, thinking, and behavior. (drpaulkilgore.com)
  • Reflux disease in which erosion does not occur Talley et al. (slideserve.com)
  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. (frontiersin.org)
  • Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disease leading to severe cognitive loss and eventual death. (frontiersin.org)
  • This figure shows known associations with Alzheimer's disease. (frontiersin.org)
  • Furthermore, there is a lack of investigations into how WMHs attributable to migraine might be distinguishable from those attributed to other etiologies, such as small vessel ischemic disease and demyelinating disease. (frontiersin.org)
  • This study aimed to categorize WMHs in patients with migraine by their size and location, so as to allow for future differentiation of migraine-specific WMHs from those attributable to other diseases, such as small vessel ischemic disease and multiple sclerosis. (frontiersin.org)
  • Research on the signs, symptoms, and pathogenesis of WNV disease has greatly intensified in the past 5 years. (cdc.gov)
  • Approximately 15% of patients follow a primary progressive or progressive relapsing course from disease onset, usually characterized by symptoms of progressive myelopathy (gait instability, spasticity, bladder symptoms) and cognitive impairment. (medscape.com)
  • Systemic lupus erythematosus is a chronic autoimmune disease characterized by loss of tolerance against nuclear and cytoplasmic self-antigens, induction of immunity and tissue inflammation. (bvsalud.org)
  • Maple syrup urine disease (MSUD) is categorized as classic (severe), intermediate, or intermittent. (nih.gov)
  • It is a syndrome of progressive deterioration of memory, cognition, behavior, and motor function in HIV-infected individuals during the late stages of the disease, when immunodeficiency is severe. (wikipedia.org)
  • The risk of developing the disease with age doubles every 5.9 years from 3.1 per 1000 persons aged 60-64 to 175 persons per 1000 at age 95+ ( WHO, 2012 ), making age the strongest risk factor for AD. (frontiersin.org)
  • Lupus nephritis (LN), the most important predictor of morbidity in SLE, develops in almost 30% of SLE patients at disease onset and in up to 50-60% within the first 10 years. (bvsalud.org)
  • Secondary hypogammaglobulinemia in patients with multiple sclerosis on anti-CD20 therapy: Pathogenesis, risk of infection, and disease management. (cuanschutz.edu)
  • Reducing the receipt of contraindicated medications in patients with Parkinson disease. (cuanschutz.edu)
  • Addison's disease: A rare disorder in which the adrenal glands do not produce enough hormones. (drpaulkilgore.com)
  • BACKGROUND: There is little information comparing the performance of community acquired central nervous system infections (CNSI) treatment by intensive care units (ICUs) specialized in infectious diseases with treatment at other ICUs. (cdc.gov)
  • METHODS: This is a retrospective observational cohort of 785 admissions with 82 cases of CNSI admitted to the ICU of an important Brazilian referral center for infectious diseases (INI) between January 2012 and January 2019. (cdc.gov)
  • Heart failure, coronary artery disease, hyperhomocysteinemia and obstructive sleep apnea are also likely of significance. (biomedcentral.com)
  • in children, the most common cause is Rasmussen syndrome, and in adults, the most common causes are cerebrovascular disease and neoplasm. (medlink.com)
  • In order to assess the relationship between cerebrovascular reserve (CVR) measured by perfusion CT with inhalation of CO 2 and the risk of ischemic events in ACS, this long-term follow-up study was conducted. (highwire.org)
  • The pathology and pathogenesis of WNV disease have been described more completely than ever before. (cdc.gov)
  • Firstly, in this review, we put the pathogenic mechanisms of the disease into a conceptual frame, giving emphasis to the role of the innate immune system in this loss of self-tolerance and the induction of the adaptive immune response. (bvsalud.org)
  • Neonates with classic MSUD are born asymptomatic but without treatment follow a predictable course: 12-24 hours. (nih.gov)
  • This chapter examines these diseases and, in those of major importance, attempts to relate them to the potentially pathogenic factors present in the human diet. (clinicalgate.com)
  • Cystic fibrosis (CF) is a multisystem disease affecting epithelia of the respiratory tract, exocrine pancreas, intestine, hepatobiliary system, and exocrine sweat glands. (nih.gov)
  • Over the past 5 years, research on WNV disease has expanded rapidly. (cdc.gov)
  • It is not unusual for a previously asymptomatic individual to present in adult years with only a thromboembolic event that is often cerebrovascular. (nih.gov)
  • Disability Adjusted Life Years (DALYs) for depression may be soon greater than that observed for cancer or HIV-related disease. (pharmacology2000.com)
  • In the United States cancer appears responsible for about 25% of deaths, only heart disease exhibits a higher percentage. (pharmacology2000.com)
  • Explanations of this concurrence includes simple coexistence at the time of the medical diagnosis, a reaction to the psychological stress of dealing with the disease, an effect resulting from the disease itself or occurring secondary to the medication used to treat the disorder. (pharmacology2000.com)
  • Several strategies are being pursued to develop effective vaccines to prevent WNV disease. (cdc.gov)
  • The expanded knowledge about WNV disease provides a new platform for future development of diagnostic tests, therapy, and vaccine development. (cdc.gov)
  • There are less data about the association between cerebrovascular reserve (CVR) and ACS. (highwire.org)