• brainstem and pons
  • The causes associated with conscious CNH are more varied than originally predicted by Plum and Swanson's study of comatose patients, although the most commonly reported causes of CNH involve infiltrative gliomas and lymphomas of the brainstem and pons. (wikipedia.org)
  • progression
  • Though the molecular mechanism behind this tumorigenesis is not entirely clear, more studies have recently been published pinpointing diverse evidence and potential roles for OLIG2 in glioma progression. (wikipedia.org)
  • It is believed that OLIG2 promotes neural stem cell and progenitor cell proliferation by opposing p53 pathway, which potentially contributes to glioma progression. (wikipedia.org)
  • proliferation
  • Glioblastomas are aggressive astrocytomas characterized by endothelial cell proliferation and abnormal vasculature, which can cause brain edema and increase patient morbidity. (diva-portal.org)
  • In particular, OLIG2 is selectively expressed in a subgroup of glioma cells that are highly tumorigenic, and is shown to be required for proliferation of human glioma cells implanted in the brain of severe combined immunodeficiency (SCID) mice. (wikipedia.org)
  • Unlike glioblastomas (WHO grade IV), anaplastic astrocytomas lack vascular proliferation and necrosis on pathologic evaluation. (wikipedia.org)
  • Glioblastomas
  • The growth rate and mean interval between onset of symptoms and diagnosis is approximately 1.5-2 years but is highly variable, being intermediate between that of low-grade astrocytomas and glioblastomas. (wikipedia.org)
  • commonly
  • In particular for pilocytic astrocytomas (that are commonly indolent bodies that may permit normal neurologic function) surgeons may decide to monitor the neoplasm's evolution and postpone surgical intervention for some time. (wikipedia.org)
  • role
  • This side of anti-neurogenicity of OLIG2 later plays a bigger role in malignancies like glioma. (wikipedia.org)
  • present
  • It is further found that the phosphorylation of triple-serine motif in OLIG2 is present in several glioma lines and is more tumorigenic than the unphosphorylated status. (wikipedia.org)