• GFAP
  • however, α-GFAP is the predominant form expressed in astrocytes. (fishersci.co.uk)
  • GFAP can co-assemble with vimentin and nestin in astrocytes, but such associations are not required for assembly. (fishersci.co.uk)
  • In the naive CNS of Cx3cr1 +/gfp and Cx3cr1 gfp/gfp mice, CX3CR1 transcription unit was exclusively active in microglial cells, as GFP expression was undetectable in neurons, NG2 + glia, and GFAP + astrocytes ( 12 ). (jimmunol.org)
  • Methods- Using a reporter mouse-expressing luciferase gene under transcriptional control of the murine glial fibrillary acidic protein (GFAP) promoter (GFAP-luc mice) and biophotonic/bioluminescent imaging as tools, we developed a model system for in vivo analysis of astrocyte activation/response in cerebral ischemia. (ahajournals.org)
  • However, astrocyte activation/GFAP signals showed cyclic, estrus-dependent variations in response to ischemic injury. (ahajournals.org)
  • Reactive astrogliosis is 1 of the key components of the cellular response to brain injury, and the passage from quiescent to reactive astrocytes is associated with strong upregulation of the intermediate-filament, glial fibrillary acidic protein (GFAP). (ahajournals.org)
  • 13 In cerebral ischemia, intensively stained GFAP-positive astrocytes accumulate in large numbers in the areas around the ischemic lesion. (ahajournals.org)
  • 14,15 To further investigate the role of astrocyte response to ischemia, we took the advantage of GFAP-luc transgenic mice. (ahajournals.org)
  • GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cells but its exact function remains poorly understood, despite the number of studies using it as a cell marker. (wikipedia.org)
  • GFAP is expressed in the central nervous system in astrocyte cells. (wikipedia.org)
  • GFAP is proposed to play a role in astrocyte-neuron interactions as well as cell-cell communication. (wikipedia.org)
  • In vitro, using antisense RNA, astrocytes lacking GFAP do not form the extensions usually present with neurons. (wikipedia.org)
  • central nervou
  • This 49kDa type III intermediate filament protein is expressed in neural tissues and distinguishes astrocytes from other glial cells during central nervous system development. (fishersci.co.uk)
  • Glial fibrillary acidic protein is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes and ependymal cells. (wikipedia.org)
  • model
  • Previous work in a co-culture model has indicated that CTE-SUMO1 accumulation within astrocyte nuclei is toxic to neighboring motor neurons. (grantome.com)
  • found
  • Furthermore, we analyzed whether alpha 1-antichymotrypsin (ACT), which is found in amyloid plaques and can influence A beta fibrillogenesis, affects the A beta uptake by human astrocytes. (lu.se)