Asthma airway resistance. Medical search. Frequent questions

This data suggest that quantitative HRCT may be a useful tool in the evaluation of peripheral airflow obstruction in children with asthma. (nih.gov)
In cases of upper airway obstruction the development of turbulent flow is a very important mechanism of increased airway resistance, this can be treated by administering Heliox, a breathing gas which is much less dense than air and consequently more conductive to laminar flow. (wikipedia.org)
Exposures of 50 to 100 ppm may be tolerated for more than 30 to 60 minutes, but higher or longer exposures can cause death from airway obstruction. (cdc.gov)
Management goals for status asthmaticus are (1) to reverse airway obstruction rapidly through the aggressive use of beta2-agonist agents and early use of corticosteroids, (2) to correct hypoxemia by monitoring and administering supplemental oxygen, and (3) to prevent or treat complications such as pneumothorax and respiratory arrest. (medscape.com)
Asthma is a chronic inflammatory disorder of the airways, characterized by recurrent, reversible, airway obstruction. (medicinenet.com)
Compared with the non-hypoxic group they were younger (8.6 (SD 2.8) v 11.2 (2.8) y, p = 0.02), and had greater airway obstruction (FEV 1 32.5 (10)% v 54.3 (26)%, p = 0.0073, 95% confidence interval (CI) −36.9 to −6.6) yet had a trend towards less breathlessness (median HMP 4 v 3, p = 0.062, CI −0.001 to 2.00) at admission. (bmj.com)
4 , 13 , 14 McFadden suggests: "Some patients are unable to sense the presence of even marked airway obstruction and have no symptoms until their respiratory reserve is virtually exhausted. (bmj.com)
Non-allergic asthma is characterized by airway obstruction and inflammation that is at least partially reversible with medication, however symptoms are NOT associated with an allergic reaction. (corporatewellnessmagazine.com)
Measurement of airway resistance before and after a dose of inhaled bronchodilator may help to diagnose bronchodilator-responsive airway obstruction. (medscape.com)
Documentation of reversibility of airway obstruction after bronchodilator therapy is central to the definition of asthma. (medscape.com)
In an outpatient or office setting, measurement of the peak flow rate by using a peak flow meter can provide useful information about obstruction in the large airways. (medscape.com)
However, a normal peak flow rate does not necessarily mean a lack of airway obstruction. (medscape.com)
Airway resistance is increased when significant obstruction is present. (medscape.com)
The reversibility of airway obstruction can be assessed by administering aerosolized bronchodilators. (medscape.com)
Traditionally, asthma has been regarded as a disease characterised by chronic inflammation and remodelling, primarily of the large airways, which leads to airflow obstruction and asthma-specific symptoms. (ersjournals.com)
Snoring is an indication of the onset or existence of some type of airway obstruction. (sleepgroupsolutions.com)
Obstructive Sleep Apnea, complete airway obstruction, is common in older, overweight men and affects significant percentages of women and children as well. (sleepgroupsolutions.com)

RESULTS: Wild type mice developed a greater degree of airway hyperresponsiveness to MCh at 1 day post exposure to Cl2 compared with TCR-delta-/- mice. (cdc.gov)
Sometimes, testing for airway hyperresponsiveness (methacholine or mannitol challenge) can help diagnose asthma, again in older children capable of performing proper technique. (medicinenet.com)
The chronic inflammation of asthma is associated with airway hyperresponsiveness that leads to recurrent symptoms, yet lung function may nevertheless remain normal. (cmaj.ca)
Identification of airway hyperresponsiveness thus has clinical value, particularly in the diagnosis of asthma in people with normal spirometry results or with symptoms uncharacteristic of asthma. (cmaj.ca)
Airway hyperresponsiveness is usually measured using direct stimuli, such as methacholine or histamine, that act by stimulating specific receptors on the bronchial smooth muscle to cause contraction and narrowing of the airways. (cmaj.ca)
Pulmonary 129 Xe MRI ventilation defect percentage (VDP) also sensitively measures asthma airway dysfunction caused by airway hyperresponsiveness, remodeling, and luminal mucus occlusions. (thorasys.com)
These tests are performed in specialized laboratories by specially trained personnel to document airway hyperresponsiveness to substances (eg, methacholine, histamine). (medscape.com)

It is not practically possible to measure airway resistance at a set absolute lung volume, therefore specific airway resistance attempts to correct for differences in lung volume at which different measurements of airway resistance were made. (wikipedia.org)
Similarly to specific airway resistance, specific airway conductance attempts to correct for differences in lung volume. (wikipedia.org)
Airway resistance (Raw), thoracic gas volume (TGV) and specific airway resistance (sRaw) were measured before, during and after exposure, and the breathing pattern was monitored during the whole session. (ersjournals.com)

All asthmatics have some degree of airway (bronchiole) inflammation. (asthma.net)
The degree of airway responsiveness can be assessed by methacholine challenge testing. (medscape.com)

The inflammation associated with asthma is characteristically eosinophilic. (cmaj.ca)
However, some patients with this condition have neutrophilic inflammation, whereas, conversely, some patients without asthma have eosinophilic inflammation. (cmaj.ca)
Our team of doctors, clinical nurse specialists and pulmonary physiologists treats a large cohort of patients with the main asthma phenotypes such as allergic asthma, eosinophilic asthma and aspirin-exacerbated respiratory disease. (tcd.ie)
Patients with eosinophilic asthma often report poor symptomatic control and quality of life. (thorasys.com)
In patients with severe asthma, eosinophilic inflammation-driven airway mucus occlusions have been measured using thoracic x-ray CT imaging. (thorasys.com)
Psychological stress leads to eosinophilic airway inflammation through activation of the hypothalamic-pituitary-adrenal pathway and autonomic nervous system. (fullscript.com)

Nonetheless, concern has been raised more recently about an increase that has since been observed in the severity of asthma symptoms and the need for more intensive care management. (medscape.com)
Figure depicting antigen presentation by the dendritic cell, with the lymphocyte and cytokine response leading to airway inflammation and asthma symptoms. (medscape.com)
What are the symptoms of asthma in a child? (medicinenet.com)
The most common symptoms of childhood asthma are coughing and wheezing. (medicinenet.com)
Symptoms are also typically exacerbated by viral upper respiratory infections, and these viral symptoms can linger for weeks in children with asthma, whereas age-controlled counterparts tend to recover much sooner. (medicinenet.com)
Tobacco smoke commonly aggravates symptoms, and secondhand tobacco smoke is not only a risk factor for developing childhood asthma but also complicates asthma control. (medicinenet.com)
The first monoclonal antibody used in the treatment of severe allergic asthma was omalizumab that showed good results in responders in terms of reduction of exacerbations, improvement of symptoms, lung function, and QoL ( Fajt and Wenzel, 2017 ). (frontiersin.org)
These symptoms can be confused of Tehran and elsewhere in the Islamic ity were recoded on a separate form, with those of asthma and lead to un- Republic of Iran. (who.int)
Due to the respiratory characteristics of asthma symptoms, using cannabis for asthma treatment is an even more far-fetched concept. (medicalmarijuana411.com)
The idea that cannabis would help treat asthma symptoms seems laughable. (medicalmarijuana411.com)
A single study from the 70's doesn't definitively prove the effectiveness of cannabis for asthma treatment, but it does support first-hand accounts of many patients who have experienced the symptoms that accompany their affliction dissipate. (medicalmarijuana411.com)
She had wheezing and allergy symptoms in childhood, and her mother and 1 cousin have confirmed asthma. (cmaj.ca)
The presence of certain key symptoms may suggest the presence of asthma, but can also result from airway inflammation alone, from chronic rather than reversible airflow limitation, or from other respiratory and nonrespiratory conditions. (cmaj.ca)
Moreover, asthma symptoms correlate poorly with abnormalities of lung function 9 and airway inflammation, 10 , 11 and thus in isolation may suggest a less severe form of the disease than is actually present. (cmaj.ca)
Asthma is an inflammatory disease 13 associated with symptoms resulting from abnormalities of airway function, in particular wide, short-term variations in airflow resistance in the intrapulmonary airways. (cmaj.ca)
Symptoms can happen each time the airways are irritated. (corporatewellnessmagazine.com)
When symptoms get more intense and/or additional symptoms appear, this is an asthma attack, also called flare-ups or exacerbations. (corporatewellnessmagazine.com)
This will help prevent the symptoms from worsening and causing a severe asthma attack. (corporatewellnessmagazine.com)
In a patient with a history of exercise-induced symptoms (eg, cough, wheeze, chest tightness or pain), the diagnosis of asthma can be confirmed with the exercise challenge. (medscape.com)
It also creates the symptoms associated with asthma. (thedrswolfson.com)
Billions of dollars are collected into Big Pharma coffers for drugs used to mask asthma symptoms. (thedrswolfson.com)
Asthma symptoms improve dramatically in so many people just by giving up all dairy, sugars and processed foods. (thedrswolfson.com)
Through better diet, nutrition and lifestyle practices, exercise-induced asthma symptoms can become a thing of the past. (thedrswolfson.com)
Asthma is a clinical diagnosis based on symptoms, detailed history and pulmonary function testing [ 1 ]. (ersjournals.com)
Hence, Hogg and colleagues, who also first used the term "small airway disease" [ 7 ], described the distal airways as the "silent zone" of the airway tree as extensive disease can be present without symptoms or changes in conventional lung function tests [ 14 ]. (ersjournals.com)
Although not fully substantiated, allergens can trigger asthma-like symptoms in lab settings, leading to the hypothesis that, at least in some cases, triggers may be found and eliminated in the environment, as is done for many human cases. (ingridking.com)
There is little doubt of the efficacy of oral GCs in the treatment of human and feline asthma symptoms. (ingridking.com)
Quercetin is more competent in inhibiting IL-8 than anti-allergic drug disodium cromoglycate, a medicine used to prevent the symptoms of asthma. (fullscript.com)
It is prescribed for patients having any symptoms of asthma or COPD. (agpharmaceuticalsnj.com)
Association of Mold With Asthma Symptoms This study investigated the sensitization to mold in patients with asthma compared to those without asthma. (medscape.com)

The aim of this review is to examine the current literature for the most recent updates on health effects of specific air pollutants and their impact on asthma, chronic obstructive pulmonary disease, lung cancer, and respiratory infection. (cdc.gov)
Asthma, chronic obstructive pulmonary disease, lung cancer, and respiratory infections all seem to be exacerbated because of exposure to a variety of environmental air pollutants with the greatest effects because of particulate matter, ozone, and nitrogen oxides. (cdc.gov)
The aim of this cross-sectional study was to evaluate the prevalence of depressed mood among asthma patients ( n = 280) attending a pulmonary clinic in Tehran and compare it with measures of severity of asthma and of health and well-being. (who.int)
Patients' individual scores on the GHQ-28 were significantly correlated with the number of asthma medications used, frequency of visits to the pulmonary clinic and frequency of hospitalizations for asthma, but not with FEV1. (who.int)
Emotions such as anxiety, anger, visits to the pulmonary clinic in the past happiness, excitement, satisfaction and to participate in the study, had a previ- year and frequency of hospital admis- neutral emotions have been shown to ous diagnosis of asthma and were in a sions for asthma exacerbations in the influence forced expiratory volume in stable medical condition with no other past year [12]. (who.int)
Unlike obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), which show a normal or increased total lung capacity (TLC), restrictive disease are associated with a decreased TLC. (medscape.com)
We have a special interest in caring for patients with severe asthma, respiratory allergy and pulmonary vasculitis. (tcd.ie)
Purpose: To measure regional specific ventilation with free-breathing hydrogen 1 (1H) magnetic resonance (MR) imaging without exogenous contrast material and to investigate correlations with hyperpolarized helium 3 (3He) MR imaging and pulmonary function test measurements in healthy volunteers and patients with asthma. (uwo.ca)
In the 1970s, the first physiological studies using indirect measurements of the distal airways (primarily nitrogen washout) focused attention on the role of small airways in diseases like asthma and chronic obstructive pulmonary disease [ 15 - 17 ]. (ersjournals.com)
The asthma studies necessitated the establishment of a pulmonary function laboratory with extensive capabilities for testing nonhuman primates under the direction of a pulmonary physiologist to assess function in animals undergoing exposure. (ucdavis.edu)
Since hypoxia can be a feature of respiratory disorders, such as asthma and chronic obstructive pulmonary disease, it may be of importance to determine if airway smooth muscle function is altered under hypoxic conditions. (gla.ac.uk)
Impaired lung function, pulmonary hypertension, and asthma are all associated with MetDys. (cdc.gov)
MetDys is a risk factor for lung function impairment, pulmonary hypertension, and asthma. (cdc.gov)

In younger children who cannot perform the proper technique for lung function testing, impulse oscillometry is used to measure airway resistance. (medicinenet.com)

Several studies have demonstrated that IL-17F plays a pivotal role in allergic airway inflammation and induces several asthma-related molecules such as CCL20. (hindawi.com)
IL-17F-induced CCL20 may attract Th17 cells into the airway resulting in the recruitment of additional Th17 cells to enhance allergic airway inflammation. (hindawi.com)
IL-17F is expressed in activated CD4 + T cells, basophils, and mast cells, three important cell types involved in allergic airway inflammation [ 3 ]. (hindawi.com)
There are probably dozens of laboratories in the world that study asthma, allergic asthma, and allergic inflammation and its various iterations. (scireq.com)
For example, if you find that allergies your cause, you may have allergic asthma. (corporatewellnessmagazine.com)
Non-Allergic asthma is triggered by factors not related to allergies. (corporatewellnessmagazine.com)
In non-allergic asthma, the immune system is not involved in the reaction. (corporatewellnessmagazine.com)
Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and is a well validated therapeutic target for the treatment of asthma, along with other allergic and inflammatory diseases. (bvsalud.org)
Quercetin reduces the hyper-reactivity of the airways in allergic asthma. (fullscript.com)
The interplay between neuroendocrine activity and psychological stress exacerbates allergic asthma. (fullscript.com)
Impact of Tobacco Smoke on Allergic Airway Disease Secondhand cigarette smoke can amplify the response to inhaled allergen, and IgE level is over 16-fold higher in nasal lavage fluid despite only 2 hours of exposure a full 4 days earlier. (medscape.com)

Airway inflammation leads to airway hyperreactivity, which causes the airways to narrow in response to various stimuli, including allergens, exercise , and cold air. (medicinenet.com)
This causes the airways to narrow, and less air flows to your lungs. (corporatewellnessmagazine.com)

CONCLUSION: The severity of airway epithelial injury after Cl2 is greater in TCR-delta-/- mice but the inflammatory response and the change in airway responsiveness to methacholine are reduced. (cdc.gov)
Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of the lung associated with structural "remodeling" inappropriate to the maintenance of normal lung function. (nih.gov)
The clinically observed distinctions between asthma and COPD are reflected by differences in the remodeling process, the patterns of inflammatory cells and cytokines, and also the predominant anatomic site at which these alterations occur. (nih.gov)
In COPD the changes begin later in life and the associated inflammatory response differs from that in asthma. (nih.gov)
Exposure to an allergen or trigger causes a characteristic form of airway inflammation in susceptible individuals, exemplified by mast cell degranulation, release of inflammatory mediators, infiltration by eosinophils, and activated T lymphocytes. (medscape.com)
Physiologically, acute asthma has two components: an early, acute bronchospastic aspect marked by smooth muscle bronchoconstriction and a later inflammatory component resulting in airway swelling and edema. (medscape.com)
Asthma is a chronic inflammatory airway disease, representing one of the most severe pathologies in developed countries. (frontiersin.org)
Cannabis is known for its anti-inflammatory properties and asthma is a disease that causes lung inflammation. (medicalmarijuana411.com)
What we do know is that it is a chronic inflammatory disease of the airways. (corporatewellnessmagazine.com)
Various chemical reactions occur, including the release of inflammatory markers called histamine and leukotrienes from mast cells lining airways. (asthma.net)
It reduces the number and activation of inflammatory immune system cells, cuts histamine levels, and relaxes airway smooth muscle. (fullscript.com)
Bronchial asthma is a chronic inflammatory disease of the respiratory tract, characterized by attacks of dyspnea, which are often accompanied by coughing and can develop into bronchial attacks. (agpharmaceuticalsnj.com)
If you have "aspirin-induced asthma," you should avoid taking acetylsalicylic acid and nonsteroidal anti-inflammatory drugs, especially since this type of illness can be very severe and the seizures occur very quickly. (agpharmaceuticalsnj.com)

MRI, eosinophil count, spirometry, oscillometry, Asthma Control Questionnaire (ACQ), Asthma Quality of Life Questionnaire (AQLQ), and St. George's Respiratory Questionnaire were completed on day 0 and 28 days after a single 30-mg subcutaneous benralizumab dose. (thorasys.com)
According to the National Asthma Education and Prevention Program guidelines, spirometry is an essential objective measure for establishing the diagnosis of asthma. (medscape.com)
In young children (3-6 y) and older children who are unable to perform the conventional spirometry maneuver, newer techniques, such as measurement of airway resistance using impulse oscillometry system, are used. (medscape.com)
The test can help to confirm the diagnosis of asthma in a patient with history of asthma but normal spirometry findings. (medscape.com)

The expression of IL-17F is seen in the airway of asthmatics and its level is correlated with disease severity. (hindawi.com)
Being aware of allergies and avoiding them can significantly help in asthma prevention by reducing the frequency or severity of attacks. (corporatewellnessmagazine.com)
Asthma Severity. (asthma.net)
However, subsequent physiological, imaging and pathological studies demonstrated that the small airways and even the lung parenchyma could be important contributors to the functional impairment seen in certain severe asthma patients, as some reports suggest asthma severity increases in proportion to the involvement of this compartment [ 5 , 6 ]. (ersjournals.com)
Endogenous and exogenous reactive oxygen species, such as superoxide anion, hydroxyl radical, hypohalite radical, and hydrogen peroxide, and reactive nitrogen species, such as nitric oxide, peroxynitrite, and nitrite, play a major role in the airway inflammation and are determinants of asthma severity. (fullscript.com)

model the more chronic type of airway inflammation. (cdc.gov)

The combination of bronchospasm and mucus hypersecretion creates airway obstructions, or narrowed airways. (asthma.net)

An individual small airway has much greater resistance than a large airway, however there are many more small airways than large ones. (wikipedia.org)

Healthy adults experience increased airway resistance at 5 ppm, sneezing and coughing at 10 ppm, and bronchospasm at 20 ppm. (cdc.gov)
Status asthmaticus can vary from a mild form to a severe form with bronchospasm, airway inflammation, and mucus plugging that can cause difficulty breathing, carbon dioxide retention, hypoxemia, and respiratory failure. (medscape.com)
It has a pronounced bronchodilatory effect, preventing or relieving bronchospasm, reduces resistance in the airways. (agpharmaceuticalsnj.com)
Proventil (Albuterol) is used to relieve the tightening and swelling of the airways muscles (bronchospasm) in children and adults suffering from this condition. (agpharmaceuticalsnj.com)

In asthma several of these structural alterations begin early in the disease process, even in the child. (nih.gov)
Asthma is the most common chronic disease in childhood. (medicinenet.com)
The functioning, psychological disturbances general health ailments and social dif- hospital is a quaternary referral centre resulting from airways disease). (who.int)
Asthma is a respiratory disease that causes inflammation of the lungs and throat, which makes breathing extremely difficult. (medicalmarijuana411.com)
Asthma is the most common chronic respiratory disease in Canada, affecting about 2.2 million adults and 0.8 million children. (cmaj.ca)
Dr. Donata Vercelli is a Regents Professor at The University of Arizona, as well as Director of the Arizona Center for the Biology of Complex Diseases, and Associate Director for the Asthma and Airway Disease Research Center. (scireq.com)
Asthma is a chronic lung disease that inflames and narrows the airways. (corporatewellnessmagazine.com)
Undergraduates who spend time in our department can expect to get first hand experience of management of such diseases as tuberculosis, lung cancer, COPD, asthma, sleep-disordered breathing and interstitial lung disease. (tcd.ie)
In the second insights into disease it should exhibit a phenotype of asthma protocol groups of rats were topically dosed with 40 ml of MDI per rat followed by three challenges with 37 mg MDI/m3. (cdc.gov)
Asthma is a common and frequent disease. (hzhongtai.com)
Any diagnostic procedure in severe asthma (or any disease) should have two aims: 1) better understanding or identifying the diagnosis, and 2) providing information on the heterogeneity of asthma phenotypes to guide therapy with the objective of improving outcomes. (ersjournals.com)
We focus on occupational chronic respiratory disease of which chronic obstructive lung disease and asthma are the most significant. (bvsalud.org)
Bronchial asthma occurs in people of all ages, but most often it occurs in children - half of them "outgrow" their bronchial disease. (agpharmaceuticalsnj.com)
I'm also a professor at the University of Manchester and do quite a lot of research on different aspects of fungal disease, particularly aspergillosis, including resistance and new diagnostic tests, and I'm also the leader and president of the Global Action Fund for Fungal Infections, which has as its main objective to improve the quality of care and therefore the outcome of patients with fungal diseases across the world. (cdc.gov)

In atopic patients with asthma, prebronchodilator baseline FEV1/FVC values showed a significant association with the H161R variant. (hindawi.com)
Such an effect in patients with asthma or other bronchospastic conditions is potentially dangerous. (nih.gov)
Few studies have analyzed the effects of daily life physical activity (PA) levels in patients with asthma: moreover, little research has been carried out on PA levels in patients suffering from severe asthma (SA). (frontiersin.org)
The GHQ-28 may be useful for screening for asthma patients who need more attention and therapeutic intervention for psychiatric disorders. (who.int)
Non-smokable options like edibles and tinctures are particularly great choices for patients with asthma. (medicalmarijuana411.com)
Beyond the benefit of sparing the lungs from smoke inhalation, edible cannabis solutions are a better option for asthma patients because it allows for a controlled, higher dosage of THC - the main chemical component in cannabis. (medicalmarijuana411.com)
Evidence also suggests that the THC within cannabis has the ability to expand the lungs and airways, therefore making breathing much easier for asthma patients. (medicalmarijuana411.com)
Recent research in adults, largely based on patients with a previous life threatening attack, has suggested that many such patients have a reduced ability to recognise the deterioration in their asthma, through a decreased ability to perceive the sensation of breathlessness. (bmj.com)
Nitrous oxide should be administered with caution to patients with chronic respiratory problems such as emphysema, chronic bronchitis, pneumothorax, and cystic fibrosis because of hypoxia due to increased airway resistance. (dentalcare.com)
Nitrous oxide is not contraindicated in patients with asthma. (dentalcare.com)
1H MR imaging-derived specific ventilation was significantly greater in the gravitational-dependent versus nondependent lung in healthy subjects (P = .02) but not in patients with asthma (P = .1). (uwo.ca)
In patients with asthma, coregistered 1H MR imaging specific ventilation and hyperpolarized 3He MR imaging maps showed that specific ventilation was diminished in corresponding 3He MR imaging ventilation defects (0.05 ± 0.04) compared with well-ventilated regions (0.09 ± 0.05) (P (uwo.ca)
Patients with chronic persistent asthma may have hyperinflation, as evidenced by an increased total lung capacity (TLC) at plethysmography. (medscape.com)
Are Dehumidifiers Good For Asthma Patients? (hzhongtai.com)
Dust mites and molds are the main allergens in asthma patients worldwide. (hzhongtai.com)
This is also the fundamental reason why asthma patients in southern China's wet areas are higher than those in northern areas. (hzhongtai.com)
Therefore, in the summer wet season, in order to control the humidity, in order to control the growth of mold, and create a comfortable and fresh environment for asthma patients, this requires practical dehumidification and moisture prevention measures. (hzhongtai.com)
If asthma patients live in a humid environment, they often relapse and cough. (hzhongtai.com)
The dehumidifier reduces the number of asthma attacks by removing too much water in the air, which can minimize bacteria and pollutants in the home and protect the health of patients. (hzhongtai.com)
Should lung biopsies be performed in patients with severe asthma? (ersjournals.com)
Identifying these different phenotypes of asthma and assigning patients to phenotype-specific treatments is one of the current conundrums in respiratory medicine. (ersjournals.com)
It is hoped this review will support rational decision-making and provide a detailed synopsis of the varied histopathological features seen in biopsies of patients with a diagnosis of severe asthma. (ersjournals.com)
It has long been appreciated that asthma is an umbrella term for patients meeting certain clinical and physiological criteria, but who differ on the basis of specific clinical, biological and/or therapeutic characteristics [ 2 ]. (ersjournals.com)
A sub-group of 370 randomly selected patients will participate in two follow-up visits on Day 5 - 8 and Day 14 - 21 where they will be tested for antibiotic resistance. (childrenshospital.org)
The panel makes a conditional recommendation for interleukin (IL)-6 receptor antagonist monoclonal antibody treatment and high-flow nasal oxygen or continuous positive airway pressure in patients with hypoxaemic respiratory failure. (bvsalud.org)
Characteristics of Suburban Homes and Allergen Concentration This study investigated the relationship between room characteristics and the actual levels of indoor allergens in the homes of suburban patients with asthma. (medscape.com)
Monotherapy or Combination Therapy for Patients With Asthma This study reviewed the treatment adherence and the effectiveness of combination therapy among adults with asthma. (medscape.com)
Healthcare Costs Associated With Asthma Treatments This study compared the cost of treating patients with inhaled corticosteroids or leukotriene receptor antagonists. (medscape.com)
However, it is difficult for patients to determine when the device is empty, which can affect asthma management. (medscape.com)
Impact of Long-acting Beta Agonist on Dose of Inhaled Corticosteroid This study investigated whether patients could maintain asthma control using a lower dose of inhaled corticosteroid (ICS) if a long-acting beta agonist (LABA) was added to the treatment regimen. (medscape.com)

This also completes the picture of barrel chest, and is another classic sign of a severe asthma episode. (asthma.net)
Indeed, whether a lung biopsy is indicated in the workup of a patient with severe asthma remains an individual decision. (ersjournals.com)

The role of gamma delta T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice. (cdc.gov)
BACKGROUND: Acute exposure to chlorine (Cl2) gas causes epithelial injury and airway dysfunction. (cdc.gov)
In asthma the epithelium appears to be more fragile than that of COPD, the epithelial reticular basement membrane (RBM) is significantly thicker, there is marked enlargement of the mass of bronchial smooth muscle, and emphysema does not occur in the asthmatic nonsmoker. (nih.gov)
In COPD, there is epithelial mucous metaplasia, airway wall fibrosis, and inflammation associated with loss of surrounding alveolar attachments to the outer wall of small airways: bronchiolar smooth muscle is increased also. (nih.gov)
Acute exposure did not affect basal airway epithelial ion transport, but 28 d after sub-chronic exposure alterations in active (Na(+) and Cl) and passive ion transport occurred. (cdc.gov)
In this study, we investigated the effects of, and determine interactions between, HFWD-consumption and silica-exposure on airway epithelial ion transport and smooth muscle reactivity in the F344 rat. (cdc.gov)

Continuous Positive Airway Pressure (CPAP) was thought for many years to be the "gold standard" of treatment for Sleep Disordered Breathing. (sleepgroupsolutions.com)

Functional studies have suggested that IL-17F is involved in asthma pathology. (hindawi.com)
In this review, we discuss the finding that IL-17F has a key role in asthma pathology and is a novel drug target for asthma. (hindawi.com)
Over 100 years ago, autopsy specimens revealed macroscopic pathology within the large airways [ 4 ]. (ersjournals.com)
Not surprisingly, our vet concurred with the radiology specialist that Uli showed classic asthma pathology related to restricted airways and defined bronchial, interstitial cell and alveolar disruption. (ingridking.com)
Airway difficulties may be encountered in numerous scenarios, including head and neck trauma, traumatic airway injury, morbid obesity with or without respiratory distress, thermal injury, upper-airway pathology (eg, Ludwig angina), and term pregnancy (to name only a few examples). (medscape.com)

The aim of this study was to compare air-trapping as quantified by high-resolution computed tomography (HRCT) of the chest with measures of lung function and airway inflammation in children with mild to moderate asthma. (nih.gov)
Other objective measures to help in the diagnosis of pediatric asthma include using a peak flow meter, which can help to estimate lung function. (medicinenet.com)
It is very important to recognize that a child can have poorly-controlled asthma despite completely normal lung function. (medicinenet.com)
Therefore, normal lung function does not preclude the diagnosis of asthma if a physician's clinical suspicion is high. (medicinenet.com)
Taking black seed by mouth along with asthma medicines can improve coughing, wheezing, and lung function in some people with asthma. (medlineplus.gov)

Beta-adrenergic receptor blockade in the bronchi and bronchioles results in increased airway resistance from unopposed parasympathetic activity. (nih.gov)
Narrowing of bronchioles raises airway resistance, e.g., in bronchial or bronchitic asthma. (manualofmedicine.com)

Wheezing is a high-pitched whistling sound produced by turbulent airflow through narrowed airways. (medicinenet.com)
This makes airway resistance increase and the work of breathing more difficult, causing shortness of breath, cough, and wheezing. (corporatewellnessmagazine.com)
Is there a relationship with asthma and wheezing in children? (medscape.com)
Is There a Link Between Wheezing and Persistent Asthma in Young Children? (medscape.com)

During an asthma attack, airways in the lungs can close up and the sufferer of the attack may experience shortness of breath, coughing, and possibly even death. (medicalmarijuana411.com)
The feeling you can't catch your breath, or shortness of breath, is a tell tale symptom of an acute (it's happening now) asthma episode. (asthma.net)

The number of bronchial vessels and the area of the wall occupied by them increase in severe corticosteroid-dependent asthma: it is likely that these increases also occur in severe COPD as they do in bronchiectasis. (nih.gov)
If flow becomes turbulent, and the pressure difference is increased to maintain flow, this response itself increases resistance. (wikipedia.org)
In an asthma exacerbation, the respiratory rate increases, the heart rate increases, and children can look as if breathing is much more difficult. (medicinenet.com)
While IV administration of high-doses of latanoprost in monkeys (i.e., 50-150 times the usual human dose) has been associated with transient increases in airway resistance and blood pressure, latanoprost ophthalmic solution has been used in individuals with bronchial asthma without inducing bronchoconstriction. (regrowth.com)
An airway enhancing botanical formula which decreases resistance in the respiratory airways and increases airflow to the lungs. (fullscript.com)

When triggers come in contact with the airways of an asthmatic, inflammation fills the airways, and they become narrow and filled with mucus. (thedrswolfson.com)

We conclude that short-term NO2 exposure at about 500 micrograms.m3 slightly affects human bronchial responsiveness in subjects with mild asthma. (ersjournals.com)
Environmental factors, such as hypoxia, may also influence the tone of the airway smooth muscle and in addition, alter its responsiveness to various pharmacological agonists. (gla.ac.uk)

Anti-IL-5 therapy, including anti-IL-5Rα (benralizumab), rapidly depletes eosinophils in the blood and airways and also reduces asthma exacerbations and improves quality-of-life scores. (thorasys.com)
There has been a growing interest in the potential role of vitamin D in asthma management, because it might help to reduce upper respiratory infections (such as the common cold) that can lead to exacerbations of asthma. (fullscript.com)

During an asthma attack the airways constrict causing an increase in airway resistance. (wikipedia.org)
Worsening airway inflammation causes the muscles wrapped around airways (bronchiolar muscles) to spasm, constrict, and squeeze airways. (asthma.net)

001), and peripheral airway resistance ( P = .04) were found in all participants. (thorasys.com)

Plethysmography indices, respiratory resistance, and reactance before and after bronchodilator with impulse oscillation (IOS), exhaled nitric oxide (eNO), total eosinophil count (TEC), and serum eosinophil cationic protein (ECP) levels were measured in 21 subjects. (nih.gov)
Airway resistance can be measured using plethysmography. (wikipedia.org)

In respiratory physiology, airway resistance is the resistance of the respiratory tract to airflow during inhalation and exhalation. (wikipedia.org)
While cannabis is most widely consumed by inhalation of smoke, there are other methods of medication that are better suited for asthma sufferers. (medicalmarijuana411.com)
The findings indicate that acute and sub-chronic COV inhalation does not appreciably affect ventilatory properties of the rat, but transient changes in airway epithelium occur. (cdc.gov)

Therefore, diseases affecting the respiratory tract can increase airway resistance. (wikipedia.org)
Antimicrobial, antibacterial and antifungal, thyme has been studied as a therapeutic substance for more than 70 diseases, including bronchitis and asthma . (oneradionetwork.com)
Dr. Vercelli's group research the complex interactions between genetics, epigenetics and the environment that control the susceptibility to complex lung diseases, such as allergy and asthma. (scireq.com)
Numerous reviews on the importance of small airways in asthma and other airway diseases have been published in recent years, including the following [ 8 - 12 ]. (ersjournals.com)

There are several important determinants of airway resistance including: The diameter of the airways Whether airflow is laminar or turbulent In fluid dynamics, the Hagen-Poiseuille equation is a physical law that gives the pressure drop in a fluid flowing through a long cylindrical pipe. (wikipedia.org)

METHODS: C57Bl/6J (wild type) and TCR-delta-/- mice exposed to Cl2 (400 ppm) for 5 minutes underwent measurements of airway responses to i.v. methacholine (MCh) at 1, 3, and 5 days after exposure. (cdc.gov)
Although many clinicians diagnose asthma on the basis of a trial of therapy, objective measurements are necessary to confirm the clinical diagnosis. (cmaj.ca)
Since then, more sophisticated invasive and noninvasive techniques for measurements of the distal airways have supported the importance of distal airway resistance [ 18 , 19 ]. (ersjournals.com)

This shows that larger airways are more prone to turbulent flow than smaller airways. (wikipedia.org)
Excessive mucus may plug the smaller airways, and this creates even more resistance to breathing. (asthma.net)

Airway resistance can also vary between inspiration and expiration: In emphysema there is destruction of the elastic tissue of the lungs which help hold the small airways open. (wikipedia.org)
The study also explains how cannabis interacts with the lungs and airway differently than cigarettes or opiates. (medicalmarijuana411.com)
The airways are tubes that carry air into and out of your lungs, according to NHLBI. (corporatewellnessmagazine.com)
The primary objective in treating Sleep Disordered Breathing is to open the airway to allow a sufficient amount of oxygen into the lungs and bloodstream. (sleepgroupsolutions.com)

The case used here focuses on the diagnosis of asthma in adults. (cmaj.ca)
Children and adults were not born to get asthma. (thedrswolfson.com)
Low blood levels of vitamin D have been linked to increased risk of asthma attacks in children and adults with asthma. (fullscript.com)

Asthmatics have an abnormally large amount of goblet cells (cells that make sputum), making them prone to developing excessive secretions (sputum) just prior to or during acute asthma episodes. (asthma.net)

Irritation caused by inhaling any type of smoke could trigger a dangerous asthma attack which could be life threatening. (medicalmarijuana411.com)
Still, one thing is consistent, when airways come into contact with an trigger, the airways become inflamed, narrow, and fill with mucus.When you have an attack, spasms of the muscles around the airways, inflammation and swelling of the mucosal membrane lining the airways, and excessive amounts of mucus contribute to airway narrowing. (corporatewellnessmagazine.com)
These are stimuli (things that arouse a response) in your environment that trigger the asthma response. (asthma.net)

The swelling also can worsen, making the airways even narrower. (corporatewellnessmagazine.com)
This causes underlying airway inflammation to worsen, making airways twitchy . (asthma.net)

Twenty subjects with mild asthma were exposed at rest in a body plethysmograph, to NO2 at 0, 260, 510 and 1,000 micrograms.m3, for 30 min on four separate days. (ersjournals.com)

They evaluated markers of induced diabetes, levels of eosinophils and airway resistance ( PMC7747657 ). (ingridking.com)

Status asthmaticus is an acute exacerbation of asthma that remains unresponsive to initial treatment with bronchodilators. (medscape.com)
Beginning in 2000, under the leadership of Dr. Charles G. Plopper (UC Davis School of Veterinary Medicine, Emeritus), an important and major effort was initiated to study the development and exacerbation of asthma by oxidant air pollutants in nonhuman primates. (ucdavis.edu)

Obstructed airways act as a barrier that resists, or acts to prevent, the flow of air out of the airways (meaning, during exhalation). (asthma.net)
This increased resistance thereby slows the movement of air during exhalation. (asthma.net)

The diagnosis of asthma in children is often purely clinical. (medicinenet.com)
Improvement with a trial of asthma medications essentially confirms the diagnosis of asthma. (medicinenet.com)
If the child is old enough, they may undergo testing to aid in the diagnosis of asthma. (medicinenet.com)
Chest X-rays can sometimes be helpful to aid in the diagnosis of asthma. (medicinenet.com)
Sara states that she has never received a diagnosis of asthma. (cmaj.ca)
Thus, a conclusive diagnosis of asthma is based on tests designed to detect rapid changes in the forced expiratory volume in 1 second (FEV 1 ) or peak expiratory flow. (cmaj.ca)
Measurement of sputum eosinophilia has been proposed for clinical use in the diagnosis of asthma. (cmaj.ca)

ii) The effect of chronic hypoxia on contractile responses in rat isolated airways. (gla.ac.uk)
iv) The effect of hypoxia on the proliferation of cultured human airway smooth muscle cells. (gla.ac.uk)
It is the failure to oxygenate that leads to hypoxia and the lack of sufficient time to secure an airway. (medscape.com)

gammadelta T cells are present in the mucosal surface of the airways and may contribute to the injury/repair response of the epithelium. (cdc.gov)
In the isolated, perfused trachea preparation the inhibitory effect of the airway epithelium on reactivity to MCh was increased at 90 d post-exposure. (cdc.gov)

Resistance to airflow in the respiratory tract is largely determined by the degree of tone in the smooth muscle layer surrounding the airways. (gla.ac.uk)

It happens due to the fact that the airways over-react to various stimuli. (agpharmaceuticalsnj.com)
Asthma is caused by hypersensitivity to stimuli. (agpharmaceuticalsnj.com)

Does 129 Xe MRI detect airway functional responses to eosinophil depletion after a single benralizumab dose and do airway mucus occlusions mediate this response? (thorasys.com)
however, in many cases, (bronchoalveolar lavage, BAL) and physiologic (Penh) endpoints it may require repeated exposures over weeks or months to to characterize asthma-like responses in rats. (cdc.gov)
In summary, these data suggest that the vigor of setting of ongoing Th2-induced chronic airway inflammation is asthma-like responses appear to be more dependent on the critical and determines the net outcome (Cohn et al. (cdc.gov)
In chronically hypoxic rats, however, the airway smooth muscle appears to be more sensitive to nitric oxide than control rats, which may explain why contractile responses are significantly smaller in the chronically hypoxic rats. (gla.ac.uk)

Using 129 Xe MRI and CT imaging together, it is feasible to measure both airway luminal occlusions and airway ventilation in relationship to anti-IL-5 therapy to ascertain the direct impact of therapy-induced eosinophil depletion on airway function. (thorasys.com)

METHODS A total of 27 children aged 5-16 years (mean age 10) admitted with acute asthma had recordings of oxygen saturation (Sa o 2 ), clinical score, forced expiratory volume in one second (FEV 1 ), and breathlessness score (HMP) at admission and at 5, 10, 24, 48, and 72 hours after admission. (bmj.com)
It is heard during an acute (it's happening now) asthma attack. (asthma.net)
Environmental factors are the primary factors leading to the recurrence or acute occurrence of asthma. (hzhongtai.com)

Anatomy26

Organisms10

Diseases45

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment69

Psychiatry and Psychology4

Phenomena and Processes71

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science5

Named Groups1

Health Care15

Obstruction17

Hyperresponsiveness7

Specific airway resistance3

Degree of airway2

Eosinophilic6

Symptoms30

Pulmonary13

Measure airway resistance1

Allergic11

Causes the airways to narrow2

Inflammatory13

Spirometry4

Severity5

Type of airway1

Mucus hypersecretion1

Small airway1

Bronchospasm4

Disease14

Patients30

Severe asthma2

Epithelial6

Continuous Positive1

Pathology5

Lung function5

Bronchioles2

Wheezing4

Shortness of Bre2

Increases5

Asthmatic1

Responsiveness2

Exacerbations2

Constrict2

Peripheral1

Plethysmography2

Inhalation3

Diseases4

Determinants1

Measurements3

Smaller airways2

Lungs4

Adults3

Asthmatics1

Trigger3

Worsen2

Mild1

Eosinophils1

Exacerbation of asthma2

Exhalation2

Diagnosis of asthma7

Hypoxia3

Epithelium2

Respiratory tract1

Stimuli2

Responses4

Luminal1

Acute3