• Methods and analysis In this prospective, randomised, controlled clinical study, one eye of each patient was injected with OVD1 (Viscopack14) or OVD2 (DuoVisc) during phacoemulsification and intraocular lens implantation. (bmj.com)
  • These methods assume patients that withdraw from the study have outcomes similar to those that complete the study. (amstat.org)
  • therefore, several curative methods have been applied and studied. (biomedcentral.com)
  • Methods and analysis The study is a three-arm cluster-randomised trial with general practices being randomised and outcomes measured at patient level. (bmj.com)
  • METHODS: The Value-based TKR study is a prospective pragmatic multi-center, stepped wedge, cluster randomized controlled trial (SW-RCT). (bvsalud.org)
  • In the past few decades various methods have been proposed to handle missing data of clinical studies, so as to assess the robustness of primary results. (springer.com)
  • Some of the methods are based on the assumption of missing at random (MAR) which assumes subjects who discontinue the treatment will maintain the treatment effect after discontinuation. (springer.com)
  • The agency, however, has expressed concern over methods based on this overly optimistic assumption, because it hardly holds for subjects discontinuing the investigational drug. (springer.com)
  • This type of methods accounts for missing data in an implicit fashion that imputation of missing data is not needed due to its underlying assumption of MAR. Since such assumption usually doesn't hold in a real clinical trial, sponsors are also required to provide additional sensitivity analyses with missing data imputed based on the MNAR assumption [ 6 , 7 ], as further evidences to support the robustness of the primary conclusion. (springer.com)
  • In the past few years, multiple-imputation (MI) based methods have been gaining more popularity and increasingly requested by regulatory agencies, because it can handle more complex or user-defined distribution/assumption in the imputation. (springer.com)
  • Given these assumptions, there are several methods for carrying out the analysis of data, including the EM algorithm, inverse probability weighting, a full Bayesian analysis, direct application of maximum likelihood and multiple imputation. (lshtm.ac.uk)
  • Here we propose a multiple imputation method targeting at "treatment policy" estimand based on the MNAR assumption. (springer.com)
  • Although multiple imputation approaches are always used as sensitivity analyses, this multiple imputation approach can be used as primary analysis for trials with sufficient retrieved dropouts or trials designed to collect retrieved dropouts. (springer.com)
  • I located twenty studies of Vraylar on www.ClinicalTrials.gov , the U.S. government-sponsored registry for clinical trials. (davidhealy.org)
  • Selection of studies Studies had to be randomised controlled trials comparing an SSRI with either placebo or an active non-SSRI control. (bmj.com)
  • 7 A more recent review of data from 77 trials submitted to the US Food and Drug Administration (FDA) found a non-significant increase in suicide rates between patients allocated to SSRIs and those allocated to placebo or other antidepressants. (bmj.com)
  • Overall, we do not believe that these two trials' results will change prescribing practices (we do not think that most HCPs had very serious safety concerns, if any, about DPP-4 inhibitors to begin with), perhaps with slightly more reticence to prescribe DPP-4 inhibitors to patients at risk for heart failure and with slightly more reassurance on pancreatic safety risks. (closeconcerns.com)
  • However, it fell short of the adequate randomized controlled trials (RCTs) and did not have the study quality or numbers to prove the effect of electroacupuncture (EA) therapy for HSP [ 10 ]. (biomedcentral.com)
  • Randomized clinical trials with at least 10 patients who had peri-implant diseases, treated with or without adjunctive antibiotics in combination with surgical or nonsurgical therapies, and with a minimum of at least 3 months of follow-up were included. (quintessence-publishing.com)
  • It can arise due to all sorts of reasons, such as faulty machinery in lab experiments, patients dropping out of clinical trials, or non-response to sensitive items in surveys. (lshtm.ac.uk)
  • This cost-effectiveness analysis was performed alongside two randomised controlled, double-blind, double-dummy, parallel group trials comparing 18 µg tiotropium inhalation capsules administered once daily in the morning via the HandiHaler® device with ipratropium 2 puffs of 20 µg administered four times daily via the metered dose inhaler (MDI) in patients with airway obstruction due to COPD 5 . (ersjournals.com)
  • In this chapter, we discuss key statistical issues for n-of-1 trials-trials of one patient treated multiple times with two or more treatments, usually in a randomized order, with the design under the control of the patient and his or her clinician. (ahrq.gov)
  • When dropouts are imbalanced between two treatment groups in such trials and when selection of subjects to be included in the analysis is related to both the exposure/treatment group and to outcome measures, a selection bias is introduced that may potentially lead to a biased treatment comparison. (medscape.com)
  • The goals were to 1) explore the ways in which respondents interpreted the call-back questions, 2) understand how they formulated answers based on those interpretations, 3) draw conclusions about the concepts measured in each question and 4) describe how each question functions and performs in the context of the purposive sample drawn for this study. (cdc.gov)
  • 8 Because suicides and suicide attempts are rare events, the inability to document an important difference may be a function of the small number of patients in single studies and meta-analyses published to date. (bmj.com)
  • Although in recent years a good number of sensitivity analyses based on missing not at random (MNAR) assumptions have been proposed, some use very conservative assumption on which it might be hard for sponsors and regulators to reach common ground. (springer.com)
  • It's well known that MI analyses based on MAR assumptions treat missing data as ignorable and therefore the impact of such implementations is questionable. (springer.com)
  • Sensitivity analyses investigated the impact of analysis assumptions and unmeasured variables. (cdc.gov)
  • This means that meta analyses are much more reliable than any single study, and when possible they should be the basis for practice recommendations]. (uottawa.ca)
  • Statistical assumptions included a 20% dropout rate in the control arm and a 30% rate in the SYD985 arm, subsequently increased to 30% and 40%, respectively. (medpagetoday.com)
  • Individual patient data was hidden or distorted, statistical tests were massaged, and a company ghostwriter spun a narrative that turned an ineffective, risky drug into a safe and effective treatment. (davidhealy.org)
  • By applying a statistical model analogous to that applied in the above mentioned paper, the present authors have previously found that weight at baseline and change in weight were significant predictors of D L,CO longitudinal increases over an 8-yr period, both in adult males and females from the Po river delta prospective epidemiological study in Italy 9 . (ersjournals.com)
  • Our goal is to help clinical researchers better understand the importance of statistical concepts to experimental success, and to encourage physicians to collaborate with statisticians on study design and analysis. (senseaboutscienceusa.org)
  • Practical and statistical issues in missing data for longitudinal patient-reported outcomes. (senseaboutscienceusa.org)
  • The basic design principles include randomization and counterbalancing, replication and blocking, the number of crossovers needed to optimize statistical power, and the choice of outcomes of interest to the patient and clinician. (ahrq.gov)
  • I thought about this for a minute: one assumption is that the dropout is non-differential, and not biased towards one drug, thereby preserving randomization. (jwatch.org)
  • So, even if the groups are balanced after randomization with respect to important (and unimportant characteristics) like age, gender, weight, baseline A1c levels, etc., the patients who actually receive the group therapy might look quite different from the patients who receive treatment as usual. (rdatagen.net)
  • In cases of dropout, the only approach is to perform a sensitivity analysis to bound the degree of potential bias. (senseaboutscienceusa.org)
  • We usually cannot assess the validity of the assumptions regarding the missingness mechanism, so it is often recommended to examine how robust the inference is to the choice of assumptions in a sensitivity analysis. (lshtm.ac.uk)
  • Treatment with SYD985 significantly improved progression-free survival in comparison with standard physician's choice treatment in patients with HER2-positive metastatic breast cancer with two prior regimens or T-DM1 (trastuzumab emtansine, Kadcyla) in the metastatic setting," she said in conclusion. (medpagetoday.com)
  • SYD985 can provide a new treatment option for patients with pretreated locally advanced or metastatic breast cancer," she added. (medpagetoday.com)
  • Future studies should focus on identifying biomarkers that will guide treatment selection. (medpagetoday.com)
  • TB programs therefore need to ensure that the economically and socially TB patients do not face barriers that keep them from seeking treatment. (who.int)
  • By addressing barriers and reasons for delay to timely diagnosis and treatment by the National TB Program (NTP), costs to TB patients, particularly among the poor, can be effectively reduced [1]. (who.int)
  • Loss of income and direct expenses trigger a downward spiral whereby the patient is less able to complete treatment, more likely to have repeat episodes, and more likely to develop drug resistance resulting in more expensive and arduous treatment [5]. (who.int)
  • A cohort prospective study of the economic burden on individuals and their households, from the start of TB symptoms to the end of treatment in Egypt. (who.int)
  • Study TB patients were followed up bi-monthly till the end of treatment regimen i.e. 6 months. (who.int)
  • Regression of atherosclerosis, as measured by both PAV and TAV, occurred in a majority of patients in both treatment groups. (jwatch.org)
  • Virtual reality (VR) has emerged as a promising treatment approach in rehabilitation for patients with multiple sclerosis (MS) due to its potential to increase patient motivation and rehabilitation adherence. (frontiersin.org)
  • Therefore, we decided to design a proof-of-concept study to assess the synthetic cannabinoid nabilone for the treatment of NMS. (springer.com)
  • A total of 38 patients will have 80% power to detect a probability of 0.231 that an observation in the treatment group is less than an observation in the placebo group using a Wilcoxon rank-sum test with a 0.050 two-sided significance level assuming a true difference of 2.5 points between nabilone and placebo in the primary outcome measure and a standard deviation of the change of 2.4 points. (springer.com)
  • However, if the consequence of withdrawal is the discontinuation from treatment, this assumption may not be valid, leading to allocation that has less than optimal characteristics. (amstat.org)
  • The flaws of this method are particularly prevalent if dropout rates differ between the treatment arms. (amstat.org)
  • We propose a response adaptive allocation ratio that adjusts for dropout, unrelated to unobserved treatment response, and factors in losses associated with discontinuation of treatment. (amstat.org)
  • Despite the intense global research endeavour to improve the treatment of patients with COVID-19, the current therapy remains insufficient, resulting in persisting high mortality. (biomedcentral.com)
  • TNF-α-blocking therapies have proved beneficial in patients with chronic inflammatory diseases and could therefore pose a new treatment option in COVID-19. (biomedcentral.com)
  • Older primary central nervous system lymphoma (PCNSL) patients have an inferior prognosis compared to younger patients because available evidence on best treatment is scarce and treatment delivery is challenging due to comorbidities and reduced performance status. (biomedcentral.com)
  • High-dose chemotherapy and autologous stem cell transplantation (HCT-ASCT) after high-dose methotrexate (MTX)-based immuno-chemotherapy has become an increasingly used treatment approach in eligible elderly PCNSL patients with promising feasibility and efficacy, but has not been compared with conventional chemotherapy approaches. (biomedcentral.com)
  • Geriatric assessment (GA) may be helpful in selecting patients for the best individual treatment choice, but no standardized GA exists to date. (biomedcentral.com)
  • The best treatment strategy for elderly PCNSL patients remains unknown. (biomedcentral.com)
  • Treatments range from palliative to curative but more toxic therapies, and there is no standardized measure to select patients for the right treatment. (biomedcentral.com)
  • Patients will be randomised in a 1:1 ratio into one of the two treatment arms. (biomedcentral.com)
  • 98 patients (25.5%) had persistent synovitis, 106 (27.6%) had received DMARD treatment during follow-up, while 68 (17.7%) were diagnosed with RA. (biomedcentral.com)
  • Features such as erosions and rheumatoid nodules reflect established disease and their value as part of the criteria is questioned in the era of early aggressive treatment, when the aim is to treat patients before bone damage occurs. (biomedcentral.com)
  • Due to HSP, poststroke patients may have difficulty with activities of rehabilitation and a deteriorated quality of life [ 3 ], which is why management or treatment of HSP is considered important. (biomedcentral.com)
  • According to definition in ICH E9 (R1), this proposed approach fully aligns with the treatment policy estimand but its assumption is much more realistic and reasonable. (springer.com)
  • Considering that ACE inhibitors or ARBs are the first-line drugs for antihypertensive treatment in patients with type 2 diabetes (T2D) and have potential "nonclassical" RAS-mediated benefits, it is meaningful to measure the change in the plasma levels of "nonclassical" RAS components after drug treatment. (biomedcentral.com)
  • The original plan was to randomize patients at a clinic to treatment or control, and then follow up with those assigned to the treatment group to see if they wanted to participate. (rdatagen.net)
  • Only human studies describing the type of treatment and the soft tissue outcome following exposure of PTFE-ms or TMs were included. (quintessence-publishing.com)
  • That outcome, however, is not clarinex 5mg tablets anytime soon, especially because so many patients and so many insurers are now seeking to limit medical expenses by denying or modifying treatment. (bluelamp-foundation.org)
  • There is an acute need for more effective treatment options to reduce the burden of this disease for patients, caregivers and society. (ersjournals.com)
  • For simplicity, we will focus on the two-treatment, block pair design in which patients receive each of two treatments in every consecutive pair of periods with separate treatment assignments within each block of two periods, either randomized or in a systematic, balanced design. (ahrq.gov)
  • One way to ensure such standards is to establish a centralized service responsible for crucial study tasks such as providing properly randomized or balanced/counterbalanced treatment sequences to the patient-clinician pair when they are designing the trial. (ahrq.gov)
  • Making assignments in blocks of size two ensures that each patient receives each treatment with the same frequency at a comparable set of times, to avoid poorly balanced designs such as AABA and AABB. (ahrq.gov)
  • Evidence on the efficacy of immunonutrition during immunotherapy in these patients is positive, but still limited some secondary endpoints, such as treatment toxicity and tolerance. (biomedcentral.com)
  • Study endpoints were: treatment response (primary endpoint: progression-free survival), treatment tolerance and toxicity, body weight, body composition, protein-calorie intake, quality of life, fatigue, muscle strength and immunological profile. (biomedcentral.com)
  • The present pilot study, which guarantees early high-quality nutritional care (assessment and treatment) to all patients in agreement with current guidelines and recommendations, could represent one of the first proofs of efficacy of early oral immunonutrition in patients with cancer undergoing immunotherapy. (biomedcentral.com)
  • The median AUC 0-48 and Cmax of rifabutin in patients taking 150 mg rifabutin tiw was significantly reduced compared to the other treatment arms. (biomedcentral.com)
  • Also, medical students are known to be less likely than the general population to identify symptoms of depression or access treatment for the disease when the need arises [ 11 ] in spite of the assumption that they have good access to health care. (researchsquare.com)
  • Thus, it has been postulated that mechanisms to facilitate early detection including prevalence studies, counselling services and treatment of depression among medical students should be provided in medical schools. (researchsquare.com)
  • https://en.wikipedia.org/wiki/Survival_analysis#Definitions_of_common_terms_in_survival_analysis Definitions of common terms in survival analysis] * '''Event''': Death, disease occurrence, disease recurrence, recovery, or other experience of interest * '''Time''': The time from the beginning of an observation period (such as surgery or beginning treatment) to (i) an event, or (ii) end of the study, or (iii) loss of contact or withdrawal from the study. (taichimd.us)
  • It is important to patients and providers to know the longer term effects of psychological treatments for IBS because the disorder has a fluctuating course, and so symptoms may reappear after treatment is completed. (uottawa.ca)
  • Individual interviews will be conducted with patients receiving the home treatment intervention and their family members. (researchprotocols.org)
  • The proposed study will address several areas where there are evidence gaps or contradictory findings relating to the home treatment of acute mental crisis. (researchprotocols.org)
  • We examined how a population susceptible to hepatitis C virus (HCV) moves through the HCV screening and linkage-to-care (SLTC) continuum across insurance providers (Medicare, Medicaid, commercial) and identified opportunities for increasing the number of patients who complete the SLTC process and receive treatment. (ajmc.com)
  • Streamlining the SLTC process by reducing the number of required visits results in more patients completing the process and receiving treatment. (ajmc.com)
  • Reducing steps in the HCV SLTC process increases the number of patients who learn their HCV status, receive appropriate care, and initiate treatment. (ajmc.com)
  • In this prospective single-center 6-months follow-up study, 32 and 16 MS patients will receive VRR or CR, respectively. (frontiersin.org)
  • REMED is a prospective, open-label, randomised controlled trial testing the superiority of dexamethasone 20 mg (dexamethasone 20 mg on days 1-5, followed by dexamethasone 10 mg on days 6-10) vs 6 mg administered once daily intravenously for 10 days in adult patients with moderate or severe ARDS due to confirmed COVID-19. (biomedcentral.com)
  • The study is a multicenter, prospective, randomized, open-label and blinded-endpoint evaluation (PROBE) design. (biomedcentral.com)
  • We conducted a prospective study of a DSME intervention using a quasi-experimental, single-group pretest-posttest design. (cdc.gov)
  • The current study reveals that the network approach offers a viable data-driven methodology for elucidating how paranoia-related mechanisms fluctuate over time and may determine its severity. (frontiersin.org)
  • However, the study was an observational study with a small sample size, and it did not measure the plasma levels of ACE2 or Ang-(1-7). (biomedcentral.com)
  • Clinical effectiveness data are sparse, but a recent observational study demonstrated lower vaccine effectiveness against influenza illness (≈20%) in patients with cancer compared with the general population (≈42%) ( 12 , 13 ). (cdc.gov)
  • As a result, the system being deployed "does not meet clinicians' needs and poses risks to the continuity of patient care. (histalk2.com)
  • The study cohort included a sample of the newly diagnosed TB patients that registered in the National TB Program (NTP) during the first quarter of 2019. (who.int)
  • it applies principles of the chronic care model, including community-clinic linkages, to the management of patients newly diagnosed with diabetes and prediabetes through screening. (cdc.gov)
  • Eligible patients had received at least two prior therapies or T-DM1 for metastatic disease. (medpagetoday.com)
  • Patients judged transplant eligible will be randomized (1:1). (biomedcentral.com)
  • Of 384 patients eligible for one year follow-up (56.3% females, mean (SD) age 45.8 (14.7) years, median (IQR) duration of arthritis 31 (10-62) days), 14.4% were anti-CCP2 positive, and 11.2% were IgM RF positive. (biomedcentral.com)
  • Study protocol DM1 eligible patients were randomized one month following pacemaker implantation into two groups: 1). (plcsignaling.com)
  • Information was obtained from 522 medical students that were eligible to participate in the study using self-administered structured questionnaire. (researchsquare.com)
  • Data gathered from the PROTein to Enhance outComes of (pre)frail paTients undergoing Cardiac Surgery Study will be published in peer-reviewed journals and presented at national and international conferences. (bmj.com)
  • PRIZE will be the first study to provide important data on the effects of febuxostat on atherosclerosis in patients with asymptomatic hyperuricemia. (biomedcentral.com)
  • The study is an initial result that will develop context-sensitive common data models for genetic rare diseases. (bvsalud.org)
  • In general, the idea of personalized decision-making support based on patient data has driven the motivation of researchers in the medical domain for more than a decade, but the overall sparsity and scarcity of data are still major limitations. (bvsalud.org)
  • This is in contrast to currently applied technology that allows us to generate and analyze patient data in diverse forms, such as tabular data on health records, medical images, genomics data, or even audio and video. (bvsalud.org)
  • Consequently, ML-assisted decision-support can be interpreted more conveniently, using more relevant patient data at hand. (bvsalud.org)
  • In this review, we will give for the first time insights towards current perspectives and potential impacts of using synthetic data generation in palliative care screening because it is a challenging prime example of highly individualized, sparsely available patient information. (bvsalud.org)
  • It imputes missing data using information from retrieved dropouts defined as subjects who remain in the study despite occurrence of intercurrent events. (springer.com)
  • Then imputed data long with completers and retrieved dropouts are analyzed altogether and finally multiple results are summarized into a single estimate. (springer.com)
  • There were also apparently concerns with ensuring that clinicians knew what data was migrated and how to find it as well as not having appropriate security rights to see critical patient care data, such as immunizations. (histalk2.com)
  • Standards should be applied in the prevention and handling of missing data for patient-centered outcomes research: a systematic review and expert consensus. (senseaboutscienceusa.org)
  • You're likely to have dropouts - and because of dropouts you'll probably have missing data. (senseaboutscienceusa.org)
  • While the best approach is to design your study to minimize the risk of missing data, our goal here is to show you how to recognize missingness when it occurs, what to do about it - and when to talk to a statistician. (senseaboutscienceusa.org)
  • If you are planning a study, or analysing a study with missing data, these guidelines (pdf, 25Kb) are for you. (lshtm.ac.uk)
  • Analysis of data with missing observations involves, firstly, constructing a suitable set of assumptions about why the data is missing in the study. (lshtm.ac.uk)
  • Although data exist on the prevalence of some immunosuppressive conditions, the total burden of these conditions in the United States remains unknown, particularly when considering patients who are receiving emerging immunosuppressive therapies ( 6 - 8 ). (cdc.gov)
  • This study uses data obtained from the Nigeria HIV/AIDS Indicator and Impact Survey (NAIIS) to describe the prevalence and distribution of HIVDR in Nigeria. (cdc.gov)
  • As of October 2021, data for the nonrandomized, quasi-experimental study and the qualitative study have been collected, and the results are expected to be published by the end of the year. (researchprotocols.org)
  • Today, most studies regarding the prevalence of homosexuality involve adult subjects (5-10%), but these figures also appear to be consistent with the available data concerning adolescents. (medscape.com)
  • Weights were assigned to individual patients, depending on their age, and standardization was carried out using weighted individual data. (who.int)
  • The objective of this study was to identify and compare predictors of three relevant outcomes of chronic arthritis in a cohort of very early arthritis patients. (biomedcentral.com)
  • The Norwegian Very Early Arthritis Cohort (NOR-VEAC) includes adult patients with at least one swollen joint of ≤16 weeks' duration. (biomedcentral.com)
  • A cohort of 10,000 HCV-susceptible patients was simulated through the HCV SLTC process using a Markov model with parameters from published literature. (ajmc.com)
  • Given that information on patient satisfaction with VRR is scarce, the primary objective of this study is to assess long-term patient satisfaction with a novel VRR program. (frontiersin.org)
  • The objective of this study protocol is to conduct a double-center, randomized, patient- and assessor-blinded, sham-controlled, parallel clinical trial in order to show the effectiveness and safety of EA therapy for stroke survivors with HSP. (biomedcentral.com)
  • The objective of this study was to evaluate a home-based DSME intervention in rural Guatemala. (cdc.gov)
  • In fact, in a pilot study, it was quite difficult to recruit some patients, because the group therapy sessions were frequently provided during working hours. (rdatagen.net)
  • We expect this double-center, randomized, sham-controlled, patient- and assessor-blinded parallel trial to explore the effectiveness and safety of EA therapy, compared with sham EA, for poststroke shoulder pain. (biomedcentral.com)
  • To improve both equity and outcome of TB management through identifying the economic barriers that hinder the proper care provided for TB patients. (who.int)
  • Patients and outcome assessors will be blinded throughout the entire study. (biomedcentral.com)
  • The primary outcome is patients' decision quality measured with the Decision Quality Instrument (DQI)-Knee Osteoarthritis questionnaire. (bvsalud.org)
  • Each grade represents a group of patients with a different prognosis, and the risk or rate (hazard) of the outcome increases with higher grades. (bmj.com)
  • Here's the rub: at the root of many biomedical studies is a need for a valid estimate of the relationship between an exposure and outcome. (senseaboutscienceusa.org)
  • Active follow-up is necessary in the absence of a may be required until the event of interest (any death reliable health information system, and it may is the outcome studied in this publication) occurs in supplement the latter in case of incomplete passive all cases studied and maintenance of surveillance on follow-up. (who.int)
  • We try to eliminate the bias due to differential dropout by removing the matched patient every time a patient randomized to therapy declines to participate. (rdatagen.net)
  • While we will not completely remove bias, it may be the best we can do given the baseline information we have about the patients. (rdatagen.net)
  • The primary analysis will use multilevel modelling to account for repeated measurement of outcomes in patients clustered within practices. (bmj.com)
  • In fact, some studies indicate that those who undergo surgery, radiation, or chemotherapy - the traditional treatments - are likely to die earlier than those who don't. (thesunmagazine.org)
  • We hypothesize that early systematic provision of ONS with a high-protein-high calorie mixture containing immunonutrients (Impact®) in addition to nutritional counseling, compared to nutritional counseling alone, is beneficial to patients with NSCLC receiving immunotherapy with or without chemotherapy. (biomedcentral.com)
  • Sixteen patients with TB-HIV co-infection received rifabutin 300 mg QD in combination with tuberculosis chemotherapy (initially pyrazinamide, isoniazid and ethambutol then only isoniazid), and were then randomized to receive isoniazid and LPV/r based ART with rifabutin 150 mg tiw or rifabutin 150 mg daily. (biomedcentral.com)
  • This study should be the basis for further evaluations of long-term efficacy and safety of the use of cannabinoids in PD patients. (springer.com)
  • We aim to compare two different doses of dexamethasone in patients with moderate to severe ARDS undergoing mechanical ventilation regarding efficacy and safety. (biomedcentral.com)
  • We designed the present study to evaluate the efficacy of early systematic provision of ONS enriched with immunonutrients compared to nutritional counseling alone, in patients with NSCLC undergoing immunotherapy. (biomedcentral.com)
  • Immunonutrition represents a promising approach also in patients with NSCLC, but evidence on its efficacy on clinical outcomes during immunotherapy is still inconclusive. (biomedcentral.com)
  • Among patients with measurable disease at baseline (about 85% of the population), the overall response rate was 28-29% in each group, but the average reduction in the target lesion was 70.2% with SYD985 versus 58.2% with standard therapy. (medpagetoday.com)
  • however, it was instructive to learn that saxagliptin did not have a significant impact on the risk of overall hypoglycemia unless patients were on sulfonylureas, or if they had a baseline A1c below 7% and were on combination therapy involving insulin. (closeconcerns.com)
  • Trough FEV 1 was improved above baseline by 120 mL after 1 yr for patients receiving tiotropium, whereas it was declined by 30 mL for patients receiving ipratropium. (ersjournals.com)
  • Among antibody-positive patients, 76% of those with Medicaid and 71% of those with Medicare and commercial insurance are lost to follow-up in baseline. (ajmc.com)
  • The cost to identify and link 1 additional infected patient to care ranges from $1586 to $2546 in baseline and $212 to $548 in consolidated. (ajmc.com)
  • The aim of this study was to evaluate the effects of body mass index (BMI) changes over an 8-yr follow-up, on longitudinal changes of vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in one second (FEV 1 ), and carbon monoxide diffusing capacity of the lung ( D L,CO ) indices in a general population sample of North Italy. (ersjournals.com)
  • Body weight, but not BMI, change was included among predictors of longitudinal change of D L,CO in adults from the Tucson Epidemiological Study of Obstructive Lung Disease, although its effect was not specifically addressed 8 . (ersjournals.com)
  • The aim of this study was to evaluate the effects of changes of BMI, over an 8-yr follow-up, on longitudinal changes of slow vital capacity (VC), FVC, FEV 1 , and D L,CO in a general population sample of North Italy. (ersjournals.com)
  • The second phase, funded under the R33, will provide support to assess the abilities of the quantitative measures developed in the R61 phase to measure tissue changes in response to therapies or manipulations that may relieve pain using rigorous, longitudinal clinical study design. (nih.gov)
  • A significant increase in the odds of suicide attempts (odds ratio 2.28, 95% confidence 1.14 to 4.55, number needed to treat to harm 684) was observed for patients receiving SSRIs compared with placebo. (bmj.com)
  • Discussion Our systematic review, which included a total of 87 650 patients, documented an association between suicide attempts and the use of SSRIs. (bmj.com)
  • This is of relevance as depression has adverse consequences including suicide, school dropout and drug abuse. (researchsquare.com)
  • This study protocol is aimed at showing the effectiveness and safety of electroacupuncture therapy for stroke survivors with shoulder pain. (biomedcentral.com)
  • When there is no dropout, our allocation ratio reduces to previously published response adaptive allocation ratios. (amstat.org)
  • Patients were randomised to tiotropium (18 µg once daily) or ipratropium (2 puffs of 20 µg administered four times daily) in a ratio of 2:1. (ersjournals.com)
  • In the late 1990s and early 2000s, clarinex maximum dosage faced with a new set of challenges: a rising tide of patient demand and a burgeoning population of uninsured patients that were unable yet to obtain sufficient coverage from commercial insurers. (bluelamp-foundation.org)
  • Future studies should test these hypotheses in high-risk patient populations, such as those affected by endothelial corneal dysfunction or glaucoma/hypertension. (bmj.com)
  • Order affordable clarinex online to reach out to new patient populations, to the extent that you can. (bluelamp-foundation.org)
  • [ 1 , 2 ] In 1993, Diamond and colleagues performed a review of studies conducted with various populations and concluded that the prevalence of predominant homosexual attraction was lower than Kinsey had predicted. (medscape.com)
  • Previous recruitment efforts in related PRAMS cognitive evaluation studies were inordinately difficult and the same was true in this study.3 Recruitment was challenging for both English- and Spanish-speaking populations. (cdc.gov)
  • We investigated the effects of olmesartan on the changes in serum ACE2 and Ang-(1-7) levels as well as kidney and vascular function in patients with type 2 diabetes and hypertension. (biomedcentral.com)
  • Screening high-risk patients to detect diabetes and prediabetes was cost-effective (7-9), and prevention of type 2 diabetes in people with prediabetes through adoption of appropriate lifestyle changes and pharmacologic interventions has been successful in experimental settings (10). (cdc.gov)
  • When compared to psychoactive medications, review studies have found CBT alone to be as effective for treating less severe forms of depression, anxiety, post-traumatic stress disorder (PTSD), tics, substance use disorders, eating disorders, and borderline personality disorder. (wikipedia.org)
  • The rationale behind this approach is derived from the hypothesis that the physician at the time of a disease-modifying anti-rheumatic drug (DMARD) prescription assumes the patient to be at high risk of developing chronic and severe disease. (biomedcentral.com)
  • Findings from this study will allow local services to improve their effectiveness in a challenging domain of public health and contribute to improving access to more effective care for people with severe mental disorders. (researchprotocols.org)
  • The EKIT tool provides (1) a systematic presentation of individual patient and disease-specific information (symptoms, expectations), (2) the fulfillment of the indication criteria and (3) health information about safety and effectiveness of TKR. (bvsalud.org)
  • Enhanced recovery protocols (ERPs), such as prehabilitation, have been associated with a reduction in complications after CS in vulnerable patients. (bmj.com)
  • Prognostic evidence arises from prognosis studies, which aim to examine and predict future outcomes (such as death, disease progression, side effects or medical complications like pre-eclampsia) in people with a particular health condition or start point (such as those developing a certain disease, undergoing surgery, or women who are pregnant). (bmj.com)
  • Immunosuppressed patients have a high risk for influenza complications and an impaired immune response to vaccines. (cdc.gov)
  • Exploration of prescribing error reporting across primary care: a qualitative study. (ahrq.gov)
  • This study includes an interventional, nonrandomized, quasi-experimental study combined with a qualitative study and an economic evaluation to be conducted over a 48-month period. (researchprotocols.org)
  • This study reports on the development of a system for standardizing root cause analysis of sentinel events . (ahrq.gov)
  • Differing perceptions of safety culture across job roles in the ambulatory setting: analysis of the AHRQ Medical Office Survey on Patient Safety Culture. (ahrq.gov)
  • Analysis is important, but study design is paramount. (rdatagen.net)
  • If a patient declines, she and her matched pair are removed from the study (i.e. their outcomes will not be included in the final analysis). (rdatagen.net)
  • A meta-analysis of observational studies of influenza vaccines identified that pooled vaccine effectiveness was 33%-67% against medically attended, laboratory-confirmed influenza illness in the overall population ( 10 ). (cdc.gov)
  • In this meta analysis of the Client Experiencing Scale, Pascual-Leone and Yeryomenko systematically reviewed the research literature and found 10 studies of 406 clients that evaluated the scale`s association with client outcomes. (uottawa.ca)
  • In their meta analysis, Laird and colleagues reviewed 41 studies that recruited almost 2,300 adult patients. (uottawa.ca)
  • A note about meta analysis: Meta analysis combines the standardized effect sizes ( d ) across many studies to estimate an average effect size. (uottawa.ca)
  • The study population had a median age of about 57, a median duration of metastatic disease of 3 to 3.5 years, and a median of four to five prior metastatic regimens. (medpagetoday.com)
  • Tiotropium is a new inhaled bronchodilator for patients with COPD with a sustained duration of action indicated for once daily dosing 4 . (ersjournals.com)
  • After choosing the identity and duration of the treatments to be given, the patient and his/her clinician must be given a sequence of treatments in such a way that the validity of the experimental process is maintained. (ahrq.gov)
  • The Ethics Committee of the Friedrich Schiller University Jena (2021-2236-AMG-ff) and the Paul-Ehrlich-Institute (4513/01) approved the study. (biomedcentral.com)
  • This cross sectional and case controlled study was performed at the perinatology clinic of the Erciyes University School of Medicine between 15.01.2020 and 01.08.2021. (biomedcentral.com)
  • Kaufman Hall's latest Physician Flash Report shows higher patient volumes helping drive revenue growth in 2021. (histalk2.com)
  • These increases are partly attributed to patients presenting for care after deferring it during 2020 and early 2021. (histalk2.com)
  • Prognostic studies indicate that the number of TKR will further increase constituting growing burden on healthcare systems. (bvsalud.org)
  • Although thousands of prognostic factor studies are published each year, often they are of variable quality and the findings are inconsistent. (bmj.com)
  • The long-term outcomes of this study are to assess long-term consequences on mortality and quality of life at 180 and 360 days. (biomedcentral.com)
  • With regard to clinical studies, large BMI values have been shown to be an independent determinant of increased diffusion indexes in groups of patients with chronic obstructive pulmonary disease (COPD) 10 and obstructive sleep-apnoea 11 . (ersjournals.com)
  • Positive ACPA status and small joint arthritis were consistent predictors of three relevant outcomes of chronic arthritis in very early arthritis patients. (biomedcentral.com)
  • The aim of this paper is to assess the health economic consequences of substituting ipratropium with the new, once-daily bronchodilator tiotropium in patients with a diagnosis of chronic obstructive pulmonary disease (COPD). (ersjournals.com)
  • Substituting tiotropium for ipratropium in chronic obstructive pulmonary disease patients offers improved health outcomes and is associated with increased costs of 180 per patient per year. (ersjournals.com)
  • In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Preventing Chronic Disease . (cdc.gov)
  • However, it is hypothetically possible that one of the statins may preferentially drive decision-making based on its effects on patient symptoms etc (whether through CVD benefits on angina or side-effects of the drugs). (jwatch.org)
  • Additionally, the study will provide information on long-term adherence, changes in motor symptoms, cognitive functions and patient-reported outcomes after the rehabilitation program. (frontiersin.org)
  • Although open-label observations report a positive effect of cannabinoids on non-motor symptoms (NMS) in Parkinson's disease (PD) patients, these effects remain to be investigated in a controlled trial for a broader use in NMS in PD patients. (springer.com)
  • Patient reported impact of symptoms in amyotrophic lateral sclerosis (PRISM-ALS): A national, cross-sectional study. (cdc.gov)
  • Nevertheless, the criteria have been widely used in the clinical setting, even in the assessment of patients with recent-onset arthritis, and it can be assumed that rheumatologists often consider the fulfilment of these criteria when evaluating the diagnosis and/or prognosis in their arthritis patients [ 6 ]. (biomedcentral.com)
  • The results of this study will inform the policy makers about the situation of economic burden among patients with TB in Egypt. (who.int)
  • The results from this study will help to gather valuable knowledge on the use of rehabilitation with a new VR tool in MS patients. (frontiersin.org)
  • Results The study enrolled 127 patients. (bmj.com)
  • Future studies are mandatory to support these preliminary results. (bmj.com)
  • Our results indicate that DuoVisc might be favoured in patients with cornea guttata or low endothelial cell count. (bmj.com)
  • They wouldn't have to worry if the study design was seen as biased, or the results too good to be true. (davidhealy.org)
  • This could affect their personal welfare, and the reliability of the study results as well. (davidhealy.org)
  • The results of this study could influence the therapy of patients with COVID-19 and affect the course of the disease worldwide, as infliximab is globally available and approved by several international drug agencies. (biomedcentral.com)
  • Based on the favourable results of these studies, it is suggested that "if the cost is not prohibitive, bronchodilation in moderate COPD could move to once-daily tiotropium" 8 . (ersjournals.com)
  • Streamlining the HCV SLTC process results in more patients who are aware of their HCV status, receive appropriate care, and are ultimately treated. (ajmc.com)
  • I think more such comparative effectiveness studies are very helpful and critical in providing cost-effective clinical care. (jwatch.org)
  • One of the key features for rehabilitation adherence is patient satisfaction with the VR rehabilitation (VRR) program, and information on user satisfaction and not only effectiveness is required to systematically include VRR in routine clinical practice. (frontiersin.org)
  • Incremental cost-effectiveness ratios were 667 per exacerbation avoided and 1084 per patient with a relevant improvement on the SGRQ. (ersjournals.com)
  • This study aims to assess the acceptability, effectiveness, and cost-effectiveness of a new CRHT intervention in Ticino, Southern Switzerland. (researchprotocols.org)
  • The main purpose of this study was to investigate the effectiveness of lifestyle counselling by phone or e-mail on body weight, in an overweight working population. (biomedcentral.com)
  • After discussing the design of the study (n=6,103, event-driven, with a glimepiride comparator group and estimated run time of six to seven years), he highlighted the exceptional differences between CAROLINA and other CVOTs for DPP-4 inhibitors, especially SAVOR-TIMI 53 (for BMS/AZ's Onglyza [saxagliptin]) and EXAMINE (for Takeda's Nesina [alogliptin]. (closeconcerns.com)
  • The concern with this design is that only those patients randomized to the intervention arm of the study have an opportunity to make a choice about participating. (rdatagen.net)
  • However, we decided to address the issue of differential non-participation in the actual design of the study. (rdatagen.net)
  • We will stagger implementation of the enhanced system across the 6 clinics allowing comparison, through a quasi-experimental design (pre-post difference with a control group), of patients treated in the enhanced system with similar patients treated in the standard system. (cdc.gov)
  • Individual characteristics of study participants associated with HIVDR were identified using a weighted multivariable logistic regression model. (cdc.gov)
  • Impact of a pharmacist-facilitated hospital discharge program: a quasi-experimental study. (ahrq.gov)
  • Sixty-two patients undergoing TKA with simple spinal analgesia and ACB were randomized to receive either LIA (group A+L) or placebo LIA (group A). Postoperative visual analog scale (VAS) score for pain, Timed Up and Go (TUG) test and quadriceps strength, total dosage of rescue analgesia, time to first rescue analgesia, and adverse events were serially evaluated from postoperative day 1 to 3 months. (jksrr.org)
  • Both groups had similarly high rates of patient satisfaction with low adverse event rates. (jksrr.org)
  • An optimized hepatitis C virus screening and linkage-to-care process reduces the number of patients lost to follow-up and improves linkage to care for Medicare, Medicaid, and commercially insured patients. (ajmc.com)
  • Many experimental studies have suggested that xanthine oxidase inhibitors have anti-atherosclerotic effects by decreasing in vitro and in vivo oxidative stress. (biomedcentral.com)
  • However, there is only limited evidence on the clinical implications of xanthine oxidase inhibitors on atherosclerotic cardiovascular disease in patients with hyperuricemia. (biomedcentral.com)
  • The diagnosis of Steinert disease, firstly Inhibitors,research,lifescience,medical based on family history and clinical evaluation, had been subsequently confirmed by genetic test in all patients, to evaluate the CTG triplet expansion. (plcsignaling.com)
  • Patients implanted with conventional dual-chamber pacing Inhibitors,research,lifescience,medical mode (DDDR group) and 2): Patients implanted with DDDR plus APP algorithm (APP ON group). (plcsignaling.com)
  • An association between change in inhibitors weight and change in the UPDRS "off" medications may therefore be elusive, as the majority of the DBS patients sustain both improvement in motor function and weight gain. (plcsignaling.com)
  • and weight in patients with and without DBS, it would be reasonable to expect worsening of the UPDRS "off" and relative weight loss in patients without DBS and improvements in the UPDRS "off" and weight gain in patients with DBS, increasing the likelihood of a correlation between improvement in motor function and weight Inhibitors,research,lifescience,medical gain. (plcsignaling.com)
  • For instance, disruption of the melanocortin system associated Inhibitors,research,lifescience,medical with DBS therapy has been implicated in weight changes in patients with PD (Escamilla-Sevilla et al. (plcsignaling.com)
  • The study aimed to determine the prevalence of depression and associated factors among medical students in Nigeria. (researchsquare.com)
  • [ 3 ] studies have shown that the prevalence of depression is higher among medical students than their peers in other faculties. (researchsquare.com)
  • [ 9 ] A study in a medical school in Nigeria revealed that the prevalence of stress among medical students is very high. (researchsquare.com)
  • [ 10 ] This supports the need for studies on prevalence of depression among medical students. (researchsquare.com)
  • We designed the PRIZE study to evaluate the effects of febuxostat on a surrogate marker of cardiovascular disease risk, ultrasonography-based intima-media thickness of the carotid artery in patients with hyperuricemia. (biomedcentral.com)
  • In Egypt, there were no published studies that have estimated the total catastrophic costs of TB diagnosis and management on patients and households. (who.int)
  • We will generate a list of patients based on a recent pre-diabetes diagnosis. (rdatagen.net)
  • Patients had a diagnosis of COPD and a forced expiratory volume in one second (FEV 1 ) ≤65% predicted normal. (ersjournals.com)
  • Since diagnosis, patients with non-small cell lung cancer (NSCLC) frequently present a variable impairment of nutritional status. (biomedcentral.com)
  • One case of uveitis (grade 4), occurred in a patient taking rifabutin 300 mg daily prior to starting ART, and grade 3 neutropenia (asymptomatic) was reported in 4 patients. (biomedcentral.com)
  • The average number of trial sites per study? (davidhealy.org)
  • In this phase-2 clinical trial, patients with COVID-19 and clinical and laboratory signs of hyperinflammation will be randomised to receive either one dose of infliximab (5 mg/kg body weight) in addition to the standard of care or the standard of care alone. (biomedcentral.com)
  • One of the appealing features for the n-of-1 trial lies in its allowing the patient and clinician to devise an individualized trial with idiosyncratic treatments and outcomes run in real-world settings. (ahrq.gov)
  • We next discuss common clinical crossover trial standards that continue to apply in n-of-1 studies. (ahrq.gov)
  • Interestingly, the integration of patient context has been insufficiently considered, but might tremendously improve the accuracy of predictive models for individual patients. (bvsalud.org)
  • Six clinics in a primary care network in New York City, 3 of which are federally qualified health centers, have established an evidence-based diabetes management system grounded in CCM principles in the context of developing a patient-centered medical home in each clinic (14). (cdc.gov)
  • Current challenges of rare diseases need to involve patients, physicians, and the research community to generate new insights on comprehensive patient cohorts. (bvsalud.org)
  • In the coming decades, general practitioners, respiratory physicians and other healthcare providers will be confronted with an increasing share of their patient population being COPD patients 2 . (ersjournals.com)
  • As defined by the National Committee for Quality Assurance, a patient-centered medical home is a health care setting that facilitates partnerships between patients and their physicians through the use of registries, information technology, and health information exchange. (cdc.gov)
  • The NMS-Nab Study is as a mono-centric phase II, randomized, placebo-controlled, double-blind, parallel-group, enriched enrollment withdrawal study. (springer.com)
  • The target patient group in which potential new criteria will be applied is probably wider and more diverse than patients fulfilling the current ACR criteria alone. (biomedcentral.com)
  • I am involved with the Diabetes Research, Education, and Action for Minorities (DREAM) Initiative, which is, among other things, estimating the effect of a group-based therapy program on weight loss for patients who have been identified as pre-diabetic (which means they have elevated HbA1c levels). (rdatagen.net)
  • After the pairs have been created, the research study coordinators reach out to the individuals who have been randomized to the therapy group in an effort to recruit participants. (rdatagen.net)
  • 2009). A potential confound of these studies is that they are relatively small and lack a control group without the DBS intervention. (plcsignaling.com)
  • Mean annual healthcare costs including the acquisition cost of the study drugs were 1721 (sem 160) in the tiotropium group and 1,541 (SEM 163) in the ipratropium group (difference 180). (ersjournals.com)
  • The quasi-experimental evaluation involves two groups: patients in the northern area of the region who were offered the CRHT service (ie, intervention group) and patients in the southern area of the region who received care as usual (ie, control group). (researchprotocols.org)
  • However, group A+L had a significantly longer time for postoperative rescue analgesia (491 minutes vs. 143 minutes, p=0.04) with less patients requiring rescue analgesia during 6 hours after surgery (16.7% vs. 43.3%, p=0.024). (jksrr.org)
  • Of note, drop-outs were rare in the PCI group (1 of 104 patients did not have PCI), whereas they were more frequent in the placebo group (8 of 95). (medscape.com)
  • Four patients of the placebo group had a dissection requiring PCI and four were withdrawn during follow-up, two because of a chest pain admission, one for a COPD exacerbation with right sided heart failure, and one for bilateral leg pain, all four of whom would likely have had worse exercise performance than average. (medscape.com)
  • Of note, of 170 patients with either isolated LAD or RCA disease, 53% of patients had proximal or ostial disease-known to cause more pronounced ischaemia-in the PCI group compared to only 36% of the placebo group. (medscape.com)
  • One-hundred and fifty CS patients will be randomised to receive either a leucine-rich protein supplement or a placebo with no supplemented protein. (bmj.com)
  • In addition to administering the study drug, we will also direct lifestyle modification in all participants, including advice on control of body weight, sleep, exercise and healthy diet. (biomedcentral.com)
  • All study sites will follow routine care as control clusters until the start of the intervention. (bvsalud.org)
  • The PRIMAIN phase II, single arm study created some evidence on conventional therapy with R-MP and procarbazine maintenance with 1- and 2-year progression free survival (PFS) rates of 46.3% and 37.3% and respective overall survival (OS) rates after 1 and 2 years of 56.7% and 47% [ 10 ]. (biomedcentral.com)
  • Adequate and complete follow-up is a prerequisite for the conduct of any survival study. (who.int)
  • Adequate and complete follow-up is a prerequisite to conducting a survival study. (who.int)
  • During the study period, a total of 8 participants were dropped, and the completion rate was 98.0% (412/420). (jmir.org)
  • The study population included participants aged 15-64years who tested positive for HIV, had a viral load at least 1000copies/ml, and had available HIV drug resistance genotypes. (cdc.gov)
  • In total, there will be 10 clusters (study sites) and 6 sequential steps over 16 month, with clusters receiving the intervention with a minimum 2 months of standard routine care. (bvsalud.org)
  • I agree that this was effectively a negative study, despite the emphasis during the presentation on the modest superiority of rosuvastatin on serum cholesterol values and total atheroma volume. (jwatch.org)
  • Given that a study on Novartis' Galvus (vildagliptin) found that the drug had an effect on ventricular size, Dr. Sattar noted that a class-wide effect cannot be ruled out. (closeconcerns.com)
  • The ATSDR is involved and I should see Dr. Wendy Kaye, which I begged and pleaded many a time from the first and Marie Socha from when the study started in 2000. (cdc.gov)
  • The likely answer is that one ADC does not fit the needs of all patients with metastatic HER2-positive breast cancer. (medpagetoday.com)