Objective: To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ϵ4 alleles, the most potent genetic risk factor for ICH. (elsevierpure.com)
Design, Setting, and Participants: This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. (elsevierpure.com)
A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. (elsevierpure.com)
APOE ϵ2 and ϵ4 did not show an association with nonlobar ICH risk in any race/ethnicity. (elsevierpure.com)
Independent associations of TOMM40 and APOE variants with body mass index. (sdu.dk)
Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
Several major APOE isoforms can be distinguished: E2, E3, and E4. (dovepress.com)
The results presented demonstrate that the association between ApoE gene and CVD may be modulated by the presence of MetS, with an increased CV burden observed among E4 allele carriers with the syndrome. (biomedcentral.com)
The characteristic components of the syndrome are mostly determined by apolipoprotein E (ApoE) modulation of atherogenic plasma Apo-B containing lipoproteins. (biomedcentral.com)
There was no correlation between carriers and noncarriers of apolipoprotein E (ApoE) allele and baseline periodontitis or cognitive decline. (naturalmedicinejournal.com)
Corbo RM, Scacchi R. Apolipoprotein E (APOE) allele distribution in the world. (medscape.com)
Common variants in the cholesteryl ester transfer protein (CETP-629C/A), lipoprotein lipase (LPL S447X), hepatic lipase (HL-480C/T) and apolipoprotein E (apoE e2/e3/e4) genes were studied in relation to LDL particle size distribution in 377 healthy, middle-aged men. (ox.ac.uk)
A model that included current age and the number of E2 alleles at the APOE locus as covariates gave a lod score of 4.1. (findzebra.com)
They suggested that this type of AD is biologically independent of APOE and that its association with E2 in their data set was the result of E4-related attrition at earlier ages. (findzebra.com)
Notably, the gene APOE identified by the 2017-based analysis has been implicated to have an association with ASD in a recent study (2018) with DNA methylation analysis. (silverchair.com)
Alleles2
Apo E has three different alleles (E2, E3 and E4) determining different and complex associations with clinical phenotype expressions. (biomedcentral.com)
In our study, the presence of at least one APOEe4 allele was associated with reduced odds of having high WMH volume, suggesting that other APOEe 307538-42-7 alleles (i.e. e2 and/or e3) may increase the odds of high WMH volume. (signsin1dayinc.com)
Variants4
Association between Apolipoprotein E Variants and Obesity-Related Traits in Mexican School Children. (cdc.gov)
Finding genes and variants for lipid levels after genome-wide association analysis. (medscape.com)
Genome-wide association study identifies variants screening. (who.int)
Polymorphism2
The distribution of apolipoprotein E gene polymorphism in Chinese civil aircrews, and a possible risk factor to their overweight and dyslipidemia is cumulative flight time. (cdc.gov)
[ 7 , 8 ] The recognition that DS is associated with trisomy 21 helped in understanding the genetic basis of this association. (medscape.com)
Smelt AH, de Beer F. Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects. (medscape.com)
Here, two batches of large-scale literature-based disease-gene relation data (updated in 2017 and 2019, respectively) and gene expression data were integrated to study the possible association between OCD and ASD at the genetic level. (silverchair.com)
Our results support the possible complex genetic associations between OCD and ASD. (silverchair.com)
Genes1
Negative association findings and research involving the serotonin transporter gene, FMR1, RELN, WNT2, HOXA1, and HOXB1 genes may be found elsewhere on this site . (neurotransmitter.net)
Phenotypes2
Using data from UK Biobank, we have previously described the associations of body shape phenotypes based on ABSI and HI with allometric body-composition indices, which similarly to ABSI and HI normalise body composition measurements for weight and height 11 . (nature.com)
In the current study, we have examined the association of body shape phenotypes based on allometric indices with serum levels of oestradiol and testosterone and their binding proteins (SHBG and albumin) and have explored heterogeneity by BMI, separately in men and women from the UK Biobank cohort, defining in men subgroups according to age and in women subgroups according to menopausal status and use of hormone replacement therapy (HRT). (nature.com)
Gene5
The observed associations were further modulated by gene-gene and gene-environment interactions. (ox.ac.uk)
In addition, they observed association for markers located near the CST3 gene, with P values between 0.002 and 0.08 for 2-locus haplotypes. (findzebra.com)
2000) reported associations between polymorphisms in the CST3 gene and late-onset AD, Monastero et al. (findzebra.com)
Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. (neurotransmitter.net)
CONCLUSIONS: A strong association of autism with SNPs within the SLC25A12 gene was demonstrated. (neurotransmitter.net)
Lesions1
Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science . (medscape.com)
Baseline2
We aimed to investigate associations between metabolites of the kynurenine pathway at baseline and post-stroke cognitive functioning over time. (bvsalud.org)
Baseline and longitudinal associations of kynurenines with PSCI and cognitive domain scores were investigated using linear mixed models, adjusted for several confounders. (bvsalud.org)
Burden1
However, the majority of studies in this field have not demonstrated any Terlipressin association between APOEe4 status and WMH burden [43?8]. (signsin1dayinc.com)
Cardiovascular risk2
Recent studies show an association between elevated plasma LDL, a well-known cardiovascular risk factor, and a higher risk of AD, and considerable evidence suggests that high HDL levels are associated with reduced CAA and lower neuroinflammation. (biomedcentral.com)
The American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, in a 2010 report on cardiovascular risk assessment in asymptomatic adults, recommends obtaining global risk scores (eg, Framingham Risk Score[9] ) and a family history of cardiovascular disease for cardiovascular risk assessment. (medscape.com)
Metabolism1
Mahley RW, Rall SC Jr. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal metabolism. (medscape.com)
Lipoproteins1
Effect of obesity, serum lipoproteins, and apolipoprotein E genotypes on mortality in hospitalized elderly patients. (cdc.gov)
Task force1
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. (jamanetwork.com)
Cognitive2
Association between vitamin A, vitamin E and apolipoprotein E status with mild cognitive impairment among elderly people in low-cost residential areas. (cdc.gov)
To observe any associations between periodontitis and dementia severity, rate of cognitive decline, or chronic inflammation in adults with mild to moderate Alzheimer's disease. (naturalmedicinejournal.com)
Prevalence1
Thus, our methodology would tend to underestimate the prevalence of OH, thereby possibly masking the potential association between OHand WMH. (signsin1dayinc.com)
Odds1
RESULTS: No evidence of associations between kynurenines and odds of PSCI were found. (bvsalud.org)
Hypertension1
In contrast to some previous studies (e.g. [49]), we did not find any significant associations between hypertension and WMH. (signsin1dayinc.com)
Distribution1
In summary, the investigated polymorphisms were associated with diverse effects on the LDL particle size distribution, consistent with respect to protein function and proposed association with CHD risk. (ox.ac.uk)
Independent1
We defined body shape using "a body shape index" (ABSI) and hip index (HI), which are independent of weight and height by design, and examined associations in multivariable generalised linear models for the UK Biobank cohort (179,902 men, 207,444 women). (nature.com)
Participants1
however, within self-identified Hispanic and black participants, no associations were found. (elsevierpure.com)
Body5
Apolipoprotein E4 association with metabolic syndrome depends on body fatness. (cdc.gov)
Associations of sex steroids and their binding proteins with body shape are unclear, because waist and hip circumference are correlated strongly with body size. (nature.com)
It is, therefore, of interest to examine associations between body shape and circulating sex steroids. (nature.com)
Inverse associations of WHR and body mass index (BMI) with total oestradiol but positive associations with free oestradiol in pre-menopausal women, as well as positive associations with total and free testosterone and inverse associations with sex hormone binding globulin (SHBG) in all women have been reported for the UK Biobank cohort 6 . (nature.com)
It remains unclear, however, what is the contribution of hip size and whether there is heterogeneity of the associations with body shape according to BMI. (nature.com)
Study2
Apolipoprotein E genotype and mortality in Southern European and Anglo-Celt patients with type 2 diabetes: the Fremantle Diabetes Study. (cdc.gov)
Obesity, Apolipoprotein E e4, and Difficulties in Activities of Daily Living Among Older Adults: a 6-Year Follow-up Study. (cdc.gov)
Results1
RESULTS: Linkage and association were observed between autistic disorder and the two SNPs, rs2056202 and rs2292813, found in SLC25A12. (neurotransmitter.net)
Ratio1
Additionally, a linear-quadratic association was found for the kynurenic acid/ quinolinic acid ratio (KA/QA), a neuroprotective index, with episodic memory (Wald χ2 = 8.27, p = .016). (bvsalud.org)
Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. (cdc.gov)
Scientific1
Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. (medscape.com)
Significant1
These associations remained significant even after confounding factor corrections. (biomedcentral.com)
Statement1
An American Health Association policy statement concluded that costs will rise to more than $1 trillion annually in the United States by the year 2030, thus suggesting the great need for preventative measures. (medscape.com)
Recent1
While we may look for other explanations for this association, the most obvious one, that periodontitis drives Alzheimer's disease progression, makes the most sense in light of other recent research and the newer hypothesis that suggests AD is an immune reaction to infection. (naturalmedicinejournal.com)