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  • aggregates
  • Accordingly, various soluble agonists are used (adenosine diphosphate [ADP], thromboxane A2 [TXA 2 ], or α‐thrombin) to activate platelets in citrate‐anticoagulated whole blood at very low shear, and the formation of small platelet aggregates (attached to fibrinogen‐coated beads to obtain better optical signals) are measured. (ahajournals.org)
  • Thrombin also anchors unstable platelet aggregates, together with fibrin, to the site of vascular injury, imparting structural stability to the thrombus, thereby preventing downstream embolization due to the effects of arterial flow ( Figure 1 ). (ahajournals.org)
  • 31. Tohg H., Takahashi H., Watanabe K. Development of large platelet aggregates from small aggregates as determined by laser-light scattering: effects of aggregant concentration and antiplatelet medication // Thromb. (medline.ru)
  • clopidogrel
  • Having one or more alleles associated with lower drug metabolism of clopidogrel (Plavix) correlated significantly with less platelet inhibition and lower risk of bleeding in clopidogrel-only studies. (medpagetoday.com)
  • Genetic testing for clopidogrel (Plavix) resistance offers no real advantage in cardiovascular outcomes for patients on the antiplatelet drug, a meta-analysis suggested. (medpagetoday.com)
  • Carrying one or more alleles associated with lower drug metabolism did correlate significantly with less platelet inhibition and lower risk of bleeding in clopidogrel-only studies analyzed by Michael V. Holmes, MBBS, MSc, of University College London, and colleagues. (medpagetoday.com)
  • The FDA issued a black box warning of diminished clopidogrel effectiveness in poor metabolizers that suggested testing for CYP2C19 genotype . (medpagetoday.com)
  • The consequences of the FDA's leap to judgment regarding CYP2C19 testing cannot be underestimated," Nissen wrote, pointing to clopidogrel as one of the most widely used drugs in all of medicine. (medpagetoday.com)
  • When the researchers examined the 26 studies that included only individuals exposed to clopidogrel, reduced-function alleles cut the absolute risk of bleeding events by five to eight events per 1,000 individuals, but at the expense of eight to 12 more cardiovascular disease events per 1,000. (medpagetoday.com)
  • The meta-analysis was limited by lack of patient-level data, differences in composite cardiovascular disease endpoints used across the studies included, and inclusion of both acute and stable heart disease studies, which might dilute associations if the magnitude of effect of clopidogrel was greater in acute than stable cases, the group acknowledged. (medpagetoday.com)
  • thrombosis
  • Stent thrombosis had the strongest overall link with reduced-function alleles (RR 1.75, 95% CI 1.50 to 2.03), corresponding to an absolute increase of 14 stent thromboses per 1,000 individuals. (medpagetoday.com)
  • Following this trial, Elwood and his research team set up the Caerphilly Heart Disease Study, with their primary focus on vascular disease, and the identification of predictors for platelet activity and thrombosis. (wikipedia.org)
  • aspirin
  • You may be instructed to refrain from taking drugs that can affect the function of normal platelets and hence the results of these tests, such as aspirin, non-steroidal anti-inflammatory drugs (NSAIDs) , or any over-the-counter medications that contain drugs such as these. (labtestsonline.org.uk)
  • resistance
  • By releasing plasminogen activator inhibitor 1, the main inhibitor of the fibrinolytic system, from the storage granules of platelets and activating thrombin‐activatable fibrinolysis inhibitor, thrombin confers resistance on the arterial thrombus against endogenous fibrinolysis. (ahajournals.org)
  • acute
  • An association has been demonstrated between long chain long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency (LCHAD) of the child and maternal HELLP and acute fatty liver of pregnancy (AFLP). (wikipedia.org)
  • count
  • Homozygous mutant animals of both sexes were sub-fertile and homozygous females had a reduced body weight, body length, heart weight, platelet count and lean mass. (wikipedia.org)
  • Platelet transfusion, is transfused to those who suffer from low platelet count. (wikipedia.org)
  • serum
  • This is most easily done by centrifugation, which packs the denser blood cells and platelets to the bottom of the centrifuge tube, leaving the liquid serum fraction resting above the packed cells. (wikipedia.org)
  • patients
  • Patients were performed colonoscopy examination for colorectal cancer and who had been foud colorectal cancer proven by biopsy.Then the colorectal cancer patients who had not been diagnosed with nonalcoholic fatty liver disease was based on blood tests and abdomen ultrasound examination. (clinicaltrials.gov)
  • Lab Tests Online-UK is an educational website designed to provide patients and carers with information on laboratory tests used in medical care. (labtestsonline.org.uk)
  • The association was confirmed when patients with the disease were found to have mutations in their SLX4 gene. (wikipedia.org)
  • kidney
  • Nephrology (from Greek nephros "kidney", combined with the suffix -logy, "the study of") is a specialty of medicine and pediatrics that concerns itself with the kidneys: the study of normal kidney function and kidney problems, the preservation of kidney health, and the treatment of kidney problems, from diet and medication to renal replacement therapy (dialysis and kidney transplantation). (wikipedia.org)
  • This large array of tests can be categorised into sub-specialities of: General or routine chemistry - commonly ordered blood chemistries (e.g., liver and kidney function tests). (wikipedia.org)
  • genetics
  • Major cognitive ageing findings of the studies have concerned the stability of intelligence from childhood to old age, the influence of genetics on cognitive function and decline, and the role of the brain's white matter integrity in successful cognitive ageing. (wikipedia.org)
  • study
  • In addition, a follow-up study, ANTARCTIC, is evaluating the value of platelet-function testing in an elderly population "with a paradigm shift towards safety. (forbes.com)
  • Model organisms have been prominent in the study of SLX4 function. (wikipedia.org)
  • In the early phases of the study, samples of fasting blood were collected for extensive testing and long-term storage, and on occasions urine and other biological samples were also taken, and aliquots stored. (wikipedia.org)
  • Thus, while the initial aims of the study focused upon vascular disease, the wealth of data collected has enabled the testing of a large number of hypotheses relevant to other diseases too. (wikipedia.org)
  • Symptoms
  • If you are concerned about your test results, you will need to arrange an appointment with your doctor so that all relevant information including age, ethnicity, health history, signs and symptoms, laboratory and other procedures (radiology, endoscopy, etc.), can be considered. (labtestsonline.org.uk)
  • When I hear about your symptoms, I think about the association between Raynaud's phenomenon and vasculitis, or inflammation of blood vessels. (zocdoc.com)
  • EP is diagnosed by a combination of characteristic symptoms, findings on a physical examination by a health provider, and the results of blood tests and x-rays. (wikipedia.org)
  • urine
  • The discipline originated in the late 19th century with the use of simple chemical reaction tests for various components of blood and urine. (wikipedia.org)
  • genes
  • Based on that, SLX4 was grouped with several other proteins produced by SLX (synthetic lethal of unknown function) genes. (wikipedia.org)
  • This included the investigation of the influence of the E4 allele on the Apolipoprotein E (APOE) gene on cognitive ageing as well as testing the effects of other candidate genes for cognitive ageing. (wikipedia.org)
  • studies
  • The survey techniques were similar and a number of questionnaires and biological tests were used in both the studies. (wikipedia.org)
  • common
  • The third and fourth waves of data collection were conducted with the main objective of testing the common cause hypothesis of cognitive ageing, which puts forward that age-related declines in physical and cognitive functioning share a common cause. (wikipedia.org)
  • renal function
  • Non small bowel syndrome, renal function i need cash now to be used in the stomach syndrome, there is to sort of the private lenders compliance. (loancheappayday.com)
  • Hypoglycaemia (due to depleted hepatic glycogen store and hyperinsulinaemia), hypokalaemia, hypophosphataemia and Metabolic alkalosis are often present, independent of renal function. (wikipedia.org)
  • weakness
  • Most common adverse effects include: Nausea (22%) Drowsiness (19%) Dizziness (12%) Vomiting (12%) Weakness (10%) Serious adverse effects include: Bleeding Low blood platelets Encephalopathy Suicidal behavior and thoughts Low body temperature Valproic acid has a black box warning for hepatotoxicity, pancreatitis, and fetal abnormalities. (wikipedia.org)
  • protein
  • Loss of ribosomal function might be predicted to affect translation and protein biosynthesis broadly and impact many tissues. (wikipedia.org)
  • Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with regulatory function upon the common pathway of coagulation (by degradating activated factor V). Lupus anticoagulant (LAC) antibodies bind to prothrombin, thus increasing its cleavage to thrombin, its active form. (wikipedia.org)
  • Because of the high cost of directly measuring HDL and LDL protein particles, blood tests are commonly performed for the surrogate value, HDL-C, i.e. the cholesterol associated with ApoA-1/HDL particles. (wikipedia.org)
  • usually
  • In addition, it also usually involves atherosclerosis, i.e. deposits (called plaques) on the interior surface of many arteries, which are composed of LDL and assorted other debris (including platelets). (wikipedia.org)
  • months
  • The diagnostic criteria require one clinical event (i.e. thrombosis or pregnancy complication) and two antibody blood tests spaced at least three months apart that confirm the presence of either lupus anticoagulant or anti-β2-glycoprotein-I (since β2-glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a less specific proxy). (wikipedia.org)
  • less
  • However, DBA is characterized by dominant inheritance, and arises from partial loss of ribosomal function, so it is possible that erythroid progenitors are more sensitive to this decreased function, while most other tissues are less affected. (wikipedia.org)