• fibrin
  • Thrombin also anchors unstable platelet aggregates, together with fibrin, to the site of vascular injury, imparting structural stability to the thrombus, thereby preventing downstream embolization due to the effects of arterial flow ( Figure 1 ). (ahajournals.org)
  • Acting on the loose primary platelet aggregates, thrombin (1) propagates aggregation by releasing ADP from platelet granules and allowing the formation of thromboxane A2, (2) provides structural stability to the thrombus by enmeshing the tight platelet aggregate with a fibrin network, and (3) makes the platelet‐rich thrombus resistant to endogenous fibrinolysis by releasing the main fibrinolysis inhibitor PAI‐1 from platelets and inducing the formation of TAFI. (ahajournals.org)
  • serum
  • This is most easily done by centrifugation, which packs the denser blood cells and platelets to the bottom of the centrifuge tube, leaving the liquid serum fraction resting above the packed cells. (wikipedia.org)
  • occur
  • however, in vivo, at sites of turbulent flow near the site of a severe stenosis and thus high shear (above ≈10 000 s −1 ), long‐lasting adhesion and aggregation occur without any requirement for platelet activation. (ahajournals.org)
  • Divalproex sodium capsules (sprinkle) are indicated as monotherapy and adjunctive therapy in the treatment of adult patients and pediatric patients down to the age of 10 years with complex partial seizures that occur either in isolation or in association with other types of seizures. (bioportfolio.com)
  • genes
  • Based on that, SLX4 was grouped with several other proteins produced by SLX (synthetic lethal of unknown function) genes. (wikipedia.org)
  • This included the investigation of the influence of the E4 allele on the Apolipoprotein E (APOE) gene on cognitive ageing as well as testing the effects of other candidate genes for cognitive ageing. (wikipedia.org)
  • genetics
  • Major cognitive ageing findings of the studies have concerned the stability of intelligence from childhood to old age, the influence of genetics on cognitive function and decline, and the role of the brain's white matter integrity in successful cognitive ageing. (wikipedia.org)
  • urine
  • In the early phases of the study, samples of fasting blood were collected for extensive testing and long-term storage, and on occasions urine and other biological samples were also taken, and aliquots stored. (wikipedia.org)
  • The discipline originated in the late 19th century with the use of simple chemical reaction tests for various components of blood and urine. (wikipedia.org)
  • study
  • In addition, a follow-up study, ANTARCTIC, is evaluating the value of platelet-function testing in an elderly population "with a paradigm shift towards safety. (forbes.com)
  • Model organisms have been prominent in the study of SLX4 function. (wikipedia.org)
  • Following this trial, Elwood and his research team set up the Caerphilly Heart Disease Study, with their primary focus on vascular disease, and the identification of predictors for platelet activity and thrombosis. (wikipedia.org)
  • Thus, while the initial aims of the study focused upon vascular disease, the wealth of data collected has enabled the testing of a large number of hypotheses relevant to other diseases too. (wikipedia.org)
  • storage
  • In citrated blood, in response to activation of platelets by ADP, collagen, or arachidonic acid, soluble agonists are released from platelet storage granules or generated by platelets (release reaction), which substantially enhances the initial platelet reaction (secondary aggregation). (ahajournals.org)
  • By releasing plasminogen activator inhibitor 1, the main inhibitor of the fibrinolytic system, from the storage granules of platelets and activating thrombin‐activatable fibrinolysis inhibitor, thrombin confers resistance on the arterial thrombus against endogenous fibrinolysis. (ahajournals.org)
  • activation
  • In contrast, in native blood, whether in vivo or in vitro, only activation by α‐thrombin binding to platelet surface glycoprotein Ibα receptors can induce platelet adhesion, dense granule secretion, and aggregation. (ahajournals.org)
  • common
  • Specific parasitic infections are diagnosed after examining a person's exposure to common parasites and performing laboratory tests to look for likely causes. (wikipedia.org)
  • The third and fourth waves of data collection were conducted with the main objective of testing the common cause hypothesis of cognitive ageing, which puts forward that age-related declines in physical and cognitive functioning share a common cause. (wikipedia.org)
  • High
  • Fundamental differences exist between thrombus generation at high shear in native blood in vivo and agonist‐induced platelet aggregation at low shear in anticoagulated blood ex vivo. (ahajournals.org)
  • Exposed to high shear, platelets with clustered membrane glycoprotein Ibα interact with the exposed A1 domains of vWF, and loose platelet aggregates are formed. (ahajournals.org)
  • High shear also induces formation of platelet‐derived microparticles, which generate thrombin. (ahajournals.org)
  • population
  • It was conducted on 1 June 1932, and tested the intelligence of almost all of Scotland's 1921-born population, 87,498 children in all. (wikipedia.org)
  • It was carried out on 4 June 1947, and tested the intelligence of 70,805 children, nearly all of Scotland's 1936-born population. (wikipedia.org)
  • main
  • Consequently, the main soluble agonists are not involved in the initial shear‐induced platelet aggregation but rather contribute to stabilization of the unstable platelet aggregate. (ahajournals.org)
  • various
  • Accordingly, various soluble agonists are used (adenosine diphosphate [ADP], thromboxane A2 [TXA 2 ], or α‐thrombin) to activate platelets in citrate‐anticoagulated whole blood at very low shear, and the formation of small platelet aggregates (attached to fibrinogen‐coated beads to obtain better optical signals) are measured. (ahajournals.org)
  • studies
  • The survey techniques were similar and a number of questionnaires and biological tests were used in both the studies. (wikipedia.org)
  • children
  • The SMS1947 was commissioned to test the theory that average intelligence in the United Kingdom was lower in the new generation due to a negative correlation between family size and the intelligence of children. (wikipedia.org)