• inhibitor
  • By releasing plasminogen activator inhibitor 1, the main inhibitor of the fibrinolytic system, from the storage granules of platelets and activating thrombin‐activatable fibrinolysis inhibitor, thrombin confers resistance on the arterial thrombus against endogenous fibrinolysis. (ahajournals.org)
  • Acting on the loose primary platelet aggregates, thrombin (1) propagates aggregation by releasing ADP from platelet granules and allowing the formation of thromboxane A2, (2) provides structural stability to the thrombus by enmeshing the tight platelet aggregate with a fibrin network, and (3) makes the platelet‐rich thrombus resistant to endogenous fibrinolysis by releasing the main fibrinolysis inhibitor PAI‐1 from platelets and inducing the formation of TAFI. (ahajournals.org)
  • fibrin
  • Thrombin also anchors unstable platelet aggregates, together with fibrin, to the site of vascular injury, imparting structural stability to the thrombus, thereby preventing downstream embolization due to the effects of arterial flow ( Figure 1 ). (ahajournals.org)
  • serum
  • This is most easily done by centrifugation, which packs the denser blood cells and platelets to the bottom of the centrifuge tube, leaving the liquid serum fraction resting above the packed cells. (wikipedia.org)
  • study
  • In addition, a follow-up study, ANTARCTIC, is evaluating the value of platelet-function testing in an elderly population "with a paradigm shift towards safety. (forbes.com)
  • Model organisms have been prominent in the study of SLX4 function. (wikipedia.org)
  • Following this trial, Elwood and his research team set up the Caerphilly Heart Disease Study, with their primary focus on vascular disease, and the identification of predictors for platelet activity and thrombosis. (wikipedia.org)
  • In the early phases of the study, samples of fasting blood were collected for extensive testing and long-term storage, and on occasions urine and other biological samples were also taken, and aliquots stored. (wikipedia.org)
  • Thus, while the initial aims of the study focused upon vascular disease, the wealth of data collected has enabled the testing of a large number of hypotheses relevant to other diseases too. (wikipedia.org)
  • Nephrology (from Greek nephros "kidney", combined with the suffix -logy, "the study of") is a specialty of medicine and pediatrics that concerns itself with the kidneys: the study of normal kidney function and kidney problems, the preservation of kidney health, and the treatment of kidney problems, from diet and medication to renal replacement therapy (dialysis and kidney transplantation). (wikipedia.org)
  • genetics
  • Major cognitive ageing findings of the studies have concerned the stability of intelligence from childhood to old age, the influence of genetics on cognitive function and decline, and the role of the brain's white matter integrity in successful cognitive ageing. (wikipedia.org)
  • whole blood
  • Accordingly, various soluble agonists are used (adenosine diphosphate [ADP], thromboxane A2 [TXA 2 ], or α‐thrombin) to activate platelets in citrate‐anticoagulated whole blood at very low shear, and the formation of small platelet aggregates (attached to fibrinogen‐coated beads to obtain better optical signals) are measured. (ahajournals.org)
  • blood tests
  • EP is diagnosed by a combination of characteristic symptoms, findings on a physical examination by a health provider, and the results of blood tests and x-rays. (wikipedia.org)
  • genes
  • Based on that, SLX4 was grouped with several other proteins produced by SLX (synthetic lethal of unknown function) genes. (wikipedia.org)
  • This included the investigation of the influence of the E4 allele on the Apolipoprotein E (APOE) gene on cognitive ageing as well as testing the effects of other candidate genes for cognitive ageing. (wikipedia.org)
  • Problems
  • Problems can result from having too few or too many platelets, or from platelets that do not work properly. (medlineplus.gov)
  • Symptoms include:[citation needed] Abdominal pain Ascites, or an abnormal buildup of fluid in the abdomen A mass in the abdomen Problems with bowel function Weight loss Pericardial mesothelioma is not well characterized, but observed cases have included cardiac symptoms, specifically constrictive pericarditis, heart failure, pulmonary embolism, and cardiac tamponade. (wikipedia.org)
  • major
  • These tests, which are variants of the classical platelet aggregometer, are based on the assumption that the secretion of agonists from activated platelets is the major determinant of thrombus growth. (ahajournals.org)
  • storage
  • In citrated blood, in response to activation of platelets by ADP, collagen, or arachidonic acid, soluble agonists are released from platelet storage granules or generated by platelets (release reaction), which substantially enhances the initial platelet reaction (secondary aggregation). (ahajournals.org)
  • activation
  • however, in vivo, at sites of turbulent flow near the site of a severe stenosis and thus high shear (above ≈10 000 s −1 ), long‐lasting adhesion and aggregation occur without any requirement for platelet activation. (ahajournals.org)
  • In contrast, in native blood, whether in vivo or in vitro, only activation by α‐thrombin binding to platelet surface glycoprotein Ibα receptors can induce platelet adhesion, dense granule secretion, and aggregation. (ahajournals.org)
  • common
  • Specific parasitic infections are diagnosed after examining a person's exposure to common parasites and performing laboratory tests to look for likely causes. (wikipedia.org)
  • The third and fourth waves of data collection were conducted with the main objective of testing the common cause hypothesis of cognitive ageing, which puts forward that age-related declines in physical and cognitive functioning share a common cause. (wikipedia.org)
  • High
  • Exposed to high shear, platelets with clustered membrane glycoprotein Ibα interact with the exposed A1 domains of vWF, and loose platelet aggregates are formed. (ahajournals.org)
  • High shear also induces formation of platelet‐derived microparticles, which generate thrombin. (ahajournals.org)
  • population
  • It was conducted on 1 June 1932, and tested the intelligence of almost all of Scotland's 1921-born population, 87,498 children in all. (wikipedia.org)
  • It was carried out on 4 June 1947, and tested the intelligence of 70,805 children, nearly all of Scotland's 1936-born population. (wikipedia.org)
  • studies
  • The survey techniques were similar and a number of questionnaires and biological tests were used in both the studies. (wikipedia.org)
  • children
  • The SMS1947 was commissioned to test the theory that average intelligence in the United Kingdom was lower in the new generation due to a negative correlation between family size and the intelligence of children. (wikipedia.org)