• genetic
  • These associations provide examples of genetic influences on differential survival and may point to pleiotropic age-dependent effects on longevity. (denigma.de)
  • There is also a strong genetic association between one variant of apolipoprotein E (apo E) and the risk for developing AD. (aaccjnls.org)
  • Individuals with an E2/E2 combination may clear dietary fat slowly and be at greater risk for early vascular disease and the genetic disorder type III hyperlipoproteinemia-94.4% of such patients are E2/E2, while only ∼2% of E2/E2 develop the disease, so other environmental and genetic factors are likely to be involved (such as cholesterol in the diet and age). (wikipedia.org)
  • proteins
  • In contrast to a few years ago, interest has now shifted to the role of intracellular amyloid components (such as APP) in AD and their association with other cytoplasmic proteins and organelles, although some still argue that the amyloid hypothesis has been overemphasized. (aaccjnls.org)
  • cardiovascular
  • 13 In the present analysis, we used the tissue microarrays to investigate the pattern and extent of apolipoprotein deposits in the arterial wall of vulnerable patients and compared these findings with asymptomatic patients who did not develop cardiovascular events during their lifetime. (ahajournals.org)
  • brain's
  • Human and nonhuman primate data suggest that in midlife, the structural integrity of myelin sheaths begins breaking down, with an accelerating age-related trajectory most evident in the brain's later-myelinating association regions. (treatmentonline.com)
  • risk
  • An association between decreasing olfactory identification, as measured by a decrease in the number of correct responses in Brief Smell Identification Test score, and an increased risk of MCI was established . (menopause.org.au)
  • found
  • A serine protease inhibitor domain, absent from the isoform differentially expressed in the brain, is found between acidic region and E2 domain. (wikipedia.org)