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  • Occludin
  • These are the tetraspanin CD81, scavenger receptor class B member I (SR-BI), and the tight junction proteins Claudin-1 and Occludin [ 9 - 12 ]. (hindawi.com)
  • The fully-developed HLCs expressed phase I, II, and III drug-metabolizing enzymes, HCV associated receptors (claudin-1, occludin, CD81, ApoE, ApoB, LDL-R) and HCV essential host factors (miR-122 and SEC14L2) comparable to the primary human hepatocyte. (biomedcentral.com)
  • genome
  • An interesting candidate, currently in phase 2 clinical trials, is based on the prime-boost strategy with the first immunization using a chimpanzee adenovirus together with a boost using a modified vaccinia Ankara vector, both expressing the nonstructural region of HCV genome. (jimmunol.org)
  • cellular receptor
  • Following an initial association with a series of attachment factors, including C-type lectins, lipoprotein receptors, and heparan sulfate (reviewed in [ 8 ]), HCV infects hepatocytes via four cellular receptor molecules. (hindawi.com)
  • complexes
  • In particular, about 60% of HCV-infected patients present cold-precipitable (cryoprecipitable) and noncryoprecipitable immune complexes that could be associated with the clinical onset of type II mixed cryoglobulinemia (MCII) [ 2 ]. (mdpi.com)
  • This immune complex-mediated vasculitis is characterized by a primary B-cell clonal proliferation accompanied by the deposition of immune complexes composed of complement factors, mono/oligoclonal IgMs with rheumatoid factor (RF) activity bound to oligo/polyclonal IgGs that, in the case of HCV infection, are mostly directed against HCV proteins [ 3 ]. (mdpi.com)
  • host
  • To date, several host- and virus-related factors have been implicated in the progression to MCII, such as the virus-induced expansion of selected subsets of B-cell clones expressing discrete immunoglobulin variable (IgV) gene subfamilies, the involvement of complement factors and the specific role of some HCV proteins. (mdpi.com)
  • allosteric
  • Here, we aimed to provide some insight into the inhibitor binding mode and allosteric regulation mechanism of HCV NS3/4A protein by using computational methods. (jove.com)
  • Finally, a dynamic model about the allosteric regulation and conformational changes of HCV NS3/4A protein was proposed and could provide fundamental insights into the allosteric mechanism of HCV NS3/4A protein function regulation and design of new potent inhibitors. (jove.com)
  • infection
  • SEC14L2, an α-tocopherol transfer protein, was expressed in HLCs, but not in Huh7 cell, had been implicated in effective HCVser infection. (biomedcentral.com)
  • Lack of associations of alpha(+)-thalassemia with the risk of Plasmodium falciparum and Plasmodium vivax infection and disease in a cohort of children aged 3-21 months from Papua New Guinea. (edu.au)
  • clinical
  • bleeding), according to a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute. (com.es)
  • cells
  • andsubsequently administering at least once a second composition comprising a viral vector comprising a nucleic acid encoding said at least one epitope of said first composition, whereby the nucleic acid of said second composition is expressed in one or more cells of the subject and at least part of the protein of said first composition is produced. (patentsencyclopedia.com)
  • Exosomes are small vesicles that transport cellular proteins, RNA, and small molecules between cells as a mechanism of intercellular communication. (biomedcentral.com)
  • Recent research has shown that HIV proteins and RNA can be packaged into exosomes and transported between cells, to pathogenic effect. (biomedcentral.com)
  • function
  • Though current treatment regimens can effectively suppress viral load to undetectable levels and preserve healthy immune function, they cannot fully alleviate all symptoms caused by the presence of the virus, such as HIV-associated neurocognitive disorders. (biomedcentral.com)
  • insights
  • Recent insights into the export of PEXEL/HTS-motif containing proteins in Plasmodium parasites. (edu.au)
  • present
  • The methods utilize one or more administrations of HCV protein compositions, followed by one or more administrations of a viral vector comprising a nucleic acid encoding a least one HCV epitope that is present in the first composition. (patentsencyclopedia.com)
  • tight
  • The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. (blogspot.com)
  • severe
  • It has been reported by several studies that about 10%-60% of HCV-infected patients presenting cryoglobulins are at risk of contracting symptomatic cryoglobulinemia, clinically characterized by association of purpura, weakness, and arthralgia, possibly complicated by severe renal and neurological involvement [ 5 , 6 ]. (mdpi.com)
  • role
  • These proteins are highly glycosylated and play an important role in cell entry. (biomedcentral.com)
  • Further residue interaction network analysis suggests the communication of the domain-domain interface play an important role in the transition from closed to open conformation of HCV NS3/4A protein. (jove.com)
  • Virus
  • Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants? (mdpi.com)