• complexes
  • In particular, about 60% of HCV-infected patients present cold-precipitable (cryoprecipitable) and noncryoprecipitable immune complexes that could be associated with the clinical onset of type II mixed cryoglobulinemia (MCII) [ 2 ]. (mdpi.com)
  • This immune complex-mediated vasculitis is characterized by a primary B-cell clonal proliferation accompanied by the deposition of immune complexes composed of complement factors, mono/oligoclonal IgMs with rheumatoid factor (RF) activity bound to oligo/polyclonal IgGs that, in the case of HCV infection, are mostly directed against HCV proteins [ 3 ]. (mdpi.com)
  • complement
  • To date, several host- and virus-related factors have been implicated in the progression to MCII, such as the virus-induced expansion of selected subsets of B-cell clones expressing discrete immunoglobulin variable (IgV) gene subfamilies, the involvement of complement factors and the specific role of some HCV proteins. (mdpi.com)
  • Being a major first line of immune defense, the complement system keeps a constant vigil against viruses. (frontiersin.org)
  • patients
  • It has been reported by several studies that about 10%-60% of HCV-infected patients presenting cryoglobulins are at risk of contracting symptomatic cryoglobulinemia, clinically characterized by association of purpura, weakness, and arthralgia, possibly complicated by severe renal and neurological involvement [ 5 , 6 ]. (mdpi.com)
  • Further
  • Further residue interaction network analysis suggests the communication of the domain-domain interface play an important role in the transition from closed to open conformation of HCV NS3/4A protein. (jove.com)