• Gamma glutamyl transferase (GGT) was significantly higher in repeat donors (70.5 ± 13.5 μl) than the first time donors (62.5 ± 13.3 μl) (P (scirp.org)
  • T. Adias, A. Igwilo and Z. Jeremiah, "Repeat Whole Blood Donation Correlates Significantly with Reductions in BMI and Lipid Profiles and Increased Gamma Glutamic Transferase (GGT) Activity among Nigerian Blood Donors," Open Journal of Blood Diseases , Vol. 2 No. 4, 2012, pp. 90-94. (scirp.org)
  • We investigated the association between alcohol consumption - measured via ethnic-specific gamma glutamyl transferase (γ-GT) cut-points - and markers of cardiac perfusion, electrical activity, and pre-clinical structural alterations. (bvsalud.org)
  • The behavioral defense coping response (DefS) as a measure of coping with emotional stress may increase alcohol intake (gamma glutamyl transferase (γGT)), the risk for coronary artery disease (CAD) and insulin sensitivity (homeostasis model assessment, HOMA). (bvsalud.org)
  • A recent publication observed that 54% of patients hospitalized for COVID-19 at a single center in China had elevated gamma-glutamyl transferase (GGT). (medscape.com)
  • Nevertheless, we observed reduced expression of gamma-glutamyl transferase 1 ( GGT1) specifically in the ileum and caecum of patients with PSC/UC. (ox.ac.uk)
  • Conclusions: The role of gamma-glutamyl transferase in maintaining the redox environment through the glutathione salvage pathway makes our observed alterations a potential pathway to PSC-associated colorectal cancer. (ox.ac.uk)
  • Gamma glutamyl transferase (GGT) is an enzyme found in cell membranes of many tissues mainly in the liver, kidney, and pancreas. (medscape.com)
  • Venkat and colleagues [ 1 ] described the clinical response to protocolized immunosuppression withdrawal in an ongoing multicenter study of 74 children who were more than 4 years post-transplantation, had normal alanine aminotransferase (ALT) and gamma-glutamyltransferase levels, and were receiving calcineurin inhibitor monotherapy. (medscape.com)
  • Influenza animal models suggest that hepatic oxidative stress leading to injury is the primary event, not viral replication, although injury from virus-specific CD8+T cells might also be at play. (medscape.com)
  • Considering the limitation of studies investigating the relationship between T. gondii and cardiovascular biomarkers, this study was focused on assessing the association of T. gondii to nine cardiovascular biomarkers. (mdpi.com)
  • The expanding list of nontraditional biomarkers is outweighed by the standard risk factors for predicting future cardiovascular events and adds only moderately to standard risk factors. (medscape.com)
  • The most informative biomarkers for predicting major cardiovascular events were BNP and the urinary albumin-to-creatinine ratio. (medscape.com)
  • This examine aimed to look at the associations of the mixed way of life components with dangers of whole and particular person microvascular problems amongst sufferers with sort 2 diabetes (T2D) and to discover the potential mediation results of metabolic biomarkers. (outfitoffice.uk)
  • Adherence to total wholesome way of life behaviors was related to a considerably decrease danger of microvascular problems in sufferers with T2D, and the favorable associations have been partially mediated by way of bettering biomarkers of glycemic management, systemic irritation, liver operate, and lipid profile. (outfitoffice.uk)
  • The assessed biomarkers and phenotypes allow for risk stratification (OS, PFS), diagnostic classification and enhance the biological understanding of the different subtypes of neuroendocrine tumors revealing potential new therapy options and clarifying known resistance mechanisms. (oncotarget.com)
  • We assessed prospectively whether NAFLD predicts future cardiovascular disease (CVD) events among type 2 diabetic individuals, independent of metabolic syndrome features and other classical risk factors. (diabetesjournals.org)
  • This relationship is independent of classical risk factors and is only partly explained by occurrence of metabolic syndrome. (diabetesjournals.org)
  • A great deal of evidence suggests that the metabolic syndrome predicts incident cardiovascular disease (CVD) ( 5 - 8 ), so it is possible to hypothesize that NAFLD patients might portend a greater CVD risk and that NAFLD itself might confer a CVD risk above that associated with individual metabolic syndrome risk factors. (diabetesjournals.org)
  • These factors also comprise the risk profile for CAD. (springeropen.com)
  • As both progression of NAFLD and increasing epicardial adipose tissue (EAT) mass have the same risk factors, therefore these two conditions might be associated with each other [ 6 ]. (springeropen.com)
  • A. Gebre-Yohannes, S. I. Rehelbeck, "Coronary Heart Disease Risk Factors among Blood Donors in North West Ethiopia," East African Medical Journal, Vol. 75, No. 9, 1998, pp. 495-500. (scirp.org)
  • Risk factors for coronary artery disease (CAD) were not formally established until the initial findings of the Framingham Heart Study in the early 1960s. (medscape.com)
  • Many risk factors are modifiable and account for the majority of the population's attributable risk for myocardial infarction (MI). (medscape.com)
  • The expanding risk factors are included in this review following but are by no means exhaustive of all the current attributing factors. (medscape.com)
  • Traditional versus nontraditional risk factors for coronary artery disease (CAD). (medscape.com)
  • The effects of a low-carbohydrate diet vs. a low-fat diet on novel cardiovascular risk factors: a randomized controlled trial. (lowcarbaction.org)
  • These findings as a whole suggest that a LC diet is equivalent to, or more effective than, a LF diet for improving some novel CVD risk factors. (lowcarbaction.org)
  • Current management approaches for patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are based on the clinical course, the patient's risk factors and the availability of the agents ( 2 ). (spandidos-publications.com)
  • This altered glucose metabolism state is associated with an increased risk of developing T2DM (Figure 1), although other parameters including excess adiposity, inflammation and dyslipidemia are risk factors associated with the development of insulin resistance, loss of pancreatic function, worsening of hyperglycemia and progression to diabetes (1). (ddw-online.com)
  • Therefore, other independent risk factors may exist that contribute significantly to CVD risk in these patients. (ddw-online.com)
  • Identification of individuals with risk factors for the development of severe alcoholic hepatitis may provide insight to the diverse clinical spectrum and prognosis of the disease. (wjgnet.com)
  • The role of potential risk factors (e.g. liver function, platelets count, number of rubber bands placed, etc.) for PRB has not yet been entirely clarified, but a better understanding of these factors could help to avoid such complications. (springer.com)
  • The aim of this retrospective multicenter study was to assess potential risk factors for procedure-related bleeding (PRB) within 30 days after first elective/prophylactic EBL in patients with liver cirrhosis and portal hypertension. (springer.com)
  • We tested which environmental, social, lifestyle, and health related factors of the individual contribute to the seasonal variations in mood and behavior and whether these influence the risks of the metabolic syndrome and major depressive disorder, both conditions having a high prevalence in industrialized populations. (hindawi.com)
  • As a bonus, other cardiovascular risk factors such as cholesterol and triglycerides also improved. (healthyfellow.com)
  • Introduction and disability-adjusted life-years because of the Smoking is one of the leading risk factors for exposure to secondhand smoke (OBERG et al. (bvsalud.org)
  • Elevated blood pressure, smoking, diabetes and hyperlipidemia still remain the main risk factors for development of the coronary heart disease, while physical inactivity, obesity, poor nutrition and low socio-economic status are considered to be the predisposing factors. (amegroups.org)
  • Data from 31 people indicated that that annatto tocotrienol - composed mainly of delta-tocotrienol - was associated with improvements in a number of cardiovascular risk factors including inflammatory cytokines, nitric oxide (NO) and C-reactive protein (CRP). (nutraingredients.com)
  • Factors associated with an increased risk for PSC recurrence include a high Model for End-Stage Liver Disease score, first-degree relative donors, post-transplant cytomegalovirus infection , and early biliary anastomotic complications. (medscape.com)
  • Ultimately, increased left ventricular distension on a pre-clinical level may elevate the risk for future cardiovascular events in this population. (bvsalud.org)
  • In building a HCC prediction model, deaths and liver transplantations should be considered as competing events because many ALD patients experience hepatic decompensations and deaths before HCC is detected. (nature.com)
  • however, the FDA denied pediatric approval due to the risk for serious side effects, including reported cases of serious dermatologic reactions, Stevens-Johnson syndrome, potential risks for hepatic impairment or multi-organ hypersensitivity, and reported psychiatric and other side effects in children. (empowerpharmacy.com)
  • Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study. (ox.ac.uk)
  • We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. (ox.ac.uk)
  • The AHA/ACC and US Preventive Services Task Force (USPSTF) use the above as their recommendations for current risk stratification. (medscape.com)
  • These findings suggest that HCC screening for all alcoholic cirrhosis may not be cost-effective, and that further risk stratification is warranted to identify ideal candidates for surveillance in alcoholic cirrhosis. (nature.com)
  • Our study aimed to determine the association between non-alcoholic fatty liver and increased epicardial adipose tissue mass with coronary artery disease severity. (springeropen.com)
  • High epicardial adipose tissue thickness may represent a marker of severity of non-alcoholic fatty liver disease as well as an independent predictor of coronary artery disease risk. (springeropen.com)
  • One of the main concerns of the cardiology studies is how to prevent coronary artery disease development and how to estimate the risk of the disease before it becomes clinically symptomatic [ 1 ]. (springeropen.com)
  • Compensatory increases in blood pressure to increase perfusion and maintain homeostasis may increase coronary artery disease risk. (bvsalud.org)
  • Congestive heart failure and chronic coronary artery disease: The level of elevation correlates with the risk of death secondary to cardiovascular disease. (medscape.com)
  • NAFLD is recently suggested to be an independent risk for cardiovascular diseases and is also associated with higher cardiovascular mortality [ 4 ]. (springeropen.com)
  • South Asians appear to have a higher independent risk for cardiovascular disease as well. (medscape.com)
  • BMIs under 20 and over 25 have been associated with higher all-cause mortality, with the risk increasing with distance from the 20-25 range. (wikipedia.org)
  • and (3) the association between in-hospital mortality and the availability of an intensive cardiac care unit (ICCU) in the hospital. (jgc301.com)
  • In hospitals with ICCU, the in-hospital risk-adjusted mortality tended to be lower (OR = 0.85, 95% CI: 0.72-1.00, P = 0.053). (jgc301.com)
  • In another study, remdesivir was shown to decrease the likelihood of patients requiring high-flow supplementary oxygen and invasive mechanical ventilation, as well as the risk of 14-day mortality, when compared to the placebo ( 8 ). (spandidos-publications.com)
  • For instance, some research has found that higher blood pressure may actually reduce the risk of balance issues, dementia and all-cause mortality in seniors. (healthyfellow.com)
  • Often, diagnostic tests or procedures are used as predictors of surgical risk or morbidity and mortality rates because, in some cases, the risk may outweigh the benefit. (basicmedicalkey.com)
  • T. Pekka and R. Salonen, "Cohort Study of Relationship between Donating Blood and the Risk of Myocardial Infarction," British Medical Journal, Vol. 314, No. 7083, 1997, pp. 793-794. (scirp.org)
  • Herein we aimed to present novel evidence on the association of two VDBP polymorphisms (rs4588) and (rs7041) with CAD in patients after acute myocardial infarction and study possible correlations of these polymorphisms with 25-hydroxyvitamin D [25(OH)D] serum levels. (amegroups.org)
  • No correlation of 25(OH)D serum levels with CAD were established but the multivariate logistic regression modelling enabled association of total vitamin D level and VDBP (rs4588) T/T genotype with CAD and anteroseptal myocardial infarction (ASMI) CAD occurrence. (amegroups.org)
  • Ambulatory blood pressure (ABPM), ECG, fasting serum cortisol and BDNF levels and cardiometabolic risk markers were obtained. (bvsalud.org)
  • In addition, TBIL and IBIL levels were negatively correlated with increased blood pressure, waist circumference, and triglyceride levels, and their highest TBIL quartile risk (Q4) was 0.479, 0.484, and 0.498 times higher than the lowest quartile (Q1). (researchsquare.com)
  • Having experienced more numerous negative life events or low levels of social support and being nonnative or a woman are predictive of affective disorder with the seasonal pattern [ 13 ]. (hindawi.com)
  • However, studies suggest that this reading should be interpreted together with Apolipoprotein B levels (particle number) to get a full picture of one's risk of cardiovascular disease. (mitohealth.com)
  • The ratio of triglycerides to HDL is a measure of risk for heart disease and metabolic disorders, and at very high levels TG can cause immediate problems like pancreatic damage. (mitohealth.com)
  • However, having higher levels of HDL does not eliminate or negate the risk associated with high apolipoprotein B or LDL-cholesterol. (mitohealth.com)
  • Association of the VDBP (rs4588) T/T genotype with CAD patients after acute MI and correlation of VDBP (rs4588) genotype G/G with higher levels of total vitamin D were found. (amegroups.org)
  • Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. (ox.ac.uk)
  • Associations were generally stronger at higher levels of BMI or alcohol consumption. (ox.ac.uk)
  • Extrahepatic cholestasis is reflected in elevated levels of conjugated (ie, direct) bilirubin, alkaline phosphatase, and gamma-glutamyltransferase (GGT). (medscape.com)
  • CONCLUSIONS: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. (ox.ac.uk)
  • This is also the same profile for those at increased risk for unrecognized underlying liver disease, especially nonalcoholic fatty liver disease. (medscape.com)
  • The seasonal variations in mood and behavior have a metabolic factor composed of weight and appetite, and greater loadings on this factor increased the risk of metabolic syndrome (odds ratio of 1.18, 95% confidence interval of 1.10 to 1.26). (hindawi.com)
  • Individuals at high risk for severe COVID-19 are typically of older age and/or present with comorbid conditions such as diabetes, cardiovascular disease, and hypertension . (medscape.com)
  • Type 2 diabetics, but also prediabetics, are at increased risk for a wide range of debilitating diseases and diabetes is the leading cause of new cases of kidney failure and blindness and of nontraumatic lower limb amputation. (ddw-online.com)
  • On this retrospective examine of 15,104 sufferers with sort 2 diabetes, members adhering 4 to five low-risk way of life behaviors versus 0 to 1 had a 35% decrease danger of diabetic retinopathy, 57% decrease danger of diabetic kidney illness, 54% decrease danger of diabetic neuropathy, and 46% decrease danger of the composite consequence. (outfitoffice.uk)
  • Long-term tality and the risk of many chronic disorders, such as observations have confirmed the physiological activ- diabetes mellitus, hypertension, heart disease, and ity of this fat emulsion on parameters relevant to other adverse health events [1,2]. (marysfamilymedicine.org)
  • RESULTS: Africans had increased incidence of hyperglycaemia and 24-hour silent ischaemic events, and elevated 24-hour blood pressure (BP) and cortisol:BDNF ratios compared to Caucasians. (bvsalud.org)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 × 10 9 /l, and a history of severe or recurrent infections, long term administration of Neupogen is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events. (medicines.org.uk)
  • As well as, albumin, HDL-C, triglycerides, apolipoprotein A, C-reactive protein, and HbA 1c collectively defined 23.20% (12.70%, 38.50%) of the associations between total way of life behaviors and whole diabetic microvascular problems. (outfitoffice.uk)
  • Our findings demonstrate how the local environment directly affects disease risk phenotypes and that genetic variation, including less common variants, can modulate individual's response to environmental challenges. (nature.com)
  • The aim of our work was to determine the association between non-alcoholic fatty liver and increased epicardial adipose tissue mass and its relation to severity of CAD. (springeropen.com)
  • In our attempts to accomplish social isolation, individuals with underlying liver disease, or risks for liver disease, should be treated similarly to other high-risk groups. (medscape.com)
  • a multimedia review journal, and recently as a member of HCVGuidelines.org, a Web-based resource from the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America, as well as educational chair for the AASLD hepatitis C special interest group. (medscape.com)
  • Subdistribution hazards model of Fine and Gray was used with deaths and liver transplantation treated as competing risks. (nature.com)
  • These data will be presented on Monday, November 7, 2022, at The Liver Meeting®, the annual meeting of the American Association for the Study of Liver Diseases (AASLD) in Washington, D.C. (biospace.com)
  • This efficacy, together with extended exposure in the largest safety database in NASH, supports a positive benefit:risk for OCA in patients with fibrosis due to NASH," said Dr. Arun Sanyal, Chair, Division of Gastroenterology/Hepatology/Nutrition & Director, Stravitz-Sanyal Liver Institute, VCU Health, Department of Internal Medicine. (biospace.com)
  • The association of thrombocytopenia, high INR (international normalized ratio) and liver dysfunction with the risk of procedure-related bleeding (PRB) remains debated and recommendations are controversial. (springer.com)
  • Significant advances in the diagnosis and management of patients with liver disease were presented at The Liver Meeting® 2014, which is the annual meeting of the American Association for the Study of Liver Diseases (AASLD). (medscape.com)
  • RÉSUMÉ Tous les patients de sexe masculin soignés en psychiatrie et en médecine générale adressés à deux hôpitaux de Basra (Iraq) de septembre 2000 à avril 200l ont été soumis à un dépistage de l'alcoolisme par le test AUDIT (Alcohol Use Disorder Identification Test). (who.int)
  • High alcohol consumers presented delayed electrical conduction in the heart accompanied by ECG-LVH, ischemic events, and increased vaso-responsiveness, predominantly in Africans. (bvsalud.org)
  • The aforementioned alcohol-related HCC prediction models, however, used conventional cox regression without competing risk analysis. (nature.com)
  • This study aimed to assess the risk and predictors of HCC in Korean patients with alcoholic cirrhosis by using competing risk analysis. (nature.com)
  • Age, alpha-fetoprotein level, and albumin level were identified as independent predictors of HCC and incorporated in the ALICE score, which discriminated low, intermediate, and high risk for HCC in alcoholic cirrhosis at the cut-off of 60 and 100. (nature.com)
  • In this study, we sought to perform a competing-risk analysis for predicting the risk and predictors of HCC in alcoholic cirrhosis patients in Korea. (nature.com)
  • After proving to be effective in hospitalized patients, its use gained approval in early‑stage disease for symptomatic outpatients who are at a high risk of progression to severe disease. (spandidos-publications.com)
  • Compared to NSBB, EBL is associated with a lower rate of adverse events, however, potential adverse events of EBL could be more severe and life-threatening (e.g. (springer.com)
  • Additional adjustment for the metabolic syndrome (as defined by National Cholesterol Education Program Adult Treatment Panel III criteria) appreciably attenuated, but did not abolish, this association (1.53, 1.1-1.7, P = 0.02). (diabetesjournals.org)
  • Too much cholesterol in the atherogenic particles can increase the risk of disease, but cholesterol itself is not inherently bad, and is an essential part of every cell in our body. (mitohealth.com)
  • Ambulatory 24-h blood pressure and electrocardiograms (ECG), 10-lead ECG left ventricular hypertrophy (LVH), ischemic events, N-terminal pro-brain natriuretic peptide (NT-proBNP), and QTc prolongation were assessed. (bvsalud.org)
  • Regression analyses revealed associations between ECG-LVH and NT-proBNP, QTc prolongation, ischemic events, and SBP, in the African high γ-GT group exclusively. (bvsalud.org)
  • Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. (ox.ac.uk)
  • The main objective of this study was to investigate the prevalence of T. gondii among adults in the United States and its association with cardiovascular health using data from the National Health and Nutrition Examination Survey (NHANES 2009-2010). (mdpi.com)
  • A total of five adverse events (1.70%) and one serious adverse event (0.34%) were related to the pathway in target group. (jgc301.com)
  • In conclusion, NAFLD is significantly associated with a moderately increased CVD risk among type 2 diabetic individuals. (diabetesjournals.org)
  • Africans, and mostly when utilizing DefS, showed higher 24h BP, a low-grade inflammatory state, central obesity, increased HOMA [4.07 (3.66, 4.47)] and more ST events compared to their Caucasian counterparts. (bvsalud.org)
  • Tissue-dependent transcriptional and bacterial associations in primary sclerosing cholangitis-associated inflammatory bowel disease. (ox.ac.uk)
  • Neupogen is indicated for the treatment of persistent neutropenia (ANC less than or equal to 1.0 × 10 9 /l) in patients with advanced HIV infection, in order to reduce the risk of bacterial infections when other options to manage neutropenia are inappropriate. (medicines.org.uk)
  • We also performed 16S ribosomal RNA (rRNA) amplicon sequencing to determine bacterial associations with PSC/UC. (ox.ac.uk)
  • Using risk-set sampling, 496 patients (control subjects) among those who remained free of diagnosed CVD during follow-up were randomly selected in a 2:1 ratio, matched for age and sex to the case subjects. (diabetesjournals.org)
  • The risk of HCC can be stratified by using a combination of readily available clinical parameters (age, AFP level, and albumin level) in patients with alcoholic cirrhosis. (nature.com)
  • However, the recent ACCORD and ADVANCE trials in patients with longstanding T2DM have shown that aggressive glucose control in such patients has no clear benefits, or may even increase CVD events (3). (ddw-online.com)
  • As a result, patients on warfarin treatment were excluded from the IES trial because the risk of experiencing a coagulation problem in switching from previous tamoxifen to exemestane could not be excluded. (pfizermedicalinformation.ca)
  • Colorectal cancer risk in patients with PSC-associated ulcerative colitis (PSC/UC) is elevated relative to patients with ulcerative colitis (UC) alone, reasons for which remain obscure. (ox.ac.uk)
  • Consider alternatives to efavirenz in patients taking other medications with a known risk of Torsade de Pointes or in patients at higher risk of Torsade de Pointes. (nih.gov)
  • It is unclear which core events drive the malignant progression of gliomas. (biomedcentral.com)
  • It is used in existing risk prediction guidelines for heart attack and stroke. (mitohealth.com)
  • Prospective studies in T2DM have shown an association between the degree of hyperglycemia and the risk of micro- and macrovascular complications, including fatal CVD events. (ddw-online.com)
  • Surveillance for HCC is recommended for high-risk groups in order to facilitate early detection and improve survival 3 . (nature.com)
  • Background Some studies have shown that a high level of bilirubin is a protective factor against the metabolic syndrome (MS), while a high level of transaminase is a risk factor for the MS. However, the results are inconsistent, and there are few cohort studies. (researchsquare.com)
  • Only high MELD, and especially high bilirubin seem to be linked to an increased risk of EBL-related bleeding. (springer.com)